KEGG ORTHOLOGY: K07419

ORTHOLOGY: K07419

Entry

K07419                      KO

Symbol

CYP2R1

Name

vitamin D 25-hydroxylase [EC:1.14.14.24]

Pathway

map00100

Steroid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00103

Cholecalciferol biosynthesis

Reaction

R03611

calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)

Disease

H01143

Vitamin D-dependent rickets

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K07419  CYP2R1; vitamin D 25-hydroxylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07419  CYP2R1; vitamin D 25-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.24  vitamin D 25-hydroxylase
     K07419  CYP2R1; vitamin D 25-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K07419  CYP2R1; vitamin D 25-hydroxylase

Other DBs

GO:

0030343

Genes

HSA:	120227(CYP2R1)

PTR:	451042(CYP2R1)

PPS:	100973299(CYP2R1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	698834(CYP2R1)

MCF:	102138775(CYP2R1)

MTHB:

126936604

MNI:

105486927

CSAB:

103239784(CYP2R1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100394527(CYP2R1)

SBQ:

101037293

CIMI:

108302167(CYP2R1)

ANAN:

105720230(CYP2R1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	244209(Cyp2r1)

MCAL:

110298348

MPAH:

110332047

RNO:	361631(Cyp2r1)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138825061 138834088(Cyp2r1)

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	612993(CYP2R1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:	113246269 130541824 130541833

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101093889(CYP2R1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

BTA:	541302(CYP2R1)

BOM:	102285419(CYP2R1)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

138092905(CYP2R1)

ODA:

120876423

CCAD:

122450097

MREE:

136174378(CYP2R1)

OVR:	110141758(CYP2R1)

MBEZ:

129554484

SSC:	100124375(CYP2R1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115839600(CYP2R1)

DDP:	132429798(CYP2R1)

DLE:

111165268

PCAD:

102978739

PSIU:

116758785

PPHC:

136127290(CYP2R1)

NASI:

112407660

ECB:	100146381(CYP2R1)

EPZ:	103557934(CYP2R1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139019062(CYP2R1)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138163704(CYP2R1)

MLAO:

141518313(CYP2R1)

OAA:

100088947

TACU:

119944132

GGA:	423065(CYP2R1)

PCOC:

116242990

MGP:	100547524 104910999

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106033854(CYP2R1)

CATA:

118249771

AFUL:

116489859

TGU:

100229624

LSR:	110468080(CYP2R1)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139590353(CYP2R1)

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCW:

CBRC:

ACOE:

138111302(CYP2R1)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

SATI:

136362364(CYP2R1)

CCIC:

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

GCL:

CSTI:

LDI:

MNB:

DPUB:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

CBOY:

140652919(CYP2R1)

CLV:

CNIC:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102564928(CYP2R1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139327592(CYP2R1)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108713716(cyp2r1.L) 108715308(cyp2r1.S)

XTR:	100127674(cyp2r1)

NPR:

108802409

RTEM:

120916935

ACAT:

141111815(CYP2R1)

BBUF:

120980988

BGAR:

122920379

DTC:	141053707(CYP2R1)

PWL:	138284657(CYP2R1)

MUO:

115468906

GSH:

117352411

DRE:	563369(cyp2r1)

SRX:

107750548

SANH:

107688167 107700616

SGH:	107585944 107594282

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141298023 141298061

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137030524(cyp2r1)

MASI:

127413295

TROS:

130564435

TDW:

130421272

MANU:

129441898(cyp2r1)

PDAB:

135749328(cyp2r1)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

TRU:

TFS:

TNG:	GSTEN00017808G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

117468460(cyp2r1)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137798974(cyp2r1)

CVE:	137887499(cyp2r1)

MSAM:

119890509

SCHU:

122873263

CUD:

121510343

SPUL:

138589254(cyp2r1)

LMIX:

132973806

ALAT:

119017554

ASTR:

137600128(cyp2r1)

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

EJA:	138213044(cyp2r1)

BFRE:

138620397(cyp2r1)

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125967561(cyp2r1)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140381363(cyp2r1)

MALB:

BSPL:

SJO:

SSCO:

GMH:

SASA:

STRU:

OTW:	112235131 112263818

OMY:	110506679 110526546

OGO:	124033625 124035615

ONE:	115116668 115121138

OKI:	109874864 109895334

OKE:	118371435 118372852

OMM:	135550481 135557827

OCLA:

139384842 139411567

SALP:

111969491 111975524

SNH:	120025336 120056899

CCLU:

121556199 121582909

ELS:

105022275

OEP:

134028541

SFM:	108934550 108940274

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

SCLV:

LPIC:

AJJ:

AFIL:

BCOO:

DSV:

RSAN:

CVS:	136986908 136986909

UDV:

129233752

SDM:

118179738

CRQ:	GCK72_015232

HRF:

124143094

HASI:

137256377

HCRA:

139464577

MMER:

123525246 123537876 123537877

RPHI:

132725786 132754871

MAEA:

128206018 128232545 128239806

LLON:

135483451

MFOO:

138001018

» show all

Reference

PMID:15465040

Authors

Shinkyo R, Sakaki T, Kamakura M, Ohta M, Inouye K

Title

Metabolism of vitamin D by human microsomal CYP2R1.

Journal

Biochem Biophys Res Commun 324:451-7 (2004)
DOI:10.1016/j.bbrc.2004.09.073

Reference

PMID:12867411

Authors

Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW

Title

De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.

Journal

J Biol Chem 278:38084-93 (2003)
DOI:10.1074/jbc.M307028200

Sequence

[hsa:120227] [mmu:244209]

All links

Ontology (1)   
   GO (1)   
Gene (565)   
   MGENES (213)   
   RefGene (347)   
   OC (5)   
All databases (566)   

Download RDF

ENZYME: 1.14.14.24

Entry

EC 1.14.14.24               Enzyme

Name

vitamin D 25-hydroxylase;
vitamin D2 25-hydroxylase;
vitamin D3 25-hydroxylase;
CYP2R1

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

calciol,NADPH---hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)

Reaction(IUBMB)

calciol + O2 + [reduced NADPH---hemoprotein reductase] = calcidiol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R03611]

Reaction(KEGG)

R03611

Substrate

calciol [CPD:C05443];
O2 [CPD:C00007];
[reduced NADPH---hemoprotein reductase] [CPD:C03024]

Product

calcidiol [CPD:C01561];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.

History

EC 1.14.14.24 created 2012 as EC 1.14.13.159, transferred 2016 to EC 1.14.14.24

Pathway

ec00100

Steroid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K07419

vitamin D 25-hydroxylase

Genes

HSA:	120227(CYP2R1)

PTR:	451042(CYP2R1)

PPS:	100973299(CYP2R1)

GGO:

101150033

PON:

100460063

PPYG:

129009000

NLE:

100593944

HMH:

116476484

SSYN:

129484385

MCC:	698834(CYP2R1)

MCF:	102138775(CYP2R1)

MTHB:

126936604

MNI:

105486927

CSAB:

103239784(CYP2R1)

CATY:

105595724

PANU:

101019230

TGE:

112606070

MLEU:

105553481

RRO:

104681937

RBB:

108535517

TFN:

117080292

PTEH:

111555069

CANG:

105521908

CJC:	100394527(CYP2R1)

SBQ:

101037293

CIMI:

108302167(CYP2R1)

ANAN:

105720230(CYP2R1)

CSYR:

103270405

MMUR:

105879993

LCAT:

123642477

PCOQ:

105818445

OGA:

100961883

MMU:	244209(Cyp2r1)

MCAL:

110298348

MPAH:

110332047

RNO:	361631(Cyp2r1)

MCOC:

116102828

ANU:

117697704

ASYL:

127697614

MUN:

110549426

CGE:

100772751

MAUA:

101831768

PROB:

127228219

PLEU:

114697605

MORG:

121457797

MFOT:

126502291

AAMP:

119823353

NGI:

103750427

HGL:

101724787

CPOC:

100714928

CCAN:

109695364

DORD:

105999202

DSP:

122117854

DMER:

138825061 138834088(Cyp2r1)

PLOP:

125360687 125362006

NCAR:

124958302

MMMA:

107135669

OCU:

100353077

OPI:

101521015

TUP:

102495100

GVR:

103603085

CFA:	612993(CYP2R1)

CLUD:

112667671

VVP:

112927044

VLG:

121476561

NPO:

129504706

AML:

100483022

UMR:

103682376

UAH:	113246269 130541824 130541833

UAR:

123791666

ELK:

111159482

LLV:

125079613

MPUF:

101694301

MNP:

132022625

MLK:

131809658

NVS:

122912746

ORO:

101369394

EJU:

114219310

ZCA:

113914132

MLX:

118004151

NSU:

110576584

LWW:

102736800

FCA:	101093889(CYP2R1)

PYU:

121018173

PCOO:

112865643

PBG:

122483590

PVIV:

125147201

LRUF:

124506182

LGF:

123601413

AJU:

106989115

PTG:

102966741

PPAD:

109271176

PUC:

125935633

PLEZ:

122200050

HHV:

120244981

BTA:	541302(CYP2R1)

BOM:	102285419(CYP2R1)

BIU:

109569609

BBUB:

102394445

BBIS:

104981447

CHX:

102190621

OAS:

101117786

BTAX:

128060219

CSUM:

138092905(CYP2R1)

ODA:

120876423

CCAD:

122450097

MREE:

136174378(CYP2R1)

OVR:	110141758(CYP2R1)

MBEZ:

129554484

SSC:	100124375(CYP2R1)

CFR:

102514910

CBAI:

105076609

CDK:

105086686

VPC:

102538766

BACU:

103007249

BMUS:

118900197

LVE:

103091120

OOR:

101270072

LALB:

132525979

GMF:	115839600(CYP2R1)

DDP:	132429798(CYP2R1)

DLE:

111165268

PCAD:

102978739

PSIU:

116758785

PPHC:

136127290(CYP2R1)

NASI:

112407660

ECB:	100146381(CYP2R1)

EPZ:	103557934(CYP2R1)

EAI:

106830430

MYB:

102258907

MYD:

102762858

MMYO:

118664863

MLF:

102430832

MDT:

132240999

MYUM:

139019062(CYP2R1)

PKL:

118712446

EFUS:

103294602

MNA:

107523752

DRO:

112303455

SHON:

118989725

AJM:

119053117

PDIC:

114499905

PHAS:

123810105

MMF:

118628167

PPAM:

129080777

HAI:

109388260

RFQ:

117029588

PALE:

102894539

PGIG:

120603242

PVP:

105301484

RAY:

107519432

MJV:

108386837

TOD:

119255496

SARA:

101554146

SFUM:

130025220

SETR:

126018922

LAV:

100673483

TMU:

101356008

ETF:

101658824

DNM:

101439538

MDO:

100029137

GAS:

123251568

SHR:

100934288

AFZ:

127540416

PCW:

110220995

TVP:

118854126

PBRV:

138163704(CYP2R1)

MLAO:

141518313(CYP2R1)

OAA:

100088947

TACU:

119944132

GGA:	423065(CYP2R1)

PCOC:

116242990

MGP:	100547524 104910999

CJO:

107314632

TPAI:

128087054

LMUT:

125694662

NMEL:

110401886

APLA:

101801210

ACYG:

106033854(CYP2R1)

CATA:

118249771

AFUL:

116489859

TGU:

100229624

LSR:	110468080(CYP2R1)

SCAN:

103827030

PMOA:

120501096

OTC:

121341489

PRUF:

121360922

ATRC:

139590353(CYP2R1)

GFR:

102036046

FAB:

101814027

OMA:

130254318

PHI:

102099647

PMAJ:

107205333

CCW:

104683405

CBRC:

103625457

ACOE:

138111302(CYP2R1)

ETL:

114060398

ZAB:

102073058

ZLE:

135448285

ACHL:

103809552

SVG:

106853173

MMEA:

130575643

SATI:

136362364(CYP2R1)

CCIC:

134044817

FPG:

101919940

FCH:

102048327

CCRI:

104159955

NNT:

104400923

SHAB:

115606396

ACUN:

113481193

TALA:

104356256

ACHC:

115352090

HALD:

104320456

HLE:

104829596

AGEN:

126046888

HHAR:

128152789

GCL:

127016618

CSTI:

104560569

LDI:

104342735

MNB:

103781454

DPUB:

104304430

AVIT:

104274069

BRHI:

104497814

EGZ:

104123157

NNI:

104010937

PCRI:

104030893

PCAO:

104041023

PADL:

103923809

AFOR:

103906838

FGA:

104083213

GSTE:

104257651

CBOY:

140652919(CYP2R1)

CLV:

102097856

CNIC:

135989218

MUI:

104542598

PGUU:

104466110

PLET:

104620107

EHS:

104504787

CMAC:

104479450

CUCA:

104068952

TEO:

104379461

BREG:

104639866

OHA:

104330140

ACAR:

104522608

CPEA:

104386761

CVF:

104291711

RTD:

128909395

CRID:

134515206

AAM:

106497145

AROW:

112968449

NPD:

112948840

TGT:

104578017

DNE:

112985674

SCAM:

104150454

ASN:

102371536

AMJ:	102564928(CYP2R1)

CPOO:

109321085

GGN:

109299111

PSS:

102462921

CMY:

102946167

CCAY:

125638148

DCC:

119857155

CPIC:

101933629

TST:

117877234

CABI:

116829045

MRV:

120403720

ACS:

100556624

ASAO:

132770506

PVT:

110083178

SUND:

121918991

PBI:

103054995

PMUR:

107295021 107295024

CTIG:

120308484

TSR:

106547328

PGUT:

117666157

PCAE:

139327592(CYP2R1)

APRI:

131185997

PTEX:

113440238

NSS:

113412480

VKO:

123021385

PMUA:

114598543

PRAF:

128415685

ZVI:

118087326

HCG:

128339634

GJA:

107120114

STOW:

125425779

EMC:

129324563

XLA:	108713716(cyp2r1.L) 108715308(cyp2r1.S)

XTR:	100127674(cyp2r1)

NPR:

108802409

RTEM:

120916935

ACAT:

141111815(CYP2R1)

BBUF:

120980988

BGAR:

122920379

DTC:	141053707(CYP2R1)

PWL:	138284657(CYP2R1)

MUO:

115468906

GSH:

117352411

DRE:	563369(cyp2r1)

SRX:

107750548

SANH:

107688167 107700616

SGH:	107585944 107594282

CCAR:

109094296

CAUA:

113049462 113052025

CGIB:

127961447 128017038

PTET:

122348327 122349639

LROH:

127168282

GRF:	141298023 141298061

OMC:

131545049

PPRM:

120490959

RKG:

130102651

MAMB:

125264640

CIDE:

127515288

CERY:

137030524(cyp2r1)

MASI:

127413295

TROS:

130564435

TDW:

130421272

MANU:

129441898(cyp2r1)

PDAB:

135749328(cyp2r1)

IPU:

108271345

IFU:

128613378

PHYP:

113536444

SMEO:

124391715

TFD:

113662954

TVC:

132849855

CGAR:

128543106

NGRA:

132899770

TRN:

134331271

AMEX:

103038630

CMAO:

118818967

EEE:

113575769

CHAR:

122132043

SPIL:

134095959

TRU:

101071742

TFS:

130521380

TNG:	GSTEN00017808G001

LCO:

104919371

NCC:

104965174

TBEN:

117471692

CGOB:

115004751

PGEO:

117468460(cyp2r1)

GACU:

117547741

EMAC:

134862709

ELY:

117257992

EFO:

125901428

PLEP:

121944915

SLUC:

116067667

ECRA:

117951119

ESP:

116693663

PFLV:

114557871

GAT:

120807653

PPUG:

119226474

AFB:

129103562

CLUM:

117751469

PSWI:

130192723

CANA:

137798974(cyp2r1)

CVE:	137887499(cyp2r1)

MSAM:

119890509

SCHU:

122873263

CUD:

121510343

SPUL:

138589254(cyp2r1)

LMIX:

132973806

ALAT:

119017554

ASTR:

137600128(cyp2r1)

MZE:

101470180

ONL:

100695816

OAU:

116327197

OLA:

101164878

OML:

112160760

CSAI:

133461755

XMA:

102237962

XCO:

114143618

XHE:

116719072

PRET:

103462441

PFOR:

103139442

PLAI:

106960642

PMEI:

106921706

GAF:

122821740

PPRL:

129364044

CVG:

107085571

CTUL:

119782678

GMU:

124867186

NFU:

107381435

KMR:

108250436

ALIM:

106530854

NWH:

119427863

AOCE:

111563276

EJA:	138213044(cyp2r1)

BFRE:

138620397(cyp2r1)

MCEP:

125005498

CSEM:

103379286

POV:

109636741

SSEN:

122772047

SSOE:

131459708

HHIP:

117755397

HSP:

118107013

PPLT:

128449085

SMAU:

118302817

LCF:

108888818

SDU:

111236567

SLAL:

111654496

XGL:

120795484

HCQ:

109525712

SSCV:

125967561(cyp2r1)

SBIA:

133497901

PEE:

133416703

PTAO:

133466895

BPEC:

110172818

ENY:	140381363(cyp2r1)

MALB:

109963208

BSPL:

114851861

SJO:

128363921

SSCO:

133983984

GMH:

115558955

SASA:

106562333 106587531

STRU:

115167088 115203237

OTW:	112235131 112263818

OMY:	110506679 110526546

OGO:	124033625 124035615

ONE:	115116668 115121138

OKI:	109874864 109895334

OKE:	118371435 118372852

OMM:	135550481 135557827

OCLA:

139384842 139411567

SALP:

111969491 111975524

SNH:	120025336 120056899

CCLU:

121556199 121582909

ELS:

105022275

OEP:

134028541

SFM:	108934550 108940274

PKI:

111842773

AANG:

118227173

AROT:

135255609

CCOG:

133130581

LOC:

102694258

PSPA:

121294963

ARUT:

117432425

PSEX:

120516858

LCM:

102347406

CMK:

103175087

RTP:

109926988

CPLA:

122557785

HOC:

132824209

LERI:

129694568 129705981

PMRN:

116945652

SCLV:

120335125

LPIC:

129263282 129267144

AJJ:

139969846

AFIL:

140137683 140161962

BCOO:

119085253

DSV:

119459200

RSAN:

119406501

CVS:	136986908 136986909

UDV:

129233752

SDM:

118179738

CRQ:	GCK72_015232

HRF:

124143094

HASI:

137256377

HCRA:

139464577

MMER:

123525246 123537876 123537877

RPHI:

132725786 132754871

MAEA:

128206018 128232545 128239806

LLON:

135483451

MFOO:

138001018

» show all

Reference

1 [PMID:12867411]

Authors

Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW

Title

De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.

Journal

J Biol Chem 278:38084-93 (2003)
DOI:10.1074/jbc.M307028200

Sequence

[hsa:120227] [mmu:244209]

Reference

2 [PMID:15465040]

Authors

Shinkyo R, Sakaki T, Kamakura M, Ohta M, Inouye K

Title

Metabolism of vitamin D by human microsomal CYP2R1.

Journal

Biochem Biophys Res Commun 324:451-7 (2004)
DOI:10.1016/j.bbrc.2004.09.073

Sequence

[hsa:120227]

Reference

3 [PMID:18511070]

Authors

Strushkevich N, Usanov SA, Plotnikov AN, Jones G, Park HW

Title

Structural analysis of CYP2R1 in complex with vitamin D3.

Journal

J Mol Biol 380:95-106 (2008)
DOI:10.1016/j.jmb.2008.03.065

Sequence

[hsa:120227]

Reference

4 [PMID:22310641]

Authors

Zhu J, Deluca HF

Title

Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

Journal

Arch Biochem Biophys 523:30-6 (2012)
DOI:10.1016/j.abb.2012.01.013

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.24

IUBMB Enzyme Nomenclature:

1.14.14.24

ExPASy - ENZYME nomenclature database:

1.14.14.24

BRENDA, the Enzyme Database:

1.14.14.24

All links

Gene (560)   
   MGENES (213)   
   RefGene (347)   
Protein sequence (666)   
   UniProt (642)   
   SWISS-PROT (3)   
   RefSeq(pep) (21)   
DNA sequence (22)   
   RefSeq(nuc) (22)   
Protein domain (6)   
   InterPro (6)   
All databases (1254)   

Download RDF

REACTION: R03611

Entry

R03611                      Reaction

Name

calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)

Definition

Calcidiol + [Oxidized NADPH---hemoprotein reductase] + H2O <=> Vitamin D3 + [Reduced NADPH---hemoprotein reductase] + Oxygen

Equation

C01561 + C03161 + C00001 <=> C05443 + C03024 + C00007

Reaction class

RC00963

C01561_C05443

Enzyme

1.14.14.24

Pathway

rn00100

Steroid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00103

Cholecalciferol biosynthesis

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.24
     R03611  Calcidiol + [Oxidized NADPH---hemoprotein reductase] + H2O <=> Vitamin D3 + [Reduced NADPH---hemoprotein reductase] + Oxygen

Orthology

K07419

vitamin D 25-hydroxylase [EC:1.14.14.24]

Other DBs

RHEA:

32906

All links

No link information was found.

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