KEGG   ORTHOLOGY: K07425
Entry
K07425                      KO                                     

Name
CYP4A
Definition
long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
Pathway
ko00071  Fatty acid degradation
ko00590  Arachidonic acid metabolism
ko00830  Retinol metabolism
ko01100  Metabolic pathways
ko03320  PPAR signaling pathway
ko04270  Vascular smooth muscle contraction
ko04750  Inflammatory mediator regulation of TRP channels
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
   00590 Arachidonic acid metabolism
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.80  long-chain fatty acid omega-monooxygenase
     K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Other DBs
RN: R01348 R07041 R07046 R07050 R08390
GO: 0052869
Genes
HSA: 1579(CYP4A11) 284541(CYP4A22)
PTR: 456835(CYP4A22) 739864
PPS: 100972678 100972920
GGO: 101143646 101144011
PON: 100173781
NLE: 100588910
MCC: 709461 721404
MCF: 102123589 102124651(CYP4A11)
CSAB: 103224871(CYP4A22)
RRO: 104662101
RBB: 108535621
MMU: 100040843(Cyp4a32) 13117(Cyp4a10) 13118(Cyp4a12b) 13119(Cyp4a14) 230639(Cyp4a29) 277753(Cyp4a12a) 435802(Cyp4a30b) 666168(Cyp4a31)
RNO: 24306(Cyp4a2) 266674(Cyp4a8) 298423(Cyp4a3) 50549(Cyp4a1)
NGI: 103740657
CFA: 475366(CYP4A38) 482506(CYP4A37) 610385(CYP4A11)
AML: 100470061
UMR: 103670742
UAH: 113249623
ORO: 101381707
BTA: 511890(CYP4A11) 516085(CYP4A22) 784417
SSC: 100522145 110255311 403326(CYP4A24)
CFR: 102523990
CDK: 105092933
MYD: 102774956
DRO: 112314476
RAY: 107514040
MJV: 108404957
MDO: 100023663
GRA: 105796537
GAB: 108474610
VUN: 114162834
CCAJ: 109816127
ADU: 107470679
AIP: 107623710
NTA: 107812114
NTO: 104099274
NAU: 109241958
 » show all
Reference
PMID:2766932
  Authors
Kimura S, Hanioka N, Matsunaga E, Gonzalez FJ
  Title
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
  Journal
DNA 8:503-16 (1989)
DOI:10.1089/dna.1.1989.8.503
  Sequence
[rno:50549 24306]
Reference
PMID:7679927
  Authors
Palmer CN, Richardson TH, Griffin KJ, Hsu MH, Muerhoff AS, Clark JE, Johnson EF
  Title
Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli.
  Journal
Biochim Biophys Acta 1172:161-6 (1993)
DOI:10.1016/0167-4781(93)90285-L
  Sequence
[hsa:1579]
Reference
  Authors
Kawashima H, Naganuma T, Kusunose E, Kono T, Yasumoto R, Sugimura K, Kishimoto T
  Title
Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.
  Journal
Arch Biochem Biophys 378:333-9 (2000)
DOI:10.1006/abbi.2000.1831
  Sequence
[hsa:1579 284541]

DBGET integrated database retrieval system