KEGG   ORTHOLOGY: K07538
Entry
K07538                      KO                                     

Name
had
Definition
6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase [EC:1.1.1.368]
Pathway
ko00362  Benzoate degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K07538  had; 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.368  6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
     K07538  had; 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
Other DBs
RN: R05581
Genes
SHD: SUTH_01655(had)
EBA: ebA5297(had)
AZA: AZKH_2148(had_bzdX)
AZI: AzCIB_1613 AzCIB_4485
AZD: CDA09_12105(had) CDA09_21785(had)
TMZ: Tmz1t_2954 Tmz1t_4042
TCL: Tchl_2144 Tchl_3418
TAK: Tharo_1302 Tharo_3372
GME: Gmet_2151(bamQ)
GBM: Gbem_1431(bamQ)
GEO: Geob_0097(bamQ)
GEM: GM21_2823
DTO: TOL2_C03830(had)
DALK: DSCA_13410
SAT: SYN_01655
RVA: Rvan_0034
BLAG: BLTE_16540
MAG: amb2144
MAGX: XM1_2899
MAGN: WV31_08585
AG: CAA12244(had)
 » show all
Reference
PMID:9746358
  Authors
Breese K, Boll M, Alt-Morbe J, Schagger H, Fuchs G
  Title
Genes coding for the benzoyl-CoA pathway of anaerobic aromatic metabolism in the bacterium Thauera aromatica.
  Journal
Eur J Biochem 256:148-54 (1998)
DOI:10.1046/j.1432-1327.1998.2560148.x
  Sequence

KEGG   ENZYME: 1.1.1.368
Entry
EC 1.1.1.368                Enzyme                                 

Name
6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-hydroxycyclohex-1-ene-1-carbonyl-CoA:NAD+ 6-oxidoreductase
Reaction(IUBMB)
6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ = 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+ [RN:R05581]
Reaction(KEGG)
R05581
Substrate
6-hydroxycyclohex-1-ene-1-carbonyl-CoA [CPD:C06749];
NAD+ [CPD:C00003]
Product
6-oxocyclohex-1-ene-1-carbonyl-CoA [CPD:C09821];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme participates in the central benzoyl-CoA degradation pathway of some anaerobic bacteria such as Thauera aromatica.
History
EC 1.1.1.368 created 2014
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07538  6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
Genes
SHD: SUTH_01655(had)
EBA: ebA5297(had)
AZA: AZKH_2148(had_bzdX)
AZI: AzCIB_1613 AzCIB_4485
AZD: CDA09_12105(had) CDA09_21785(had)
TMZ: Tmz1t_2954 Tmz1t_4042
TCL: Tchl_2144 Tchl_3418
TAK: Tharo_1302 Tharo_3372
GME: Gmet_2151(bamQ)
GBM: Gbem_1431(bamQ)
GEO: Geob_0097(bamQ)
GEM: GM21_2823
DTO: TOL2_C03830(had)
DALK: DSCA_13410
SAT: SYN_01655
RVA: Rvan_0034
BLAG: BLTE_16540
MAG: amb2144
MAGX: XM1_2899
MAGN: WV31_08585
 » show all
Reference
1  [PMID:10406950]
  Authors
Laempe D, Jahn M, Fuchs G
  Title
6-Hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase and 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase, enzymes of the benzoyl-CoA pathway  of anaerobic aromatic metabolism in the denitrifying bacterium Thauera aromatica.
  Journal
Eur J Biochem 263:420-9 (1999)
DOI:10.1046/j.1432-1327.1999.00504.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.368
IUBMB Enzyme Nomenclature: 1.1.1.368
ExPASy - ENZYME nomenclature database: 1.1.1.368
BRENDA, the Enzyme Database: 1.1.1.368

KEGG   REACTION: R05581
Entry
R05581                      Reaction                               

Name
6-hydroxycyclohex-1-ene-1-carbonyl-CoA:NAD+ 6-oxidoreductase
Definition
6-Hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ <=> 6-Oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00850  C06749_C09821
Enzyme
Pathway
rn00362  Benzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA
Orthology
K07538  6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase [EC:1.1.1.368]
Other DBs
RHEA: 18268

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