KEGG   ORTHOLOGY: K07412
Entry
K07412                      KO                                     
Symbol
CYP2B
Name
cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
   00590 Arachidonic acid metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07412  CYP2B; cytochrome P450 family 2 subfamily B
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07412  CYP2B; cytochrome P450 family 2 subfamily B
Other DBs
RN: R03408 R07001 R07048 R07050 R07051 R07052 R08390 R08391 R08392
Genes
OGA: 105888244
MMU: 13088(Cyp2b10) 13089(Cyp2b13) 13090(Cyp2b19) 13094(Cyp2b9) 243881(Cyp2b23)
MCAL: 110288965 110297861 110298448 110298729 110298847
MPAH: 110336742
RNO: 103691072 103691092 24300(Cyp2b1) 286953(Cyp2b3) 292728(Cyp2b21) 29295(Cyp2b12) 361523(Cyp2b2) 685222(Cyp2b15)
MCOC: 116100420 116101862 116101866
MUN: 110566202
CGE: 100759787 100760248 100762876 100763166 100763652 100765152 100765441 113837198 113838302
MAUA: 101833813 101844221 101844487 101844759 110339371 110339777 121135526 121135543
PLEU: 114681539 114681540 114685303 114685307 114685311 114709908
OCU: 100327257(CYP2B4) 100328947(CYP2B5) 100328948 100353574
OPI: 101530662
CFA: 474177(CYP2B6)
CLUD: 112645436
VVP: 112928354
VLG: 121485519
EJU: 114202558
MLX: 118022638
NSU: 110590260
PPAD: 109261476
HHV: 120243430
BTA: 504769(CYP2B6) 530571
SSC: 102165015 403104(CYP2B22)
MYB: 102245131
MYD: 102751643
MMYO: 118674745
PKL: 118702365
DRO: 112319965
PDIC: 114511724
PHAS: 123823834
MMF: 118639252
RFQ: 117035075
PGIG: 120595325
RAY: 107521826
MJV: 108405662
TMU: 101341442
MDO: 100018927
SHR: 100931571
OAA: 100074363
CABI: 116833843
CCLU: 121567425
PCHN: 125047440
PCLA: 123773186
PPOI: 119094960
 » show all
Reference
PMID:6306654 (CYP2B2)
  Authors
Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y
  Title
Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.
  Journal
Proc Natl Acad Sci U S A 80:3958-62 (1983)
DOI:10.1073/pnas.80.13.3958
  Sequence
[rno:361523]
Reference
PMID:3396451 (CYP2B3)
  Authors
Labbe D, Jean A, Anderson A
  Title
A constitutive member of the rat cytochrome P450IIB subfamily: full-length coding sequence of the P450IIB3 cDNA.
  Journal
DNA 7:253-60 (1988)
DOI:10.1089/dna.1988.7.253
  Sequence
[rno:286953]
Reference
PMID:3219345 (CYP2B9 CYP2B10)
  Authors
Noshiro M, Lakso M, Kawajiri K, Negishi M
  Title
Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.
  Journal
Biochemistry 27:6434-43 (1988)
DOI:10.1021/bi00417a035
  Sequence
[mmu:13094 13088]
Reference
PMID:2116765 (CYP2B11)
  Authors
Graves PE, Elhag GA, Ciaccio PJ, Bourque DP, Halpert JR
  Title
cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
  Journal
Arch Biochem Biophys 281:106-15 (1990)
DOI:10.1016/0003-9861(90)90419-y
  Sequence
[cfa:474177]
Reference
PMID:1445240 (CYP2B12)
  Authors
Friedberg T, Grassow MA, Bartlomowicz-Oesch B, Siegert P, Arand M, Adesnik M, Oesch F
  Title
Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver.
  Journal
Biochem J 287 ( Pt 3):775-83 (1992)
DOI:10.1042/bj2870775
  Sequence
[rno:29295]
Reference
PMID:8294026 (CYP2B15)
  Authors
Nakayama K, Suwa Y, Mizukami Y, Sogawa K, Fujii-Kuriyama Y
  Title
Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene.
  Journal
Gene 136:333-6 (1993)
DOI:10.1016/0378-1119(93)90490-t
  Sequence
[rno:685222]
Reference
PMID:9799616 (CYP2B19)
  Authors
Keeney DS
  Title
The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes.
  Journal
Genomics 53:417-9 (1998)
DOI:10.1006/geno.1998.5533
  Sequence
[mmu:13090]
Reference
PMID:11159754 (CYP2B21)
  Authors
Brookman-Amissah N, Mackay AG, Swann PF
  Title
Isolation and sequencing of the cDNA of a novel cytochrome P450 from rat oesophagus.
  Journal
Carcinogenesis 22:155-60 (2001)
DOI:10.1093/carcin/22.1.155
  Sequence
[rno:292728]
Reference
PMID:16315095 (CYP2B22)
  Authors
Kawahigashi H, Hirose S, Ozawa K, Ido Y, Kojima M, Ohkawa H, Ohkawa Y
  Title
Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants.
  Journal
Transgenic Res 14:907-17 (2005)
DOI:10.1007/s11248-005-0199-x
  Sequence
[ssc:403104]

KEGG   ORTHOLOGY: K07413
Entry
K07413                      KO                                     
Symbol
CYP2C
Name
cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00590 Arachidonic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00591 Linoleic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07413  CYP2C; cytochrome P450 family 2 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07413  CYP2C; cytochrome P450 family 2 subfamily C
Other DBs
RN: R03408 R07042 R07043 R07048 R07050 R07051 R07052 R07054 R07055 R07056 R08390 R08392
Genes
PON: 100449185
MCC: 100424240(CYP2C76)
MCF: 102114994(CYP2C76)
MTHB: 126962035 126962036
CATY: 105576142 105581754
PANU: 101012275 101026117
TGE: 112631566
RRO: 104664669 104664684
RBB: 108543807 108543808
TFN: 117069747 117069809
CJC: 100391987(CYP2C76)
SBQ: 101040831
MMU: 107141(Cyp2c50) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 226105(Cyp2c70) 226143(Cyp2c23) 404195(Cyp2c54) 433247(Cyp2c68) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65)
RNO: 171518(Cyp2c22) 171521(Cyp2c13) 25011(Cyp2c12) 29277(Cyp2c11) 29298(Cyp2c7) 293989(Cyp2c6v1) 499353(Cyp2c24) 83790(Cyp2c23)
OCU: 100328549(CYP2C5) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328938(CYP2C16) 100345193 100346305 100346743(CYP2C1) 100349436(CYP2C4) 100353203 100353460 103351405
CFA: 100688697 415122(CYP2C18)
BTA: 505468 510380(CYP2C19) 511498 535243(CYP2C18) 616593(CYP2C87) 785540
SSC: 100739741 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403215(CYP2C49)
BACU: 103017669
LVE: 103084494
DLE: 111172397
DRO: 112300219
AJM: 119064549
PALE: 102891905
PVP: 105301394
MJV: 108409895
GGA: 100858007(RP11-400G3.5) 414833(CYP2C45)
PCOC: 116234486
MGP: 100544448
CJO: 107315788
NMEL: 110399446
PMOA: 120499733
ETL: 114065370
ACHL: 103805798
HALD: 104315668
HLE: 104831888
CSTI: 104561375
CMAC: 104476783
MUI: 104534424
MNB: 103771400
OHA: 104329922
ACAR: 104529274
AVIT: 104273142
TEO: 104374656
BRHI: 104492082
TGT: 104566795
CPOO: 109315166
CMY: 102931882
TSR: 106538299
XLA: 108699286 379297(cyp2a6.1.S) 444542(cyp2c8.2.L)
XTR: 448236(cyp2c8.2)
NPR: 108800780
RTP: 109917556
BFO: 118416246
BBEL: 109470437
HAZT: 108665260
RSAN: 119373421
RMP: 119167648
HRF: 124113633
CRG: 105333836
OSN: 115231110
AG: AAC08738(CYP2C41) BAA02001(CYP2C26) BAA02002(CYP2C27) BAA02003(CYP2C28) CAA44753(CYP2C25)
 » show all
Reference
PMID:2831965 (CYP2C2)
  Authors
Imai Y, Komori M, Sato R
  Title
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.
  Journal
Biochemistry 27:80-8 (1988)
DOI:10.1021/bi00401a014
  Sequence
[ocu:100328924]
Reference
PMID:3335521 (CYP2C7)
  Authors
Kimura H, Yoshioka H, Sogawa K, Sakai Y, Fujii-Kuriyama Y
  Title
Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for  P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression.
  Journal
J Biol Chem 263:701-7 (1988)
  Sequence
[rno:29298]
Reference
PMID:8611037 (CYP2C11)
  Authors
Biagini C, Celier C
  Title
cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells.
  Journal
Arch Biochem Biophys 326:298-305 (1996)
DOI:10.1006/abbi.1996.0079
  Sequence
[rno:29277]
Reference
PMID:2820951 (CYP2C14)
  Authors
Imai Y
  Title
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.
  Journal
J Biochem 101:1129-39 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121977
  Sequence
[ocu:100328936]
Reference
PMID:2263487 (CYP2C23)
  Authors
Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR
  Title
cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.
  Journal
Nucleic Acids Res 18:7156 (1990)
DOI:10.1093/nar/18.23.7156
  Sequence
[rno:83790]
Reference
PMID:8114672 (CYP2C25 CYP2C26 CYP2C27)
  Authors
Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T
  Title
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
  Journal
Mol Pharmacol 45:228-36 (1994)
  Sequence
Reference
PMID:7771794 (CYP2C28)
  Authors
Sakuma T, Yokoi T, Kamataki T
  Title
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
  Journal
Arch Biochem Biophys 319:267-73 (1995)
DOI:10.1006/abbi.1995.1291
  Sequence
Reference
PMID:8130255 (CYP2C29)
  Authors
Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H
  Title
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.
  Journal
Biochim Biophys Acta 1184:299-301 (1994)
DOI:10.1016/0005-2728(94)90237-2
  Sequence
[mmu:13095]
Reference
PMID:9721182 (CYP2C37)
  Authors
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA
  Title
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.
  Journal
Arch Biochem Biophys 357:45-57 (1998)
DOI:10.1006/abbi.1998.0806
  Sequence
[mmu:13096]
Reference
PMID:9492393 (CYP2C41)
  Authors
Blaisdell J, Goldstein JA, Bai SA
  Title
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
  Journal
Drug Metab Dispos 26:278-83 (1998)
  Sequence
Reference
PMID:15102943 (CYP2C50)
  Authors
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC
  Title
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
  Journal
Mol Pharmacol 65:1148-58 (2004)
DOI:10.1124/mol.65.5.1148
  Sequence
[mmu:107141]
Reference
PMID:2263625 (CYP2C70)
  Authors
Emi Y, Chijiiwa C, Omura T
  Title
A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.
  Journal
Proc Natl Acad Sci U S A 87:9746-50 (1990)
DOI:10.1073/pnas.87.24.9746
  Sequence
[rno:171518]

KEGG   ORTHOLOGY: K07415
Entry
K07415                      KO                                     
Symbol
CYP2E1
Name
cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map05204  Chemical carcinogenesis - DNA adducts
map05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00590 Arachidonic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00591 Linoleic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00982 Drug metabolism - cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00983 Drug metabolism - other enzymes
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   04932 Non-alcoholic fatty liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Other DBs
RN: R03408 R07000 R07001 R07021 R07022 R07046 R07055 R07056 R07066 R07068 R07075 R07088 R07089 R07090 R07098 R07099 R07107 R07112 R08303 R08304 R09421 R11904
Genes
HSA: 1571(CYP2E1)
PTR: 450857(CYP2E1)
PPS: 100981327(CYP2E1)
GGO: 101151246
PON: 100173813(CYP2E1)
NLE: 100594173
MCC: 114669719 114669866 678688(CYP2E1)
MCF: 102136686
MTHB: 126963293 126963295
CSAB: 103245979(CYP2E1)
RRO: 104680852
RBB: 108543398
TFN: 117082874
PTEH: 111522057
CJC: 100397922(CYP2E1)
SBQ: 101046377
CSYR: 103265545
MMUR: 105861495
LCAT: 123649856
OGA: 100958050
MMU: 13106(Cyp2e1)
MCAL: 110297258
MPAH: 110329381
RNO: 25086(Cyp2e1)
MCOC: 116103187
MUN: 110540184
CGE: 100765891
MAUA: 101843716
PLEU: 114693387
MORG: 121457665
MFOT: 126498260
AAMP: 119809971
NGI: 103725848
HGL: 101722366
CPOC: 100727914
CCAN: 109701182
NCAR: 124974930
OCU: 100342322 100342572(CYP2E)
OPI: 101532509
TUP: 102496668
CFA: 415128(CYP2E1)
CLUD: 112672552
VVP: 112928781
VLG: 121485389
AML: 100472056
UMR: 103658635
UAH: 113252104
UAR: 123800068
ELK: 111145414
LLV: 125085126
MPUF: 101673971
ORO: 101365364
EJU: 114221828
ZCA: 113923429
MLX: 117998120
LWW: 102726765
FCA: 554227(CYP2E2)
PYU: 121037436
PBG: 122493427
PTG: 102969051
PPAD: 109256725
AJU: 106987509
HHV: 120245389
BTA: 282213(CYP2E1)
BOM: 102281471
BIU: 109553162
BBUB: 102416619
CHX: 102182294
OAS: 100568285(CYP2E1)
ODA: 120873945
CCAD: 122446540
SSC: 403216(CYP2E1)
CFR: 102510124
CBAI: 105067428
CDK: 105096474
VPC: 102526191
BACU: 102997947
LVE: 103086718
OOR: 101275906
DLE: 111172152
PCAD: 102993260
PSIU: 116741596
ECB: 100066422(CYP2E1)
EPZ: 103556383
EAI: 106841091
MYB: 102260262
MYD: 102760593
MMYO: 118669676
MLF: 102427162
PKL: 118719546
HAI: 109383522(CYP2E1)
DRO: 112300228
AJM: 119059516
PDIC: 114497239
PHAS: 123828775
MMF: 118632687
RFQ: 117036334
TOD: 119234161
ETF: 101646741
DNM: 101420221
MDO: 100015828
GAS: 123236454
PCW: 110214053
OAA: 100092254
MMER: 123542169
 » show all
Reference
PMID:3782137
  Authors
Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ
  Title
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.
  Journal
J Biol Chem 261:16689-97 (1986)
  Sequence
[hsa:1571]

KEGG   ORTHOLOGY: K07408
Entry
K07408                      KO                                     
Symbol
CYP1A1
Name
cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05207 Chemical carcinogenesis - receptor activation
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Other DBs
RN: R02354 R02355 R03089 R03408 R03629 R07000 R07001 R07021 R07022 R07079 R07080 R07081 R07085 R07087 R07098 R07099 R08390 R08392 R09418 R09423 R09442
Genes
HSA: 1543(CYP1A1)
PTR: 453744(CYP1A1)
PPS: 100976184(CYP1A1)
GGO: 101129522
PON: 100457153
NLE: 100585507
MCC: 678694(CYP1A1)
MCF: 102129994(CYP1A1)
MTHB: 126960000
CSAB: 103245331(CYP1A1)
CATY: 105600061
PANU: 101001307
TGE: 112627760
RRO: 104672151
RBB: 108531476
TFN: 117070364
PTEH: 111529702
CJC: 100393083(CYP1A1)
SBQ: 101038217
CSYR: 103271646
MMUR: 105854864
LCAT: 123624369
OGA: 100955410
MMU: 13076(Cyp1a1)
MCAL: 110301270
MPAH: 110328033
RNO: 24296(Cyp1a1)
MCOC: 116071961
MUN: 110558545
CGE: 100751269
MAUA: 101844540
PLEU: 114690337
MORG: 121445349
MFOT: 126507531
AAMP: 119808952
NGI: 103736921
HGL: 101707509
CPOC: 100135512(Cyp1a1)
CCAN: 109701505
DORD: 105982352
DSP: 122098438
NCAR: 124977051
OCU: 100328613(CYP1A1)
OPI: 101533768
TUP: 102484009
CFA: 100686778(CYP1A1)
CLUD: 112675585
VVP: 112908776
VLG: 121484958
AML: 100473028
UMR: 103678992
UAH: 113240972
UAR: 123790682
ELK: 111153267
LLV: 125105138
MPUF: 101676222
ORO: 101382250
EJU: 114206471
ZCA: 113910089
MLX: 118003748
NSU: 110583893
LWW: 102739666
FCA: 554347(CYP1A1)
PYU: 121041992
PBG: 122468425
LRUF: 124508019
PTG: 102966263
PPAD: 109262691
AJU: 106979443
HHV: 120235772
BTA: 282870(CYP1A1)
BOM: 102283235
BIU: 109575587
BBUB: 102399021
CHX: 102170823
OAS: 100170113(CYP1A1)
ODA: 120875451
CCAD: 122419730
SSC: 403103(CYP1A1)
CFR: 102518111
CBAI: 105069192
CDK: 105087262
VPC: 102530468
BACU: 103008057
LVE: 103071513
OOR: 101287158
DLE: 111177818
PCAD: 102984326
PSIU: 116749907
ECB: 100062285(CYP1A1)
EPZ: 103552317
EAI: 106831264
MYB: 102262349
MYD: 102762200
MMYO: 118675915
MLF: 102437172
MNA: 107535216
PKL: 118728867
HAI: 109396247
DRO: 112301821
SHON: 118987754
PDIC: 114492343
PHAS: 123825280
MMF: 118643668
RFQ: 117024155
PALE: 102892046
PGIG: 120597850
PVP: 105306836
RAY: 107510533
MJV: 108388606
TOD: 119237890
SARA: 101550604
LAV: 100665901
TMU: 101359275
ETF: 101661225
DNM: 101423437
MDO: 100029871
GAS: 123232970
SHR: 100927711
PCW: 110213927
OAA: 100080942(CYP1A1)
ZVI: 118084457
STOW: 125424760
BBEL: 109480286
GAE: 121368990
CRG: 105329067
 » show all
Reference
PMID:2989797
  Authors
Jaiswal AK, Gonzalez FJ, Nebert DW
  Title
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
  Journal
Nucleic Acids Res 13:4503-20 (1985)
DOI:10.1093/nar/13.12.4503
  Sequence
[hsa:1543]
Reference
PMID:3019683
  Authors
Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y
  Title
Structure and drug inducibility of the human cytochrome P-450c gene.
  Journal
Eur J Biochem 159:219-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09857.x
  Sequence
[hsa:1543]

KEGG   ORTHOLOGY: K07409
Entry
K07409                      KO                                     
Symbol
CYP1A2
Name
cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00232  Caffeine metabolism
map00380  Tryptophan metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00591 Linoleic acid metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00982 Drug metabolism - cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05207 Chemical carcinogenesis - receptor activation
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05208 Chemical carcinogenesis - reactive oxygen species
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Other DBs
RN: R03408 R03629 R07000 R07001 R07021 R07022 R07055 R07056 R07098 R07099 R07939 R07943 R07945 R08293 R08294 R08392 R09405 R09407 R09408
Genes
HSA: 1544(CYP1A2)
PTR: 735881(CYP1A2)
PPS: 100975837(CYP1A2)
GGO: 101130358
PON: 100172368(CYP1A2)
NLE: 100586622
MCF: 102130662(CYP1A2)
MTHB: 126959999
CSAB: 103245329(CYP1A2)
CATY: 105600060
PANU: 101002117
TGE: 112627775
RRO: 104672152
RBB: 108531494
TFN: 117071589
PTEH: 111529709
CJC: 100392712(CYP1A2)
SBQ: 101037899
CSYR: 103271647
MMUR: 105854822
LCAT: 123624379
OGA: 100955723
MMU: 13077(Cyp1a2)
MCAL: 110301271
MPAH: 110328034
RNO: 24297(Cyp1a2)
MCOC: 116071962
MUN: 110558530
CGE: 100755851
MAUA: 101825565
PLEU: 114690345
NGI: 103736875
CPOC: 100135513(Cyp1a2)
CCAN: 109695949
NCAR: 124977052
OCU: 100328937(CYP1A2)
TUP: 102484432
CFA: 494010(CYP1A2)
VVP: 112917417
VLG: 121484959
AML: 100472774
UMR: 103678991
UAH: 113240971
UAR: 123790681
ELK: 111153221
LLV: 125105139
MPUF: 101677117
ORO: 101381962
EJU: 114206434
ZCA: 113910367
MLX: 118002935
NSU: 110584050
LWW: 102742108
FCA: 554345(CYP1A2)
PYU: 121041994
PBG: 122468422
LRUF: 124508017
PTG: 102966939
PPAD: 109262688
AJU: 106979449
HHV: 120235751
BTA: 503552(CYP1A2)
BOM: 102280158
BIU: 109575670
BBUB: 102399561
CHX: 102170554
OAS: 101109214
ODA: 120875452
CCAD: 122419767
SSC: 100152910(CYP1A2)
CFR: 102518362
CBAI: 105069191
CDK: 105087261
VPC: 102530734
BACU: 103007560
LVE: 103071784
OOR: 101287407
DLE: 111177607
PCAD: 102984795
PSIU: 116749085
ECB: 100062244(CYP1A2)
EPZ: 103552315
EAI: 106831265
MYB: 102262040
MYD: 102761918
MMYO: 118675919
MLF: 102437484
MNA: 107535217
HAI: 109396253
DRO: 112301801
SHON: 118987676
AJM: 119046569
PDIC: 114492026
PHAS: 123825158
MMF: 118637248
RFQ: 117022727
PGIG: 120597823
PVP: 111732470
MJV: 108388607
TOD: 119237889
SARA: 101544097
LAV: 100666189
TMU: 101359541
ETF: 101661749
MDO: 100029908
GAS: 123232968
SHR: 116421952
PCW: 110213926
MMER: 123552212
 » show all
Reference
PMID:3755823
  Authors
Jaiswal AK, Nebert DW, Gonzalez FJ
  Title
Human P3(450): cDNA and complete amino acid sequence.
  Journal
Nucleic Acids Res 14:6773-4 (1986)
DOI:10.1093/nar/14.16.6773
  Sequence
[hsa:1544]

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