KEGG   ORTHOLOGY: K07425
Entry
K07425                      KO                                     

Name
CYP4A
Definition
long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
Pathway
ko00071  Fatty acid degradation
ko00590  Arachidonic acid metabolism
ko00830  Retinol metabolism
ko01100  Metabolic pathways
ko03320  PPAR signaling pathway
ko04270  Vascular smooth muscle contraction
ko04750  Inflammatory mediator regulation of TRP channels
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
   00590 Arachidonic acid metabolism
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.80  long-chain fatty acid omega-monooxygenase
     K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Other DBs
RN: R01348 R07041 R07046 R07050 R08390
GO: 0052869
Genes
HSA: 1579(CYP4A11) 284541(CYP4A22)
PTR: 456835(CYP4A22) 739864
PPS: 100972678 100972920
GGO: 101143646 101144011
PON: 100173781
NLE: 100588910
MCC: 709461 721404
MCF: 102123589 102124651(CYP4A11)
CSAB: 103224871(CYP4A22)
RRO: 104662101
RBB: 108535621
CJC: 100387637 100409032
SBQ: 101042627 101050377
MMU: 100040843(Cyp4a32) 13117(Cyp4a10) 13118(Cyp4a12b) 13119(Cyp4a14) 230639(Cyp4a29) 277753(Cyp4a12a) 435802(Cyp4a30b) 666168(Cyp4a31)
MCAL: 110288135 110292084 110293093 110293094 110293391 110293392
MPAH: 110315778 110322859 110322974 110323152 110323837
RNO: 24306(Cyp4a2) 266674(Cyp4a8) 298423(Cyp4a3) 50549(Cyp4a1)
MUN: 110539795 110539797 110541278 110550763
CGE: 100767149 100767636 100767921 100768211 100768783
NGI: 103740657
HGL: 101696405 101699948 101700306
CCAN: 109680520 109695457
OCU: 100328576(CYP4A5) 100328612 100328944(CYP4A7) 100328946(CYP4A6) 100341018 103350283
TUP: 102473669 102474347 102476589 102477006 102497099
CFA: 475366(CYP4A38) 482506(CYP4A37) 610385(CYP4A11)
VVP: 112912763 112914749 112914751 112914960
AML: 100470061
UMR: 103670742
UAH: 113249623
ORO: 101381707
ELK: 111142795 111142984 111143116 111143122
FCA: 101083281 101094994 111559047
PTG: 102968444 102968736
PPAD: 109266930 109266933
AJU: 106973482 106974137 113597990
BTA: 511890(CYP4A11) 516085(CYP4A22) 784417
BOM: 102268504 102270081 102286095
BIU: 109556325 109556328
BBUB: 102406283 102414760
CHX: 102168409 102172683 102174619 102178903 102181495 108633240
OAS: 101105610 114114831 114114832
SSC: 100522145 110255311 403326(CYP4A24)
CFR: 102523990
CDK: 105092933
BACU: 103000297 103000849
LVE: 103085729 103086011
OOR: 101272104 101272359 101277841 101283895
DLE: 111171202 111171379
PCAD: 102978094 102982895
ECB: 100064020 100064092
EPZ: 103565698 103567431
EAI: 106833744 106833789 106833867
MYB: 102261051 102262344
MYD: 102774956
DRO: 112314476
RAY: 107514040
MJV: 108404957
TMU: 101345950 101346203
MDO: 100023663
SHR: 100924239 100924766 100925023
PCW: 110209309 110209310
LGI: LOTGIDRAFT_122078
GRA: 105796537
GHI: 107941574 107944444
GAB: 108474610
VUN: 114162834
CCAJ: 109816127
ADU: 107470679
AIP: 107623710
NTA: 107812114
NTO: 104099274
NAU: 109241958
SRE: PTSG_09918
 » show all
Reference
PMID:2766932
  Authors
Kimura S, Hanioka N, Matsunaga E, Gonzalez FJ
  Title
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
  Journal
DNA 8:503-16 (1989)
DOI:10.1089/dna.1.1989.8.503
  Sequence
[rno:50549 24306]
Reference
PMID:7679927
  Authors
Palmer CN, Richardson TH, Griffin KJ, Hsu MH, Muerhoff AS, Clark JE, Johnson EF
  Title
Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli.
  Journal
Biochim Biophys Acta 1172:161-6 (1993)
DOI:10.1016/0167-4781(93)90285-L
  Sequence
[hsa:1579]
Reference
  Authors
Kawashima H, Naganuma T, Kusunose E, Kono T, Yasumoto R, Sugimura K, Kishimoto T
  Title
Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.
  Journal
Arch Biochem Biophys 378:333-9 (2000)
DOI:10.1006/abbi.2000.1831
  Sequence
[hsa:1579 284541]

  All links  
Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (14)   
   KEGG PATHWAY (14)   
Chemical reaction (10)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
   KEGG RCLASS (4)   
Gene (184)   
   KEGG GENES (165)   
   KEGG MGENES (7)   
   OC (12)   
Protein sequence (79)   
   UniProt (66)   
   SWISS-PROT (13)   
Literature (3)   
   PubMed (3)   
All databases (294)   

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