K07424                      KO                                     
cytochrome P450 family 3 subfamily A [EC:]
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
   00591 Linoleic acid metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
   05207 Chemical carcinogenesis - receptor activation
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor  unspecific monooxygenase
     K07424  CYP3A; cytochrome P450 family 3 subfamily A
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K07424  CYP3A; cytochrome P450 family 3 subfamily A
Other DBs
RN: R02356 R03408 R07055 R07056 R08390 R08391 R08392
CATY: 105584469
CSYR: 103261808 103277234
MMUR: 105868221 105868329 109729598
LCAT: 123631584 123631585 123631588 123631589
OGA: 100949611
MMU: 100041375(Cyp3a41b) 13112(Cyp3a11) 13113(Cyp3a13) 13114(Cyp3a16) 337924(Cyp3a44) 53973(Cyp3a41a) 56388(Cyp3a25)
MCAL: 110287807 110288178 110294273 110294771
MPAH: 110312811 110313181 110314995 110315701 110315884
RNO: 170509(Cyp3a62) 171352(Cyp3a9) 252931(Cyp3a18) 25642(Cyp3a23-3a1) 266682(Cyp3a2)
MCOC: 116070965 116071005 116071007 116104705 116104706 116104707
HGL: 101700489
CPOC: 100301487(Cyp3a17) 100379244(Cyp3a14) 100379245(Cyp3a15) 100719785 100734717 100734998
OCU: 100328954(CYP3A6)
TUP: 102494214
CFA: 415127(CYP3A26) 489851
ORO: 101368110
MLX: 117999383
NSU: 110571974
FCA: 100642187(CYP3A132) 100652377(CYP3A131)
PTG: 102957386(CYP3A131) 102957670
BTA: 282214(CYP3A5) 507988(CYP3A4) 517246(CYP3A24) 526682(CYP3A5)
SSC: 100126281(CYP3A46) 100144468(CYP3A22) 403324(CYP3A29)
BACU: 103014952
LVE: 103081108
PCAD: 102979137
PSIU: 116739882
ECB: 100067041(CYP3A93) 100067064(CYP3A89) 100067084(CYP3A94) 100067109(CYP3A95) 100067131(CYP3A96) 100067154(CYP3A97) 102149219
MYB: 102263738
PKL: 118703231
HAI: 109378053
TOD: 119241615
GGA: 414832(CYP3A5) 416477(CYP3A4)
MGP: 678668(CYP3A80) 678669(CYP3A37)
SCAN: 103817855
TALA: 104362186
CCRI: 104158338
ACAR: 104523907
AVIT: 104269979
NPD: 112959868
SCAM: 104153925
AMJ: 102570482(CYP3A) 102570712
CPOO: 109314709
XLA: 100037189(cyp3a4.2.L) 108718493 398964(cyp3a4.1.L) 495363(cyp3a5.L)
XTR: 100487054 100487846 100494419(cyp3a4.2) 548503(cyp3a4.3)
DRE: 324340(cyp3c1) 492759(cyp3c3) 553969(cyp3a65) 558473(cyp3c2) 558541(cyp3c4)
OLA: 100125817(cyp3a40) 101155293 101155406(cyp3a) 101155538
CVG: 107089887
CSEM: 103387006
POV: 109633951
MALB: 109970725
SALP: 112075201
LCM: 102365730
CMK: 103185125
RTP: 109917933
CSET: 123309823
PRAP: 110992351
SLIU: 111348641
OBI: 106870822
TDC: 119344950
 » show all
PMID:3785219 (CYP3A2)
Gonzalez FJ, Song BJ, Hardwick JP
Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.
Mol Cell Biol 6:2969-76 (1986)
PMID:1339292 (CYP3A11)
Yanagimoto T, Itoh S, Muller-Enoch D, Kamataki T
Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.
Biochim Biophys Acta 1130:329-32 (1992)
PMID:2001406 (CYP3A12)
Ciaccio PJ, Graves PE, Bourque DP, Glinsmann-Gibson B, Halpert JR
cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.
Biochim Biophys Acta 1088:319-22 (1991)
PMID:11284050 (CYP3A25)
Dai D, Bai R, Hodgson E, Rose RL
Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.
J Biochem Mol Toxicol 15:90-9 (2001)
PMID:21781753 (CYP3A28)
Natsuhori M, van Raak M, Ligtenberg M, Kleij L, Ten Berge D, Zweers-Zeilmaker WM, de Groene EM, van Miert AS, Witkamp RF, Horbach GJ
Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells.
Environ Toxicol Pharmacol 3:17-24 (1997)
PMID:9682441 (CYP3A29)
Nissen PH, Wintero AK, Fredholm M
Mapping of porcine genes belonging to two different cytochrome P450 subfamilies.
Anim Genet 29:7-11 (1998)
PMID:10775455 (CYP3A41)
Sakuma T, Takai M, Endo Y, Kuroiwa M, Ohara A, Jarukamjorn K, Honma R, Nemoto N
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
Arch Biochem Biophys 377:153-62 (2000)
PMID:16414346 (CYP3C1)
Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T, Chung WG, Buhler DR
CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio).
Biochem Biophys Res Commun 340:1039-46 (2006)
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
J Mol Evol 57:200-11 (2003)

DBGET integrated database retrieval system