KEGG   ORTHOLOGY: K07419
Entry
K07419                      KO                                     
Symbol
CYP2R1
Name
vitamin D 25-hydroxylase [EC:1.14.14.24]
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00103  Cholecalciferol biosynthesis
Reaction
R03611  calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)
Disease
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K07419  CYP2R1; vitamin D 25-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07419  CYP2R1; vitamin D 25-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.24  vitamin D 25-hydroxylase
     K07419  CYP2R1; vitamin D 25-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07419  CYP2R1; vitamin D 25-hydroxylase
Other DBs
GO: 0030343
Genes
HSA: 120227(CYP2R1)
PTR: 451042(CYP2R1)
PPS: 100973299(CYP2R1)
GGO: 101150033
PON: 100460063
PPYG: 129009000
NLE: 100593944
HMH: 116476484
SSYN: 129484385
MCC: 698834(CYP2R1)
MCF: 102138775(CYP2R1)
MTHB: 126936604
MNI: 105486927
CSAB: 103239784(CYP2R1)
CATY: 105595724
PANU: 101019230
TGE: 112606070
MLEU: 105553481
RRO: 104681937
RBB: 108535517
TFN: 117080292
PTEH: 111555069
CANG: 105521908
CJC: 100394527(CYP2R1)
SBQ: 101037293
CIMI: 108302167(CYP2R1)
ANAN: 105720230(CYP2R1)
CSYR: 103270405
MMUR: 105879993
LCAT: 123642477
PCOQ: 105818445
OGA: 100961883
MMU: 244209(Cyp2r1)
MCAL: 110298348
MPAH: 110332047
RNO: 361631(Cyp2r1)
MCOC: 116102828
ANU: 117697704
ASYL: 127697614
MUN: 110549426
CGE: 100772751
MAUA: 101831768
PROB: 127228219
PLEU: 114697605
MORG: 121457797
MFOT: 126502291
AAMP: 119823353
NGI: 103750427
HGL: 101724787
CPOC: 100714928
CCAN: 109695364
DORD: 105999202
DSP: 122117854
DMER: 138825061 138834088(Cyp2r1)
NCAR: 124958302
MMMA: 107135669
OCU: 100353077
OPI: 101521015
TUP: 102495100
GVR: 103603085
CFA: 612993(CYP2R1)
CLUD: 112667671
VVP: 112927044
VLG: 121476561
NPO: 129504706
AML: 100483022
UMR: 103682376
UAR: 123791666
ELK: 111159482
LLV: 125079613
MPUF: 101694301
MNP: 132022625
MLK: 131809658
NVS: 122912746
ORO: 101369394
EJU: 114219310
ZCA: 113914132
MLX: 118004151
NSU: 110576584
LWW: 102736800
FCA: 101093889(CYP2R1)
PYU: 121018173
PCOO: 112865643
PBG: 122483590
PVIV: 125147201
LRUF: 124506182
LGF: 123601413
AJU: 106989115
PTG: 102966741
PPAD: 109271176
PUC: 125935633
PLEZ: 122200050
HHV: 120244981
BTA: 541302(CYP2R1)
BOM: 102285419(CYP2R1)
BIU: 109569609
BBUB: 102394445
BBIS: 104981447
CHX: 102190621
OAS: 101117786
BTAX: 128060219
CSUM: 138092905(CYP2R1)
ODA: 120876423
CCAD: 122450097
MREE: 136174378(CYP2R1)
OVR: 110141758(CYP2R1)
MBEZ: 129554484
SSC: 100124375(CYP2R1)
CFR: 102514910
CBAI: 105076609
CDK: 105086686
VPC: 102538766
BACU: 103007249
BMUS: 118900197
LVE: 103091120
OOR: 101270072
LALB: 132525979
GMF: 115839600(CYP2R1)
DDP: 132429798(CYP2R1)
DLE: 111165268
PCAD: 102978739
PSIU: 116758785
PPHC: 136127290(CYP2R1)
NASI: 112407660
ECB: 100146381(CYP2R1)
EPZ: 103557934(CYP2R1)
EAI: 106830430
MYB: 102258907
MYD: 102762858
MMYO: 118664863
MLF: 102430832
MDT: 132240999
MYUM: 139019062(CYP2R1)
PKL: 118712446
EFUS: 103294602
MNA: 107523752
DRO: 112303455
SHON: 118989725
AJM: 119053117
PDIC: 114499905
PHAS: 123810105
MMF: 118628167
PPAM: 129080777
HAI: 109388260
RFQ: 117029588
PALE: 102894539
PGIG: 120603242
PVP: 105301484
RAY: 107519432
MJV: 108386837
TOD: 119255496
SARA: 101554146
SFUM: 130025220
SETR: 126018922
LAV: 100673483
TMU: 101356008
ETF: 101658824
DNM: 101439538
MDO: 100029137
GAS: 123251568
SHR: 100934288
AFZ: 127540416
PCW: 110220995
TVP: 118854126
PBRV: 138163704(CYP2R1)
MLAO: 141518313(CYP2R1)
OAA: 100088947
TACU: 119944132
GGA: 423065(CYP2R1)
PCOC: 116242990
CJO: 107314632
TPAI: 128087054
LMUT: 125694662
NMEL: 110401886
APLA: 101801210
ACYG: 106033854(CYP2R1)
CATA: 118249771
AFUL: 116489859
TGU: 100229624
LSR: 110468080(CYP2R1)
SCAN: 103827030
PMOA: 120501096
OTC: 121341489
PRUF: 121360922
ATRC: 139590353(CYP2R1)
GFR: 102036046
FAB: 101814027
OMA: 130254318
PHI: 102099647
PMAJ: 107205333
CCW: 104683405
CBRC: 103625457
ACOE: 138111302(CYP2R1)
ETL: 114060398
ZAB: 102073058
ZLE: 135448285
ACHL: 103809552
SVG: 106853173
MMEA: 130575643
SATI: 136362364(CYP2R1)
CCIC: 134044817
FPG: 101919940
FCH: 102048327
CCRI: 104159955
NNT: 104400923
SHAB: 115606396
ACUN: 113481193
TALA: 104356256
ACHC: 115352090
HALD: 104320456
HLE: 104829596
AGEN: 126046888
HHAR: 128152789
GCL: 127016618
CSTI: 104560569
LDI: 104342735
MNB: 103781454
DPUB: 104304430
AVIT: 104274069
BRHI: 104497814
EGZ: 104123157
NNI: 104010937
PCRI: 104030893
PCAO: 104041023
PADL: 103923809
AFOR: 103906838
FGA: 104083213
GSTE: 104257651
CBOY: 140652919(CYP2R1)
CLV: 102097856
CNIC: 135989218
MUI: 104542598
PGUU: 104466110
PLET: 104620107
EHS: 104504787
CMAC: 104479450
CUCA: 104068952
TEO: 104379461
BREG: 104639866
OHA: 104330140
ACAR: 104522608
CPEA: 104386761
CVF: 104291711
RTD: 128909395
CRID: 134515206
AAM: 106497145
AROW: 112968449
NPD: 112948840
TGT: 104578017
DNE: 112985674
SCAM: 104150454
ASN: 102371536
AMJ: 102564928(CYP2R1)
CPOO: 109321085
GGN: 109299111
PSS: 102462921
CMY: 102946167
CCAY: 125638148
DCC: 119857155
CPIC: 101933629
TST: 117877234
CABI: 116829045
MRV: 120403720
ACS: 100556624
ASAO: 132770506
PVT: 110083178
SUND: 121918991
PBI: 103054995
CTIG: 120308484
TSR: 106547328
PGUT: 117666157
PCAE: 139327592(CYP2R1)
APRI: 131185997
PTEX: 113440238
NSS: 113412480
VKO: 123021385
PMUA: 114598543
PRAF: 128415685
ZVI: 118087326
HCG: 128339634
GJA: 107120114
STOW: 125425779
EMC: 129324563
XLA: 108713716(cyp2r1.L) 108715308(cyp2r1.S)
XTR: 100127674(cyp2r1)
NPR: 108802409
RTEM: 120916935
ACAT: 141111815(CYP2R1)
BBUF: 120980988
BGAR: 122920379
DTC: 141053707(CYP2R1)
PWL: 138284657(CYP2R1)
MUO: 115468906
GSH: 117352411
DRE: 563369(cyp2r1)
SRX: 107750548
CCAR: 109094296
LROH: 127168282
OMC: 131545049
PPRM: 120490959
RKG: 130102651
MAMB: 125264640
CIDE: 127515288
CERY: 137030524(cyp2r1)
MASI: 127413295
TROS: 130564435
TDW: 130421272
MANU: 129441898(cyp2r1)
PDAB: 135749328(cyp2r1)
IPU: 108271345
IFU: 128613378
PHYP: 113536444
SMEO: 124391715
TFD: 113662954
TVC: 132849855
CGAR: 128543106
NGRA: 132899770
TRN: 134331271
AMEX: 103038630
CMAO: 118818967
EEE: 113575769
CHAR: 122132043
SPIL: 134095959
TRU: 101071742
TFS: 130521380
LCO: 104919371
NCC: 104965174
TBEN: 117471692
CGOB: 115004751
PGEO: 117468460(cyp2r1)
GACU: 117547741
EMAC: 134862709
ELY: 117257992
EFO: 125901428
PLEP: 121944915
SLUC: 116067667
ECRA: 117951119
ESP: 116693663
PFLV: 114557871
GAT: 120807653
PPUG: 119226474
AFB: 129103562
CLUM: 117751469
PSWI: 130192723
CANA: 137798974(cyp2r1)
CVE: 137887499(cyp2r1)
MSAM: 119890509
SCHU: 122873263
CUD: 121510343
SPUL: 138589254(cyp2r1)
LMIX: 132973806
ALAT: 119017554
ASTR: 137600128(cyp2r1)
MZE: 101470180
ONL: 100695816
OAU: 116327197
OLA: 101164878
OML: 112160760
CSAI: 133461755
XMA: 102237962
XCO: 114143618
XHE: 116719072
PRET: 103462441
PFOR: 103139442
PLAI: 106960642
PMEI: 106921706
GAF: 122821740
PPRL: 129364044
CVG: 107085571
CTUL: 119782678
GMU: 124867186
NFU: 107381435
KMR: 108250436
ALIM: 106530854
NWH: 119427863
AOCE: 111563276
EJA: 138213044(cyp2r1)
BFRE: 138620397(cyp2r1)
MCEP: 125005498
CSEM: 103379286
POV: 109636741
SSEN: 122772047
SSOE: 131459708
HHIP: 117755397
HSP: 118107013
PPLT: 128449085
SMAU: 118302817
LCF: 108888818
SDU: 111236567
SLAL: 111654496
XGL: 120795484
HCQ: 109525712
SSCV: 125967561(cyp2r1)
SBIA: 133497901
PEE: 133416703
PTAO: 133466895
BPEC: 110172818
ENY: 140381363(cyp2r1)
MALB: 109963208
BSPL: 114851861
SJO: 128363921
SSCO: 133983984
GMH: 115558955
ELS: 105022275
OEP: 134028541
PKI: 111842773
AANG: 118227173
AROT: 135255609
CCOG: 133130581
LOC: 102694258
PSPA: 121294963
ARUT: 117432425
PSEX: 120516858
LCM: 102347406
CMK: 103175087
RTP: 109926988
CPLA: 122557785
HOC: 132824209
PMRN: 116945652
SCLV: 120335125
AJJ: 139969846
BCOO: 119085253
DSV: 119459200
RSAN: 119406501
UDV: 129233752
SDM: 118179738
HRF: 124143094
HASI: 137256377
HCRA: 139464577
LLON: 135483451
MFOO: 138001018
 » show all
Reference
  Authors
Shinkyo R, Sakaki T, Kamakura M, Ohta M, Inouye K
  Title
Metabolism of vitamin D by human microsomal CYP2R1.
  Journal
Biochem Biophys Res Commun 324:451-7 (2004)
DOI:10.1016/j.bbrc.2004.09.073
Reference
  Authors
Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW
  Title
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.
  Journal
J Biol Chem 278:38084-93 (2003)
DOI:10.1074/jbc.M307028200
  Sequence
[hsa:120227] [mmu:244209]

KEGG   ENZYME: 1.14.14.24
Entry
EC 1.14.14.24               Enzyme                                 
Name
vitamin D 25-hydroxylase;
vitamin D2 25-hydroxylase;
vitamin D3 25-hydroxylase;
CYP2R1
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
calciol,NADPH---hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)
Reaction(IUBMB)
calciol + O2 + [reduced NADPH---hemoprotein reductase] = calcidiol + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R03611]
Reaction(KEGG)
R03611
Substrate
calciol [CPD:C05443];
O2 [CPD:C00007];
[reduced NADPH---hemoprotein reductase] [CPD:C03024]
Product
calcidiol [CPD:C01561];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3. While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyse the reaction in vitro, only CYP2R1 is thought to catalyse the reaction in humans in vivo [4]. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
History
EC 1.14.14.24 created 2012 as EC 1.14.13.159, transferred 2016 to EC 1.14.14.24
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K07419  vitamin D 25-hydroxylase
Genes
HSA120227(CYP2R1)
PTR451042(CYP2R1)
PPS100973299(CYP2R1)
GGO101150033
PON100460063
PPYG129009000
NLE100593944
HMH116476484
SSYN129484385
MCC698834(CYP2R1)
MCF102138775(CYP2R1)
MTHB126936604
MNI105486927
CSAB103239784(CYP2R1)
CATY105595724
PANU101019230
TGE112606070
MLEU105553481
RRO104681937
RBB108535517
TFN117080292
PTEH111555069
CANG105521908
CJC100394527(CYP2R1)
SBQ101037293
CIMI108302167(CYP2R1)
ANAN105720230(CYP2R1)
CSYR103270405
MMUR105879993
LCAT123642477
PCOQ105818445
OGA100961883
MMU244209(Cyp2r1)
MCAL110298348
MPAH110332047
RNO361631(Cyp2r1)
MCOC116102828
ANU117697704
ASYL127697614
MUN110549426
CGE100772751
MAUA101831768
PROB127228219
PLEU114697605
MORG121457797
MFOT126502291
AAMP119823353
NGI103750427
HGL101724787
CPOC100714928
CCAN109695364
DORD105999202
DSP122117854
DMER138825061 138834088(Cyp2r1)
PLOP125360687 125362006
NCAR124958302
MMMA107135669
OCU100353077
OPI101521015
TUP102495100
GVR103603085
CFA612993(CYP2R1)
CLUD112667671
VVP112927044
VLG121476561
NPO129504706
AML100483022
UMR103682376
UAH113246269 130541824 130541833
UAR123791666
ELK111159482
LLV125079613
MPUF101694301
MNP132022625
MLK131809658
NVS122912746
ORO101369394
EJU114219310
ZCA113914132
MLX118004151
NSU110576584
LWW102736800
FCA101093889(CYP2R1)
PYU121018173
PCOO112865643
PBG122483590
PVIV125147201
LRUF124506182
LGF123601413
AJU106989115
PTG102966741
PPAD109271176
PUC125935633
PLEZ122200050
HHV120244981
BTA541302(CYP2R1)
BOM102285419(CYP2R1)
BIU109569609
BBUB102394445
BBIS104981447
CHX102190621
OAS101117786
BTAX128060219
CSUM138092905(CYP2R1)
ODA120876423
CCAD122450097
MREE136174378(CYP2R1)
OVR110141758(CYP2R1)
MBEZ129554484
SSC100124375(CYP2R1)
CFR102514910
CBAI105076609
CDK105086686
VPC102538766
BACU103007249
BMUS118900197
LVE103091120
OOR101270072
LALB132525979
GMF115839600(CYP2R1)
DDP132429798(CYP2R1)
DLE111165268
PCAD102978739
PSIU116758785
PPHC136127290(CYP2R1)
NASI112407660
ECB100146381(CYP2R1)
EPZ103557934(CYP2R1)
EAI106830430
MYB102258907
MYD102762858
MMYO118664863
MLF102430832
MDT132240999
MYUM139019062(CYP2R1)
PKL118712446
EFUS103294602
MNA107523752
DRO112303455
SHON118989725
AJM119053117
PDIC114499905
PHAS123810105
MMF118628167
PPAM129080777
HAI109388260
RFQ117029588
PALE102894539
PGIG120603242
PVP105301484
RAY107519432
MJV108386837
TOD119255496
SARA101554146
SFUM130025220
SETR126018922
LAV100673483
TMU101356008
ETF101658824
DNM101439538
MDO100029137
GAS123251568
SHR100934288
AFZ127540416
PCW110220995
TVP118854126
PBRV138163704(CYP2R1)
MLAO141518313(CYP2R1)
OAA100088947
TACU119944132
GGA423065(CYP2R1)
PCOC116242990
MGP100547524 104910999
CJO107314632
TPAI128087054
LMUT125694662
NMEL110401886
APLA101801210
ACYG106033854(CYP2R1)
CATA118249771
AFUL116489859
TGU100229624
LSR110468080(CYP2R1)
SCAN103827030
PMOA120501096
OTC121341489
PRUF121360922
ATRC139590353(CYP2R1)
GFR102036046
FAB101814027
OMA130254318
PHI102099647
PMAJ107205333
CCW104683405
CBRC103625457
ACOE138111302(CYP2R1)
ETL114060398
ZAB102073058
ZLE135448285
ACHL103809552
SVG106853173
MMEA130575643
SATI136362364(CYP2R1)
CCIC134044817
FPG101919940
FCH102048327
CCRI104159955
NNT104400923
SHAB115606396
ACUN113481193
TALA104356256
ACHC115352090
HALD104320456
HLE104829596
AGEN126046888
HHAR128152789
GCL127016618
CSTI104560569
LDI104342735
MNB103781454
DPUB104304430
AVIT104274069
BRHI104497814
EGZ104123157
NNI104010937
PCRI104030893
PCAO104041023
PADL103923809
AFOR103906838
FGA104083213
GSTE104257651
CBOY140652919(CYP2R1)
CLV102097856
CNIC135989218
MUI104542598
PGUU104466110
PLET104620107
EHS104504787
CMAC104479450
CUCA104068952
TEO104379461
BREG104639866
OHA104330140
ACAR104522608
CPEA104386761
CVF104291711
RTD128909395
CRID134515206
AAM106497145
AROW112968449
NPD112948840
TGT104578017
DNE112985674
SCAM104150454
ASN102371536
AMJ102564928(CYP2R1)
CPOO109321085
GGN109299111
PSS102462921
CMY102946167
CCAY125638148
DCC119857155
CPIC101933629
TST117877234
CABI116829045
MRV120403720
ACS100556624
ASAO132770506
PVT110083178
SUND121918991
PBI103054995
PMUR107295021 107295024
CTIG120308484
TSR106547328
PGUT117666157
PCAE139327592(CYP2R1)
APRI131185997
PTEX113440238
NSS113412480
VKO123021385
PMUA114598543
PRAF128415685
ZVI118087326
HCG128339634
GJA107120114
STOW125425779
EMC129324563
XLA108713716(cyp2r1.L) 108715308(cyp2r1.S)
XTR100127674(cyp2r1)
NPR108802409
RTEM120916935
ACAT141111815(CYP2R1)
BBUF120980988
BGAR122920379
DTC141053707(CYP2R1)
PWL138284657(CYP2R1)
MUO115468906
GSH117352411
DRE563369(cyp2r1)
SRX107750548
SANH107688167 107700616
SGH107585944 107594282
CCAR109094296
CAUA113049462 113052025
CGIB127961447 128017038
PTET122348327 122349639
LROH127168282
GRF141298023 141298061
OMC131545049
PPRM120490959
RKG130102651
MAMB125264640
CIDE127515288
CERY137030524(cyp2r1)
MASI127413295
TROS130564435
TDW130421272
MANU129441898(cyp2r1)
PDAB135749328(cyp2r1)
IPU108271345
IFU128613378
PHYP113536444
SMEO124391715
TFD113662954
TVC132849855
CGAR128543106
NGRA132899770
TRN134331271
AMEX103038630
CMAO118818967
EEE113575769
CHAR122132043
SPIL134095959
TRU101071742
TFS130521380
TNGGSTEN00017808G001
LCO104919371
NCC104965174
TBEN117471692
CGOB115004751
PGEO117468460(cyp2r1)
GACU117547741
EMAC134862709
ELY117257992
EFO125901428
PLEP121944915
SLUC116067667
ECRA117951119
ESP116693663
PFLV114557871
GAT120807653
PPUG119226474
AFB129103562
CLUM117751469
PSWI130192723
CANA137798974(cyp2r1)
CVE137887499(cyp2r1)
MSAM119890509
SCHU122873263
CUD121510343
SPUL138589254(cyp2r1)
LMIX132973806
ALAT119017554
ASTR137600128(cyp2r1)
MZE101470180
ONL100695816
OAU116327197
OLA101164878
OML112160760
CSAI133461755
XMA102237962
XCO114143618
XHE116719072
PRET103462441
PFOR103139442
PLAI106960642
PMEI106921706
GAF122821740
PPRL129364044
CVG107085571
CTUL119782678
GMU124867186
NFU107381435
KMR108250436
ALIM106530854
NWH119427863
AOCE111563276
EJA138213044(cyp2r1)
BFRE138620397(cyp2r1)
MCEP125005498
CSEM103379286
POV109636741
SSEN122772047
SSOE131459708
HHIP117755397
HSP118107013
PPLT128449085
SMAU118302817
LCF108888818
SDU111236567
SLAL111654496
XGL120795484
HCQ109525712
SSCV125967561(cyp2r1)
SBIA133497901
PEE133416703
PTAO133466895
BPEC110172818
ENY140381363(cyp2r1)
MALB109963208
BSPL114851861
SJO128363921
SSCO133983984
GMH115558955
SASA106562333 106587531
STRU115167088 115203237
OTW112235131 112263818
OMY110506679 110526546
OGO124033625 124035615
ONE115116668 115121138
OKI109874864 109895334
OKE118371435 118372852
OMM135550481 135557827
OCLA139384842 139411567
SALP111969491 111975524
SNH120025336 120056899
CCLU121556199 121582909
ELS105022275
OEP134028541
SFM108934550 108940274
PKI111842773
AANG118227173
AROT135255609
CCOG133130581
LOC102694258
PSPA121294963
ARUT117432425
PSEX120516858
LCM102347406
CMK103175087
RTP109926988
CPLA122557785
HOC132824209
LERI129694568 129705981
PMRN116945652
SCLV120335125
LPIC129263282 129267144
AJJ139969846
AFIL140137683 140161962
BCOO119085253
DSV119459200
RSAN119406501
CVS136986908 136986909
UDV129233752
SDM118179738
CRQGCK72_015232
HRF124143094
HASI137256377
HCRA139464577
MMER123525246 123537876 123537877
RPHI132725786 132754871
MAEA128206018 128232545 128239806
LLON135483451
MFOO138001018
 » show all
Reference
1  [PMID:12867411]
  Authors
Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW
  Title
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.
  Journal
J Biol Chem 278:38084-93 (2003)
DOI:10.1074/jbc.M307028200
  Sequence
[hsa:120227] [mmu:244209]
Reference
2  [PMID:15465040]
  Authors
Shinkyo R, Sakaki T, Kamakura M, Ohta M, Inouye K
  Title
Metabolism of vitamin D by human microsomal CYP2R1.
  Journal
Biochem Biophys Res Commun 324:451-7 (2004)
DOI:10.1016/j.bbrc.2004.09.073
  Sequence
[hsa:120227]
Reference
3  [PMID:18511070]
  Authors
Strushkevich N, Usanov SA, Plotnikov AN, Jones G, Park HW
  Title
Structural analysis of CYP2R1 in complex with vitamin D3.
  Journal
J Mol Biol 380:95-106 (2008)
DOI:10.1016/j.jmb.2008.03.065
  Sequence
[hsa:120227]
Reference
4  [PMID:22310641]
  Authors
Zhu J, Deluca HF
  Title
Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?
  Journal
Arch Biochem Biophys 523:30-6 (2012)
DOI:10.1016/j.abb.2012.01.013
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.24
IUBMB Enzyme Nomenclature: 1.14.14.24
ExPASy - ENZYME nomenclature database: 1.14.14.24
BRENDA, the Enzyme Database: 1.14.14.24

KEGG   REACTION: R03611
Entry
R03611                      Reaction                               
Name
calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)
Definition
Calcidiol + [Oxidized NADPH---hemoprotein reductase] + H2O <=> Vitamin D3 + [Reduced NADPH---hemoprotein reductase] + Oxygen
Equation
Reaction class
RC00963  C01561_C05443
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00103  Cholecalciferol biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.24
     R03611  Calcidiol + [Oxidized NADPH---hemoprotein reductase] + H2O <=> Vitamin D3 + [Reduced NADPH---hemoprotein reductase] + Oxygen
Orthology
K07419  vitamin D 25-hydroxylase [EC:1.14.14.24]
Other DBs
RHEA: 32906

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