KEGG   ORTHOLOGY: K07437
Entry
K07437                      KO                                     

Name
CYP26A
Definition
cytochrome P450 family 26 subfamily A
Pathway
ko00830  Retinol metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07437  CYP26A; cytochrome P450 family 26 subfamily A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07437  CYP26A; cytochrome P450 family 26 subfamily A
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP26 family
   K07437  CYP26A; cytochrome P450 family 26 subfamily A
Other DBs
RN: R08390 R08392
Genes
HSA: 1592(CYP26A1)
PTR: 450614(CYP26A1)
PPS: 103782775
GGO: 101144264
PON: 100435184
NLE: 100594290
MCC: 699519(CYP26A1)
MCF: 102132859
CSAB: 103216270
RRO: 104676509
RBB: 108532598
CJC: 100388379(CYP26A1)
SBQ: 101048379
MMU: 13082(Cyp26a1)
MCAL: 110285520
MPAH: 110329726
RNO: 154985(Cyp26a1)
CGE: 100755549
NGI: 103747274
HGL: 101699044
CCAN: 109690719
OCU: 100346910
TUP: 102494189
CFA: 486804(CYP26A1)
VVP: 112913898
AML: 100481237
UMR: 103668081
UAH: 113243079
ORO: 101378675
ELK: 111145318
FCA: 101086422
PTG: 102972644
PPAD: 109264664
AJU: 106965851
BTA: 539047(CYP26A1)
BOM: 102266920
BIU: 109553251
BBUB: 102416634
CHX: 102175265
OAS: 101103439
SSC: 100124374(CYP26A1)
CFR: 102503915
CDK: 105084236
BACU: 103016462
LVE: 103076802
OOR: 101277533
DLE: 111172487
PCAD: 102990856
ECB: 100061805(CYP26A1)
EPZ: 103551245
EAI: 106845090
MYB: 102264106
MYD: 102757095
MNA: 107543270
HAI: 109380908
DRO: 112307388
PALE: 102877717
RAY: 107514019
MJV: 108400363
LAV: 100654869
TMU: 101342550
MDO: 100023867
SHR: 100934553
PCW: 110192764
GGA: 408183(CYP26A1)
MGP: 100540904
CJO: 107315945
NMEL: 110400547
APLA: 101801058
ACYG: 106041199
TGU: 100225627
LSR: 110475813
SCAN: 103813914
GFR: 102045174
FAB: 101811650
PHI: 102106735
PMAJ: 107206536
CCAE: 111931195
CCW: 104697916
ETL: 114071863
FPG: 101918170
FCH: 102055579
CLV: 102092845
EGZ: 104129061
NNI: 104012959
ACUN: 113481448
PADL: 103925996
AAM: 106491528
AMJ: 102575941(CYP26A1)
PSS: 102454505
CMY: 102939037
CPIC: 101950326
ACS: 100564658
PVT: 110073571
PBI: 103064486
PMUR: 107283401
TSR: 106555019
PMUA: 114597332
GJA: 107106479
XLA: 398094(cyp26a1.S) 496314(cyp26a1.L)
XTR: 548901(cyp26a1)
NPR: 108788826
DRE: 30381(cyp26a1)
IPU: 108273895(cyp26a1)
PHYP: 113527613
AMEX: 103044660
EEE: 113584635
TRU: 101063989
LCO: 104928862
NCC: 104942514
MZE: 101468649
ONL: 100695684
OLA: 101156925(cyp26a1)
XMA: 102237203
XCO: 114150457
PRET: 103482193
CVG: 107087635
KMR: 108245157
ALIM: 106531514
AOCE: 111565182
CSEM: 103381669
POV: 109626586
LCF: 108876786
SDU: 111237093
SLAL: 111664285
HCQ: 109529274
BPEC: 110154377
MALB: 109966688
ELS: 105025284
PKI: 111853683
LCM: 102365386
CMK: 103180634
RTP: 109927150
CIN: 100185941
APLC: 110982498
PCAN: 112564620
OBI: 106882427
TCC: 18614214
GAB: 108477206
DZI: 111304682
VRA: 106768563
VAR: 108337510
CCAJ: 109817436
LANG: 109359597
PPER: 18784094
MCHA: 111005488
CMAX: 111468378
JCU: 105650507
HBR: 110637986
VVI: 100259055
NTO: 104097993
NAU: 109207527
INI: 109172509
OEU: 111380933
LSV: 111889182
SOE: 110784874
ATR: 18443289
APRO: F751_6686
AMR: AM1_B0302
MAR: MAE_48830
MPK: VL20_3541
 » show all
Reference
PMID:9228017
  Authors
White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Petkovich M
  Title
cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450.
  Journal
J Biol Chem 272:18538-41 (1997)
DOI:10.1074/jbc.272.30.18538
  Sequence
[hsa:1592]

KEGG   ORTHOLOGY: K12664
Entry
K12664                      KO                                     

Name
CYP26B
Definition
cytochrome P450 family 26 subfamily B
Pathway
ko00830  Retinol metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K12664  CYP26B; cytochrome P450 family 26 subfamily B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K12664  CYP26B; cytochrome P450 family 26 subfamily B
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP26 family
   K12664  CYP26B; cytochrome P450 family 26 subfamily B
Other DBs
RN: R08390 R08392
Genes
HSA: 56603(CYP26B1)
PTR: 738157
PPS: 100990990
GGO: 101126229
PON: 100446166
NLE: 100584815
MCC: 704750
MCF: 102131789
CSAB: 103220070(CYP26B1)
RRO: 104661347
RBB: 108532622
CJC: 100393102(CYP26B1)
SBQ: 101035734
MMU: 232174(Cyp26b1)
MCAL: 110296452
MPAH: 110316287
RNO: 312495(Cyp26b1)
CGE: 100756748
NGI: 103726965
HGL: 101714280
CCAN: 109696331
OCU: 100341926
TUP: 102488396
CFA: 483120(CYP26B1)
VVP: 112916748
AML: 100479222
UMR: 103671821
UAH: 113244073
ORO: 101367347
ELK: 111148077
FCA: 101100712
PTG: 102959380
PPAD: 109262761
AJU: 106967773
BTA: 540868(CYP26B1)
BOM: 102272258
BIU: 109565943
BBUB: 102416091
CHX: 102187233
OAS: 101110922
SSC: 100521659
CFR: 102520321
CDK: 105101462
BACU: 102997198
LVE: 103084950
OOR: 101286392
DLE: 111167902
PCAD: 102982571
ECB: 100059609(CYP26B1)
EPZ: 103557120
EAI: 106828299
MYB: 102260625
MYD: 102763747
MNA: 107529280
HAI: 109385401
DRO: 112298127
PALE: 102885574
RAY: 107502948
MJV: 108402254
LAV: 100676717
TMU: 101354796
SHR: 100926797
PCW: 110218442
OAA: 100075935
GGA: 428809(CYP26B1)
MGP: 100544938
CJO: 107314121
NMEL: 110398722
APLA: 101804465
ACYG: 106043174
TGU: 100221095
LSR: 110468712
GFR: 102043042
FAB: 101817696
PHI: 102109019
PMAJ: 107202637
CCAE: 111929164
CCW: 104697667
ETL: 114072005
FPG: 101913040
FCH: 102047896
CLV: 102085715
EGZ: 104128341
NNI: 104019167
ACUN: 113479260
PADL: 103914285
AAM: 106493458
ASN: 102388048
AMJ: 102567612(CYP26B1)
PSS: 102450173
CMY: 102946478
CPIC: 101953793
PVT: 110079849
PBI: 103052492
PMUR: 107297447
PMUA: 114604437
GJA: 107106000
XLA: 100170648(cyp26b1.L) 108706485(cyp26b1.S)
XTR: 780112(cyp26b1)
NPR: 108790844
DRE: 324188(cyp26b1)
IPU: 108267534
PHYP: 113540460
AMEX: 103033177
EEE: 113579806
TRU: 101076120
LCO: 104929718
NCC: 104949566
MZE: 101471303
ONL: 100690880
OLA: 101159703(cyp26b1)
XMA: 102220969
XCO: 114157289
PRET: 103480607
CVG: 107094667
NFU: 107376907
KMR: 108249672
ALIM: 106523830
AOCE: 111569154
CSEM: 103388995
POV: 109634943
LCF: 108902785
SDU: 111233339
SLAL: 111657889
HCQ: 109506933
BPEC: 110163435
MALB: 109974207
OTW: 112241180
SALP: 112075274
ELS: 105010221
SFM: 108920646
PKI: 111857380
LCM: 102357972
MYI: 110453273
LAK: 106169000
GAB: 108452680
RCN: 112189824
SPEN: 107025617
SOT: 102588032
CQI: 110701847
SYW: SYNW1408
SYNR: KR49_00825
SYND: KR52_08615
SYH: Syncc8109_1119(cypX)
SYNW: SynWH8103_01582(cypX)
PMF: P9303_03561(cypX)
 » show all
Reference
  Authors
White JA, Ramshaw H, Taimi M, Stangle W, Zhang A, Everingham S, Creighton S, Tam SP, Jones G, Petkovich M
  Title
Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.
  Journal
Proc Natl Acad Sci U S A 97:6403-8 (2000)
DOI:10.1073/pnas.120161397
  Sequence
[hsa:56603]

KEGG   ORTHOLOGY: K12665
Entry
K12665                      KO                                     

Name
CYP26C
Definition
cytochrome P450 family 26 subfamily C
Pathway
ko00830  Retinol metabolism
ko01100  Metabolic pathways
Disease
H02083  Focal facial dermal dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K12665  CYP26C; cytochrome P450 family 26 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K12665  CYP26C; cytochrome P450 family 26 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP26 family
   K12665  CYP26C; cytochrome P450 family 26 subfamily C
Other DBs
RN: R08390 R08392
Genes
HSA: 340665(CYP26C1)
PTR: 100610581
PPS: 100989646
GGO: 101143888
PON: 100434810
NLE: 100593952
MCC: 699391
MCF: 102132475
RRO: 104676508
RBB: 108532596
CJC: 100388017(CYP26C1)
SBQ: 101048691
MMU: 546726(Cyp26c1)
MCAL: 110285854
MPAH: 110313554
RNO: 308190(Cyp26c1)
CGE: 100755258
NGI: 103747273
HGL: 101708363
CCAN: 109690718
OCU: 100346650
TUP: 102493504
CFA: 608216(CYP26C1)
VVP: 112913894
AML: 100484497
UAH: 113243078
ORO: 101378970
ELK: 111144664
FCA: 101093894
PTG: 102972355
PPAD: 109264665
AJU: 106965845
BTA: 539048(CYP26C1)
BOM: 102270163
BIU: 109579096
BBUB: 102396855
CHX: 106503632
OAS: 101104703
SSC: 100739552
CFR: 102508857
CDK: 105084365
BACU: 103016735
LVE: 103076534
OOR: 101277292
DLE: 111172488
PCAD: 102991140
ECB: 100071239
EPZ: 103551257
EAI: 106845080
MYB: 102245396
MYD: 102765165
MNA: 107543251
HAI: 109380907
DRO: 112307409
PALE: 102894547
RAY: 107514017
MJV: 108400362
LAV: 100675746
TMU: 101342295
MDO: 100023898
SHR: 100918833
PCW: 110192755
OAA: 100074724
GGA: 423806(CYP26C1)
MGP: 100542130
CJO: 107315949
NMEL: 110399532
APLA: 101801251
ACYG: 106048341
TGU: 100218943
LSR: 110475659
SCAN: 103813913
GFR: 102045214
FAB: 101811844
PHI: 102113431
PMAJ: 107206529
CCAE: 111930924
CCW: 104697915
ETL: 114071746
FPG: 101914181
FCH: 102055745
CLV: 102086918
NNI: 104013868
ACUN: 113481447
PADL: 103926005
AAM: 106491513
AMJ: 102577027
PSS: 102453949
CMY: 102944483
CPIC: 101934998
ACS: 100564860
PVT: 110073558
PBI: 103066292
PMUR: 107283386
TSR: 106551127
PMUA: 114597334
GJA: 107106470
XLA: 108696124(cyp26c1.L) 735026(cyp26c1.S)
XTR: 100489980(cyp26c1)
NPR: 108788831
DRE: 554036(cyp26c1)
IPU: 108270418(CYP26C1)
PHYP: 113544973
AMEX: 103028126
EEE: 113591990
TRU: 101072612
LCO: 104937509
NCC: 104957939
MZE: 101468064
ONL: 100705715
OLA: 101163759
XMA: 102219328
XCO: 114138040
PRET: 103477363
CVG: 107097168
NFU: 107395366
KMR: 108246633
ALIM: 106520090
AOCE: 111586172
CSEM: 103387173
POV: 109645155
LCF: 108872855
SDU: 111224227
SLAL: 111670140
HCQ: 109510250
BPEC: 110153148
MALB: 109963802
ELS: 105010533
LCM: 102365117
CMK: 103180630
RTP: 109912065
CIN: 100187485
 » show all
Reference
  Authors
Taimi M, Helvig C, Wisniewski J, Ramshaw H, White J, Amad M, Korczak B, Petkovich M
  Title
A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid.
  Journal
J Biol Chem 279:77-85 (2004)
DOI:10.1074/jbc.M308337200
  Sequence
[hsa:340665]
Reference
  Authors
Zhong G, Ortiz D, Zelter A, Nath A, Isoherranen N
  Title
CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins.
  Journal
Mol Pharmacol 93:489-503 (2018)
DOI:10.1124/mol.117.111039
  Sequence
[hsa:340665]

KEGG   REACTION: R08392
Entry
R08392                      Reaction                               

Definition
Retinoate + NADPH + H+ + Oxygen <=> all-trans-4-Hydroxyretinoic acid + NADP+ + H2O
Equation
Comment
CYP1A1/2, CYP2A6, CYP2B6, CYP2C8/9/18, CYP3A4/5/7, CYP26, CYP2S1
Reaction class
RC00001  C00005_C00006
RC00723  C00777_C16677
Enzyme
1.14.13.-       1.14.14.1       1.14.14.-
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Orthology
K07408  cytochrome P450 family 1 subfamily A polypeptide 1 [EC:1.14.14.1]
K07409  cytochrome P450 family 1 subfamily A polypeptide 2 [EC:1.14.14.1]
K07411  cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
K07412  cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
K07413  cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
K07420  cytochrome P450 family 2 subfamily S polypeptide 1 [EC:1.14.14.1]
K07424  cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
K07437  cytochrome P450 family 26 subfamily A
K12664  cytochrome P450 family 26 subfamily B
K12665  cytochrome P450 family 26 subfamily C
K17683  cytochrome P450 family 2 subfamily A polypeptide 6 [EC:1.14.13.-]
K17689  cytochrome P450 family 3 subfamily A polypeptide 4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.13.-]
K17690  cytochrome P450 family 3 subfamily A polypeptide 5 [EC:1.14.14.1]
K17691  cytochrome P450 family 3 subfamily A polypeptide 7 [EC:1.14.14.1]
K17709  cytochrome P450 family 2 subfamily B polypeptide 6 [EC:1.14.13.-]
K17718  cytochrome P450 family 2 subfamily C polypeptide 8 [EC:1.14.14.1]
K17719  cytochrome P450 family 2 subfamily C polypeptide 9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
K17720  cytochrome P450 family 2 subfamily C polypeptide 18 [EC:1.14.14.1]

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