KEGG ORTHOLOGY: K07370

ORTHOLOGY: K07370

Entry

K07370                      KO

Symbol

BTK

Name

Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]

Pathway

map04064

NF-kappa B signaling pathway

map04380

Osteoclast differentiation

map04611

Platelet activation

map04662

B cell receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map05169

Epstein-Barr virus infection

map05340

Primary immunodeficiency

Disease

H00085

Agammaglobulinemias

H00254

Growth hormone deficiency

H02035

Isolated growth hormone deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
   04662 B cell receptor signaling pathway
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
   04664 Fc epsilon RI signaling pathway
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
  09163 Immune disease
   05340 Primary immunodeficiency
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  TEC family
   K07370  BTK; Bruton agammaglobulinemia tyrosine kinase

Other DBs

GO:

0004715

Genes

HSA:

695(BTK)

PTR:	465759(BTK)

PPS:	100992723(BTK)

GGO:	101141049(BTK)

PON:	100443503(BTK)

PPYG:

129024908(BTK)

NLE:	100594539(BTK)

HMH:	116811871(BTK)

SSYN:

129476405(BTK)

MCC:	703000(BTK)

MCF:	102123534(BTK)

MTHB:

126945989

MNI:	105499313(BTK)

CSAB:

103232359(BTK)

CATY:

105592035(BTK)

PANU:

101008275(BTK)

TGE:	112615467(BTK)

MLEU:

105528165(BTK)

RRO:	104659579(BTK)

RBB:	108544993(BTK)

TFN:	117085522(BTK)

PTEH:

111536504(BTK)

CANG:

105520681(BTK)

CJC:	100406337(BTK)

SBQ:	101054345(BTK)

CIMI:

108287438(BTK)

ANAN:

105707832(BTK)

CSYR:

103254974(BTK)

MMUR:

105873066(BTK)

PCOQ:

105814900(BTK)

OGA:	100956054(BTK)

MMU:	12229(Btk)

MCAL:

110286488(Btk)

MPAH:

110313310(Btk)

RNO:	367901(Btk)

MCOC:

116088560(Btk)

ANU:	117694372(Btk)

ASYL:

127674917(Btk)

MUN:	110541656(Btk)

CGE:	100772144(Btk)

MAUA:

101840648(Btk)

PROB:

127218588(Btk)

PLEU:

114697015(Btk)

MORG:

121436695 121437155

MFOT:

126493562

AAMP:

119804704(Btk)

NGI:	103746197(Btk)

HGL:	101715242(Btk)

CPOC:

100714123(Btk)

CCAN:

109692203(Btk)

DORD:

105999931(Btk)

DSP:	122096887(Btk)

DMER:

138840184(Btk)

PLOP:

125343604(Btk)

NCAR:

124971859

MMMA:

107156260(Btk)

ITI:	101966579(Btk)

OCU:

100354225

OPI:	101516844(BTK)

TUP:	102472301(BTK)

GVR:	103600402(BTK)

CLUD:

112649417(BTK)

VVP:	112925763(BTK)

VLG:	121482285(BTK)

NPO:	129518807(BTK)

AML:	100472303(BTK)

UMR:	103672987(BTK)

UAH:	113244303(BTK)

UAR:	123793929(BTK)

ELK:

111159177

LLV:

125091607

MPUF:

101685094(BTK)

MNP:	132006911(BTK)

MLK:	131821271(BTK)

NVS:	122896979(BTK)

ORO:	101368233(BTK)

EJU:	114202535(BTK)

ZCA:	113930696(BTK)

MLX:	118022875(BTK)

NSU:	110585603(BTK)

LWW:	102733386(BTK)

FCA:	101088062(BTK)

PYU:	121024937(BTK)

PCOO:

112871134(BTK)

PBG:	122477972(BTK)

PVIV:

125156915(BTK)

LRUF:

124509577

LGF:	123594175(BTK)

AJU:

106984233

PTG:	102948492(BTK)

PPAD:

109258849(BTK)

PUC:

125931830

HHV:	120220893(BTK)

BTA:	533459(BTK)

BOM:	102284433(BTK)

BIU:	109555469(BTK)

BBUB:

102397606(BTK)

BBIS:

104998915(BTK)

CHX:	102176204(BTK)

OAS:	101105725(BTK)

BTAX:

128069852(BTK)

CSUM:

138070814(BTK)

ODA:	120881312(BTK)

CCAD:

122434992(BTK)

MREE:

136153317(BTK)

OVR:	110124408(BTK)

MBEZ:

129534995(BTK)

SSC:	100627308(BTK)

CFR:	102521853(BTK)

CBAI:

105080742(BTK)

CDK:	105085487(BTK)

VPC:	102534116(BTK)

BACU:

103007481(BTK)

BMUS:

118888611(BTK)

LVE:	103086425(BTK)

OOR:	101282522(BTK)

LALB:

132512987(BTK)

GMF:	115843941(BTK)

DDP:	132418571(BTK)

DLE:	111178233(BTK)

PCAD:

102991038(BTK)

PSIU:

116747469(BTK)

PPHC:

136142522(BTK)

NASI:

112400660(BTK)

ECB:	100057626(BTK)

EPZ:	103542797(BTK)

EAI:	106823084(BTK)

MYB:	102248642(BTK)

MYD:	102758552(BTK)

MMYO:

118654418(BTK)

MLF:	102422436(BTK)

MDT:	132223978(BTK)

PKL:	118720037(BTK)

EFUS:

103299705(BTK)

MNA:	107524029(BTK)

DRO:	112321325(BTK)

SHON:

118996677(BTK)

AJM:	119038485(BTK)

PDIC:

114505208(BTK)

PHAS:

123805219(BTK)

MMF:	118635763(BTK)

PPAM:

129069600(BTK)

HAI:	109374529(BTK) 109391632(TIMM29)

RFQ:	117024681(BTK)

PALE:

102878592(BTK)

PGIG:

120611559(BTK)

PVP:	105308057(BTK)

RAY:	107503613(BTK)

MJV:	108397835(BTK)

TOD:	119246027(BTK)

SARA:

101559413(BTK)

SFUM:

130032647(BTK)

SETR:

125998575(BTK)

LAV:	100670387(BTK)

TMU:

101356880

ETF:	101649952(BTK)

DNM:	101426005(BTK)

MDO:	100022891(BTK)

GAS:	123253279(BTK)

SHR:	100929183(BTK)

AFZ:

127542490

PCW:	110192312(BTK)

TVP:	118832940(BTK)

PBRV:

138143941(BTK)

MLAO:

141503202(BTK)

OAA:	100080912(BTK)

TACU:

119929721(BTK)

GGA:	374075(BTK)

PCOC:

116229562(BTK)

MGP:	100540531(BTK)

CJO:	107312560(BTK)

TPAI:

128076116(BTK)

LMUT:

125699747(BTK)

NMEL:

110403020(BTK)

APLA:

101801225(BTK)

ACYG:

106037664(BTK)

CATA:

118245633(BTK)

AFUL:

116494396(BTK)

TGU:	100219452(BTK)

LSR:	110472678(BTK)

SCAN:

103824231(BTK)

PMOA:

120506161(BTK)

OTC:	121331749(BTK)

PRUF:

121363163(BTK)

ATRC:

139597367(BTK)

GFR:	102034670(BTK)

FAB:	101820538(BTK)

OMA:	130253332(BTK)

PHI:	102110408(BTK)

PMAJ:

107203971(BTK)

CCAE:

111929395(BTK)

CCW:	104691647(BTK)

CBRC:

103617844(BTK)

ACOE:

138110549(BTK)

ETL:	114066193(BTK)

ZAB:	102073407(BTK)

ZLE:	135447911(BTK)

ACHL:

103810257(BTK)

SVG:	106853738(BTK)

MMEA:

130577298(BTK)

HRT:	120762102(BTK)

SATI:

136370516(BTK)

CCIC:

134049990(BTK)

FPG:	101911050(BTK)

FCH:	102050747(BTK)

CCRI:

104166356(BTK)

NNT:	104410008(BTK)

SHAB:

115612603(BTK)

ACUN:

113479932(BTK)

TALA:

104364132(BTK)

ACHC:

115333865(BTK)

HALD:

104314423(BTK)

HLE:	104832564(BTK)

AGEN:

126050343

HHAR:

128153851(BTK)

GCL:

127019524

CSTI:

104563929(BTK)

LDI:	104352532(BTK)

MNB:	103768553(BTK)

DPUB:

104306357(BTK)

PPUS:

135183835(BTK)

AVIT:

104278685(BTK)

BRHI:

104490616(BTK)

EGZ:	104135432(BTK)

NNI:	104015352(BTK)

PCRI:

104039059(BTK)

PCAO:

104046387(BTK)

PADL:

103923328(BTK)

AFOR:

103904783(BTK)

FGA:	104073335(BTK)

GSTE:

104261635(BTK)

CBOY:

140658666(BTK)

CLV:	102089403(BTK)

CNIC:

135993291(BTK)

MUI:	104536215(BTK)

PGUU:

104463734(BTK)

PLET:

104623390(BTK)

EHS:	104506278(BTK)

CMAC:

104482145(BTK)

CUCA:

104069017(BTK)

TEO:	104378674(BTK)

BREG:

104634291(BTK)

OHA:	104329560(BTK)

ACAR:

104530109(BTK)

CPEA:

104388334(BTK)

CVF:	104290171(BTK)

RTD:	128914722(BTK)

CRID:

134520558(BTK)

AAM:	106484985(BTK)

AROW:

112966366(BTK)

NPD:	112960427(BTK)

TGT:	104576116(BTK)

DNE:	112989771(BTK)

SCAM:

104152353(BTK)

ASN:	102379774(BTK)

AMJ:	102562876(BTK)

CPOO:

109310934(BTK)

GGN:	109300532(BTK)

PSS:	102452612(BTK)

CMY:	102945423(BTK)

CCAY:

125642112(BTK)

DCC:	119861584(BTK)

CPIC:

101931069(BTK)

TST:	117883246(BTK)

CABI:

116820013(BTK)

MRV:	120372414(BTK)

ACS:	100561192(btk)

ASAO:

132763025(BTK)

PVT:	110084914(BTK)

SUND:

121937322(BTK)

PBI:	103065824(BTK)

PMUR:

107291582(BTK)

CTIG:

120302396(BTK)

TSR:	106538787(BTK) 106544086

PGUT:

117669513(BTK)

PCAE:

139322915(BTK)

APRI:

131183862(BTK)

PTEX:

113437804(BTK)

VKO:	123022084(BTK)

PMUA:

114589272(BTK)

PRAF:

128406373(BTK)

ZVI:	118088505(BTK)

HCG:	128335541(BTK)

GJA:	107123933(BTK)

EMC:	129341194(BTK)

XLA:	108698274(btk.L)

XTR:	100170477(btk)

NPR:	108799566(BTK)

RTEM:

120913056(BTK)

BBUF:

120977595(BTK)

BGAR:

122946795(BTK)

DTC:	141087521(BTK)

PWL:	138265598(BTK)

MUO:	115474308(BTK)

GSH:	117360250(BTK)

DRE:	568653(btk)

SRX:	107740143 107742472

SANH:

107680332 107680953(btk)

SGH:	107554824 107593204

CCAR:

109087940(btk)

CAUA:

113075391 113081212 113114126

CGIB:

127971689 128027459

PTET:

122357446(btk)

LROH:

127176171(btk)

GRF:	141288407(btk)

OMC:	131553271(btk)

PPRM:

120466134(btk)

RKG:	130103927(btk)

MAMB:

125258799(btk)

CIDE:

127494513

CERY:

137021569(btk)

MASI:

127412974 127417906

TROS:

130563440(btk)

TDW:	130438275(btk)

MANU:

129422467(btk)

PDAB:

135758319(btk)

IPU:

108269130

IFU:	128611339(btk)

PHYP:

113542865(btk)

SMEO:

124386142(btk)

TFD:	113635851(btk)

TVC:	132855475(btk)

CGAR:

128532030(btk)

NGRA:

132890598(btk)

TRN:	134308117 134308125

AMEX:

103034846(btk)

CMAO:

118807097(btk)

EEE:	113573405(btk)

CHAR:

105911755(btk)

SPIL:

134068652(btk)

TRU:	101073533(btk)

TFS:	130531550(btk)

TNG:	GSTEN00029283G001

LCO:	104925368(btk)

NCC:	104964530(btk)

TBEN:

117488719(btk)

CGOB:

115014295(btk)

PGEO:

117453540(btk)

GACU:

117541065(btk)

EMAC:

134859590(btk)

ELY:	117260742 117261478(btk)

EFO:	125894121(btk)

PLEP:

121948558(btk)

SLUC:

116052272(btk)

ECRA:

117952215(btk)

ESP:	116696721(btk)

PFLV:

114562534(btk)

GAT:	120818207(btk)

PPUG:

119211097(btk)

AFB:	129089645(btk)

CLUM:

117737142(btk)

PSWI:

130209377(btk)

CANA:

137795045(btk)

CVE:	137875678(btk)

MSAM:

119888677(btk)

SCHU:

122880464(btk)

CUD:	121516738(btk)

SPUL:

138597965(btk)

LMIX:

132982178(btk)

ALAT:

119007475(btk)

ASTR:

137602908(btk)

MZE:	101467854(btk)

ONL:	100711194(btk)

OAU:	116321038(btk)

OLA:	101168549(btk)

OML:	112153478(btk)

CSAI:

133447187(btk)

XMA:	102229275(btk)

XCO:	114139713(btk)

XHE:	116714919(btk)

PRET:

103471526(btk)

PFOR:

103151723(btk)

PLAI:

106949973(btk)

PMEI:

106920035(btk)

GAF:	122837087(btk)

PPRL:

129360798 129360810

CVG:	107093425(btk)

CTUL:

119781000(btk)

GMU:	124860234(btk)

NFU:	107377689(btk)

KMR:	108231212(btk)

ALIM:

106514519(btk)

NWH:	119408852(btk)

AOCE:

111577298(btk)

EJA:	138210964(btk)

BFRE:

138618486(btk)

MCEP:

125007890(btk)

CSEM:

103390584(btk)

POV:	109627038(btk)

SSEN:

122778020(btk)

SSOE:

131472124(btk)

HHIP:

117768787(btk)

HSP:	118112325(btk)

PPLT:

128446017(btk)

SMAU:

118319376(btk)

LCF:

108895374

SDU:	111232725(btk)

SLAL:

111648188(btk)

XGL:	120785601(btk)

HCQ:	109515846(btk)

SSCV:

125985848(btk)

SBIA:

133508502(btk)

PEE:	133408063(btk)

PTAO:

133484818(btk)

BPEC:

110158863

ENY:	140350124(btk)

MALB:

109956117(btk)

BSPL:

114864556(btk)

SJO:	128363187(btk)

SSCO:

133985429(btk)

GMH:	115552105(btk)

SASA:

100194909(btk)

STRU:

115169806(btk)

OTW:	112221095(btk)

OMY:	110488987(btk)

OGO:	123993575(btk)

ONE:	115130866(btk)

OKI:	109864893(btk)

OKE:	118380475(btk)

OMM:	135538654(btk)

OCLA:

139366409

SALP:

111965886(btk)

SNH:	120047991(btk)

CCLU:

121534936 121540741

ELS:	105025807(btk)

OEP:	134032222(btk)

SFM:	108922820(btk) 108931000

PKI:	111833669(btk) 111835079

AANG:

118223100(btk) 118234831

AROT:

135251664 135263008

CCOG:

133123859(btk) 133133846

LOC:	102682236(btk)

PSPA:

121295222 121318801(btk)

ARUT:

117430388(btk)

PSEX:

120537234(btk)

LCM:	102346267(BTK)

RTP:	109912332(btk)

CPLA:

122557051(btk)

HOC:	132820426(btk)

HAKA:

140734492(btk)

PMRN:

LRJ:

CRG:

CANU:

CVN:

HSY:

RES:

Reference

PMID:20206686

Authors

Bradshaw JM

Title

The Src, Syk, and Tec family kinases: distinct types of molecular switches.

Journal

Cell Signal 22:1175-84 (2010)
DOI:10.1016/j.cellsig.2010.03.001

Sequence

[hsa:695]

Reference

PMID:8380905

Authors

Vetrie D, Vorechovsky I, Sideras P, Holland J, Davies A, Flinter F, Hammarstrom L, Kinnon C, Levinsky R, Bobrow M, et al.

Title

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.

Journal

Nature 361:226-33 (1993)
DOI:10.1038/361226a0

Sequence

[hsa:695]

All links

Ontology (1)   
   GO (1)   
Gene (561)   
   MGENES (285)   
   RefGene (272)   
   OC (4)   
All databases (562)   

Download RDF

DBGET integrated database retrieval system