KEGG   ORTHOLOGY: K07425
Entry
K07425                      KO                                     
Symbol
CYP4A
Name
long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
Pathway
map00071  Fatty acid degradation
map00590  Arachidonic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map03320  PPAR signaling pathway
map04270  Vascular smooth muscle contraction
map04750  Inflammatory mediator regulation of TRP channels
Reaction
R01348  fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)
R07041  arachidonic acid:oxygen 1-oxidoreductase
R07046  
R07050  
R08390  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
   00590 Arachidonic acid metabolism
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.80  long-chain fatty acid omega-monooxygenase
     K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Other DBs
GO: 0052869
Genes
MNI: 105494979
CJC: 100409032(CYP4A11)
SBQ: 101042627 101050377
CIMI: 108312793(CYP4A11)
MMU: 100040843(Cyp4a32) 13117(Cyp4a10) 13118(Cyp4a12b) 13119(Cyp4a14) 230639(Cyp4a29) 277753(Cyp4a12a) 435802(Cyp4a30b) 666168(Cyp4a31)
MCAL: 110288135 110292084 110293093 110293094 110293391 110293392
MPAH: 110315778 110322859 110322974 110323152 110323837
RNO: 120102953(Cyp4a2l1) 24306(Cyp4a2) 266674(Cyp4a8) 298423(Cyp4a3) 50549(Cyp4a1)
MCOC: 116095748 116095749
ANU: 117708416 117708417 117708418 117708593 117708624
ASYL: 127680047 127680048 127680049 127681096
MUN: 110539795 110539797 110541278 110550763
CGE: 100767149 100767636 100767921 100768211 100768783
MAUA: 101823194 101832451 101832714 101844652 121132790
PROB: 127225173 127225174 127225177 127225182
PLEU: 114706710 114706721 114706732
MORG: 121448088 121448117 121448279 121448311 121448312 121448313
MFOT: 126495749 126495750 126515836 126515837
AAMP: 119816437 119816439 119816441 119817231 119817918 119817919
NGI: 103740657
HGL: 101696405 101699948 101700306
CPOC: 100713503 100723678
CCAN: 109680520 109695457
DORD: 105986129 105986133 105986168
DSP: 122104709 122104733 122104750
DMER: 138803374 138803376
PLOP: 125355114 125355115 125355117 125355118
NCAR: 124963626 124978267 124978271
MMMA: 107141795 107141796
ITI: 101955536 101977410 101977879
OPI: 101530008 101530261
TUP: 102473669 102474347 102476589 102477006 102497099
CFA: 475366(CYP4A38) 610385(CYP4A11)
CLUD: 112642531 112642532 112642533
VVP: 112912763 112914749 112914751 112914960
VLG: 121481291
NPO: 129520483 129520757 129520759 129520761
AML: 100470061
UMR: 103670742
UAH: 113249623 125280889 130543466 130543468 130543470
UAR: 123793725 123793728
ELK: 111142795 111142984 111143116 111143122
LLV: 125097015 125097017
MPUF: 101672647 101673985 101674954
MNP: 132000827
MLK: 131809952 131810435 131810436 131810494
NVS: 122899935 122899936 122899939
ORO: 101381707
ZCA: 113926815 113926818
NSU: 110578763
LWW: 102736045
FCA: 101083281(CYP4A106) 101094994(CYP4A37) 105260823(CYP4A105P) 111559047
PCOO: 112863589 112872102
PBG: 122480461 122480462 122480465 122480466 122480467
PVIV: 125172295 125172298 125172299
LRUF: 124515379 124515967 124515969
LGF: 123597831 123597832
AJU: 106973482 106973520 113597990
PTG: 102968444 102968736
PPAD: 109266930 109266933
PUC: 125912647
PLEZ: 122226974 122226975 122226976
HHV: 120226329 120227630 120227720
BTA: 511890(CYP4A11) 516085(CYP4A22) 784417(CYP4A59)
BOM: 102268504 102286095
BIU: 109556325 109556328
BBUB: 102406283 102409965 102414760
BBIS: 104984604 104984605
CHX: 102168409 102172683 102174619 102178903 102181495 108633240
OAS: 101105610 114114831 114114832
BTAX: 128044335 128044409 128044669 128045807
CSUM: 138072592 138073642 138074365 138095511
ODA: 120856188 120856189 120856192 120856597
CCAD: 122428024 122436501
MREE: 136152299 136152313 136152329 136152343 136152381
OVR: 110121530 110126279
MBEZ: 129540745 129540761 129540794 129540797 129540799 129540800 129540822
SSC: 100522145 110255311 403326(CYP4A24)
CFR: 102523990
CBAI: 105065866
CDK: 105092933
VPC: 102540610
BACU: 103000297 103000849
BMUS: 118890091 118890097
LVE: 103085729 103086011
OOR: 101272104 101272359 101283895
LALB: 132516209 132516212
GMF: 115860512
DLE: 111171202 111171379
PCAD: 102978094 102982895
PSIU: 116752311 116752331 116752345 116756601
PPHC: 136122952 136138489
NASI: 112395849 112395850 112400409 112400415
ECB: 100064020 100064092
EPZ: 103565698 103567431
EAI: 106833789 106833867
MYB: 102261051 102262344
MYD: 102774956
MMYO: 118675984 118676913
MLF: 102442952
MDT: 132231121 132231123
MYUM: 139003334 139003336
PKL: 118724854 118724860
EFUS: 103284218 129150260
DRO: 112314476
SHON: 118982431 119001574 119002900
AJM: 119037796 119054461
PDIC: 114496226 114496231 114496696
PHAS: 123827701 123830268 123831612 123832102
MMF: 118626316
PPAM: 129069982
RFQ: 117026835
RAY: 107514040
MJV: 108404957
TOD: 119237232 119237234 119237235
SARA: 101542897 101543177 101551078
SFUM: 130031028 130031094 130031122 130031123
SETR: 126011409 126011411 126011413 126011415 126011416 126011427
TMU: 101345950 101346203
ETF: 101638864 101652360 101652679
DNM: 101422541
MDO: 100023663
GAS: 123245820 123256178
SHR: 100924239 100924766 100925023
AFZ: 127563367
PCW: 110209309 110209310
TVP: 118845836 118847820
PBRV: 138164836 138165371
MQU: 129002320
DPOL: 127850593
 » show all
Reference
PMID:2766932 (CYP4A1)
  Authors
Kimura S, Hanioka N, Matsunaga E, Gonzalez FJ
  Title
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
  Journal
DNA 8:503-16 (1989)
DOI:10.1089/dna.1.1989.8.503
  Sequence
[rno:50549]
Reference
PMID:3410047 (CYP4A10)
  Authors
Earnshaw D, Dale JW, Goldfarb PS, Gibson GG
  Title
Differential splicing in the 3' non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA.
  Journal
FEBS Lett 236:357-61 (1988)
DOI:10.1016/0014-5793(88)80055-3
  Sequence
[rno:50549]
Reference
PMID:9271096 (CYP4A14)
  Authors
Heng YM, Kuo CS, Jones PS, Savory R, Schulz RM, Tomlinson SR, Gray TJ, Bell DR
  Title
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.
  Journal
Biochem J 325 ( Pt 3):741-9 (1997)
DOI:10.1042/bj3250741
  Sequence
[mmu:13119]
Reference
PMID:11931657 (CYP4A24)
  Authors
Lundell K
  Title
Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25].
  Journal
Biochem J 363:297-303 (2002)
DOI:10.1042/0264-6021:3630297
  Sequence
[ssc:403326]

  All links  
Ontology (1)   
   GO (1)   
Gene (27)   
   MGENES (15)   
   OC (12)   
All databases (28)   

Download RDF
DBGET integrated database retrieval system