KEGG   ORTHOLOGY: K07412
Entry
K07412                      KO                                     
Symbol
CYP2B
Name
cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map05207  Chemical carcinogenesis - receptor activation
Reaction
R03408  
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07048  
R07050  
R07051  
R07052  
R08390  
R08391  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
   00590 Arachidonic acid metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07412  CYP2B; cytochrome P450 family 2 subfamily B
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07412  CYP2B; cytochrome P450 family 2 subfamily B
Genes
PCOQ: 105820475 105820477 105820598
OGA: 105888244
MMU: 13088(Cyp2b10) 13089(Cyp2b13) 13090(Cyp2b19) 13094(Cyp2b9) 243881(Cyp2b23)
MCAL: 110288440 110288965 110297861 110298448 110298729 110298847
MPAH: 110336742
RNO: 103691072(Cyp2b14) 103691092 24300(Cyp2b1) 286953(Cyp2b3) 292728(Cyp2b21) 29295(Cyp2b12) 361523(Cyp2b2) 685222(Cyp2b15)
MCOC: 116100420 116101862 116101866
ANU: 117710642 117710646 117714125
MUN: 110541208 110541305 110561195 110566202
CGE: 100759787 100760248 100762876 100763166 100763652 100765152 100765441 113837198 113838302
MAUA: 101833813 101844221 101844487 101844759 110339371 110339777 121135526 121135543
PROB: 127238392 127238393 127238561 127238677
PLEU: 114681539 114681540 114685303 114685307 114685311 114709908
MORG: 121449160 121449161 121449216 121449230 121449273 121449308 121449313
MFOT: 126491014 126491015 126491016 126491474 126492551 126492557 126492560 126494574 126494580
AAMP: 119820529 119820530 119820531 119820542 119820560 119820577 119820578 119821048 119821050
NGI: 103734444 103734445
HGL: 101700457 101713256
CPOC: 100719649 100720199 100728848
CCAN: 109680163 109703253
DORD: 106000902 106002870
DSP: 122097399 122097400
PLOP: 125338988 125338999
NCAR: 124966667 124966693 124966955
MMMA: 107151434 107151634
OCU: 100327257(CYP2B4) 100328947(CYP2B5) 100328948 100353574 127486083
OPI: 101530662
TUP: 102479421 102494535
GVR: 103600497
CFA: 474177(CYP2B6)
CLUD: 112645436
VVP: 112928354
VLG: 121485519
NPO: 129499612
AML: 100464347 100471209
UMR: 103677389 103677390
UAH: 113243545 113243547
UAR: 123782650 123782733
ELK: 111161484 111161535
LLV: 125089181 125089182
MPUF: 101673760 101674033
MNP: 132005762 132005763
MLK: 131817740 131817741
NVS: 122912057 122912058
ORO: 101366852 101385757
EJU: 114202558
ZCA: 113936245 113936360
MLX: 118022638
NSU: 110590260
FCA: 105259649(CYP2B6) 105260134
PYU: 121026667 121026668
PCOO: 112851322
PBG: 122494012 122494013
PVIV: 125152576 125153441 125153673
LRUF: 124511102 124511733
PPAD: 109261476
PUC: 125915742
AJU: 128313207 128313238
HHV: 120243430
BTA: 504769(CYP2B6) 530571(CYP2B39)
BOM: 102282243 102287777
BIU: 109572039 109573028
BBUB: 102389842 102403709
BBIS: 104995375 104995377
CHX: 102169213 102177329 108633257 108634920
OAS: 105614373 114117814 114117992
BTAX: 128063721 128063735 128063836 128063962
ODA: 120872403 120872470 120873272 120873273 120873274
CCAD: 122420841 122420842 122421523 122421559
MBEZ: 129546790
SSC: 102165015 403104(CYP2B22)
CFR: 102506939 102510644
CBAI: 105062874 105062875
CDK: 105093362 105093363
VPC: 102540531 102541423
ECB: 100068569 100068603
EPZ: 103562352 103562353 103567950
EAI: 106843260 106843311 106843807 123281262
MYB: 102245131
MYD: 102751643
MMYO: 118674745
MLF: 102434131 102434449
MDT: 132216860
PKL: 118702365
EFUS: 103284293
DRO: 112319965
AJM: 119042877 119064581
PDIC: 114511724
PHAS: 123823834
MMF: 118639252
PPAM: 129076628
HAI: 109376598 109376600
RFQ: 117035075
PGIG: 120595325
PVP: 105311372 105311521
RAY: 107521826
MJV: 108405662
TOD: 119248644 119249343 119249344
SARA: 101545542 101545812 101546075 101546339 101546853 101547109 101552590
SETR: 126027511 126028124 126028126 126028128 126028134 126028139 126028181 126028182 126028540 126028542
LAV: 100667350 100677786
TMU: 101341442
ETF: 101648079 101648692
DNM: 101434321 101439883
MDO: 100018927
GAS: 123242991 123242992
SHR: 100931571 105749943
AFZ: 127556219
PCW: 110198215 110198316 110203819 110204171
TVP: 118837371 118837372 118837766 118837784
OAA: 100074363
CABI: 116833843
ASAO: 132780095
PCHN: 125047440
HAME: 121875618
PCLA: 123773186
HAZT: 108665744 108667155 108682011
PPOI: 119094960
ABRU: 129968506
UDV: 129220285 129233366
SDM: 118179726 118184819
CANU: 128178189
OED: 130048152
PMAX: 117329675 117330042
RPHI: 132737651
OSN: 115217139 115217246 115217542 115231109 115231157
 » show all
Reference
PMID:6306654 (CYP2B2)
  Authors
Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y
  Title
Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.
  Journal
Proc Natl Acad Sci U S A 80:3958-62 (1983)
DOI:10.1073/pnas.80.13.3958
  Sequence
[rno:361523]
Reference
PMID:3396451 (CYP2B3)
  Authors
Labbe D, Jean A, Anderson A
  Title
A constitutive member of the rat cytochrome P450IIB subfamily: full-length coding sequence of the P450IIB3 cDNA.
  Journal
DNA 7:253-60 (1988)
DOI:10.1089/dna.1988.7.253
  Sequence
[rno:286953]
Reference
PMID:3219345 (CYP2B9 CYP2B10)
  Authors
Noshiro M, Lakso M, Kawajiri K, Negishi M
  Title
Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.
  Journal
Biochemistry 27:6434-43 (1988)
DOI:10.1021/bi00417a035
  Sequence
[mmu:13094 13088]
Reference
PMID:2116765 (CYP2B11)
  Authors
Graves PE, Elhag GA, Ciaccio PJ, Bourque DP, Halpert JR
  Title
cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
  Journal
Arch Biochem Biophys 281:106-15 (1990)
DOI:10.1016/0003-9861(90)90419-y
  Sequence
[cfa:474177]
Reference
PMID:1445240 (CYP2B12)
  Authors
Friedberg T, Grassow MA, Bartlomowicz-Oesch B, Siegert P, Arand M, Adesnik M, Oesch F
  Title
Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver.
  Journal
Biochem J 287 ( Pt 3):775-83 (1992)
DOI:10.1042/bj2870775
  Sequence
[rno:29295]
Reference
PMID:8294026 (CYP2B15)
  Authors
Nakayama K, Suwa Y, Mizukami Y, Sogawa K, Fujii-Kuriyama Y
  Title
Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene.
  Journal
Gene 136:333-6 (1993)
DOI:10.1016/0378-1119(93)90490-t
  Sequence
[rno:685222]
Reference
PMID:9799616 (CYP2B19)
  Authors
Keeney DS
  Title
The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes.
  Journal
Genomics 53:417-9 (1998)
DOI:10.1006/geno.1998.5533
  Sequence
[mmu:13090]
Reference
PMID:11159754 (CYP2B21)
  Authors
Brookman-Amissah N, Mackay AG, Swann PF
  Title
Isolation and sequencing of the cDNA of a novel cytochrome P450 from rat oesophagus.
  Journal
Carcinogenesis 22:155-60 (2001)
DOI:10.1093/carcin/22.1.155
  Sequence
[rno:292728]
Reference
PMID:16315095 (CYP2B22)
  Authors
Kawahigashi H, Hirose S, Ozawa K, Ido Y, Kojima M, Ohkawa H, Ohkawa Y
  Title
Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants.
  Journal
Transgenic Res 14:907-17 (2005)
DOI:10.1007/s11248-005-0199-x
  Sequence
[ssc:403104]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical reaction (16)   
   KEGG ENZYME (1)   
   KEGG REACTION (9)   
   KEGG RCLASS (6)   
Gene (350)   
   KEGG GENES (303)   
   KEGG MGENES (2)   
   RefGene (40)   
   OC (5)   
Literature (9)   
   PubMed (9)   
All databases (388)   

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KEGG   ORTHOLOGY: K07413
Entry
K07413                      KO                                     
Symbol
CYP2C
Name
cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R03408  
R07042  
R07043  
R07048  
R07050  
R07051  
R07052  
R07054  
R07055  
R07056  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00590 Arachidonic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00591 Linoleic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07413  CYP2C; cytochrome P450 family 2 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07413  CYP2C; cytochrome P450 family 2 subfamily C
Genes
PON: 100449185
PPYG: 129006201
MCC: 100424240(CYP2C76)
MCF: 102114994(CYP2C76) 135965165
MTHB: 126962035 126962036
MNI: 105470210
CATY: 105576142 105581754
PANU: 101012275 101026117
TGE: 112631566
MLEU: 105553702 105553718
RRO: 104664669 104664684
RBB: 108543807 108543808
TFN: 117069747 117069809
PTEH: 111538683 111538726
CANG: 105527570
CJC: 100391987
SBQ: 101040831
CIMI: 108282285(CYP2C76)
ANAN: 105708280(CYP2C76)
CSYR: 103250328 103254835 103255987 103265697 103270233 103277163 110596230
MMUR: 105872488 105873460
LCAT: 123650042 123650046 123650138
PCOQ: 105818461 105824363
OGA: 100941342 100944925 100949727
MMU: 100043108(Cyp2c69) 107141(Cyp2c50) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 226105(Cyp2c70) 226143(Cyp2c23) 404195(Cyp2c54) 433247(Cyp2c68) 545288(Cyp2c67) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65)
MCAL: 110285234 110285299 110285416 110285739 110286013 110288497
MPAH: 110318652 110321409 110323738 110329470 110333565
RNO: 100361492(Cyp2c55) 100361547(Cyp2c7l1) 100911718 100912265(Cyp2c66) 120093077 120098584 134483996 134485234 171518(Cyp2c22) 171521(Cyp2c13) 25011(Cyp2c12) 29277(Cyp2c11) 29298(Cyp2c7) 293989(Cyp2c6v1) 499353(Cyp2c24) 83790(Cyp2c23)
MCOC: 116072985 116072994 116101173 116103883
ANU: 117695924 117704125 117704160 117707817 117707833 117710720 117710944 117711779 117712125 117714049 117714760 117715357
MUN: 110540047 110540048 110540049 110540723 110541031 110541449 110546312 110552973 110554760
CGE: 100751491 100751762 100751778 100752064 100752358 100753681 100754177 100754462 100756757 100757240 100757723 100772776 100773851 113830663 113834830
MAUA: 101823450 101829294 101830378 101831088 101831527 101832144 101832611 101841752 101842021
PROB: 127233403 127233429 127233439 127233441 127233442 127233443 127233444
PLEU: 114687277 114687280 114702470 114706456 114706863 114706876 114706883 114706891 114706892
MORG: 121453776 121453777 121453779 121453780 121453915 121453926 121453935 121453936 121453949 121453973 121453987 121453988 121453999 121454098 121454106 121454325 121454361 121454788
MFOT: 126503086 126511077 126511085
AAMP: 119808112 119808461 119808473 119808480 119808972 119811688 119814029 119818815 119824915 119824922
NGI: 103729081 103732440 103732443 103732444 103732445 103732447 103744062 103749112 103752530
HGL: 101708592 101710990
CPOC: 100716044 100719102
CCAN: 109675594 109686866 109686867
DORD: 105999354 105999358 105999359 105999360 105999362 105999363 105999364 105999365 105999366 106001658 106001659 106001669
DSP: 122115684 122115686 122115687 122115688 122115689 122115690 122115692 122115694 122115695 122115696 122115698 122115699 122115821 122115856 122115857
PLOP: 125342134 125346230 125346232 125346233 125346234 125346235 125346236 125346238 125346239 125346241 125346243
NCAR: 124984664 124984711 124984718 124984740 124984981 124985051 124985100 124985193 124985263 124985323 124985911 124985912 124985914
MMMA: 107149731 107149732 107149742 107149743
OCU: 100328549(CYP2C5) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328938(CYP2C16) 100345193 100346305 100346743(CYP2C1) 100349436(CYP2C4) 100353460 103351405
OPI: 101519662 101519910 101520157 101520641 101524854 101525811 101526220 101526786 101527195 101527783 101528381 101528927 101529516 101529922
TUP: 102467726 102501371 102503066
GVR: 103609510 103609514 103609927 103610437 103610588
CFA: 100688697 415122(CYP2C18)
CLUD: 112672099 112672554 112672584
VVP: 112917651 112917654 112928780
VLG: 121484666 121485285 121485560
NPO: 129493642 129493856 129493884
AML: 100468534 100470213 100471407
UMR: 103659697 103670756
UAH: 113243099 113251748 125282749
UAR: 123777781 123783991 123783992 123783994 123791300 123800006 123800347
ELK: 111144935 111144947
LLV: 125085077 125085209
MPUF: 101687589 101688450
MNP: 132016643 132016644
MLK: 131828623 131828625
NVS: 122898982 122898983
ORO: 101365057 101365655 101383285
EJU: 114205328 114205474 114221836
ZCA: 113919561 113923367 113923499
MLX: 118024006 118024011
NSU: 110589090 110589295
LWW: 102741683 102742186
FCA: 101089396(CYP2C41) 101089804
PYU: 121037024 121037025
PCOO: 112854419 112854424
PBG: 122493051 122493053
PVIV: 125148038 125148039
LRUF: 124506212 124507012
PTG: 102957879 102958169
PPAD: 109264681 109264682
PUC: 125932819 125933400
AJU: 106965832 106965834
HHV: 120230588 120230589 120230594
BTA: 505468(CYP2C88) 510380(CYP2C89) 511498(CYP2C23) 535243(CYP2C90) 616593(CYP2C87) 785540(CYP2C281)
BOM: 102266046 102268262 102279786 102280731 102282716 102285833
BIU: 109553136 109553148 109553149 109553151 109553186 109579059
BBUB: 102391944 102392701 102398418 102401059 102401347
BBIS: 104983529 104983530 104985773 104990182 104990186 105002722
CHX: 100861186 102169851 102180722 102185708 102185739 102188304 106503891 108633308
OAS: 100534653(CYP2C19) 100568290(CYP2C18) 101106641 101107056 101107486 101120535
BTAX: 128067928 128067935 128067944 128067982 128067983 128067984 128068009
ODA: 120873493 120873494 120873527 120873718 120873719 120873724
CCAD: 122446106 122446108 122446110 122446562 122446680 122446729 122446733
MBEZ: 129555150 129555520 129555964 129555969 129555971 129555972 129555974 129555975
SSC: 100739741 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403215(CYP2C49)
CFR: 102505530 102520553 102520945 102521185 102521601
CBAI: 105081748 105081809 105081810 105081811 105081813
CDK: 105084249 105084251 105084253 105084254 105084313
VPC: 102533247 102534924 102535318 102535571 102541494
BACU: 103017669
BMUS: 118882389
LVE: 103084494
OOR: 101280390 101281073
DLE: 111172397
PCAD: 102978514 102990258
PSIU: 116741310 116741704
NASI: 112392977
ECB: 100061367 100061400 100061440(CYP2C92) 100061470 100061502 100061579(CYP2C113) 100061609 100070400
EPZ: 103555431 103555432 103559687 103559691 103563727 103564575
EAI: 106828038 106842115 106842116 106842117 106842118 106846082 106846096 106846703
MYB: 102259201 102262062
MYD: 102757298 102761651
MMYO: 118669861 118669862 118669933 118669936
MLF: 102425332 102439008 102439973
MDT: 132214162 132214163 132214164 132214227
PKL: 118719320 118719322 118719385
EFUS: 103288419 103288420 103288471
MNA: 107542552 107542558 107543271
DRO: 112300219
SHON: 118988005 118999525
AJM: 119064549
PDIC: 114496070 114496071 114496072 114497455
PHAS: 123828810 123828873 123829140 123829141 123829142
MMF: 118632032 118632707
PPAM: 129077061 129077108
HAI: 109379576 109380905 109380969 109380970
RFQ: 117036205 117036207 117036211 117036262 117036412
PALE: 102891905
PGIG: 120608941 120609277 120609279
PVP: 105301394
MJV: 108409895
TOD: 119234464 119234519
SARA: 101538594 101538863 101539126 101539748 101540186 101541249 101541695 101542671 101545907 101546049 101546518 101547469 101548282 101548987 101549253 101549522 101550043 105943477
SETR: 125994861 125994862 125994864 126033411 126033848
LAV: 100666635 100675653 100676133 100676880
TMU: 101340781 101346446 101346874 101350013 101350258
ETF: 101650213 101650523 101655109 101655637 101655958
DNM: 101414777 101433008 101433204 101434138 101434218 101435423 101436676 101437101 101437727
MDO: 100020348 100023149 100023204 100023235 100026569 100026598 100026618 100026637 100028608
GAS: 123232993 123233004 123233006 123236366 123236629 123238227 123238228 123238230 123238233 123238234 123238235 123238257
SHR: 100915447 100918856 100919120 100920607 100927632 100928062 100933015 100933766
AFZ: 127551720 127551721 127551783 127552019 127552033 127552034
PCW: 110192769 110200600 110200601 110213986 110215468
TVP: 118828026 118828039 118828040 118828042 118828043 118828044 118828045 118828046 118828051 118828056 118828058 118828060 118828118 118828175 118828284 118828583 118828771 118828830 118830249 118830250 118859159
GGA: 100858007(RP11-400G3.5) 414833(CYP2C45)
PCOC: 116234486
MGP: 100544448
CJO: 107315788
TPAI: 128077571 128077572 128077573
LMUT: 125694067 125694068 125694069 125694070 125694071
NMEL: 110399446
APLA: 101797318 101805432 113844003
ACYG: 106034197 106046725
CATA: 118243351 118255579
AFUL: 116491444 116491640 116491641 116491642 116496669
TGU: 100219254 100228872
LSR: 110475152 110480306
SCAN: 103813978 103819903
PMOA: 120499733
OTC: 121338316 121341821
PRUF: 121354193 121357631
GFR: 102041497 102043152
FAB: 101806491 101815619
OMA: 130255070 130260372
PHI: 102100933 102107291
PMAJ: 107207028 107212622
CCAE: 111931097 111937179
CCW: 104695623 104697085
CBRC: 103613784 103624459
ETL: 114065370
ZAB: 102067353 102073503 102074741
ZLE: 135449336 135455550 135460995
ACHL: 103805798
SVG: 106855352 106862297
MMEA: 130581013
HRT: 120748109
SATI: 136364239 136369197 136369528
FPG: 101913238 101916760
FCH: 102048002 102059256
CCRI: 104159509 104168852
NNT: 104399782 104405230
SHAB: 115608667 115608730 115608831 115616648
ACUN: 113481765 113486792
TALA: 104360444 104363792
ACHC: 115341565 115348476
HALD: 104315668
HLE: 104831888
AGEN: 126042554 126043766
GCL: 127017485 127023938
CSTI: 104561375
LDI: 104343172 104353803
MNB: 103771400
DPUB: 104297684 104301981
AVIT: 104273142
BRHI: 104492082
EGZ: 104125355 104129118
NNI: 104010978 104018935
PCRI: 104034656 104037972
PCAO: 104045589 104049798
PADL: 103915567 103918695
AFOR: 103897610 103903595
FGA: 104073873 104081578
GSTE: 104260632 104264065
CLV: 102087915 102098038
MUI: 104534424
PGUU: 104461775 104467274
PLET: 104623081 104626155
EHS: 104504230 104516609
CMAC: 104476783
CUCA: 104060040 104060777 104067911
TEO: 104374656
BREG: 104630155 104637583
OHA: 104329922
ACAR: 104529274
CPEA: 104391477 104398212
CVF: 104281946 104289750
RTD: 128911029 128911351 128911515 128911560 128911561 128917900
AAM: 106498947 106499405
AROW: 112961017 112970877
NPD: 112950986 112956875
TGT: 104566795
DNE: 112980237 112995565
SCAM: 104141787 104143382
ASN: 102372575 102385966 102386218
AMJ: 102572949 102573559 102573618
CPOO: 109315166
GGN: 109287335 109287406
CMY: 102931882
CCAY: 125621101
DCC: 119842814 119847395
CPIC: 101945572 101950120
TST: 117887460 117888580 117888938
CABI: 116822417 116822898
MRV: 120382954 120388953
ACS: 100552964 100554667 100560019 100561903 100562097 100562300 100562499 100565059
ASAO: 132761864 132761881 132763575 132764077 132768594 132769293 132780888 132781058 132781361 132781421 132781507 132781595 132781659 132781729
PVT: 110070438 110084010 110090724
SUND: 121915628 121918763 121918778 121918807 121927308 121927315
PBI: 103054127 103067414
PMUR: 107286792 107296151
CTIG: 120296915 120298505 120298506 120317803
TSR: 106538299
PGUT: 117659140
APRI: 131190555 131190557
PTEX: 113435173 113437257
NSS: 113414159 113426274
VKO: 123035026 123035029
PMUA: 114590635 114590640 114590645 114590724 114590725 114590727 114590728
PRAF: 128407548 128407555 128407562 128407576 128407585 128407593 128407603 128407604 128408551
ZVI: 118079426 118079919 118079920 118079922 118080863 118080874
HCG: 128343349
EMC: 129324116
XLA: 108699286 379297(cyp2a6.1.S) 444542(cyp2c8.2.L)
XTR: 448236(cyp2c8.2)
NPR: 108800780
RTEM: 120913341 120936065 120936220
BBUF: 120978128 121009418
BGAR: 122923772 122923881 122940043 122941761 122945938 122946510
CPLA: 122542870
HOC: 132836798
LERI: 129714142 129714143
LRJ: 133341215 133341226
BFO: 118416246
BBEL: 109470437
SCLV: 120338348 120339246 120345724 120346076
MNZ: 135219059
HAZT: 108665260
DSV: 119449464 119459204
RSAN: 119373421
PMEO: 129596816 129596855
HRF: 124113633
HRJ: 124262364 124281202 124291019
CRG: 105333836
CANU: 128179353
CVN: 111099468 111099985 111137423
RPHI: 132743744
OSN: 115231110
LJP: 135468420 135468424
AG: AAC08738(CYP2C41) BAA02001(CYP2C26) BAA02002(CYP2C27) BAA02003(CYP2C28) CAA44753(CYP2C25)
 » show all
Reference
PMID:2831965 (CYP2C2)
  Authors
Imai Y, Komori M, Sato R
  Title
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.
  Journal
Biochemistry 27:80-8 (1988)
DOI:10.1021/bi00401a014
  Sequence
[ocu:100328924]
Reference
PMID:3335521 (CYP2C7)
  Authors
Kimura H, Yoshioka H, Sogawa K, Sakai Y, Fujii-Kuriyama Y
  Title
Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for  P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression.
  Journal
J Biol Chem 263:701-7 (1988)
  Sequence
[rno:29298]
Reference
PMID:8611037 (CYP2C11)
  Authors
Biagini C, Celier C
  Title
cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells.
  Journal
Arch Biochem Biophys 326:298-305 (1996)
DOI:10.1006/abbi.1996.0079
  Sequence
[rno:29277]
Reference
PMID:2820951 (CYP2C14)
  Authors
Imai Y
  Title
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.
  Journal
J Biochem 101:1129-39 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121977
  Sequence
[ocu:100328936]
Reference
PMID:2263487 (CYP2C23)
  Authors
Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR
  Title
cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.
  Journal
Nucleic Acids Res 18:7156 (1990)
DOI:10.1093/nar/18.23.7156
  Sequence
[rno:83790]
Reference
PMID:8114672 (CYP2C25 CYP2C26 CYP2C27)
  Authors
Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T
  Title
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
  Journal
Mol Pharmacol 45:228-36 (1994)
  Sequence
[ag:CAA44753 BAA02001 BAA02002]
Reference
PMID:7771794 (CYP2C28)
  Authors
Sakuma T, Yokoi T, Kamataki T
  Title
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
  Journal
Arch Biochem Biophys 319:267-73 (1995)
DOI:10.1006/abbi.1995.1291
  Sequence
[ag:BAA02003]
Reference
PMID:8130255 (CYP2C29)
  Authors
Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H
  Title
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.
  Journal
Biochim Biophys Acta 1184:299-301 (1994)
DOI:10.1016/0005-2728(94)90237-2
  Sequence
[mmu:13095]
Reference
PMID:9721182 (CYP2C37)
  Authors
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA
  Title
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.
  Journal
Arch Biochem Biophys 357:45-57 (1998)
DOI:10.1006/abbi.1998.0806
  Sequence
[mmu:13096]
Reference
PMID:9492393 (CYP2C41)
  Authors
Blaisdell J, Goldstein JA, Bai SA
  Title
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
  Journal
Drug Metab Dispos 26:278-83 (1998)
  Sequence
[ag:AAC08738]
Reference
PMID:15102943 (CYP2C50)
  Authors
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC
  Title
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
  Journal
Mol Pharmacol 65:1148-58 (2004)
DOI:10.1124/mol.65.5.1148
  Sequence
[mmu:107141]
Reference
PMID:2263625 (CYP2C70)
  Authors
Emi Y, Chijiiwa C, Omura T
  Title
A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.
  Journal
Proc Natl Acad Sci U S A 87:9746-50 (1990)
DOI:10.1073/pnas.87.24.9746
  Sequence
[rno:171518]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (20)   
   KEGG ENZYME (1)   
   KEGG REACTION (12)   
   KEGG RCLASS (7)   
Gene (1111)   
   KEGG GENES (966)   
   KEGG MGENES (93)   
   RefGene (50)   
   OC (2)   
Literature (12)   
   PubMed (12)   
All databases (1162)   

Download RDF
KEGG   ORTHOLOGY: K07415
Entry
K07415                      KO                                     
Symbol
CYP2E1
Name
cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map05204  Chemical carcinogenesis - DNA adducts
map05208  Chemical carcinogenesis - reactive oxygen species
Reaction
R03408  
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07046  
R07055  
R07056  
R07066  bromobenzene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07068  bromobenzene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07075  4-bromophenol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07088  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07089  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07090  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07107  trichloroethanol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07112  1,2-dibromoethane,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08303  
R08304  
R09421  
R11904  acetylhydrazine,NADPH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00590 Arachidonic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00591 Linoleic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00982 Drug metabolism - cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00983 Drug metabolism - other enzymes
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   04932 Non-alcoholic fatty liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Genes
HSA: 1571(CYP2E1)
PTR: 450857(CYP2E1)
PPS: 100981327(CYP2E1)
GGO: 101151246
PON: 100173813(CYP2E1)
PPYG: 129006033
NLE: 100594173
HMH: 116481584
SSYN: 129463845
MCC: 114669719 114669866 678688(CYP2E1)
MCF: 102136686 135965219
MTHB: 126963293 126963295
MNI: 105471354
CSAB: 103245979(CYP2E1)
CATY: 105598973 105599024
TGE: 112631352 112631637
MLEU: 105538035
RRO: 104680852
RBB: 108543398
TFN: 117082874
PTEH: 111522057
CANG: 105511789
CJC: 100397922(CYP2E1)
SBQ: 101046377
CIMI: 108297222(CYP2E1)
ANAN: 105732195(CYP2E1)
CSYR: 103265545
MMUR: 105861495
LCAT: 123649856
PCOQ: 105823486
OGA: 100958050
MMU: 13106(Cyp2e1)
MCAL: 110297258
MPAH: 110329381
RNO: 25086(Cyp2e1)
MCOC: 116103187
ANU: 117715822
MUN: 110540184
CGE: 100765891
MAUA: 101843716
PROB: 127228509
PLEU: 114693387
MORG: 121457665
MFOT: 126498260
AAMP: 119809971
NGI: 103725848
HGL: 101722366
CPOC: 100727914
CCAN: 109701182
DORD: 105998603 106000254 106001755
DSP: 122095015 122095017 122127841
PLOP: 125345916 125362239(Bet1l) 125364785
NCAR: 124974930
MMMA: 107152888
OCU: 100342322 100342572
OPI: 101532509
TUP: 102496668
GVR: 103609289
CFA: 415128(CYP2E1)
CLUD: 112672552
VVP: 112928781
VLG: 121485389
NPO: 129523248
AML: 100472056
UMR: 103658635
UAR: 123800068
ELK: 111145414
LLV: 125085126
MPUF: 101673971
MNP: 132016915
MLK: 131830489
NVS: 122899062
ORO: 101365364
EJU: 114221828
ZCA: 113923429
MLX: 117998120
NSU: 110583667 110587118
LWW: 102726765
FCA: 554227(CYP2E1) 554344(CYP2E1)
PYU: 121037436
PCOO: 112854449
PBG: 122493427
PVIV: 125147891 125147989
LRUF: 124506779 124506780
PTG: 102969051
PPAD: 109256725
PUC: 125933090
AJU: 106987509
HHV: 120245389
BTA: 282213(CYP2E1)
BOM: 102281471
BIU: 109553162
BBUB: 102416619
BBIS: 104984098
CHX: 102182294
OAS: 100568285(CYP2E1)
BTAX: 128067945
ODA: 120873945
CCAD: 122446540
MBEZ: 129555934
SSC: 403216(CYP2E1)
CFR: 102510124
CBAI: 105067428
CDK: 105096474
VPC: 102526191
BACU: 102997947
BMUS: 118882825
LVE: 103086718
OOR: 101275906
DLE: 111172152
PCAD: 102993260
PSIU: 116741596
NASI: 112411197
ECB: 100066422(CYP2E1)
EPZ: 103556383
EAI: 106841091
MYB: 102260262
MYD: 102760593
MMYO: 118669676
MLF: 102427162
MDT: 132214409
PKL: 118719546
EFUS: 103288678
DRO: 112300228
AJM: 119059516
PDIC: 114497239
PHAS: 123828775
MMF: 118632687
PPAM: 129079804
HAI: 109383522
RFQ: 117036334
TOD: 119234161
SETR: 126033572
TMU: 101343596 101344375
ETF: 101646741
DNM: 101420221
MDO: 100015828
GAS: 123236454
AFZ: 127546978 127546992
PCW: 110214053
TVP: 118829200
OAA: 100092254
ABRU: 129957670
MMER: 123542169
 » show all
Reference
PMID:3782137
  Authors
Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ
  Title
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.
  Journal
J Biol Chem 261:16689-97 (1986)
  Sequence
[hsa:1571]

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (39)   
   KEGG REACTION (22)   
   KEGG RCLASS (17)   
Gene (201)   
   KEGG GENES (163)   
   KEGG MGENES (8)   
   RefGene (24)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (265)   

Download RDF
KEGG   ORTHOLOGY: K07408
Entry
K07408                      KO                                     
Symbol
CYP1A1
Name
cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
Reaction
R02354  
R02355  
R03089  
R03408  
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08390  
R08392  
R09418  
R09423  
R09442  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05207 Chemical carcinogenesis - receptor activation
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Genes
HSA: 1543(CYP1A1)
PTR: 453744(CYP1A1)
PPS: 100976184(CYP1A1)
GGO: 101129522
PON: 100457153
PPYG: 129014419
NLE: 100585507
HMH: 116481900
SSYN: 129482256
MCC: 678694(CYP1A1)
MCF: 102129994(CYP1A1)
MTHB: 126960000
MNI: 105490958
CSAB: 103245331(CYP1A1)
CATY: 105600061
PANU: 101001307
TGE: 112627760
MLEU: 105530835
RRO: 104672151
RBB: 108531476
TFN: 117070364
PTEH: 111529702
CANG: 105505165
CJC: 100393083(CYP1A1)
SBQ: 101038217
CIMI: 108298444(CYP1A1)
ANAN: 105716625 135275116
CSYR: 103271646
MMUR: 105854864
LCAT: 123624369
PCOQ: 105807306
OGA: 100955410
MMU: 13076(Cyp1a1)
MCAL: 110301270
MPAH: 110328033
RNO: 24296(Cyp1a1)
MCOC: 116071961
ANU: 117698968
MUN: 110558545
CGE: 100751269
MAUA: 101844540
PROB: 127231800
PLEU: 114690337
MORG: 121445349
MFOT: 126507531
AAMP: 119808952
NGI: 103736921
HGL: 101707509
CPOC: 100135512(Cyp1a1)
CCAN: 109701505
DORD: 105982352
DSP: 122098438
NCAR: 124977051
MMMA: 107137939
OCU: 100328613
OPI: 101533768
TUP: 102484009
GVR: 103588057
CFA: 100686778(CYP1A1)
CLUD: 112675585
VVP: 112908776
VLG: 121484958
NPO: 129506483
AML: 100473028
UMR: 103678992
UAH: 113240972
UAR: 123790682
ELK: 111153267
LLV: 125105138
MPUF: 101676222
MNP: 131999167
MLK: 131835779
NVS: 122893452
ORO: 101382250
EJU: 114206471
ZCA: 113910089
MLX: 118003748
NSU: 110583893
LWW: 102739666
FCA: 554347(CYP1A1)
PYU: 121041992
PCOO: 112855107
PBG: 122468425
PVIV: 125168946
LRUF: 124508019
PTG: 102966263
PPAD: 109262691
PUC: 125910157
AJU: 106979443
HHV: 120235772
BTA: 282870(CYP1A1)
BOM: 102283235
BIU: 109575587
BBUB: 102399021
BBIS: 104990991
CHX: 102170823
OAS: 100170113(CYP1A1)
BTAX: 128066562
ODA: 120875451
CCAD: 122419730
MBEZ: 129550459
SSC: 403103(CYP1A1)
CFR: 102518111
CBAI: 105069192
CDK: 105087262
VPC: 102530468
BACU: 103008057
BMUS: 118891077
LVE: 103071513
OOR: 101287158
DLE: 111177818
PCAD: 102984326
PSIU: 116749907
NASI: 112410978
ECB: 100062285(CYP1A1)
EPZ: 103552317
EAI: 106831264
MYB: 102262349
MYD: 102762200
MMYO: 118675915
MLF: 102437172
MDT: 132212050
PKL: 118728867
EFUS: 103300190
MNA: 107535216
DRO: 112301821
SHON: 118987754
AJM: 119041322 119041329
PDIC: 114492343
PHAS: 123825280
MMF: 118643668
PPAM: 129064162
HAI: 109396247
RFQ: 117024155
PALE: 102892046
PGIG: 120597850
PVP: 105306836
RAY: 107510533
MJV: 108388606
TOD: 119237890
SARA: 101550604
SETR: 126015044
LAV: 100665901
TMU: 101359275
ETF: 101661225
DNM: 101423437
MDO: 100029871
GAS: 123232970
SHR: 100927711
AFZ: 127551979
PCW: 110213927
TVP: 118828075 118828076
OAA: 100080942(CYP1A1)
ZVI: 118084457
STOW: 125424760
BBEL: 109480286
SCLV: 120326955 120337706 120347324
LPIC: 129258591 129274985
PVUL: 126810086 126812565 126815240 126823790 126825192
GAE: 121368990
HRF: 124120352 124120359 124131529 124140277
HRJ: 124268175 124276990 124282406
CRG: 105329067
CANU: 128190897
OED: 125647398 125648732
MMER: 123540564 123540605 123541431 123546444 123546459 123546828 123549057 123557949 123562948 123562951
RPHI: 132713371 132719301 132727684 132731161 132731163 132733404 132733414 132736383 132738690 132744217 132754874 132757640
DPOL: 127850854
MAEA: 128206276 128206748 128228746 128236623
ATEN: 116286948 116286970 116287897
XEN: 124435028 124452841 124452890
HSY: 130646034
 » show all
Reference
PMID:2989797
  Authors
Jaiswal AK, Gonzalez FJ, Nebert DW
  Title
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
  Journal
Nucleic Acids Res 13:4503-20 (1985)
DOI:10.1093/nar/13.12.4503
  Sequence
[hsa:1543]
Reference
PMID:3019683
  Authors
Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y
  Title
Structure and drug inducibility of the human cytochrome P-450c gene.
  Journal
Eur J Biochem 159:219-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09857.x
  Sequence
[hsa:1543]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (33)   
   KEGG ENZYME (1)   
   KEGG REACTION (21)   
   KEGG RCLASS (11)   
Gene (447)   
   KEGG GENES (215)   
   KEGG MGENES (21)   
   RefGene (198)   
   OC (13)   
Literature (2)   
   PubMed (2)   
All databases (505)   

Download RDF
KEGG   ORTHOLOGY: K07409
Entry
K07409                      KO                                     
Symbol
CYP1A2
Name
cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00232  Caffeine metabolism
map00380  Tryptophan metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
Reaction
R03408  
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07055  
R07056  
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07939  caffeine:oxygen oxidoreductase (N3-demethylating)
R07943  
R07945  
R08293  
R08294  
R08392  
R09405  
R09407  
R09408  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00591 Linoleic acid metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00982 Drug metabolism - cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05207 Chemical carcinogenesis - receptor activation
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05208 Chemical carcinogenesis - reactive oxygen species
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Genes
HSA: 1544(CYP1A2)
PTR: 735881(CYP1A2)
PPS: 100975837(CYP1A2)
GGO: 101130358
PON: 100172368(CYP1A2)
PPYG: 129014441
NLE: 100586622
HMH: 116481901
SSYN: 129482258
MCF: 102130662(CYP1A2)
MTHB: 126959999
MNI: 105490960
CSAB: 103245329(CYP1A2)
CATY: 105600060
PANU: 101002117
TGE: 112627775
MLEU: 105530834
RRO: 104672152
RBB: 108531494
TFN: 117071589
PTEH: 111529709
CANG: 105505164
CJC: 100392712(CYP1A2)
SBQ: 101037899
ANAN: 105714471 135276964
CSYR: 103271647
MMUR: 105854822
LCAT: 123624379
PCOQ: 105807254
OGA: 100955723
MMU: 13077(Cyp1a2)
MCAL: 110301271
MPAH: 110328034
RNO: 24297(Cyp1a2)
MCOC: 116071962
ANU: 117698970
MUN: 110558530
CGE: 100755851
MAUA: 101825565
PROB: 127231801
PLEU: 114690345
MORG: 121445350 121445351 121445352
MFOT: 126507532 126507533 126507534
AAMP: 119808953 119808954 119808956
NGI: 103736875
CPOC: 100135513(Cyp1a2)
CCAN: 109695949
DORD: 105982353 105982354 105982355
DSP: 122098436 122098439
PLOP: 125368231
NCAR: 124977052
MMMA: 107137940
OCU: 100328937
TUP: 102484432
GVR: 103588056
CFA: 494010(CYP1A2)
CLUD: 112675583 112675584
VVP: 112917417
VLG: 121484959
NPO: 129506143
AML: 100472774
UMR: 103678991
UAH: 113240971
UAR: 123790681
ELK: 111153221
LLV: 125105139
MPUF: 101677117
MNP: 131999166
MLK: 131835777
NVS: 122893016
ORO: 101381962
EJU: 114206434
ZCA: 113910367
MLX: 118002935
NSU: 110584050
LWW: 102742108
FCA: 554345(CYP1A2)
PYU: 121041994
PCOO: 112855160
PBG: 122468422
PVIV: 125168378
LRUF: 124508017
PTG: 102966939
PPAD: 109262688
PUC: 125910173
AJU: 106979449
HHV: 120235751
BTA: 503552(CYP1A2)
BOM: 102280158
BIU: 109575670
BBUB: 102399561
BBIS: 104991054
CHX: 102170554
OAS: 101109214
BTAX: 128066814
ODA: 120875452
CCAD: 122419767
MBEZ: 129550128
SSC: 100152910(CYP1A2)
CFR: 102518362
CBAI: 105069191
CDK: 105087261
VPC: 102530734
BACU: 103007560
BMUS: 118891291
LVE: 103071784
OOR: 101287407
DLE: 111177607
PCAD: 102984795
PSIU: 116749085
NASI: 112410949
ECB: 100062244(CYP1A2)
EPZ: 103552315
EAI: 106831265
MYB: 102262040
MYD: 102761918
MMYO: 118675919
MLF: 102437484
MDT: 132226266
MNA: 107535217
DRO: 112301801
SHON: 118987676
AJM: 119046569
PDIC: 114492026
PHAS: 123825158
MMF: 118637248
HAI: 109396253
RFQ: 117022727
PGIG: 120597823
PVP: 111732470
MJV: 108388607
TOD: 119237889
SARA: 101544097
SETR: 126015076
LAV: 100666189
TMU: 101359541
ETF: 101661749
DNM: 101424165 101426385 101432104
MDO: 100029908
GAS: 123232968
SHR: 116421952
AFZ: 127551978
PCW: 110213926
TVP: 118828084
TCF: 131883248
MMER: 123552212
HSY: 130644429
 » show all
Reference
PMID:3755823
  Authors
Jaiswal AK, Nebert DW, Gonzalez FJ
  Title
Human P3(450): cDNA and complete amino acid sequence.
  Journal
Nucleic Acids Res 14:6773-4 (1986)
DOI:10.1093/nar/14.16.6773
  Sequence
[hsa:1544]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (24)   
   KEGG PATHWAY (24)   
Chemical reaction (34)   
   KEGG ENZYME (1)   
   KEGG REACTION (19)   
   KEGG RCLASS (14)   
Gene (183)   
   KEGG GENES (160)   
   KEGG MGENES (5)   
   RefGene (7)   
   OC (11)   
Literature (1)   
   PubMed (1)   
All databases (245)   

Download RDF
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