KEGG   ORTHOLOGY: K07537
Entry
K07537                      KO                                     

Name
dch
Definition
cyclohexa-1,5-dienecarbonyl-CoA hydratase [EC:4.2.1.100]
Pathway
ko00362  Benzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K07537  dch; cyclohexa-1,5-dienecarbonyl-CoA hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.100  cyclohexa-1,5-dienecarbonyl-CoA hydratase
     K07537  dch; cyclohexa-1,5-dienecarbonyl-CoA hydratase
Other DBs
RN: R05597
GO: 0018823
Genes
SHD: SUTH_01654(dch)
EBA: ebA5296(dch)
AZA: AZKH_2147(dch)
AZI: AzCIB_4483
AZD: CDA09_12110 CDA09_21775
TMZ: Tmz1t_2952
TCL: Tchl_2146 Tchl_3416
TAK: Tharo_1304
GME: Gmet_2150(bamR)
GBM: Gbem_1432(bamR)
GEO: Geob_0098(bamR)
GEM: GM21_2822
DML: Dmul_24930(dch)
DWD: DSCW_14370(fadB)
DALK: DSCA_13400
SAT: SYN_01653
RVA: Rvan_0036
BLAG: BLTE_16520
MAG: amb2142
MAGX: XM1_2897
MAGN: WV31_08595
FPL: Ferp_1031
GAC: GACE_0804
AG: CAA12246(dch)
 » show all
Reference
PMID:9746358
  Authors
Breese K, Boll M, Alt-Morbe J, Schagger H, Fuchs G
  Title
Genes coding for the benzoyl-CoA pathway of anaerobic aromatic metabolism in the bacterium Thauera aromatica.
  Journal
Eur J Biochem 256:148-54 (1998)
DOI:10.1046/j.1432-1327.1998.2560148.x
  Sequence

KEGG   ENZYME: 4.2.1.100
Entry
EC 4.2.1.100                Enzyme                                 

Name
cyclohexa-1,5-dienecarbonyl-CoA hydratase;
cyclohexa-1,5-diene-1-carbonyl-CoA hydratase;
dienoyl-CoA hydratase;
cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect);
6-hydroxycyclohex-1-enecarbonyl-CoA hydro-lyase (cyclohexa-1,5-dienecarbonyl-CoA-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
6-hydroxycyclohex-1-ene-1-carbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming)
Reaction(IUBMB)
6-hydroxycyclohex-1-ene-1-carbonyl-CoA = cyclohexa-1,5-diene-1-carbonyl-CoA + H2O [RN:R05597]
Reaction(KEGG)
R05597
Substrate
6-hydroxycyclohex-1-ene-1-carbonyl-CoA [CPD:C06749]
Product
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
H2O [CPD:C00001]
Comment
Forms part of the anaerobic benzoate degradation pathway, which also includes EC 1.3.8.6 [glutaryl-CoA dehydrogenase (ETF)], EC 1.3.7.8 (benzoyl-CoA reductase) and EC 4.2.1.55 (3-hydroyxbutyryl-CoA dehydratase).
History
EC 4.2.1.100 created 2000, modified 2001
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07537  cyclohexa-1,5-dienecarbonyl-CoA hydratase
Genes
SHD: SUTH_01654(dch)
EBA: ebA5296(dch)
AZA: AZKH_2147(dch)
AZI: AzCIB_4483
AZD: CDA09_12110 CDA09_21775
TMZ: Tmz1t_2952
TCL: Tchl_2146 Tchl_3416
TAK: Tharo_1304
GME: Gmet_2150(bamR)
GBM: Gbem_1432(bamR)
GEO: Geob_0098(bamR)
GEM: GM21_2822
DML: Dmul_24930(dch)
DWD: DSCW_14370(fadB)
DALK: DSCA_13400
SAT: SYN_01653
RVA: Rvan_0036
BLAG: BLTE_16520
MAG: amb2142
MAGX: XM1_2897
MAGN: WV31_08595
FPL: Ferp_1031
GAC: GACE_0804
 » show all
Reference
1  [PMID:9738901]
  Authors
Laempe D, Eisenreich W, Bacher A, Fuchs G.
  Title
Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica.
  Journal
Eur J Biochem 255:618-27 (1998)
DOI:10.1046/j.1432-1327.1998.2550618.x
  Sequence
Reference
2  [PMID:8990279]
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
3  [PMID:8436125]
  Authors
Koch J, Eisenreich W, Bacher A, Fuchs G.
  Title
Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism.
  Journal
Eur J Biochem 211:649-61 (1993)
DOI:10.1111/j.1432-1033.1993.tb17593.x
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.100
IUBMB Enzyme Nomenclature: 4.2.1.100
ExPASy - ENZYME nomenclature database: 4.2.1.100
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.100
BRENDA, the Enzyme Database: 4.2.1.100
CAS: 214355-79-0

KEGG   REACTION: R05597
Entry
R05597                      Reaction                               

Name
6-hydroxycyclohex-1-ene-1-carbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming)
Definition
Cyclohexa-1,5-diene-1-carbonyl-CoA + H2O <=> 6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
Equation
Reaction class
RC03168  C06322_C06749
Enzyme
Pathway
rn00362  Benzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
Orthology
K07537  cyclohexa-1,5-dienecarbonyl-CoA hydratase [EC:4.2.1.100]
Other DBs
RHEA: 21859

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