Entry
Symbol
CYP4A
Name
long-chain fatty acid omega-monooxygenase [EC:
1.14.14.80 ]
Pathway
map04270 Vascular smooth muscle contraction
map04750 Inflammatory mediator regulation of TRP channels
Reaction
R01348 fatty acid,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)
R07041 arachidonic acid:oxygen 1-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09103 Lipid metabolism
00071 Fatty acid degradation
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
00590 Arachidonic acid metabolism
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
09108 Metabolism of cofactors and vitamins
00830 Retinol metabolism
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
09150 Organismal Systems
09152 Endocrine system
03320 PPAR signaling pathway
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
09153 Circulatory system
04270 Vascular smooth muscle contraction
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.80 long-chain fatty acid omega-monooxygenase
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
Cytochrome P450 [BR:ko00199 ]
Cytochrome P450, animal type
CYP4 family
K07425 CYP4A; long-chain fatty acid omega-monooxygenase
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Kimura S, Hanioka N, Matsunaga E, Gonzalez FJ
Title
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
Journal
Sequence
Reference
Authors
Earnshaw D, Dale JW, Goldfarb PS, Gibson GG
Title
Differential splicing in the 3' non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA.
Journal
Sequence
Reference
Authors
Heng YM, Kuo CS, Jones PS, Savory R, Schulz RM, Tomlinson SR, Gray TJ, Bell DR
Title
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.
Journal
Sequence
Reference
Authors
Lundell K
Title
Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25].
Journal
Sequence