KEGG   ORTHOLOGY: K07415
Entry
K07415                      KO                                     
Symbol
CYP2E1
Name
cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map05204  Chemical carcinogenesis - DNA adducts
map05208  Chemical carcinogenesis - reactive oxygen species
Reaction
R03408  
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07046  
R07055  
R07056  
R07066  bromobenzene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07068  bromobenzene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07075  4-bromophenol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07088  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07089  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07090  1,1-dichloroethylene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07107  trichloroethanol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07112  1,2-dibromoethane,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08303  
R08304  
R09421  
R11904  acetylhydrazine,NADPH:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00590 Arachidonic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00591 Linoleic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00982 Drug metabolism - cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00983 Drug metabolism - other enzymes
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   04932 Non-alcoholic fatty liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Genes
HSA: 1571(CYP2E1)
PTR: 450857(CYP2E1)
PPS: 100981327(CYP2E1)
GGO: 101151246
PON: 100173813(CYP2E1)
PPYG: 129006033
NLE: 100594173
HMH: 116481584
SSYN: 129463845
MCC: 114669719 114669866 678688(CYP2E1)
MCF: 102136686 135965219
MTHB: 126963293 126963295
MNI: 105471354
CSAB: 103245979(CYP2E1)
CATY: 105598973 105599024
TGE: 112631352 112631637
MLEU: 105538035
RRO: 104680852
RBB: 108543398
TFN: 117082874
PTEH: 111522057
CANG: 105511789
CJC: 100397922(CYP2E1)
SBQ: 101046377
CIMI: 108297222(CYP2E1)
ANAN: 105732195(CYP2E1)
CSYR: 103265545
MMUR: 105861495
LCAT: 123649856
PCOQ: 105823486
OGA: 100958050
MMU: 13106(Cyp2e1)
MCAL: 110297258
MPAH: 110329381
RNO: 25086(Cyp2e1)
MCOC: 116103187
ANU: 117715822
MUN: 110540184
CGE: 100765891
MAUA: 101843716
PROB: 127228509
PLEU: 114693387
MORG: 121457665
MFOT: 126498260
AAMP: 119809971
NGI: 103725848
HGL: 101722366
CPOC: 100727914
CCAN: 109701182
DORD: 105998603 106000254 106001755
DSP: 122095015 122095017 122127841
PLOP: 125345916 125362239(Bet1l) 125364785
NCAR: 124974930
MMMA: 107152888
OCU: 100342322 100342572
OPI: 101532509
TUP: 102496668
GVR: 103609289
CFA: 415128(CYP2E1)
CLUD: 112672552
VVP: 112928781
VLG: 121485389
NPO: 129523248
AML: 100472056
UMR: 103658635
UAR: 123800068
ELK: 111145414
LLV: 125085126
MPUF: 101673971
MNP: 132016915
MLK: 131830489
NVS: 122899062
ORO: 101365364
EJU: 114221828
ZCA: 113923429
MLX: 117998120
NSU: 110583667 110587118
LWW: 102726765
FCA: 554227(CYP2E1) 554344(CYP2E1)
PYU: 121037436
PCOO: 112854449
PBG: 122493427
PVIV: 125147891 125147989
LRUF: 124506779 124506780
PTG: 102969051
PPAD: 109256725
PUC: 125933090
AJU: 106987509
HHV: 120245389
BTA: 282213(CYP2E1)
BOM: 102281471
BIU: 109553162
BBUB: 102416619
BBIS: 104984098
CHX: 102182294
OAS: 100568285(CYP2E1)
BTAX: 128067945
ODA: 120873945
CCAD: 122446540
MBEZ: 129555934
SSC: 403216(CYP2E1)
CFR: 102510124
CBAI: 105067428
CDK: 105096474
VPC: 102526191
BACU: 102997947
BMUS: 118882825
LVE: 103086718
OOR: 101275906
DLE: 111172152
PCAD: 102993260
PSIU: 116741596
NASI: 112411197
ECB: 100066422(CYP2E1)
EPZ: 103556383
EAI: 106841091
MYB: 102260262
MYD: 102760593
MMYO: 118669676
MLF: 102427162
MDT: 132214409
PKL: 118719546
EFUS: 103288678
DRO: 112300228
AJM: 119059516
PDIC: 114497239
PHAS: 123828775
MMF: 118632687
PPAM: 129079804
HAI: 109383522
RFQ: 117036334
TOD: 119234161
SETR: 126033572
TMU: 101343596 101344375
ETF: 101646741
DNM: 101420221
MDO: 100015828
GAS: 123236454
AFZ: 127546978 127546992
PCW: 110214053
TVP: 118829200
OAA: 100092254
ABRU: 129957670
MMER: 123542169
 » show all
Reference
PMID:3782137
  Authors
Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ
  Title
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.
  Journal
J Biol Chem 261:16689-97 (1986)
  Sequence
[hsa:1571]

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (39)   
   KEGG REACTION (22)   
   KEGG RCLASS (17)   
Gene (201)   
   KEGG GENES (163)   
   KEGG MGENES (8)   
   RefGene (24)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (265)   

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KEGG   ORTHOLOGY: K17689
Entry
K17689            Tight     KO                                     
Symbol
CYP3A4
Name
cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04976  Bile secretion
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Reaction
R02356  
R03408  
R05727  quinine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07055  
R07056  
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08256  
R08257  
R08264  
R08268  
R08269  
R08271  
R08272  
R08274  
R08275  
R08276  
R08277  
R08285  
R08286  
R08287  
R08293  
R08294  
R08303  
R08304  
R08312  
R08313  
R08318  
R08339  
R08340  
R08341  
R08342  
R08343  
R08390  
R08391  
R08392  
R09404  
R09408  
R09423  
Disease
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00591 Linoleic acid metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00982 Drug metabolism - cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00983 Drug metabolism - other enzymes
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   05207 Chemical carcinogenesis - receptor activation
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.32  albendazole monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.55  quinine 3-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.56  1,8-cineole 2-exo-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.57  taurochenodeoxycholate 6alpha-hydroxylase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Other DBs
GO: 0047638 0033780 0050591
Genes
HSA: 1576(CYP3A4)
PTR: 463582(CYP3A4)
PPS: 100976899(CYP3A4)
GGO: 101149513
PON: 100436782
PPYG: 129041698
NLE: 100593175
SSYN: 129489604
MCC: 678670(CYP3A4)
MCF: 102144258(CYP3A4)
MTHB: 126950475
MNI: 105497389
CSAB: 103246766
CATY: 105584402
PANU: 101026757
TGE: 112621193
MLEU: 105543708
RRO: 104673585
RBB: 108538168
TFN: 117072034
PTEH: 111530171 111534893
CANG: 105513064
CJC: 100404344(CYP3A4)
SBQ: 101037403
CIMI: 108308036(CYP3A4)
ANAN: 105719456(CYP3A4)
CSYR: 103252931
MMUR: 105868328 105868331
LCAT: 123631591 123631593
PCOQ: 105806078
OGA: 100948865
 » show all
Reference
PMID:3267210 (CYP3A4)
  Authors
Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR
  Title
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
  Journal
DNA 7:79-86 (1988)
DOI:10.1089/dna.1988.7.79
  Sequence
[hsa:1576]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x
Reference
PMID:9056237 (CYP3A21)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100404344]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (88)   
   KEGG ENZYME (5)   
   KEGG REACTION (44)   
   KEGG RCLASS (39)   
Gene (35)   
   KEGG GENES (34)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (154)   

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