KEGG ORTHOLOGY: K07408

ORTHOLOGY: K07408

Entry

K07408                      KO

Symbol

CYP1A1

Name

cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]

Pathway

map00140

Steroid hormone biosynthesis

map00380

Tryptophan metabolism

map00830

Retinol metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map01100

Metabolic pathways

map04913

Ovarian steroidogenesis

map05204

Chemical carcinogenesis - DNA adducts

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

map05417

Lipid and atherosclerosis

Reaction

R02354

R02355

R03089

R03408

R03629

melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase

R07000

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07001

naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07021

1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07022

1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07079

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07080

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07081

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07085

benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07087

9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07098

trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07099

trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R08390

R08392

R09418

R09423

R09442

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05207 Chemical carcinogenesis - receptor activation
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP1 family
   K07408  CYP1A1; cytochrome P450 family 1 subfamily A1

Genes

HSA:	1543(CYP1A1)

PTR:	453744(CYP1A1)

PPS:	100976184(CYP1A1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	678694(CYP1A1)

MCF:	102129994(CYP1A1)

MTHB:

126960000

MNI:

105490958

CSAB:

103245331(CYP1A1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100393083(CYP1A1)

SBQ:

101038217

CIMI:

108298444(CYP1A1)

ANAN:

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13076(Cyp1a1)

MCAL:

110301270

MPAH:

110328033

RNO:	24296(Cyp1a1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

100135512(Cyp1a1)

CCAN:

DORD:

DSP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	100686778(CYP1A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	554347(CYP1A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	282870(CYP1A1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:	100170113(CYP1A1)

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	403103(CYP1A1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100062285(CYP1A1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:	119041322 119041329

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:	118828075 118828076

OAA:	100080942(CYP1A1)

ZVI:

118084457

STOW:

125424760

BBEL:

109480286

SCLV:

120326955 120337706 120347324

LPIC:

129258591 129274985

PVUL:

126810086 126812565 126815240 126823790 126825192

GAE:

121368990

HRF:	124120352 124120359 124131529 124140277

HRJ:	124268175 124276990 124282406

CRG:

105329067

CANU:

128190897

OED:	125647398 125648732

MMER:

123540564 123540605 123541431 123546444 123546459 123546828 123549057 123557949 123562948 123562951

RPHI:

132713371 132719301 132727684 132731161 132731163 132733404 132733414 132736383 132738690 132744217 132754874 132757640

DPOL:

127850854

MAEA:

128206276 128206748 128228746 128236623

ATEN:

116286948 116286970 116287897

XEN:	124435028 124452841 124452890

HSY:

130646034

» show all

Reference

PMID:2989797

Authors

Jaiswal AK, Gonzalez FJ, Nebert DW

Title

Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.

Journal

Nucleic Acids Res 13:4503-20 (1985)
DOI:10.1093/nar/13.12.4503

Sequence

[hsa:1543]

Reference

PMID:3019683

Authors

Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y

Title

Structure and drug inducibility of the human cytochrome P-450c gene.

Journal

Eur J Biochem 159:219-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09857.x

Sequence

[hsa:1543]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (33)   
   KEGG ENZYME (1)   
   KEGG REACTION (21)   
   KEGG RCLASS (11)   
Gene (447)   
   KEGG GENES (215)   
   KEGG MGENES (21)   
   RefGene (198)   
   OC (13)   
Literature (2)   
   PubMed (2)   
All databases (505)   

Download RDF

ORTHOLOGY: K07410

Entry

K07410                      KO

Symbol

CYP1B1

Name

cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]

Pathway

map00140

Steroid hormone biosynthesis

map00380

Tryptophan metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map04913

Ovarian steroidogenesis

map05204

Chemical carcinogenesis - DNA adducts

map05206

MicroRNAs in cancer

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

Reaction

R03088

R03090

R03629

melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase

R07079

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07080

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07081

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07085

benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07087

9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R09416

R09418

R09442

Disease

H01159

Anterior segment dysgenesis

H01203

Primary congenital glaucoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05204 Chemical carcinogenesis - DNA adducts
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05207 Chemical carcinogenesis - receptor activation
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP1 family
   K07410  CYP1B1; cytochrome P450 family 1 subfamily B1

Genes

HSA:	1545(CYP1B1)

PTR:	459163(CYP1B1)

PPS:	100989599(CYP1B1)

GGO:

PPYG:

NLE:

HMH:

SSYN:

MCC:	710385(CYP1B1)

MCF:	102146810(CYP1B1)

MTHB:

126933548

MNI:

105464862

CSAB:

103220462(CYP1B1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100395270(CYP1B1)

SBQ:

101049264

CIMI:

108293778(CYP1B1)

ANAN:

105733181(CYP1B1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13078(Cyp1b1)

MCAL:

110312728

MPAH:

110335735

RNO:	25426(Cyp1b1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	483038(CYP1B1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:	111158468 111158469

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101099873(CYP1B1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	511470(CYP1B1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100070088(CYP1B1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:	100079784(CYP1B1)

GGA:	421466(CYP1B1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106029463(CYP1B1)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

FAB:

OMA:

PHI:

PMAJ:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

SVG:

MMEA:

HRT:

SATI:

136359346(CYP1B1)

FPG:

FCH:

SHAB:

ACUN:

TALA:

ACHC:

HLE:

AGEN:

GCL:

DPUB:

EGZ:

NNI:

PADL:

AFOR:

CLV:

CUCA:

CPEA:

RTD:

AAM:

AROW:

NPD:

DNE:

ASN:	102377626 102384287

AMJ:	102560255(CYP1B1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108716653(cyp1b1.L) 108717803(cyp1b1.S)

XTR:	100490477(cyp1b1)

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	100150054(cyp1b1)

SRX:	107719205 107747251

SANH:

107665613 107676394

SGH:	107549156 107586077

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137020866(cyp1b1)

MASI:

TROS:

TDW:

MANU:

IPU:	100313516(cyp1b)

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

LCO:

NCC:	104946527 104949720

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:	100653403(cyp1b1)

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

MALB:

BSPL:

SJO:

SASA:

STRU:

OTW:	112252828 112252866

OMY:	100381269(cyp1b1) 110502297

OGO:

124041418

ONE:	115113365 115135284

OKI:	109889798 109899606

OKE:	118369530 118401769

SALP:

111952066 111978757

SNH:	120017899 120045592

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116939745 116943149 116948393

LRJ:	133339223 133347278 133352819

SCLV:

CRG:

CANU:

CVN:

OED:	125657726 125670494

MMER:

123544838

RPHI:

132723153 132751856 132757626

MAEA:

128228812

XEN:	124445177 124446641

» show all

Reference

PMID:8175734

Authors

Sutter TR, Tang YM, Hayes CL, Wo YY, Jabs EW, Li X, Yin H, Cody CW, Greenlee WF

Title

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

Journal

J Biol Chem 269:13092-9 (1994)
DOI:10.1016/S0021-9258(17)36803-5

Sequence

[hsa:1545]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Disease (2)   
   KEGG DISEASE (2)   
Chemical reaction (16)   
   KEGG ENZYME (1)   
   KEGG REACTION (11)   
   KEGG RCLASS (4)   
Gene (525)   
   KEGG GENES (409)   
   KEGG MGENES (55)   
   RefGene (57)   
   OC (4)   
Literature (1)   
   PubMed (1)   
All databases (563)   

Download RDF

DBGET integrated database retrieval system