KEGG ORTHOLOGY: K07508

ORTHOLOGY: K07508

Entry

K07508                      KO

Symbol

ACAA2

Name

acetyl-CoA acyltransferase 2 [EC:2.3.1.16]

Pathway

map00062

Fatty acid elongation

map00071

Fatty acid degradation

map00280

Valine, leucine and isoleucine degradation

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01212

Fatty acid metabolism

Module

M00085

Fatty acid elongation in mitochondria

M00087

beta-Oxidation

Reaction

R00238

acetyl-CoA:acetyl-CoA C-acetyltransferase

R00391

acyl-CoA:acetyl-CoA C-acyltransferase

R00927

acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase

R01177

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

R03778

octanoyl-CoA:acetyl-CoA C-acyltransferase

R03858

lauroyl-CoA:acetyl-CoA C-acyltransferase

R03991

myristoyl-CoA:acetylCoA C-myristoyltransferase

R04546

R04742

decanoyl-CoA:acetyl-CoA C-acyltransferase

R04747

hexanoyl-CoA:acetyl-CoA C-acyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
   00071 Fatty acid degradation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07508  ACAA2; acetyl-CoA acyltransferase 2
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.16  acetyl-CoA C-acyltransferase
     K07508  ACAA2; acetyl-CoA acyltransferase 2

Other DBs

GO:

0003988

Genes

HSA:	10449(ACAA2)

PTR:	455414(ACAA2)

PPS:	100986504(ACAA2)

GGO:	101146857(ACAA2)

PON:	100171644(ACAA2)

PPYG:

129018813(ACAA2)

NLE:	100595632(ACAA2)

HMH:	116468550(ACAA2)

SSYN:

129493468(ACAA2)

MCC:	709350(ACAA2)

MCF:	101865671(ACAA2)

MTHB:

126941317

MNI:	105489396(ACAA2)

CSAB:

103222430(ACAA2)

CATY:

105592504(ACAA2)

PANU:

101012951(ACAA2)

TGE:	112611277(ACAA2)

MLEU:

105531185(ACAA2)

RRO:	104656838(ACAA2)

RBB:	108539750(ACAA2)

TFN:	117063912(ACAA2) 117083992

PTEH:

111539668(ACAA2)

CANG:

105502358(ACAA2)

CJC:	100402284(ACAA2)

SBQ:	101036389(ACAA2)

CIMI:

108305099(ACAA2)

ANAN:

105709025(ACAA2)

CSYR:

103266899(ACAA2)

MMUR:

105874245(ACAA2)

LCAT:

123621943(ACAA2)

PCOQ:

105808881(ACAA2)

OGA:	100958557(ACAA2)

MMU:	52538(Acaa2)

MCAL:

110284792(Acaa2)

MPAH:

110333199(Acaa2)

RNO:	170465(Acaa2)

MCOC:

116087353(Acaa2)

ANU:	117720173(Acaa2)

ASYL:

127663835(Acaa2)

MUN:	110561488(Acaa2)

CGE:	100765829(Acaa2)

MAUA:

101828915(Acaa2)

PROB:

127234357(Acaa2)

PLEU:

114694872(Acaa2)

MORG:

121438798(Acaa2)

MFOT:

126507317

AAMP:

119814212(Acaa2)

NGI:	103724572(Acaa2)

HGL:	101721744(Acaa2)

CPOC:

100715434(Acaa2)

CCAN:

109698177(Acaa2)

DORD:

105987579(Acaa2)

DSP:	122104322(Acaa2)

PLOP:

125364172(Acaa2)

NCAR:

124965793

MMMA:

107139510(Acaa2)

ITI:	101965134(Acaa2)

OCU:

100339733

OPI:	101529594(ACAA2)

TUP:	102473069(ACAA2)

GVR:	103609291(ACAA2)

CFA:	490568(ACAA2)

CLUD:

112648122(ACAA2)

VVP:	112925318(ACAA2)

VLG:	121489297(ACAA2)

NPO:	129508696(ACAA2)

AML:	100476344(ACAA2)

UMR:	103664100(ACAA2)

UAH:	113253408(ACAA2)

UAR:	123787380(ACAA2)

ELK:

111142457

LLV:

125081701

MPUF:

101687319(ACAA2)

MNP:	132023620(ACAA2)

MLK:	131810871(ACAA2)

NVS:	122902889(ACAA2)

ORO:	101378384(ACAA2)

EJU:	114205018(ACAA2)

ZCA:	113913091(ACAA2)

MLX:	118004702(ACAA2)

NSU:	110577100(ACAA2)

LWW:	102733309(ACAA2)

FCA:	101089302(ACAA2)

PYU:	121032937(ACAA2)

PCOO:

112868251(ACAA2)

PBG:	122470761(ACAA2)

PVIV:

125149408(ACAA2)

LRUF:

124517051

PTG:	102967396(ACAA2)

PPAD:

109275723(ACAA2)

PUC:

125914608

AJU:

106974956

HHV:	120229676(ACAA2)

BTA:	522006(ACAA2)

BOM:	102270140(ACAA2)

BBUB:

102391006(ACAA2)

BBIS:

104995804(ACAA2)

CHX:	102183474(ACAA2)

OAS:	101111925(ACAA2)

BTAX:

128067415(ACAA2)

CSUM:

138097533(ACAA2)

ODA:	120880995(ACAA2)

CCAD:

122425461(ACAA2)

MREE:

136166460(ACAA2)

MBEZ:

129549844(ACAA2)

SSC:	100312959(ACAA2)

CFR:	102510739(ACAA2)

CBAI:

105073958(ACAA2)

CDK:	105103279(ACAA2)

VPC:	102536826(ACAA2)

BACU:

103010085(ACAA2)

BMUS:

118880084(ACAA2)

LVE:	103089821(ACAA2)

OOR:	101280546(ACAA2)

DLE:	111180263(ACAA2)

PCAD:

102982675(ACAA2)

PSIU:

116739273(ACAA2)

NASI:

112407470(ACAA2)

ECB:	100069345(ACAA2)

EPZ:	103547459(ACAA2)

EAI:	106834604(ACAA2)

MYB:	102258815(ACAA2)

MYD:	102756865(ACAA2)

MMYO:

118663396(ACAA2)

MLF:	102423649(ACAA2)

MDT:	132240007(ACAA2)

PKL:	118708032(ACAA2)

EFUS:

103292168(ACAA2)

MNA:	107546630(ACAA2)

DRO:	112322907(ACAA2)

SHON:

118978584(ACAA2)

AJM:	119063650(ACAA2)

PDIC:

114506451(ACAA2)

PHAS:

123826347(ACAA2)

MMF:	118619001(ACAA2)

PPAM:

129078713(ACAA2)

HAI:	109376904(ACAA2)

RFQ:	117011944(ACAA2)

PALE:

102895865(ACAA2)

PGIG:

120585516(ACAA2)

PVP:	105292509(ACAA2)

MJV:	108400223(ACAA2)

TOD:	119243044(ACAA2)

SARA:

101550180(ACAA2)

SFUM:

130045323(ACAA2)

SETR:

126020085(ACAA2)

LAV:	100669834(ACAA2)

ETF:	101645394(ACAA2)

DNM:	101414975(ACAA2)

MDO:	100020101(ACAA2)

GAS:	123252209(ACAA2)

SHR:	100919041(ACAA2)

AFZ:

127543507

PCW:	110198152(ACAA2)

TVP:	118855249(ACAA2)

PBRV:

138174150(ACAA2)

OAA:	100077748(ACAA2)

GGA:	426847(ACAA2)

PCOC:

116231380(ACAA2)

MGP:	100543276(ACAA2)

CJO:	107305710(ACAA2)

TPAI:

128074326(ACAA2)

LMUT:

125686959(ACAA2)

NMEL:

110390054(ACAA2)

APLA:

101791052(ACAA2)

ACYG:

106037343(ACAA2)

CATA:

118254586(ACAA2)

AFUL:

116500921(ACAA2)

TGU:	100231849(ACAA2)

LSR:	110478717(ACAA2)

SCAN:

103820669(ACAA2)

PMOA:

120513688(ACAA2)

OTC:	121346103(ACAA2)

PRUF:

121350379(ACAA2)

GFR:	102031671(ACAA2)

FAB:	101820899(ACAA2)

OMA:	130265225(ACAA2)

PHI:	102099098(ACAA2)

PMAJ:

107198381(ACAA2)

CCAE:

111940954(ACAA2)

CCW:	104686724(ACAA2)

CBRC:

103615659(ACAA2)

ACOE:

138103317(ACAA2)

ETL:	114064115(ACAA2)

ZAB:	102063959(ACAA2)

ZLE:	135459985(ACAA2)

ACHL:

103802382(ACAA2)

SVG:	106865053(ACAA2)

MMEA:

130580744(ACAA2)

HRT:	120765692(ACAA2)

SATI:

136374608(ACAA2)

FPG:	101917832(ACAA2)

FCH:	102058082(ACAA2)

CCRI:

104161533

NNT:	104413091(ACAA2)

SHAB:

115601130(ACAA2)

ACUN:

113489837(ACAA2)

TALA:

104357364(ACAA2)

ACHC:

115337441(ACAA2)

HALD:

104317092(ACAA2)

HLE:	104841385(ACAA2)

AGEN:

126035605

HHAR:

128137153(ACAA2)

GCL:

127027230

CSTI:

104555521(ACAA2)

LDI:	104354115(ACAA2)

MNB:	103777496(ACAA2)

PPUS:

135173445(ACAA2)

AVIT:

104270496(ACAA2)

BRHI:

104488940 104496984(ACAA2)

EGZ:	104134191(ACAA2)

NNI:	104010858(ACAA2)

PCRI:

104025677(ACAA2)

PCAO:

104041008

PADL:

103919461(ACAA2)

AFOR:

103894446(ACAA2)

FGA:	104070464(ACAA2)

GSTE:

104263982(ACAA2)

CLV:	102090854(ACAA2)

MUI:	104540605(ACAA2)

PGUU:

104463522(ACAA2)

PLET:

104627658(ACAA2)

EHS:	104512621(ACAA2)

CMAC:

104479179(ACAA2)

CUCA:

104063574(ACAA2)

TEO:	104383357(ACAA2)

BREG:

104633145(ACAA2)

OHA:	104335613(ACAA2)

ACAR:

104525372(ACAA2)

CPEA:

104392324 104398396(ACAA2)

CVF:	104282855(ACAA2)

RTD:	128902111 128902953

AAM:	106487890(ACAA2)

AROW:

112978618(ACAA2)

NPD:	112947775(ACAA2)

TGT:	104570727(ACAA2) 104577213

DNE:	112994469(ACAA2)

SCAM:

104138525(ACAA2)

ASN:	102376718(ACAA2)

AMJ:	102568981(ACAA2)

CPOO:

109307727(ACAA2)

GGN:	109298024(ACAA2)

PSS:	102446655(ACAA2)

CMY:	102938453(ACAA2)

CCAY:

125637026(ACAA2)

DCC:	119855505(ACAA2)

CPIC:

101948785(ACAA2)

TST:	117879173(ACAA2)

CABI:

116817764(ACAA2)

MRV:	120407484(ACAA2)

ACS:	100554020(acaa2)

ASAO:

132766870(ACAA2)

PVT:	110090044(ACAA2)

SUND:

121922842(ACAA2)

PBI:	103049409(ACAA2)

PMUR:

107284131(ACAA2)

CTIG:

120317454(ACAA2)

TSR:	106545855(ACAA2)

PGUT:

117654831(ACAA2)

APRI:

131192113(ACAA2)

PTEX:

113445657(ACAA2)

NSS:	113411342(ACAA2)

VKO:	123023993(ACAA2)

PMUA:

114606439(ACAA2)

PRAF:

128423395(ACAA2)

ZVI:	118077071(ACAA2)

HCG:	128347967(ACAA2)

GJA:	107109968(ACAA2)

STOW:

125436609(ACAA2)

EMC:	129334603(ACAA2)

XLA:	108705465(acaa2.S) 380424(acaa2.L)

XTR:	779631(acaa2)

NPR:	108790694(ACAA2)

RTEM:

120926716(ACAA2) 120943975

BBUF:

120992249(ACAA2)

BGAR:

122937233(ACAA2)

MUO:

115462877

GSH:	117355703(ACAA2)

DRE:	406325(acaa2)

SRX:	107752996 107754401(acaa2)

SANH:

107671002

SGH:	107559599(acaa2)

CAUA:

113106963(acaa2)

CGIB:

127964058

PTET:

122350830(acaa2)

LROH:

127170258(acaa2)

OMC:	131545485(acaa2)

PPRM:

120489722(acaa2)

MAMB:

125279346(acaa2)

CIDE:

127517686

CERY:

137026199(acaa2)

MASI:

127414512

TROS:

130568146(acaa2)

TDW:	130406868(acaa2)

MANU:

129413496(acaa2)

IPU:

100304819

IFU:	128607699(acaa2)

PHYP:

113533324(acaa2)

SMEO:

124400027(acaa2)

TFD:	113658509(acaa2)

TVC:	132853200(acaa2)

TRN:	134317546(acaa2)

AMEX:

103039096(acaa2)

CMAO:

118813505(acaa2)

EEE:	113590681(acaa2)

CHAR:

105898472(acaa2)

SPIL:

134088750(acaa2)

TRU:	101062577(acaa2)

TFS:	130526095(acaa2)

TNG:	GSTEN00029578G001

LCO:	104921655(acaa2)

NCC:	104956691(acaa2)

TBEN:

117473064(acaa2)

CGOB:

115013918(acaa2)

PGEO:

117451965(acaa2)

GACU:

117560526(acaa2)

EMAC:

134874070(acaa2)

ELY:	117252366(acaa2)

EFO:	125890570(acaa2)

PLEP:

121944348(acaa2)

SLUC:

116054451(acaa2)

ECRA:

117945493(acaa2)

ESP:	116689740(acaa2)

PFLV:

114555635(acaa2)

GAT:	120831083(acaa2)

PPUG:

119225245(acaa2)

AFB:	129101325(acaa2)

CLUM:

117736793(acaa2)

PSWI:

130196995(acaa2)

CANA:

137779004(acaa2)

CVE:	137867484(acaa2)

MSAM:

119891199(acaa2)

SCHU:

122875680(acaa2)

CUD:	121510452(acaa2)

SPUL:

138610402(acaa2)

LMIX:

132974504(acaa2)

ALAT:

119019518(acaa2)

ASTR:

137592478(acaa2)

MZE:	101475921(acaa2)

ONL:	100699406(acaa2)

OAU:	116311007(acaa2)

OLA:	101171672(acaa2)

OML:	112148074(acaa2)

CSAI:

133451127(acaa2)

XMA:	102225065(acaa2)

XCO:	114154595(acaa2)

XHE:	116729793(acaa2)

PRET:

103470032(acaa2)

PFOR:

103145834(acaa2)

PLAI:

106956800(acaa2)

PMEI:

106921746(acaa2)

GAF:	122826529(acaa2)

PPRL:

129366003(acaa2)

CVG:	107089652(acaa2)

CTUL:

119778132(acaa2)

GMU:	124877320(acaa2)

NFU:	107394253(acaa2)

KMR:	108233695(acaa2)

NWH:	119413240(acaa2)

AOCE:

111577286(acaa2)

EJA:	138215751(acaa2)

BFRE:

138626267(acaa2)

MCEP:

125012240(acaa2)

CSEM:

103397146 103397771(acaa2)

POV:	109637054(acaa2)

SSEN:

122769394(acaa2)

HHIP:

117768157(acaa2)

HSP:	118115012(acaa2)

PPLT:

128438202(acaa2)

SMAU:

118313372(acaa2)

LCF:

108881684

SDU:	111236472(acaa2)

SLAL:

111665974(acaa2)

XGL:	120805072(acaa2)

HCQ:	109527328(acaa2)

SSCV:

125994108(acaa2)

SBIA:

133499457(acaa2)

PEE:	133399968(acaa2)

PTAO:

133475144(acaa2)

BPEC:

110155754(acaa2)

MALB:

109956563(acaa2)

BSPL:

114863021(acaa2)

SJO:	128364519(acaa2)

SSCO:

133979093(acaa2)

SASA:

106580430(THIM) 106585052(THIM)

STRU:

115164358 115200294

OTW:	112248600 112262751(acaa2)

OMY:	110525808 110536192(acaa2)

OGO:	124034212 124035238(acaa2)

ONE:	115111718 115140188

OKI:	109881322 109896036

OKE:	118371612 118393337

SALP:

111957767 111974321

SNH:	120039009(acaa2) 120054931

CCLU:

121573178(acaa2) 121584970

ELS:	105014304(acaa2)

SFM:	108920128(acaa2)

PKI:	111854352(acaa2)

AANG:

118237582(acaa2)

CCOG:

133131752 133139875(acaa2)

LOC:	102693198(acaa2)

PSPA:

121317725(acaa2) 121327200

ARUT:

117409644(acaa2)

PSEX:

120527222(acaa2)

LCM:	102358248(ACAA2)

CMK:	103187341(acaa2)

RTP:	109912458(acaa2)

CPLA:

122564480(acaa2)

HOC:	132832136(acaa2)

LERI:

129711954(acaa2)

PMRN:

116953611(ACAA2)

LRJ:	133355141(ACAA2)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115927202 588288

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG4600(yip2)

DER:

6541725

DSE:

6611877

DSI:	Dsimw501_GD23636(Dsim_GD23636)

DYA:	Dyak_GE18877(Dyak_yip2)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17721

DAZ:

108611047

DNV:

115562949

DHE:

111603572

DVI:	6629152(yip2)

CCAT:

101449329

BOD:

106616657

BDR:

105223749

RZE:	108374170 108375335 108379974

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ002342

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114871649 114871657

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105669845(yip2) 136996908

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124220508(yip2)

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:	115881821 115888029

AGRG:

ATD:

CSET:

HAXR:

AGB:	108914001 108916293

LDC:	111504790 111504795

DVV:

114340791

NVL:

108566331

DCOR:

135799269(yip2)

APLN:

108734407

PPYR:

116170798 116170807

OTU:

111417632

BMOR:

100500748(at1) 101738252 105841738

BMAN:

114244590 114244618 114244619

MSEX:

115451051 115451052 115451054 115451059

DPL:	KGM_206001 KGM_206002

BANY:

112047648 112047649 112047650

MJU:

123875923

NIQ:	126774993 126774994 126774995 126774996

VCD:	124537495 124537496 124537498

MCIX:

123661630 123661631 123661632

PMAC:

106716645 106716779 106716780

PPOT:

106102070 106102197 106102490

PXU:	106114431 106114531

BPHI:

137921303 137921731 137921781

PRAP:

111000172 111000181 111000183

PBX:	123714932 123714933 123715610

PNAP:

125057069 125057070 125057410

ZCE:	119831596 119831597 119831950

CCRC:

123699090 123699091 123699095

LSIN:

126972088 126972089 126972091

AAGE:

121737055 121737056

HAW:	110379955 110379956 110379969 110379979

HZE:	124637957 124638209 124638371

TNL:	113502219 113502224 113502233 113502255

SLIU:

111347791 111348340 111349030 111350202 111350624 111350638

OFU:	114364375 114364376 114364383

ATRA:

106136453 106136454 106136458

GMW:	113515766 113515776 113515777

PXY:	105384039 105394722 125488443

PGW:	126374723 126374724 126374725

LGLY:

125234432 125234615 125234855

CSTB:

134749284 134749315 134749583

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106682661(yip2)

NLU:

111050307

HVI:	124354687 124372051

MQU:	128996283 128996329

PHU:	Phum_PHUM043260

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110860027 110860110

DPX:	DAPPUDRAFT_58917

DMK:	116923473 123472519

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123771639(yip2)

CQD:	128698082(yip2)

PTRU:

ESN:

MNZ:

MRJ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

CVS:	136984058(yip2)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F53A2.7(acaa-2)

CBR:

CBG_24278

CRQ:	GCK72_008370

NAI:	NECAME_09686

HRO:	HELRODRAFT_186335

LGI:	LOTGIDRAFT_219437

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_19473

AQU:

100636926

CNE:

CNA05060

CNB:

CNBA4880

CNG:	CNAG_00524

CGI:	CGB_A5350W

CDEU:

CNBG_1392

CDEP:

91086977(L203_102766)

KMG:	30161116(I203_105493)

KNE:	92183891(IAR55_006633)

TMS:	TREMEDRAFT_24275

TASA:

A1Q1_00430

CCAC:

CcaHIS019_0401110(CcaverHIS019_0401110)

RSX:	RhiXN_09637

UMA:	UMAG_03298

PFP:	PFL1_05545

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_00588

PTRC:

PtA15_2A784

PSTR:

Pst134EA_000707

MLR:	MELLADRAFT_47555

RIE:	OCT59_026413

MBR:	MONBRDRAFT_38241

SRE:	PTSG_00975

PTI:	PHATRDRAFT_45947

FCY:	FRACYDRAFT_268162(ACAT2)

TPS:	THAPSDRAFT_34809(KCT1)

NGD:	NGA_0450401(KCT2)

PIF:	PITG_07197

PSOJ:

PHYSODRAFT_480767

BLAC:

94351691(CCR75_007964)

SPAR:

SPRG_15243

» show all

Reference

PMID:8241273

Authors

Abe H, Ohtake A, Yamamoto S, Satoh Y, Takayanagi M, Amaya Y, Takiguchi M, Sakuraba H, Suzuki Y, Mori M, et al.

Title

Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase.

Journal

Biochim Biophys Acta 1216:304-6 (1993)
DOI:10.1016/0167-4781(93)90160-f

Sequence

[hsa:10449]

Reference

PMID:25478839

Authors

Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK.

Title

The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.

Journal

Acta Crystallogr D Biol Crystallogr 70:3212-25 (2014)
DOI:10.1107/S1399004714023827

Sequence

[hsa:10449]

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (14)   
   KEGG PATHWAY (12)   
   KEGG MODULE (2)   
Chemical reaction (15)   
   KEGG ENZYME (1)   
   KEGG REACTION (10)   
   KEGG RCLASS (4)   
Gene (4933)   
   KEGG GENES (819)   
   KEGG MGENES (641)   
   RefGene (3452)   
   OC (21)   
Literature (2)   
   PubMed (2)   
All databases (4967)   

Download RDF

ORTHOLOGY: K07509

Entry

K07509                      KO

Symbol

HADHB

Name

acetyl-CoA acyltransferase [EC:2.3.1.16]

Pathway

map00062

Fatty acid elongation

map00071

Fatty acid degradation

map00280

Valine, leucine and isoleucine degradation

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01212

Fatty acid metabolism

Module

M00085

Fatty acid elongation in mitochondria

M00087

beta-Oxidation

Reaction

R00238

acetyl-CoA:acetyl-CoA C-acetyltransferase

R00391

acyl-CoA:acetyl-CoA C-acyltransferase

R00927

acetyl-CoA:propanoyl-CoA 2-C-acetyltransferase

R01177

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

R03778

octanoyl-CoA:acetyl-CoA C-acyltransferase

R03858

lauroyl-CoA:acetyl-CoA C-acyltransferase

R03991

myristoyl-CoA:acetylCoA C-myristoyltransferase

R04546

R04742

decanoyl-CoA:acetyl-CoA C-acyltransferase

R04747

hexanoyl-CoA:acetyl-CoA C-acyltransferase

Disease

H00525

Disorders of mitochondrial fatty-acid oxidation

H01352

Mitochondrial trifunctional protein deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K07509  HADHB; acetyl-CoA acyltransferase
   00071 Fatty acid degradation
    K07509  HADHB; acetyl-CoA acyltransferase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07509  HADHB; acetyl-CoA acyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.16  acetyl-CoA C-acyltransferase
     K07509  HADHB; acetyl-CoA acyltransferase

Other DBs

GO:

0003988

Genes

HSA:	3032(HADHB)

PTR:	459080(HADHB)

PPS:	100978867(HADHB)

GGO:	101126225(HADHB)

PON:	100451914(HADHB)

PPYG:

129026848(HADHB)

NLE:	100594135(HADHB)

HMH:	116480442(HADHB)

SSYN:

129467778(HADHB)

MCC:	698025(HADHB)

MCF:	102143422(HADHB)

MTHB:

126933657

MNI:	105479790(HADHB)

CSAB:

103220641(HADHB)

CATY:

105578647(HADHB)

PANU:

101005262 101015521(HADHB)

TGE:	112637001(HADHB)

MLEU:

105534011(HADHB)

RRO:	104677890(HADHB)

RBB:	108532680(HADHB)

TFN:	117062603(HADHB)

PTEH:

111554459(HADHB)

CANG:

105517694(HADHB)

CJC:	100393472(HADHB)

SBQ:	101047392(HADHB)

CIMI:

108301311(HADHB)

ANAN:

105706959(HADHB)

CSYR:

103270681(HADHB) 103272354

MMUR:

105884366(HADHB) 109731342

LCAT:

123636689(HADHB)

PCOQ:

105816867(HADHB)

OGA:	100947025(HADHB)

MMU:	231086(Hadhb)

MCAL:

110294692(Hadhb)

MPAH:

110324296(Hadhb)

RNO:	171155(Hadhb)

MCOC:

116080907(Hadhb)

ANU:	117716893(Hadhb)

ASYL:

127687510(Hadhb)

MUN:	110547681(Hadhb)

CGE:	100758239(Hadhb)

MAUA:

101836616(Hadhb)

PROB:

127220060(Hadhb)

PLEU:

114688599 114696496(Hadhb)

MORG:

121439590 121439638

MFOT:

126490741

AAMP:

119806472(Hadhb)

NGI:	103735656(Hadhb)

HGL:	101725212(Hadhb)

CPOC:

100725220(Hadhb)

CCAN:

109685833(Hadhb)

DORD:

105983590(Hadhb)

DSP:	122122477(Hadhb)

PLOP:

125356662(Hadhb)

NCAR:

124963690

MMMA:

107137443(Hadhb)

ITI:	101955769(Hadhb)

OCU:	100347496 100355110

OPI:	101532201(HADHB)

TUP:	102490283(HADHB) 102493259

GVR:	103597541(HADHB)

CFA:	481043 607926(HADHB)

CLUD:

112649382 112664672(HADHB)

VVP:	112908533(HADHB)

VLG:	121490697 121490719(HADHB) 121491344

NPO:	129510828(HADHB) 129510960 129518202

AML:	100469907(HADHB)

UMR:	103671671(HADHB)

UAH:	113270781(HADHB)

UAR:	123799940(HADHB)

ELK:

111154153

LLV:

125108851

MPUF:

101690106(HADHB)

MNP:	132021199(HADHB)

MLK:	131807279(HADHB)

NVS:	122915246(HADHB)

ORO:	101364557(HADHB)

EJU:	114205822(HADHB)

ZCA:	113910313 113938678(HADHB)

MLX:	118007671(HADHB) 118009943

NSU:	110587298(HADHB)

LWW:	102746075(HADHB)

FCA:	101084279(HADHB)

PYU:	121044513(HADHB)

PCOO:

112864065(HADHB)

PBG:	122497373(HADHB)

PVIV:

125161694(HADHB)

LRUF:

124503760 124509609

PTG:	102966174(HADHB)

PPAD:

109267291(HADHB)

PUC:	125937109 125937323

AJU:

106967831

HHV:	120235790(HADHB)

BTA:	281811(HADHB)

BOM:	102286383(HADHB)

BIU:	109566316(HADHB)

BBUB:

102397671(HADHB)

BBIS:

104989052(HADHB)

CHX:	102188776(HADHB)

OAS:	101109685(HADHB)

BTAX:

128055984(HADHB)

CSUM:

138072919(HADHB)

ODA:	120851588(HADHB)

CCAD:

122441977(HADHB)

MREE:

136163896(HADHB)

MBEZ:

129540010(HADHB)

SSC:	397017(HADHB)

CFR:	102507636(HADHB)

CBAI:

105063858(HADHB)

CDK:	105098512(HADHB)

VPC:	102540024(HADHB)

BACU:

103002167(HADHB)

BMUS:

118906030(HADHB)

LVE:	103086899(HADHB)

OOR:	101287376(HADHB)

DLE:	111174989(HADHB)

PCAD:

102977338(HADHB)

PSIU:

116764789(HADHB)

NASI:

112412807(HADHB)

ECB:	100071371(HADHB)

EPZ:	103546461(HADHB)

EAI:	106832480(HADHB) 123286739

MYB:	102263535(HADHB)

MYD:	102752001(HADHB)

MMYO:

118669209(HADHB)

MLF:	102432768(HADHB)

MDT:	132213577(HADHB)

PKL:	118717225(HADHB)

EFUS:

103305541(HADHB)

MNA:	107534209(HADHB)

DRO:	112297765(HADHB)

SHON:

119001367(HADHB)

AJM:	119050403(HADHB)

PDIC:

114500229(HADHB)

PHAS:

123822437(HADHB)

MMF:	118627708 118630869(HADHB)

PPAM:

129067150(HADHB)

HAI:	109383145(HADHB)

RFQ:	117033225(HADHB)

PALE:

102889560(HADHB)

PGIG:

120621877(HADHB)

PVP:	105289755(HADHB)

RAY:	107505206(HADHB)

MJV:	108401860 118966967

TOD:	119231441 119259490(HADHB)

SARA:

101543065(HADHB) 101556512

SFUM:

130031773(HADHB)

SETR:

126024036(HADHB)

LAV:	100671092(HADHB)

TMU:

101353742

ETF:	101658281(HADHB)

DNM:	101445811(HADHB)

MDO:	100618372(HADHB)

GAS:	123237090(HADHB)

SHR:	100926185(HADHB)

AFZ:

127548773

PCW:	110206511(HADHB)

TVP:	118841881(HADHB)

PBRV:

138149110(HADHB)

OAA:	100078294(HADHB)

PCOC:

116230689(HADHB)

MGP:	100548234(HADHB)

CJO:	107312380(HADHB)

TPAI:

128085408(HADHB)

LMUT:

125689789(HADHB)

NMEL:

110397115(HADHB)

APLA:

101799509(HADHB)

ACYG:

106048393 136786303

CATA:

118259053(HADHB)

AFUL:

116488106(HADHB)

LSR:	110478449(HADHB)

SCAN:

103824692(HADHB)

PMOA:

120502646(HADHB)

OTC:	121336466(HADHB)

PRUF:

121358331(HADHB)

GFR:	102031582(HADHB)

FAB:	101813933(HADHB)

OMA:	130251911(HADHB)

PHI:	102103886(HADHB)

PMAJ:

107198788(HADHB)

CCAE:

111922398(HADHB)

CCW:	104683134(HADHB)

CBRC:

103623524(HADHB)

ACOE:

138108802(HADHB)

ETL:	114072281(HADHB)

ZAB:	102070868(HADHB)

ZLE:	135446265(HADHB)

ACHL:

103805354(HADHB)

SVG:	106860388(HADHB)

MMEA:

130586204(HADHB)

HRT:	120751015(HADHB)

SATI:

136358652(HADHB)

FPG:	101914495(HADHB)

FCH:	102059513(HADHB)

CCRI:

104163099(HADHB)

NNT:	104406141(HADHB)

SHAB:

115609414(HADHB)

ACUN:

113478820(HADHB)

TALA:

104357578(HADHB)

ACHC:

115350832(HADHB)

HALD:

104322249(HADHB)

HLE:	104830745(HADHB)

AGEN:

126046487

HHAR:

128151711(HADHB)

GCL:

127015302

MNB:	103772204(HADHB)

DPUB:

104304357(HADHB)

PPUS:

135176991(HADHB)

AVIT:

104278326(HADHB)

BRHI:

104502166

EGZ:	104130919(HADHB)

NNI:	104014721(HADHB)

PCRI:

104036957(HADHB)

PCAO:

104050099(HADHB)

PADL:

103923906(HADHB)

AFOR:

103895520(HADHB)

FGA:	104070061(HADHB)

GSTE:

104251097(HADHB)

CLV:	102092691(HADHB)

MUI:

104535894

PGUU:

104468927(HADHB)

PLET:

104618669(HADHB)

EHS:	104515580(HADHB)

CMAC:

104475942(HADHB)

CUCA:

104061774(HADHB)

TEO:	104376857(HADHB)

BREG:

104636705(HADHB)

OHA:	104337459(HADHB)

CPEA:

104392737(HADHB)

CVF:	104291162(HADHB)

RTD:	128906714(HADHB)

AAM:	106499628(HADHB)

AROW:

112972948(HADHB)

NPD:	112956292(HADHB)

TGT:	104568021(HADHB)

DNE:	112989868(HADHB)

SCAM:

104140729(HADHB)

ASN:	102387623(HADHB)

AMJ:	102559598(HADHB)

CPOO:

109312070(HADHB)

PSS:	102461261(HADHB)

CMY:	102938987(HADHB)

CCAY:

125634811(HADHB)

DCC:	119852600(HADHB)

CPIC:

101942506(HADHB)

TST:	117875456(HADHB)

CABI:

116823898(HADHB)

MRV:	120400400(HADHB)

ACS:	100558242(hadhb)

ASAO:

132761724(HADHB)

PVT:	110090548(HADHB)

SUND:

121922379(HADHB)

PBI:	103052587(HADHB)

PMUR:

107291032(HADHB)

CTIG:

120309142(HADHB)

TSR:	106541762(HADHB)

PGUT:

117667657(HADHB)

APRI:

131188980(HADHB)

PTEX:

113441627(HADHB)

NSS:	113414590(HADHB)

VKO:	123018761(HADHB)

PMUA:

114594985(HADHB)

PRAF:

128411512(HADHB)

ZVI:	118082903(HADHB)

HCG:	128325127(HADHB)

GJA:	107113773(HADHB)

STOW:

125443952(HADHB)

EMC:	129336055(HADHB)

XLA:	108717269(hadhb.L) 379769(hadhb.S)

XTR:	394747(hadhb)

NPR:	108802535(HADHB)

RTEM:

120936095(HADHB)

BBUF:

120997122(HADHB)

BGAR:

122933726(HADHB)

MUO:	115467009(HADHB)

GSH:	117357411(HADHB)

DRE:	336606(hadhb)

SRX:	107719432 107721451

SANH:

107690999 107697210(hadhb)

SGH:	107550362 107593292

CCAR:

109113064

CAUA:

113075079 113120633 113120669

CGIB:

127938900 127984389

PTET:

122324595(hadhb)

LROH:

127182946(hadhb)

OMC:	131526915(hadhb)

PPRM:

120460164(hadhb)

RKG:	130103215(hadhb)

MAMB:

125278518(hadhb)

CIDE:

127502129

CERY:

137019204(hadhb)

MASI:

127409668 127415662

TROS:

130565765(hadhb)

TDW:	130434945(hadhb)

MANU:

129429042(hadhb)

IPU:

108257741

IFU:	128618997(hadhb)

PHYP:

113529092(hadhb)

SMEO:

124400830(hadhb)

TFD:	113658600(hadhb)

TVC:	132855060(hadhb)

TRN:	134319838(hadhb)

AMEX:

103046325(hadhb)

CMAO:

118815191(hadhb)

EEE:	113591047(hadhb)

CHAR:

105907315(hadhb)

SPIL:

134098519(hadhb)

TRU:	101076593(hadhb)

TFS:	130515772(hadhb)

TNG:	GSTEN00024878G001

LCO:	104925674(hadhb)

NCC:	104960957(hadhb)

TBEN:

117487033(hadhb)

CGOB:

115028772(hadhb)

PGEO:

117440166(hadhb)

GACU:

117534855(hadhb)

EMAC:

134876830(hadhb)

ELY:	117270333(hadhb)

EFO:	125896960(hadhb)

PLEP:

121955952(hadhb)

SLUC:

116066352(hadhb)

ECRA:

117961547(hadhb)

ESP:	116706630(hadhb)

PFLV:

114573388(hadhb)

GAT:	120807880(hadhb)

PPUG:

119194992(hadhb)

AFB:	129107099(hadhb)

CLUM:

117727686(hadhb)

PSWI:

130202927(hadhb)

CANA:

137785576(hadhb)

CVE:	137870943(hadhb)

MSAM:

119908988(hadhb)

SCHU:

122863276(hadhb)

CUD:	121521091(hadhb)

SPUL:

138584485(hadhb)

LMIX:

132984751(hadhb)

ALAT:

119012502(hadhb)

ASTR:

137613297(hadhb)

MZE:	101471466(hadhb)

ONL:	100709781(hadhb)

OAU:	116311410(hadhb)

OLA:	101156136(hadhb)

OML:	112158327(hadhb)

CSAI:

133418559(hadhb)

XMA:	102232549(hadhb)

XCO:	114158666(hadhb)

XHE:	116734222(hadhb)

PRET:

103457287(hadhb)

PFOR:

103155031(hadhb)

PLAI:

106951104(hadhb)

PMEI:

106927984(hadhb)

GAF:	122825050(hadhb)

PPRL:

129375438(hadhb)

CVG:

107082845

CTUL:

119778355(hadhb)

GMU:	124882541(hadhb)

NFU:	107377791(hadhb)

KMR:	108233358(hadhb)

ALIM:

106532026(hadhb)

NWH:	119418344(hadhb)

AOCE:

111589018(hadhb)

EJA:	138205574(hadhb)

BFRE:

138630875(hadhb)

CSEM:

103381162(hadhb)

POV:	109646259(hadhb)

SSEN:

122784600(hadhb)

HHIP:

117758687(hadhb)

HSP:	118099612(hadhb)

PPLT:

128460014(hadhb)

SMAU:

118290396(hadhb)

LCF:

108888909

SDU:	111240320(hadhb)

SLAL:

111661536(hadhb)

XGL:	120789099(hadhb)

HCQ:	109528731(hadhb)

SSCV:

125990235(hadhb)

SBIA:

133496653(hadhb)

PEE:	133416885(hadhb)

PTAO:

133468526(hadhb)

BPEC:

110175575(hadhb)

MALB:

109962386(hadhb)

BSPL:

114849605(hadhb)

SJO:	128376732(hadhb)

SSCO:

133997436(hadhb)

SASA:

106608385(hadhb)

STRU:

115207341(hadhb)

OTW:	112238055(hadhb)

OMY:	110522673(hadhb)

OGO:	123995487(hadhb)

ONE:	115122832(hadhb)

OKI:	109877892(hadhb)

OKE:	118378232(hadhb)

SALP:

112072179(hadhb)

SNH:	120035874(hadhb)

CCLU:

121542757(hadhb)

ELS:	105018050(hadhb)

SFM:	108929413(hadhb)

PKI:	111851523(hadhb)

AANG:

118230437(hadhb)

CCOG:

133128512(hadhb)

LOC:	102684108(hadhb)

PSPA:

121315589 121317461

ARUT:

117402250 117410351

PSEX:

120516961 120525653(hadhb)

LCM:	102362426(HADHB)

CMK:	103183148(hadhb)

RTP:

109910715

CPLA:

122540288(hadhb)

HOC:	132835048(hadhb)

LERI:

129697176(hadhb)

PMRN:

116951401(HADHB)

LRJ:	133340860(HADHB)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

DME:	Dmel_CG4581(Mtpbeta)

DER:

6548203

DSE:

6615789

DSI:	Dsimw501_GD25003(Dsim_GD25003)

DYA:	Dyak_GE11519

DAN:

DSR:

DPO:

DPE:

DMN:	108160578 117188168

DWI:

6641047

DGR:

6559984

DMO:	Dmoj_GI20722

DAZ:

108616638

DNV:

108657704

DHE:

111600059

DVI:	116651109(Mtpbeta) 6625016

CCAT:

101457951

BOD:

106626828

BDR:

105226875

RZE:	108360490 108377479 108380508 108380509

AOQ:

129246106

TDA:	119679380 119679406

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ018065

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105677772(Mtpbeta)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124214073(Mtpbeta)

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

135799700(Mtpbeta)

APLN:

108738753

PPYR:

116168318

OTU:	111419226 111424458

BMOR:

101738740

BMAN:

114247892

MSEX:

115445888

DPL:	KGM_216161

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137925451(Mtpbeta)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113494349 113506203

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

113369788 113369961 113371210

CCRN:

123290986

API:

100167580

DNX:

107161702

AGS:	114120876 114120914

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111045885 111057619

HVI:	124360385 124373537

MQU:

128994063

PHU:	Phum_PHUM204290

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_50689

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123756400(Mtpbeta)

CQD:	128694614(Mtpbeta)

PTRU:

123506794

ESN:

126986238

MNZ:

135219440

MRJ:	136848620(Mtpbeta)

HAZT:

EAF:

LSM:

TCF:

PPOI:

119090329 119090425 119114899

ISC:	120836359 8052273

DSV:

RSAN:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136987575(Mtpbeta)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_B0303.3(hadb-1)

CBR:

CBG_06885

CRQ:	GCK72_009313

NAI:	NECAME_06001

BMY:	BM_BM1745(Bm1745)

LOA:	LOAG_07710

TSP:

Tsp_08803

HRO:	HELRODRAFT_99230

LGI:	LOTGIDRAFT_157797

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

LJP:

LAK:	106161772 106179809

OVI:	T265_10899

LLON:

135486027 135493694

NVE:	5498574 5507540

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114540421 114542419

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_50073

MBR:	MONBRDRAFT_26653

SRE:	PTSG_10306

PTI:	PHATR_28068(KCT3)

FCY:	FRACYDRAFT_207731

TPS:	THAPSDRAFT_3627

AAF:	AURANDRAFT_37445(AAT)

PIF:	PITG_01208

PSOJ:

PHYSODRAFT_559946

BLAC:

94346199(CCR75_002431)

SPAR:

SPRG_07368

EHX:	EMIHUDRAFT_434807 EMIHUDRAFT_445047(ACAT1)

GTT:	GUITHDRAFT_159886

SOK:	D0B54_04585

SINI:

LIMN:

CPRV:

RXY:

Reference

PMID:8135828

Authors

Kamijo T, Aoyama T, Komiyama A, Hashimoto T

Title

Structural analysis of cDNAs for subunits of human mitochondrial fatty acid beta-oxidation trifunctional protein.

Journal

Biochem Biophys Res Commun 199:818-25 (1994)
DOI:10.1006/bbrc.1994.1302

Sequence

[hsa:3032]

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