KEGG ORTHOLOGY: K07434

KEGG

ORTHOLOGY: K07434

Entry

K07434                      KO

Symbol

CYP19A

Name

aromatase [EC:1.14.14.14]

Pathway

Steroid hormone biosynthesis

Metabolic pathways

Ovarian steroidogenesis

Module

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

Reaction

androstenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)

19-oxoandrostenedione,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)

testosterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (19-hydroxylating)

19-oxotestosterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (aromatizing, formate-forming)

19-hydroxyandrostenedione,NADPH---hemoprotein reductase:oxygen 19-oxidoreductase

19-hydroxytestosterone,NADPH---hemoprotein reductase:oxygen 19-oxidoreductase

Disease

Aromatase excess syndrome

Aromatase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07434  CYP19A; aromatase
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07434  CYP19A; aromatase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07434  CYP19A; aromatase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.14  aromatase
     K07434  CYP19A; aromatase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP19 family
   K07434  CYP19A; aromatase

Genes

HSA:	1588(CYP19A1)

PTR:	453433(CYP19A1)

PPS:	100984744(CYP19A1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	678697(CYP19A1)

MCF:	102117886(CYP19A1)

MTHB:

MNI:

CSAB:

103245629(CYP19A1)

CATY:

PANU:

100997810 116272542

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100411557(CYP19A1)

SBQ:

CIMI:

108286664(CYP19A1)

ANAN:

105710056(CYP19A1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13075(Cyp19a1)

MCAL:

MPAH:

RNO:	25147(Cyp19a1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

109675669 109679172

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100328545(CYP19A1)

OPI:

TUP:

GVR:

CFA:	494003(CYP19A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101094932(CYP19A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	281740(CYP19A1)

BOM:

BIU:

BBUB:

BBIS:

CHX:	100861413(CYP19A1) 102172726

OAS:	100144423(CYP19)

BTAX:

128054322 128054328

ODA:	120852986 120853641

CCAD:

MBEZ:

SSC:	403331(CYP19A1) 403332(CYP19A2) 403333(CYP19A3)

CFR:	102519005 116664105

CBAI:

CDK:	105086637 105106135 116153434

VPC:

BACU:

103011787 103012080

BMUS:

118890681 118890682 118890683

LVE:	103080853 103081312

OOR:	101270659 101283540

DLE:	111170860 111170861 111171015

PCAD:

102982383 102982657 102995165

PSIU:

116749060 116749147

NASI:

112397422 112397499

ECB:	100009712(CYP19A1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

GGA:	414854(CYP19A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106033779(CYP19A1)

CATA:

AFUL:

TGU:	751777(CYP19A1)

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136366790(CYP19A1)

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CSTI:

LDI:

MNB:

DPUB:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

CLV:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102566432(CYP19A1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:	100565397(cyp19a1)

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	373656(cyp19a1.L)

XTR:	100036594(cyp19a1)

NPR:

RTEM:

BBUF:

120985817 120985818

BGAR:

122927630 122927631

MUO:

GSH:

DRE:	30390(cyp19a1a) 60640(cyp19a1b)

SRX:	107746936 107748317

SANH:

107674832 107700584

SGH:	107571340 107588541

CCAR:

109051432 109068452 109072133

CAUA:

113042873 113061867 113082814 113118576

CGIB:

127934323 127977536 128014519

PTET:

122330655 122362496

LROH:

127156350 127181253

OMC:	131524768 131534839

PPRM:

120477771 120485850

RKG:	130089396 130106434

MAMB:

125246945 125254507

CIDE:

127500194 127507121

CERY:

137014956(cyp19a1b) 137023122(cyp19a1a)

MASI:

127436251 127456148

TROS:

130549838 130551793

TDW:	130413969 130435397

MANU:

129419642 129433099

IPU:	100304581 108264511

IFU:	128607126 128618683

PHYP:

113530142 113534440

SMEO:

124392156 124395700

TFD:

TVC:	132851508 132856826

TRN:	134311698 134323481

AMEX:

CMAO:

118804009 118811907

EEE:	113577298 113584485

CHAR:

105889015 105892489

TRU:	100379639(pfcyp19b-tstr) 101076508(pfcyp19a)

TFS:	130514159 130535683

TNG:	GSTEN00018058G001 GSTEN00025591G001

LCO:	104920192 104932825

NCC:	104960111 104962728

TBEN:

117471655 117491915

CGOB:

115009664 115024369

PGEO:

GACU:

117538803 117549393

EMAC:

134863227 134877208

ELY:	117258936 117261795

EFO:	125886862 125904127

PLEP:

121947240 121949866

SLUC:

116038508 116054646

ECRA:

117939964 117949645

ESP:	116691016 116693877

PFLV:

114557236 114559505

GAT:	120808695 120811580

PPUG:

119196278 119197603

AFB:	129105323 129108358

CLUM:

117732474 117750439

PSWI:

MSAM:

119890709 119893898

SCHU:

122875290 122875399

CUD:	121515762 121524971

ALAT:

119017644 119023827

MZE:	101468629 106675461 112431276

ONL:	100534396 100708217

OAU:	116311653 116326742

OLA:	100125815(cyp19b) 101174651

OML:	112152291 112161048

CSAI:

133444884 133456348

XMA:	102231498 102236527

XCO:	114142484 114159678

XHE:	116718071 116736226

PRET:

103462065 103466459

PFOR:

103143597 103156494

PLAI:

106947725 106960953

PMEI:

106912224 106932411

GAF:	122835378 122841295

PPRL:

129369686 129370875

CVG:	107085369 107096869

CTUL:

119782422 119792512

GMU:	124867322 124881651

NFU:	107373024 107388638

KMR:	108230104 108250266

ALIM:

106521145 106530933 106536387

NWH:	119416354 119423009

AOCE:

111565746 111577263

MCEP:

125005804 125014725

CSEM:

103378914 103380488

POV:	109624148 109624967

SSEN:

122772648 122776510

HHIP:

117754230 117762605 117778658

HSP:	118103743 118109472 118122615 124851147

PPLT:

128440846 128444440

SMAU:

118301847 118315259

LCF:	108876685 108887913

SDU:	111223187 111229564

SLAL:

111656853 111666923

XGL:	120793548 120794915

HCQ:	109507515 109525752

SSCV:

125967127 125970121

SBIA:

133497695 133502032

PEE:	133399339 133402410

PTAO:

133467229 133478541

BPEC:

110169315 110172912

MALB:

109963333 109974150

BSPL:

114852301 114857594

SJO:	128359247 128361936

SASA:

106562534 106584746(CYP19B) 106587170(CYP19)

STRU:

115166948 115192897 115203363

OTW:	112241217 112264373

OMY:	110506809 110506810 110521201

OGO:	124017811 124037481

ONE:	115116861 115144680

OKI:	109895311 109897677

OKE:	118359379 118382159

SALP:

112068480 112073830

SNH:	120048793 120048801 120052328

CCLU:

121540733 121579689

ELS:	105018178 105022679

SFM:

PKI:

AANG:

LOC:

PSPA:

121294903 121299384

ARUT:

117428169 117429562

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

BFO:	118411241 118413506

BBEL:

109471188 109481437

BCOO:

HSY:

Reference

PMID:2973313 (CYP19A1)

Authors

Harada N

Title

Cloning of a complete cDNA encoding human aromatase: immunochemical identification and sequence analysis.

Journal

Biochem Biophys Res Commun 156:725-32 (1988)
DOI:10.1016/S0006-291X(88)80903-3

Sequence

[hsa:1588]

DBGET integrated database retrieval system