KEGG ORTHOLOGY: K07763

ORTHOLOGY: K07763

Entry

K07763                      KO

Symbol

MMP14

Name

matrix metalloproteinase-14 (membrane-inserted) [EC:3.4.24.80]

Pathway

map04668

TNF signaling pathway

map04912

GnRH signaling pathway

map04928

Parathyroid hormone synthesis, secretion and action

Disease

H02089

Winchester syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K07763  MMP14; matrix metalloproteinase-14 (membrane-inserted)
09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K07763  MMP14; matrix metalloproteinase-14 (membrane-inserted)
   04928 Parathyroid hormone synthesis, secretion and action
    K07763  MMP14; matrix metalloproteinase-14 (membrane-inserted)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K07763  MMP14; matrix metalloproteinase-14 (membrane-inserted)
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.80  membrane-type matrix metalloproteinase-1
     K07763  MMP14; matrix metalloproteinase-14 (membrane-inserted)
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M10
   K07763  MMP14; matrix metalloproteinase-14 (membrane-inserted)

Genes

HSA:	4323(MMP14)

PTR:	742887(MMP14)

PPS:	100990208(MMP14)

GGO:	101142469(MMP14)

PON:	100171646(MMP14)

PPYG:

129012809(MMP14)

NLE:	100606407(MMP14)

HMH:	116484897(MMP14)

SSYN:

129489367(MMP14)

MCC:	712429(MMP14)

MCF:	102132205(MMP14)

MTHB:

126958269

MNI:	105499628(MMP14)

CSAB:

103231446(MMP14)

CATY:

105598793(MMP14)

PANU:

101021138(MMP14)

TGE:	112629015(MMP14)

MLEU:

105547169(MMP14)

RRO:	104674133(MMP14)

RBB:	108523596(MMP14)

TFN:	117069995(MMP14)

PTEH:

111554785(MMP14)

CANG:

105503789(MMP14)

CJC:	100389088(MMP14)

SBQ:	101041075(MMP14)

CIMI:

108315352(MMP14)

ANAN:

105727007(MMP14)

CSYR:

103267686(MMP14)

MMUR:

105864715(MMP14)

LCAT:

123620578(MMP14)

PCOQ:

105814481(MMP14)

OGA:	100957810(MMP14)

MMU:	17387(Mmp14)

MCAL:

110309210(Mmp14)

MPAH:

110325048(Mmp14)

RNO:	81707(Mmp14)

MCOC:

116084514(Mmp14)

ANU:	117705214(Mmp14)

MUN:	110550039(Mmp14)

CGE:	100689336(Mmp14)

MAUA:

101828511(Mmp14)

PROB:

127230416(Mmp14)

PLEU:

114708709(Mmp14)

MORG:

121435038(Mmp14)

MFOT:

126490920

AAMP:

119800000(Mmp14)

NGI:	103739479(Mmp14)

HGL:	101723795(Mmp14)

CPOC:

100732039(Mmp14)

CCAN:

109685808(Mmp14) 109689717

DORD:

105992545(Mmp14)

DSP:	122113480(Mmp14)

PLOP:

125363479(Mmp14)

NCAR:

124974865

MMMA:

107148235(Mmp14)

OCU:	100009598(MMP14)

OPI:	101516419(MMP14)

TUP:	102468813(MMP14)

GVR:	103585554(MMP14)

CFA:	403823(MMP14)

CLUD:

112657051(MMP14)

VVP:	112926491(MMP14)

VLG:	121493160(MMP14)

NPO:	129499441(MMP14)

AML:	100468621(MMP14)

UMR:	103681059(MMP14)

UAH:	113246072(MMP14)

UAR:	123795799(MMP14)

ELK:

111158421

LLV:

125104089

MPUF:

101689912(MMP14)

MNP:	131999791(MMP14)

MLK:	131836341(MMP14)

NVS:	122893172(MMP14)

ORO:	101369821(MMP14)

EJU:	114217869(MMP14)

ZCA:	113909394(MMP14)

MLX:	118003628(MMP14)

NSU:	110585608(MMP14)

LWW:	102730388(MMP14)

FCA:	101089776(MMP14)

PYU:	121031488(MMP14)

PCOO:

112855695(MMP14)

PBG:	122468871(MMP14)

PVIV:

125168909(MMP14)

LRUF:

124508807

PTG:	102953674(MMP14)

PPAD:

109255047(MMP14)

PUC:

125909706

AJU:

106988210

HHV:	120240441(MMP14)

BTA:	281915(MMP14)

BOM:	102281987(MMP14)

BIU:	109564819(MMP14)

BBUB:

102413520(MMP14)

BBIS:

104981988(MMP14)

CHX:	100861171(MMP14)

OAS:	443116(MMP14)

BTAX:

128053747(MMP14)

ODA:	120853412(MMP14)

CCAD:

122443218(MMP14)

MBEZ:

129562985(MMP14)

SSC:	397471(MMP14)

CFR:	102513570(MMP14)

CBAI:

105068764(MMP14)

CDK:	105096970(MMP14)

VPC:	102525752(MMP14)

BACU:

103003307(MMP14)

BMUS:

118890456(MMP14)

LVE:	103081188(MMP14)

OOR:	101284790(MMP14)

DLE:	111164185(MMP14)

PCAD:

102987825(MMP14)

PSIU:

116748985(MMP14)

NASI:

112397473(MMP14)

ECB:	100034170(MMP14)

EPZ:	103556751(MMP14)

EAI:	106840662(MMP14)

MYB:	102240202(MMP14)

MYD:	102761559(MMP14)

MMYO:

118679356(MMP14)

MLF:	102431406(MMP14)

MDT:	132240293(MMP14)

PKL:	118724917(MMP14)

EFUS:

103301531(MMP14)

MNA:	107531691(MMP14)

DRO:	112301504(MMP14)

SHON:

118980961(MMP14)

AJM:	119037284(MMP14)

PDIC:

114491682(MMP14)

PHAS:

123820486(MMP14)

MMF:	118616019(MMP14)

PPAM:

129074125(MMP14)

HAI:	109393698(MMP14)

RFQ:	117024113(MMP14)

PALE:

102887003(MMP14)

PGIG:

120593901(MMP14)

PVP:	105300520(MMP14)

RAY:	107498042(MMP14)

MJV:	108400026(MMP14)

TOD:	119238905(MMP14)

SARA:

101551659(MMP14)

SETR:

126001357(MMP14)

LAV:	100671131(MMP14)

TMU:

101345768

ETF:	101656746(MMP14)

DNM:	101420058(MMP14)

MDO:	100030382(MMP14)

GAS:	123236026(MMP14)

SHR:	100932143(MMP14)

AFZ:

127551035

PCW:	110223023(MMP14)

TVP:	118830349(MMP14)

OAA:	100091029(MMP14)

LSR:

110481924

PMOA:

120512485

PHI:	102107021(MMP14)

AGEN:

126037221

ASN:	102368749(MMP14)

AMJ:	102558609(MMP14)

CMY:	102943947(MMP14)

CCAY:

125622589(MMP14)

DCC:	119841791(MMP14)

CPIC:

101945719(MMP14)

CABI:

116818422(MMP14)

MRV:	120380346(MMP14)

ACS:	100553534(mmp14)

ASAO:

132777648(MMP14)

PVT:	110087815(MMP14)

SUND:

121934813(MMP14)

PBI:	103064383(MMP14)

PMUR:

107295092(MMP14)

CTIG:

120317985(MMP14)

TSR:	106550394(MMP14)

PGUT:

117658208(MMP14)

APRI:

131197583(MMP14)

PTEX:

113448731(MMP14) 113451750

NSS:	113422251(MMP14) 113427188

VKO:	123018636(MMP14)

PMUA:

114581663(MMP14)

PRAF:

128399506(MMP14)

ZVI:	118095008(MMP14)

HCG:	128329770(MMP14)

GJA:	107109121(MMP14)

EMC:	129338762(MMP14)

XLA:	108707025 407753(mmp14.L)

XTR:	594950(mmp14)

NPR:	108786770(MMP14)

RTEM:

120941067(MMP14)

BBUF:

120989035(MMP14)

BGAR:

122923469(MMP14)

MUO:	115456955(MMP14)

GSH:	117350258(MMP14)

DRE:	373882(mmp14a) 566945(mmp14b)

SRX:	107706348 107738136 107753930

SANH:

107668983 107669100 107691938 107704286

SGH:	107557973 107562471(mmp14) 107588203 107591383

CCAR:

109060080 109064679 109111707 109111713

CAUA:

113044985 113052124 113052125 113105708 113119884

CGIB:

127933340 127951000 127962211 128017137

PTET:

122323463(mmp14b) 122349364(mmp14a)

LROH:

127168695(mmp14a) 127182330(mmp14b)

OMC:	131520650(mmp14b) 131544302(mmp14a)

PPRM:

120462605(mmp14a) 120465105(mmp14b)

RKG:	130076154(mmp14b) 130102601(mmp14a)

MAMB:

125251639(mmp14b) 125264498(mmp14a)

CIDE:

127494064 127515365

CERY:

137002989(mmp14b) 137030204(mmp14a)

MASI:

127412145 127440633 127442247 127445441

TROS:

130553967(mmp14a) 130554170(mmp14b)

TDW:	130417209(mmp14b) 130428394(mmp14a)

MANU:

129440312(mmp14a) 129441835(mmp14b)

IPU:	108267832 108267934(mmp14a)

IFU:	128609516(mmp14b) 128610251(mmp14a)

PHYP:

113525614 113540329

SMEO:

124386873(mmp14b) 124387269(mmp14a)

TFD:	113633887(mmp14b) 113663174(mmp14a)

TVC:	132848324(mmp14b) 132848843(mmp14a)

TRN:	134311692(mmp14a) 134312203

AMEX:

103024760(mmp14a) 103041213(mmp14b)

CMAO:

118825668(mmp14a) 118825730(mmp14b)

EEE:	113578328 113589197(mmp14)

CHAR:

105895553(mmp14a) 105907068(mmp14b)

TRU:	101061607 101073560

TFS:	130522245(mmp14a) 130539565(mmp14b)

TNG:	GSTEN00015140G001 GSTEN00025878G001

LCO:	104927972 104932902

NCC:	104952609 104956583

TBEN:

117488121(mmp14a) 117488510(mmp14b)

CGOB:

115022907 115023741

PGEO:

117462031(mmp14b) 117463873(mmp14a)

GACU:

117539229(mmp14a) 117556619(mmp14b)

EMAC:

134865988(mmp14b) 134872261(mmp14a)

ELY:	117246202(mmp14a) 117272256(mmp14b)

EFO:	125883715(mmp14a) 125901619(mmp14b)

PLEP:

121952037(mmp14b) 121961947(mmp14a)

SLUC:

116043318(mmp14a) 116055111(mmp14b)

ECRA:

117934665(mmp14a) 117954333(mmp14b)

ESP:	116684895 116699164 116707003

PFLV:

114545892(mmp14) 114565145

GAT:	120816303(mmp14b) 120821932(mmp14a)

PPUG:

119209171(mmp14b) 119222503(mmp14a)

AFB:	129088883(mmp14b) 129093101(mmp14a)

CLUM:

117746697(mmp14b) 117747783(mmp14a)

PSWI:

130197928(mmp14b) 130211969(mmp14a)

MSAM:

119902498(mmp14b) 119912139(mmp14a)

SCHU:

122869956(mmp14a) 122887183(mmp14b)

CUD:	121504664(mmp14a) 121520493(mmp14b)

ALAT:

119011743(mmp14b) 119027665(mmp14a)

MZE:	101464934 101486213

ONL:	100691693 100695964

OAU:	116312338(mmp14a) 116333767(mmp14b)

OLA:	100125428(mmp14) 101171699

OML:	112147164(mmp14b) 112156455(mmp14a)

CSAI:

133420119(mmp14a) 133452983(mmp14b)

XMA:	102236291 102236856

XCO:	114146537 114157472

XHE:	116721687 116732222

PRET:

103475992 103478877

PFOR:

103138402 103145985(mmp14)

PLAI:

106934757 106944750

PMEI:

106918840(mmp14) 106926970

GAF:	122820067(mmp14a) 122840722(mmp14b)

PPRL:

129362045(mmp14b) 129379472(mmp14a)

CVG:	107087725 107101469(mmp14)

CTUL:

119773355(mmp14a) 119793328(mmp14b)

GMU:	124870019(mmp14b) 124881091(mmp14a)

NFU:	107377284(mmp14) 107384247

KMR:	108238671(mmp14b) 108245890(mmp14a)

ALIM:

106517892 106526432 106535469

NWH:	119408978(mmp14a) 119414992(mmp14b)

AOCE:

111577984 111587803

MCEP:

125010467(mmp14b) 125022045(mmp14a)

CSEM:

103388226(mmp14) 103396588

POV:	109640512 109641241

SSEN:

122766893(mmp14a) 122778576(mmp14b)

HHIP:

117778918(mmp14b) 117779297(mmp14a)

HSP:	118102417(mmp14a) 118117847(mmp14b)

PPLT:

128430205(mmp14a) 128454880(mmp14b)

SMAU:

118287780(mmp14a) 118310471(mmp14b)

LCF:	108883931(mmp14b) 108903045(mmp14a)

SDU:	111223843 111235670

SLAL:

111647186 111666536

XGL:	120797566(mmp14a) 120799114(mmp14b)

HCQ:	109508489 109512811

SSCV:

125973364 125984530

SBIA:

133494704(mmp14a) 133510391(mmp14b)

PEE:	133397616(mmp14a) 133411425(mmp14b)

PTAO:

133472402(mmp14a) 133489369(mmp14b)

BPEC:

110170349 110172013

MALB:

109962674 109974431

BSPL:

114844813(mmp14b) 114850074(mmp14a)

SJO:	128369257(mmp14b) 128384020(mmp14a)

SASA:

106569443 106577791 106600280 106608848

STRU:

115157316 115169490 115194394 115198396

OTW:	112214636(mmp14a) 112226707 112235598 112260764

OMY:	110500495(mmp14a) 110508483(mmp14b) 110530599 110531636

OGO:	124008505 124009973 124014257 124041589(mmp14b)

ONE:	115102780 115114675 115133442 115137978

OKI:	109871780 109875099 109896970 109906435

OKE:	118368870 118392084(mmp14a) 118394992(mmp14b) 118401873

SALP:

111953232 111956641 111979299 112080231

SNH:	120020209 120030301 120049716 120055633

CCLU:

121535634 121572618 121581129(mmp14b) 123482924

ELS:	105020567 105021572

SFM:	108930930 108937864(mmp14) 114911942

PKI:	111837704 111854546

AANG:

118234064(mmp14b)

PSPA:

121305269 121306845

ARUT:

117398173(mmp14b)

PSEX:

120524476

LCM:	102355301(MMP14)

LERI:

129716140

PMRN:

116946025

LRJ:

133340387

BFO:	118403865 118405991 118406077 118407203 118407405 118407406 118410626 118416517 118418696 118422022 118426409 118431106

BBEL:

109462286 109465428 109467309 109468271 109468435 109474289 109479373 109480028 109480908 109486532

CIN:	100175506 100181633 100184312

SCLV:

120329469 120332934

SPU:	105436437 105439065 105441790 115919166 115921774 115923431 115924100 115924102 576018 576145 581157 581457 582797(MMP14) 583799 585680 592649 752715

LPIC:

129254576 129262185 129273667 129275862 129275958 129276242 129281158 129281296 129281756 129281797 129281986

APLC:

110981585 110981864 110982266 110986275 110986843 110986844 110986855 110986884 110990105

ARUN:

117290679 117290753 117292406 117292650 117303830 117303899 117303996

AJC:	117109985 117110040 117110050 117124559 117124573

SKO:	100369238 100369384 100373845 100373999 100377895 100378191

DME:	Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)

DER:	6548508 6553563

DSE:

6618866

DSI:	Dsimw501_GD20010(Dsim_GD20010) Dsimw501_GD24926(Dsim_GD24926)

DYA:	Dyak_GE11424

DAN:

DSR:

DPO:

DPE:

DMN:	108160136 117185778

DWI:

6640267

DGR:	6560466 6563713

DMO:	Dmoj_GI19538

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:	106622068 106627693

BDR:	105230249 105230978

RZE:	108363354 108372064

AOQ:	129235386 129243716

TDA:	119675513 119679599

MDE:

101888990

SCAC:

106082756 106086034

LCQ:

111679245

LSQ:	119606779 119608562 119614438 119615725

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	5566822 5575548 5575549 5575550 5575574

AALB:

109410819 109410820 109410823 109421170 109421241 109421242 109425677 115256248 115256255 115256256 115256258 115266864 115266868 115266869

ASUA:

134202688 134204596 134204597 134204600 134210845 134217899 134217900 134217901 134217906

CQU:	CpipJ_CPIJ010856 CpipJ_CPIJ012497 CpipJ_CPIJ015719 CpipJ_CPIJ016690 CpipJ_CPIJ016691 CpipJ_CPIJ016692

CPII:

120414643 120414880 120421278 120421289 120421290 120421291

CNS:

BCOO:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:	117608294 117608429

MGEN:

117217405

NMEA:

116426310

CGIG:

122400960 122402161

SOC:	105198300 105205971

MPHA:

105835181 105835693

AEC:

105151121

ACEP:

105619997

PBAR:

105422417 105424243 105424383 105426446

VEM:

105566274

HST:

105190364

DQU:	106744935 106748962

CFO:

105255413

FEX:

115241861

LHU:	105675698(Mmp1)

PGC:	109858212 109861586 109861889 109861992 109862219 109863338

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100113893(Mmp1)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

107268792 107270395 107272043

DSM:	124404461 124410561

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	103313084 103313085 657261(Mmp-1)

DPA:

SOY:

AGRG:

ATD:

CSET:

123311328 123312265 123312267

AGB:	108910021 108910921

LDC:	111512850 111512852

NVL:	108563139 108563140 108566081

APLN:

108741148 112904568

PPYR:

116163807 116172083 116172517 116182295

OTU:	111415936 111417845 111424932

BMOR:

100144547(Mmp1)

BMAN:

114249403

MSEX:

115445748 119191609 119193430

DPL:	KGM_204463

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119830077 119830092 119830249

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

113370190 113371077 113374433

CCRN:

123305758

API:

100164006

DNX:

107166270

AGS:	114124803 114124805

RMD:

113560497

ACOO:

126840413 126841334 126841381

DVT:	126904256 126908124 126908125 126908127 126908128

BTAB:

109040286

DCI:

103519571

CLEC:

106669674

HHAL:

106677886 106677898 106677916 106691851

NLU:	111057664 111058731

HVI:

124359559

MQU:	128991305 128991307 128992215 128992550 128998645

PHU:	Phum_PHUM302710

FOC:

113213791

TPAL:

117643377

ZNE:	110834801 110834804 110840851

CSEC:

111865495 111865497 111866716 111866774

SGRE:

126336836

BROR:

134532171

IEL:	124154986 124161113

FCD:	110860548 110860649 110860650 110860652 110860657

DPX:	DAPPUDRAFT_229419 DAPPUDRAFT_303785 DAPPUDRAFT_325672 DAPPUDRAFT_325673

DMK:

116916797

DPZ:	124314058 124316241

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123744861 123744862 123759852

CQD:	128684114 128706577

PTRU:

123501683

ESN:

127005132

MNZ:	135214873 135214874

HAZT:

108667780

EAF:	111699680 111708257 111710507

LSM:	121129741 121130249

TCF:	131878984 131879453 131879972

PPOI:

119097459 119097462 119109535 119109675

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136976270(Mmp1)

PTEP:

107450087 107450091

ABRU:

129960348 129963441

UDV:	129219355 129219910 129235214

SDM:	118183209 118205650

LPOL:

106461522 106467071 106469092

PMEO:

129593539 129593831 129593890 129594261 129595739

HRO:	HELRODRAFT_108967 HELRODRAFT_193602 HELRODRAFT_193603

LGI:	LOTGIDRAFT_158923 LOTGIDRAFT_160600 LOTGIDRAFT_200320 LOTGIDRAFT_231475

PVUL:

126821564

PCAN:

112555453 112562988

BGT:	106051365 106074476

GAE:	121367749 121376669

HRF:	124112473 124113799 124116437 124116459 124120008

HRJ:	124253143 124256263 124261822 124277101

CRG:	105319539 105333479

CANU:

128161283 128180086

CVN:	111099717 111137713 111138285

OED:	125647353 125659971 125664093

MYI:	110455345 110459519 110462871

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

128219387 128220403 128231158 128232486

OBI:	106869299 106873152 106876107 106879964

OSN:	115209377 115224271 115230377

LJP:	135463054 135476346 135477109 135479108

LAK:	106152579 106152606 106155462 106156796 106163428 106164145 106168179

LLON:

135494680 135499819

NVE:	5500606 5506166 5509262 5510262 5510263 5512892 5520492 5520493

EPA:	110231292 110238012 110238646 110239804 110251669 110254069

ATEN:

116286904 116289580 116302034 116302824

ADF:	107349768 107349780

AMIL:

114963032 114966306 114966308

PDAM:

113669026 113674901 113674903 113678590 113679792 113684651 113684653 113685983

SPIS:

111324455 111324555 111324941 111324943 111324944 111324945 111324968 111342087

DGT:	114517718 114522163 114542131

XEN:	124434705 124441150 124441151 124457226

HMG:	100199631 100200849 100200988 100201138 100201778 100202503 100204953 101234798 101239608 101241586 105843571

HSY:	130612801 130625523

RES:	135689046 135692180 135692181 135696270

» show all

Reference

PMID:19631700

Authors

Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C

Title

Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.

Journal

Biochim Biophys Acta 1803:3-19 (2010)
DOI:10.1016/j.bbamcr.2009.07.004

Reference

PMID:7721107

Authors

Takino T, Sato H, Yamamoto E, Seiki M

Title

Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domain.

Journal

Gene 155:293-8 (1995)
DOI:10.1016/0378-1119(94)00637-8

Sequence

[hsa:4323]

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