KEGG   ORTHOLOGY: K07413
Entry
K07413                      KO                                     
Symbol
CYP2C
Name
cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00590 Arachidonic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00591 Linoleic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07413  CYP2C; cytochrome P450 family 2 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07413  CYP2C; cytochrome P450 family 2 subfamily C
Other DBs
RN: R03408 R07042 R07043 R07048 R07050 R07051 R07052 R07054 R07055 R07056 R08390 R08392
Genes
PON: 100449185
MCC: 100424240(CYP2C76)
MCF: 102114994(CYP2C76)
MTHB: 126962035 126962036
MNI: 105470210
CATY: 105576142 105581754
PANU: 101012275 101026117
TGE: 112631566
MLEU: 105553702 105553718
RRO: 104664669 104664684
RBB: 108543807 108543808
TFN: 117069747 117069809
PTEH: 111538683 111538726
CANG: 105527570
CJC: 100391987(CYP2C76)
SBQ: 101040831
CIMI: 108282285(CYP2C76)
CSYR: 103250328 103254835 103255987 103265697 103270233 103277163 110596230
MMUR: 105872488 105873460
LCAT: 123650042 123650046 123650138
PCOQ: 105818461 105824363
OGA: 100941342 100944925 100949727
MMU: 107141(Cyp2c50) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 226105(Cyp2c70) 226143(Cyp2c23) 404195(Cyp2c54) 433247(Cyp2c68) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65)
MCAL: 110285234 110285299 110285739 110286013 110288497
MPAH: 110318652 110321409 110323738 110333565
RNO: 171518(Cyp2c22) 171521(Cyp2c13) 25011(Cyp2c12) 29277(Cyp2c11) 29298(Cyp2c7) 293989(Cyp2c6v1) 499353(Cyp2c24) 83790(Cyp2c23)
MCOC: 116072985 116072994 116101173 116103883
ANU: 117695924 117704125 117704160 117707817 117710944 117711779 117712125 117714049 117714760 117715357
MUN: 110540047 110540049 110540723 110541031 110546312 110552973 110554760
CGE: 100751491 100751762 100751778 100752064 100752358 100753681 100754177 100754462 100756757 100757240 100757723 100772776 100773851 113834830
MAUA: 101823450 101829294 101830378 101831088 101832144 101832611 101841752
PROB: 127233403 127233429 127233441 127233442 127233443
PLEU: 114687280 114702470 114706456 114706863 114706876 114706883 114706891 114706892
MORG: 121453776 121453777 121453779 121453780 121453926 121453935 121453936 121453949 121453973 121453987 121453988 121453999 121454098 121454106 121454325 121454361
MFOT: 126503086 126511077
AAMP: 119808112 119808461 119808473 119808480 119811688 119814029 119818815 119824915 119824922
NGI: 103729081 103732440 103732443 103732445 103732447 103744062 103749112 103752530
HGL: 101708592 101710990
CPOC: 100716044 100719102
CCAN: 109675594 109686866 109686867
DORD: 105999354 105999358 105999359 105999360 105999362 105999363 105999364 105999365 105999366 106001658 106001659 106001669
DSP: 122115684 122115686 122115687 122115688 122115689 122115690 122115692 122115694 122115695 122115696 122115698 122115699 122115821 122115856 122115857
PLOP: 125342134 125346230 125346232 125346233 125346234 125346235 125346236 125346238 125346239 125346241 125346243
NCAR: 124984664 124984711 124984718 124984740 124984981 124985051 124985100 124985193 124985263 124985323 124985911 124985912 124985914
OCU: 100328549(CYP2C5) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328938(CYP2C16) 100345193 100346305 100346743(CYP2C1) 100349436(CYP2C4) 100353460 103351405
OPI: 101519662 101519910 101520157 101520641 101524854 101525811 101526220 101526786 101527195 101527783 101528381 101528927 101529516 101529922
TUP: 102467726 102501371 102503066
GVR: 103609510 103609514 103609927 103610437 103610588
CFA: 100688697 415122(CYP2C18)
CLUD: 112672099 112672554 112672584
VVP: 112917651 112917654 112928780
VLG: 121484666 121485285 121485560
NPO: 129493642 129493856 129493884
AML: 100468534 100470213 100471407
UMR: 103659697 103670756
UAH: 113243099 113249437 113251748 113252105
UAR: 123777781 123783991 123783992 123783994 123791300 123800006 123800347
ELK: 111144935 111144947
LLV: 125085077 125085209
MPUF: 101687589 101688450
NVS: 122898982 122898983
ORO: 101365057 101365655 101383285
EJU: 114205328 114205474 114221836
ZCA: 113919561 113923367 113923499
MLX: 118024006 118024011
NSU: 110589090 110589295
LWW: 102741683 102742186
FCA: 101089396 101089804
PYU: 121037024 121037025
PCOO: 112854419 112854424
PBG: 122493051 122493053
LRUF: 124506212 124507012
PTG: 102957879 102958169
PPAD: 109264681 109264682
PUC: 125932819 125933400
AJU: 106965832 106965834
HHV: 120230588 120230589 120230594
BTA: 505468 510380(CYP2C19) 511498 535243(CYP2C18) 616593(CYP2C87) 785540
BOM: 102266046 102268262 102279786 102280731 102282716 102285833
BIU: 109553136 109553148 109553149 109553151 109553186 109579059
BBUB: 102391944 102392701 102398418 102401059 102401347
BBIS: 104983529 104983530 104985773 104990182 104990186 105002722
CHX: 100861186 102169851 102180722 102185708 102185739 102188304 106503891 108633308
OAS: 100534653(CYP2C19) 100568290(CYP2C18) 101106641 101107056 101107486 101120535
BTAX: 128067928 128067935 128067944 128067982 128067983 128067984 128068009
ODA: 120873493 120873494 120873527 120873718 120873719 120873724
CCAD: 122446106 122446108 122446110 122446562 122446680 122446729 122446733
SSC: 100739741 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403215(CYP2C49)
CFR: 102505530 102520553 102520945 102521185 102521601
CBAI: 105081748 105081809 105081810 105081811 105081813
CDK: 105084249 105084251 105084253 105084254 105084313
VPC: 102533247 102534924 102535318 102535571 102541494
BACU: 103017669
LVE: 103084494
OOR: 101280390 101281073
DLE: 111172397
PCAD: 102978514 102990258
PSIU: 116741310 116741704
NASI: 112392977
ECB: 100061367 100061400 100061440(CYP2C92) 100061470 100061502 100061579(CYP2C113) 100061609 100070400
EPZ: 103555431 103555432 103559687 103559691 103563727 103564575
EAI: 106828038 106842115 106842116 106842117 106842118 106846082 106846096 106846703
MYB: 102259201 102262062
MYD: 102757298 102761651
MMYO: 118669861 118669862 118669933 118669936
MLF: 102425332 102439008 102439973
MNA: 107542552 107542558 107543271
PKL: 118719320 118719322 118719385
HAI: 109379576 109380905 109380969 109380970
DRO: 112300219
SHON: 118988005 118999525
AJM: 119064549
PDIC: 114496070 114496071 114496072 114497455
PHAS: 123828810 123828873 123829140 123829141 123829142
MMF: 118632032 118632707
RFQ: 117036205 117036207 117036211 117036262 117036412
PALE: 102891905
PGIG: 120608941 120609277 120609279
PVP: 105301394
MJV: 108409895
TOD: 119234464 119234465 119234519
SARA: 101538594 101538863 101539126 101539748 101540186 101541249 101541695 101542671 101545907 101546049 101546518 101547469 101548282 101548987 101549253 101549522 101550043 105943477
LAV: 100666635 100675653 100676133 100676880
TMU: 101340781 101346446 101346874 101350013 101350258
ETF: 101650213 101650523 101655109 101655637 101655958
DNM: 101414777 101433008 101433204 101434138 101434218 101435423 101436676 101437101 101437727
MDO: 100020348 100023149 100023204 100023235 100026569 100026598 100026618 100026637 100028608
GAS: 123232993 123233004 123233006 123236366 123236629 123238227 123238228 123238230 123238233 123238234 123238235 123238257
SHR: 100915447 100918856 100920607 100927632 100928062 100933015 100933766
AFZ: 127551720 127551721 127551783 127552019 127552033 127552034
PCW: 110192769 110200600 110200601 110213986 110215468
GGA: 100858007(RP11-400G3.5) 414833(CYP2C45)
PCOC: 116234486
MGP: 100544448
CJO: 107315788
TPAI: 128077571 128077572 128077573
NMEL: 110399446
APLA: 101797318 101805432 113844003
ACYG: 106034197 106046725
AFUL: 116491444 116491640 116491641 116491642 116496669
TGU: 100219254 100228872
LSR: 110475152 110480306
SCAN: 103813978 103819903
PMOA: 120499733
OTC: 121338316 121341821
PRUF: 121354193 121357631
GFR: 102041497 102043152
FAB: 101806491 101815619
PHI: 102100933 102107291
PMAJ: 107207028 107212622
CCAE: 111931097 111937179
CCW: 104695623 104697085
CBRC: 103613784 103624459
ETL: 114065370
ZAB: 102067353 102073503 102074741
ACHL: 103805798
SVG: 106855352 106862297
FPG: 101913238 101916760
FCH: 102048002 102059256
CLV: 102087915 102098038
EGZ: 104125355 104129118
NNI: 104010978 104018935
PLET: 104623081 104626155
PCRI: 104034656 104037972
PCAO: 104045589 104049798
ACUN: 113481765 113486792
TALA: 104360444 104363792
PADL: 103915567 103918695
AFOR: 103897610 103903595
ACHC: 115341565 115348476
HALD: 104315668
HLE: 104831888
AGEN: 126042554 126043766
GCL: 127017485 127023938
CCRI: 104159509 104168852
CSTI: 104561375
EHS: 104504230 104516609
CMAC: 104476783
MUI: 104534424
BREG: 104630155
FGA: 104073873 104081578
GSTE: 104260632 104264065
LDI: 104343172 104353803
MNB: 103771400
OHA: 104329922
NNT: 104399782 104405230
SHAB: 115608667 115608730 115608831 115616648
DPUB: 104297684 104301981
PGUU: 104461775 104467274
ACAR: 104529274
CPEA: 104391477 104398212
AVIT: 104273142
CVF: 104281946 104289750
CUCA: 104060040 104060777 104067911
TEO: 104374656
BRHI: 104492082
AAM: 106498947 106499405
AROW: 112961017 112970877
NPD: 112950986 112956875
TGT: 104566795
DNE: 112980237 112995565
SCAM: 104141787 104143382
ASN: 102372575 102385966 102386218
AMJ: 102572949 102573559 102573618
CPOO: 109315166
GGN: 109287335 109287406
CMY: 102931882
CPIC: 101945572 101950120
TST: 117887460 117888580 117888938
CABI: 116822417 116822898
MRV: 120382954 120388953
ACS: 100552964 100553664 100554667 100561903 100562097 100562499 100565059
PVT: 110070438 110084010 110090724
SUND: 121915628 121918763 121918778 121918807 121927308 121927315
PBI: 103054127 103067414
PMUR: 107286792 107296151
CTIG: 120296915 120298505 120298506 120317803
TSR: 106538299
PGUT: 117659886 117660189
PTEX: 113435173 113437257
NSS: 113414159 113426274
VKO: 123035026 123035029
PMUA: 114590635 114590645 114590724 114590725 114590727 114590728
ZVI: 118079426 118079919 118079920 118079922 118080863 118080874
HCG: 128343349
XLA: 108699286 379297(cyp2a6.1.S) 444542(cyp2c8.2.L)
XTR: 448236(cyp2c8.2)
NPR: 108800780
RTEM: 120913341 120936065 120936220
BBUF: 120978128 121009418
BGAR: 122923772 122923881 122940043 122941761 122945938 122946510
RTP: 109917556
CPLA: 122542870
BFO: 118416246
BBEL: 109470437
SCLV: 120338348 120339246 120345724 120346076
HAZT: 108665260
DSV: 119449464 119459204
RSAN: 119373421
RMP: 119167648
PMEO: 129596816 129596855
HRF: 124113633
HRJ: 124262364 124281202 124291019
CRG: 105333836
OSN: 115231110
AG: AAC08738(CYP2C41) BAA02001(CYP2C26) BAA02002(CYP2C27) BAA02003(CYP2C28) CAA44753(CYP2C25)
 » show all
Reference
PMID:2831965 (CYP2C2)
  Authors
Imai Y, Komori M, Sato R
  Title
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.
  Journal
Biochemistry 27:80-8 (1988)
DOI:10.1021/bi00401a014
  Sequence
[ocu:100328924]
Reference
PMID:3335521 (CYP2C7)
  Authors
Kimura H, Yoshioka H, Sogawa K, Sakai Y, Fujii-Kuriyama Y
  Title
Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for  P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression.
  Journal
J Biol Chem 263:701-7 (1988)
  Sequence
[rno:29298]
Reference
PMID:8611037 (CYP2C11)
  Authors
Biagini C, Celier C
  Title
cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells.
  Journal
Arch Biochem Biophys 326:298-305 (1996)
DOI:10.1006/abbi.1996.0079
  Sequence
[rno:29277]
Reference
PMID:2820951 (CYP2C14)
  Authors
Imai Y
  Title
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.
  Journal
J Biochem 101:1129-39 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121977
  Sequence
[ocu:100328936]
Reference
PMID:2263487 (CYP2C23)
  Authors
Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR
  Title
cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.
  Journal
Nucleic Acids Res 18:7156 (1990)
DOI:10.1093/nar/18.23.7156
  Sequence
[rno:83790]
Reference
PMID:8114672 (CYP2C25 CYP2C26 CYP2C27)
  Authors
Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T
  Title
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
  Journal
Mol Pharmacol 45:228-36 (1994)
  Sequence
[ag:CAA44753 BAA02001 BAA02002]
Reference
PMID:7771794 (CYP2C28)
  Authors
Sakuma T, Yokoi T, Kamataki T
  Title
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
  Journal
Arch Biochem Biophys 319:267-73 (1995)
DOI:10.1006/abbi.1995.1291
  Sequence
[ag:BAA02003]
Reference
PMID:8130255 (CYP2C29)
  Authors
Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H
  Title
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.
  Journal
Biochim Biophys Acta 1184:299-301 (1994)
DOI:10.1016/0005-2728(94)90237-2
  Sequence
[mmu:13095]
Reference
PMID:9721182 (CYP2C37)
  Authors
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA
  Title
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.
  Journal
Arch Biochem Biophys 357:45-57 (1998)
DOI:10.1006/abbi.1998.0806
  Sequence
[mmu:13096]
Reference
PMID:9492393 (CYP2C41)
  Authors
Blaisdell J, Goldstein JA, Bai SA
  Title
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
  Journal
Drug Metab Dispos 26:278-83 (1998)
  Sequence
[ag:AAC08738]
Reference
PMID:15102943 (CYP2C50)
  Authors
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC
  Title
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
  Journal
Mol Pharmacol 65:1148-58 (2004)
DOI:10.1124/mol.65.5.1148
  Sequence
[mmu:107141]
Reference
PMID:2263625 (CYP2C70)
  Authors
Emi Y, Chijiiwa C, Omura T
  Title
A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.
  Journal
Proc Natl Acad Sci U S A 87:9746-50 (1990)
DOI:10.1073/pnas.87.24.9746
  Sequence
[rno:171518]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (20)   
   KEGG ENZYME (1)   
   KEGG REACTION (12)   
   KEGG RCLASS (7)   
Gene (878)   
   KEGG GENES (818)   
   KEGG MGENES (8)   
   RefGene (50)   
   OC (2)   
Literature (12)   
   PubMed (12)   
All databases (929)   

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KEGG   ORTHOLOGY: K17721
Entry
K17721                      KO                                     
Symbol
CYP2C19
Name
cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
   00591 Linoleic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.-
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Other DBs
RN: R07046 R07055 R07056 R08275 R08285 R08343
GO: 0018675 0018676 0052741
Genes
HSA: 1557(CYP2C19)
PTR: 740956(CYP2C19)
PPS: 100995695(CYP2C19)
GGO: 101151965
PON: 100439483
NLE: 100601437
HMH: 116457271
PTEH: 111552212
CJC: 100389947(CYP2C19)
SBQ: 101041912
CIMI: 108281686(CYP2C19)
CSYR: 103277060
PCOQ: 105822723
OGA: 100950266
GAS: 123236335 123238232
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1557]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (15)   
   KEGG ENZYME (4)   
   KEGG REACTION (6)   
   KEGG RCLASS (5)   
Gene (17)   
   KEGG GENES (16)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (52)   

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KEGG   ORTHOLOGY: K17719
Entry
K17719                      KO                                     
Symbol
CYP2C9
Name
cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00591 Linoleic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00982 Drug metabolism - cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.-
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Other DBs
RN: R07048 R07050 R07051 R07055 R07056 R07079 R07080 R07081 R07085 R07087 R08267 R08275 R08285 R08324 R08325 R08326 R08390 R08392
GO: 0018675 0018676 0052741
Genes
HSA: 1559(CYP2C9)
PTR: 100616515(CYP2C9)
PPS: 100996034(CYP2C9)
GGO: 101126456
PON: 100450749
NLE: 100591471
HMH: 116457268
MCC: 678686(CYP2C75) 678695(CYP2C9)
MCF: 102115450(CYP2C9) 102147103(CYP2C19)
MTHB: 126962028 126962032
MNI: 105479916 105479949
CSAB: 103216299(CYP2C19) 103216301(CYP2C9)
CATY: 105575618 105581138 105586929 105586938
PANU: 100997824 101012978
TGE: 112631549 112631550
MLEU: 105534699 105534700 105535382 105536626
RRO: 104665355 104666123
TFN: 117083900 117092015
PTEH: 111531037
CANG: 105501587 105504516 105504517
DORD: 106001520
NCAR: 124985776
 » show all
Reference
PMID:3196692
  Authors
Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP
  Title
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
  Journal
Biochemistry 27:6929-40 (1988)
DOI:10.1021/bi00418a039
  Sequence
[hsa:1559]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (18)   
   KEGG PATHWAY (18)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (33)   
   KEGG ENZYME (3)   
   KEGG REACTION (18)   
   KEGG RCLASS (12)   
Gene (41)   
   KEGG GENES (39)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (100)   

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KEGG   ORTHOLOGY: K17718
Entry
K17718                      KO                                     
Symbol
CYP2C8
Name
cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
   00591 Linoleic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Other DBs
RN: R07042 R07043 R07048 R07050 R07055 R07056 R08312 R08390 R08392
Genes
HSA: 1558(CYP2C8)
PTR: 450909(CYP2C8)
PPS: 100967379(CYP2C8)
GGO: 101127173
PON: 100447840
NLE: 100602226
HMH: 116457254
MCC: 100534648(CYP2C93) 678683(CYP2C8) 702239
MCF: 102116849 102117212(CYP2C8) 102119308(CYP2C93)
MTHB: 126962030 126962037
MNI: 105470206 105470207 105481168
CSAB: 103216303(CYP2C8) 103216308
CATY: 105576140 105576141 105587200
PANU: 101022842(CYP2C8) 101023648
TGE: 112631270 112631271
MLEU: 105535381 105553656 105553690
RRO: 104665592
RBB: 108541196
TFN: 117069764
PTEH: 111529253
CANG: 105504518 105527573
CJC: 100390915(CYP2C8)
SBQ: 101041387
CIMI: 108281688(CYP2C8)
CSYR: 103260641
LCAT: 123650043 123650045 123650047 123650048
PCOQ: 105822696
OGA: 100941864 100942590
GVR: 103597628 103609276 103609277 103610831 103610943
SUND: 121921666
CTIG: 120296912 120296913 120298508 120317800 120317801
RMP: 119168129
CRG: 105344043
 » show all
Reference
PMID:3500169
  Authors
Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH
  Title
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
  Journal
J Biol Chem 262:16072-9 (1987)
  Sequence
[hsa:1558]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (16)   
   KEGG ENZYME (1)   
   KEGG REACTION (9)   
   KEGG RCLASS (6)   
Gene (61)   
   KEGG GENES (60)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (97)   

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