KEGG ORTHOLOGY: K07360

ORTHOLOGY: K07360

Entry

K07360                      KO

Symbol

ZAP70

Name

tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]

Pathway

map04014

Ras signaling pathway

map04064

NF-kappa B signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map05135

Yersinia infection

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05340

Primary immunodeficiency

Disease

H00093

Combined immunodeficiency

H02540

Infantile-onset multisystem autoimmune disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04064 NF-kappa B signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04660 T cell receptor signaling pathway
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04658 Th1 and Th2 cell differentiation
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
   04659 Th17 cell differentiation
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
  09163 Immune disease
   05340 Primary immunodeficiency
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07360  ZAP70; tyrosine-protein kinase ZAP-70
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K07360  ZAP70; tyrosine-protein kinase ZAP-70
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  SYK family
   K07360  ZAP70; tyrosine-protein kinase ZAP-70

Other DBs

GO:

0004715

Genes

HSA:	7535(ZAP70)

PTR:	459427(ZAP70)

PPS:

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:	102135442(ZAP70)

MTHB:

126934295

MNI:

105490058

CSAB:

103241092(ZAP70)

CATY:

105583698(ZAP70)

PANU:

101008565 116270368

TGE:

112604729

MLEU:

105531655(ZAP70)

RRO:

RBB:

TFN:

PTEH:

CANG:

105522125(ZAP70)

CJC:

100390922

SBQ:	101036932(ZAP70)

CIMI:

108301032

ANAN:

105706424 135273059 135273177

CSYR:

103256352

MMUR:

105883661

LCAT:

123637224

PCOQ:

105808257(ZAP70)

OGA:

100944134

MMU:	22637(Zap70)

MCAL:

110297598

MPAH:

110321893

RNO:	301348(Zap70)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103738088(Zap70)

HGL:	101716577(Zap70)

CPOC:

100713473

CCAN:

109695320

DORD:

105988287(Zap70)

DSP:

122121358

DMER:

138804288(Zap70) 138807808

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

TUP:	102469719(ZAP70)

GVR:	103582470 103610308

CFA:	100271860(ZAP70)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

101682004(ZAP70)

MNP:

132021583

MLK:

131808568

NVS:

122915688

ORO:	101377393(ZAP70)

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101097059(ZAP70)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:	102969244(ZAP70)

PPAD:

PUC:

PLEZ:

HHV:

BTA:	504509(ZAP70)

BOM:	102287403(ZAP70)

BIU:

109565800

BBUB:

102408544

BBIS:

104980820(ZAP70)

CHX:

102176695

OAS:

101112639

BTAX:

128056450

CSUM:

138077523(ZAP70)

ODA:

120883562

CCAD:

122441383

MREE:

136163031(ZAP70)

OVR:	110145456(ZAP70)

MBEZ:

129539813

SSC:

100739325

CFR:

102509559

CBAI:

105072189(ZAP70)

CDK:

105099801

VPC:

102535826

BACU:

103014268(ZAP70)

BMUS:

118906079

LVE:	103074297(ZAP70)

OOR:

101286910

LALB:

132531642

GMF:	115843144(ZAP70)

DLE:

111187417

PCAD:

102996375

PSIU:

116764531

PPHC:

136134146(ZAP70)

NASI:

112398972

ECB:	100147296(ZAP70)

EPZ:	103561441(ZAP70)

EAI:

106842544

MYB:	102259670(ZAP70)

MYD:	102775001(ZAP70)

MMYO:

118652481

MLF:

102418755

MDT:

132213040

MYUM:

139020166(ZAP70)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

101542134(ZAP70)

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	100025187(ZAP70)

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138175743(ZAP70)

MLAO:

141501247(ZAP70)

TACU:

119950537

GGA:	420086(ZAP70)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106048412(ZAP70)

CATA:

118260542

AFUL:

116499164

TGU:

100229988

LSR:	110478014(ZAP70)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139602255(ZAP70)

GFR:	102034810(ZAP70)

FAB:	101809285(ZAP70)

OMA:

130264618

PHI:	102108601(ZAP70)

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138099651(ZAP70)

ETL:

114070354

ZAB:

102067049

ZLE:

135458835

ACHL:

103808683(ZAP70)

SVG:

106857062

MMEA:

130586292

HRT:

120763509

SATI:

136371931(ZAP70)

CCIC:

134054332

FPG:	101916784(ZAP70)

FCH:

102059049

CCRI:

104166677(ZAP70)

NNT:	104405591(ZAP70)

SHAB:

ACUN:

TALA:

ACHC:

HALD:

104318887(ZAP70)

HLE:	104828554(ZAP70)

AGEN:

126041782

HHAR:

128147995

GCL:

127025586

CSTI:

104551177(ZAP70)

LDI:	104350202(ZAP70)

MNB:	103769728(ZAP70)

DPUB:

104309483(ZAP70)

PPUS:

135192068

AVIT:

104272432

BRHI:

104497430(ZAP70)

EGZ:

104132036

NNI:	104018770(ZAP70)

PCRI:

104037735(ZAP70)

PCAO:

104043221(ZAP70)

PADL:

103921148(ZAP70)

AFOR:

103900447

FGA:	104080535(ZAP70)

GSTE:

104262554(ZAP70)

CBOY:

140643531(ZAP70)

CLV:

102088841

CNIC:

135999144

MUI:	104539949(ZAP70)

PGUU:

104465787(ZAP70)

PLET:

104619578(ZAP70)

EHS:	104514526(ZAP70)

CMAC:

104483940(ZAP70)

CUCA:

104063473

TEO:	104371008(ZAP70)

BREG:

104641115(ZAP70)

OHA:	104335639(ZAP70)

ACAR:

104530201

CPEA:

104392900(ZAP70)

CVF:	104290087(ZAP70)

RTD:

128900535

CRID:

134526212

AAM:	106486099(ZAP70)

AROW:

112972325

NPD:

112949075

TGT:	104568052(ZAP70)

DNE:

112989597

SCAM:

104139149(ZAP70)

ASN:

AMJ:

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:	106542969(ZAP70)

PGUT:

117677512

PCAE:

139308304(ZAP70)

APRI:

131188271

PTEX:

113434916

NSS:

113420949

VKO:	123021393 123021463

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108706868(zap70.S) 446840(zap70.L)

XTR:	448557(zap70)

NPR:

108798239

RTEM:

120916246

ACAT:

141108031(ZAP70)

BBUF:

120989581

BGAR:

122946439

DTC:	141048488(ZAP70)

PWL:	138268015(ZAP70)

MUO:

115479942

GSH:

117365392

DRE:	553615(zap70)

SRX:	107731183 107745809

SANH:

107676994 107695253

SGH:	107548917 107585931

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141287709(zap70)

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137026995(zap70)

MASI:

127424295

TROS:

130568558

TDW:

130440164

MANU:

129414277(zap70)

PDAB:

135729266(zap70)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

TRU:

TFS:

TNG:	GSTEN00019257G001

LCO:

104921819

NCC:	104944350(zap70)

TBEN:

117496052

CGOB:

115006798

PGEO:

117444945(zap70)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137793555(zap70)

CVE:	137870375(zap70)

MSAM:

119900445

SCHU:

122877824

CUD:

121512790

SPUL:

138607020(zap70)

LMIX:

132967910

ALAT:

119029322

ASTR:

137598866(zap70)

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

106516821(zap70)

NWH:

119430560

AOCE:

111580186

EJA:	138200497(zap70)

BFRE:

138632498(zap70)

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125968921(zap70)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140354141(zap70)

MALB:

BSPL:

SJO:

SSCO:

GMH:

SASA:

STRU:

OTW:	112242249 112250942

OMY:	110521509 110524376

OGO:	123997009 124037725

ONE:	115108383 115144959

OKI:	109897908 109902571

OKE:	118359179 118390472

OMM:	135512851 135556454

OCLA:

139406581 139410173

SALP:

111971408 111975278

SNH:	120051818 120054481

CCLU:

ELS:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:	102357488(ZAP70)

CMK:

RTP:

CPLA:

HOC:

LERI:

HAKA:

140739702(zap70)

PMRN:

LRJ:

BBEL:

SCLV:

LPIC:

OFU:

TCF:

VDE:

VJA:

UDV:

SDM:

OED:

MMER:

DGT:

XEN:	124443747 124445826

HSY:	130635496 130635613

» show all

Reference

PMID:14985102

Authors

Kuroyama H, Ikeda T, Kasai M, Yamasaki S, Tatsumi M, Utsuyama M, Saito T, Hirokawa K

Title

Identification of a novel isoform of ZAP-70, truncated ZAP kinase.

Journal

Biochem Biophys Res Commun 315:935-41 (2004)
DOI:10.1016/j.bbrc.2004.01.127

Sequence

[hsa:7535]

All links

Ontology (1)   
   GO (1)   
Gene (375)   
   MGENES (218)   
   RefGene (152)   
   OC (5)   
All databases (376)   

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