KEGG ORTHOLOGY: K07868

ORTHOLOGY: K07868

Entry

K07868 KO

Name

RHOBTB1_2

Definition

Rho-related BTB domain-containing protein 1/2

Pathway

ko04120

Ubiquitin mediated proteolysis

Disease

H00606

Early infantile epileptic encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K07868  RHOBTB1_2; Rho-related BTB domain-containing protein 1/2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K07868  RHOBTB1_2; Rho-related BTB domain-containing protein 1/2
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K07868  RHOBTB1_2; Rho-related BTB domain-containing protein 1/2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul3 complex
    Adoptor and target recognizing subunit (BTB)
     K07868  RHOBTB1_2; Rho-related BTB domain-containing protein 1/2
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Rho Family
   RhoBTB
    K07868  RHOBTB1_2; Rho-related BTB domain-containing protein 1/2

Genes

HSA:	23221(RHOBTB2) 9886(RHOBTB1)

PTR:	450482(RHOBTB1) 464050(RHOBTB2)

PPS:	100972407(RHOBTB2) 100995265(RHOBTB1)

GGO:	109024873(RHOBTB2) 109025381(RHOBTB1)

PON:	100174455(RHOBTB2) 100294551(RHOBTB1)

NLE:	100584666(RHOBTB1) 100602112(RHOBTB2)

MCC:	699132(RHOBTB1) 716607(RHOBTB2)

MCF:	101925744(RHOBTB1) 102134397(RHOBTB2)

CSAB:

103215466(RHOBTB2) 103216144(RHOBTB1)

RRO:	104663680(RHOBTB1) 104663982(RHOBTB2)

RBB:	108517521(RHOBTB1) 108540790(RHOBTB2)

CJC:	100407365(RHOBTB1) 100414447(RHOBTB2)

SBQ:	101035271(RHOBTB1) 101048268(RHOBTB2)

MMU:	246710(Rhobtb2) 69288(Rhobtb1)

MCAL:

110302863(Rhobtb1) 110309139(Rhobtb2)

MPAH:

110325494(Rhobtb2) 110326282(Rhobtb1)

RNO:	306004(Rhobtb2) 309722(Rhobtb1)

MUN:	110555375(Rhobtb1) 110557079 110557080

CGE:	100767011(Rhobtb1) 100770205(Rhobtb2)

NGI:	103737469(Rhobtb1) 103747978(Rhobtb2)

HGL:	101696728(Rhobtb2) 101716321(Rhobtb1)

CCAN:

109689703(Rhobtb2) 109695111(Rhobtb1)

OCU:	100345646(RHOBTB2) 100352605(RHOBTB1)

TUP:	102470624(RHOBTB2) 102490724(RHOBTB1)

CFA:	100856331(RHOBTB2) 488998(RHOBTB1)

VVP:	112926810(RHOBTB2) 112931040(RHOBTB1)

AML:	100476537(RHOBTB2) 100477541(RHOBTB1)

UMR:	103667742(RHOBTB1) 103673311(RHOBTB2)

UAH:	113259077(RHOBTB1) 113269988(RHOBTB2)

ORO:	101362742(RHOBTB2) 101369145(RHOBTB1)

ELK:	111145246 111157406

FCA:	101080740(RHOBTB1) 101085882(RHOBTB2)

PTG:	102952680(RHOBTB2) 102970002(RHOBTB1)

PPAD:

109264296(RHOBTB1) 109277334(RHOBTB2)

AJU:	106981114(RHOBTB2) 106989883(RHOBTB1)

BTA:	540513(RHOBTB1) 784567(RHOBTB2)

BOM:	102276450(RHOBTB1)

BIU:	109553734(RHOBTB1) 109562550 109563120 109563121

BBUB:

102394479(RHOBTB2) 102406070 102415941(RHOBTB1)

CHX:	100861107(RHOBTB1) 102190957(RHOBTB2)

OAS:	101120983(RHOBTB1) 443007(RHOBTB2)

SSC:	100152436(RHOBTB2) 100153330(RHOBTB1)

CFR:	102504736(RHOBTB2) 102511812(RHOBTB1)

CDK:	105093853(RHOBTB1) 105102525(RHOBTB2)

BACU:

103005024(RHOBTB2) 103013950(RHOBTB1)

LVE:	103073568(RHOBTB2) 103091530(RHOBTB1)

OOR:	101271707(RHOBTB1) 101274108(RHOBTB2)

DLE:	111167595(RHOBTB1) 111169005(RHOBTB2)

PCAD:

102987897(RHOBTB1) 114486909(RHOBTB2)

ECB:	100057764(RHOBTB2) 100062805(RHOBTB1)

EPZ:	103552763(RHOBTB2) 103559221(RHOBTB1)

EAI:	106826167(RHOBTB1) 106847701(RHOBTB2)

MYB:	102246424(RHOBTB1) 102253672(RHOBTB2)

MYD:	102752250(RHOBTB2) 102760225(RHOBTB1)

MNA:	107536103(RHOBTB2) 107543324(RHOBTB1)

HAI:	109375966(RHOBTB2) 109380627(RHOBTB1)

DRO:	112305189(RHOBTB2) 112305596(RHOBTB1)

PALE:

102879621(RHOBTB2) 102885346(RHOBTB1)

RAY:	107501468(RHOBTB1) 107509217(RHOBTB2)

MJV:	108393206(RHOBTB2) 108404732(RHOBTB1)

LAV:	100663419(RHOBTB2) 100669185(RHOBTB1)

TMU:	101340314 101343558

MDO:	100018851(RHOBTB1) 100030651(RHOBTB2)

SHR:	100917992(RHOBTB2) 100923897(RHOBTB1)

PCW:	110200402(RHOBTB2) 110216375(RHOBTB1)

OAA:	100075048(RHOBTB2) 100077703(RHOBTB1)

GGA:	107056274 419536(RHOBTB2) 423664(RHOBTB1)

MGP:	100543643(RHOBTB2) 100550445(RHOBTB1)

CJO:	107306825 107315681(RHOBTB1) 107323673(RHOBTB2)

NMEL:

110387164(RHOBTB2) 110390960 110399723(RHOBTB1)

APLA:

101800229(RHOBTB1)

ACYG:

106031406(RHOBTB1) 106049701(RHOBTB2)

TGU:	100219969(RHOBTB2) 100226077(RHOBTB1) 115494853

LSR:	110468730 110473040(RHOBTB1) 110480331(RHOBTB2)

SCAN:

103814058(RHOBTB1) 103824424(RHOBTB2)

GFR:	102034068(RHOBTB1) 102041252(RHOBTB2)

FAB:	101811746 101816605(RHOBTB2) 101821602(RHOBTB1)

PHI:	102102178 102104814(RHOBTB1) 102108355(RHOBTB2)

PMAJ:

107198927 107206656(RHOBTB1) 107213951(RHOBTB2)

CCAE:

111931550(RHOBTB1) 111938817(RHOBTB2)

CCW:	104690172(RHOBTB1) 104694880(RHOBTB2) 120409949

ETL:	114063891(RHOBTB1) 114069859(RHOBTB2) 114071793

FPG:	101911153(RHOBTB2) 101912744(RHOBTB1) 101924848

FCH:	102057567(RHOBTB2) 102058757(RHOBTB1)

CLV:	102083944(RHOBTB1) 102091709(RHOBTB2)

EGZ:	104123535(RHOBTB2) 104124645(RHOBTB1)

NNI:	104013462(RHOBTB1) 104019530(RHOBTB2)

ACUN:

113481932(RHOBTB1)

PADL:

103913110(RHOBTB2) 103918505(RHOBTB1)

AAM:	106485708(RHOBTB2) 106486979(RHOBTB1)

ASN:	102374327(RHOBTB2) 102375427 102385593(RHOBTB1)

AMJ:	102568902(RHOBTB2) 102577314 106737181(RHOBTB1)

PSS:	102448449(RHOBTB1) 102459279(RHOBTB2)

CMY:	102930533 102938451(RHOBTB1) 102943370(RHOBTB2)

CPIC:

101932902 101939254(RHOBTB1) 101945156(RHOBTB2)

ACS:	100558177 100562439(rhobtb1) 100567103(rhobtb2)

PVT:	110072185(RHOBTB2) 110079818 110090862(RHOBTB1)

PBI:	103055893(RHOBTB2) 103058021(RHOBTB1) 103063534

PMUR:

107295864 107297331(RHOBTB1) 107299235(RHOBTB2) 107301020

TSR:	106538916 106549231(RHOBTB1) 106556310(RHOBTB2)

PMUA:

114585365(RHOBTB2) 114597160(RHOBTB1) 114598052

GJA:	107107292(RHOBTB2) 107114754(RHOBTB1) 107117626

XLA:	108696080(rhobtb1.L) 108704855 108706470 108711624(rhobtb2.L) 108712692(rhobtb2.S) 444105(rhobtb1.S)

XTR:	100038184(rhobtb1) 100144291(rhobtb2) 116408406

NPR:	108792830(RHOBTB2) 108801174 108804794(RHOBTB1)

DRE:	100537290(rhobtb1) 553415(rhobtb4) 565844(rhobtb2b) 792631(si:dkey-263f15.2)

SRX:	107710844 107718339 107718705 107718938 107727061 107745661 107746840 107758646

SANH:

107654062 107658608 107665202 107676653 107678456 107680668 107689301 107695540

SGH:	107552568 107553166 107553600 107574350 107588985 107593502(rhobtb1) 107596573 107602072

CCAR:

109048171 109049918 109055371 109060888 109063418 109068704

IPU:	108255835 108266035(rhobtb2) 108273459(rhobtb1)

PHYP:

113527753(rhobtb1) 113533297(rhobtb2) 113536916

AMEX:

103021786 103022493(rhobtb1) 103034624(rhobtb2)

EEE:	113577030(rhobtb1) 113578167(rhobtb2) 113580498

TRU:	101073498(rhobtb2)

TNG:	GSTEN00020440G001 GSTEN00028740G001

LCO:	104918085 104931153(rhobtb2)

NCC:	104951955 104965044(rhobtb2)

MZE:	101470080 101471930(rhobtb2)

ONL:	100706307(rhobtb2) 100707935

OLA:	101161977 101172825(rhobtb2)

XMA:	102234696 102235838(rhobtb2)

XCO:	114154544 114154600(rhobtb2)

PRET:

103470451 103470504(rhobtb2)

CVG:	107084546 107093856(rhobtb2)

NFU:	107393762(rhobtb2) 107393854

KMR:	108236574 108242833(rhobtb4)

ALIM:

106532562(rhobtb2) 106534802

AOCE:

111578647(rhobtb2) 111583603

CSEM:

103398230(rhobtb2)

POV:	109633603(rhobtb2) 109633810

LCF:	108878231 108878492(rhobtb2)

SDU:	111226638 111230789(rhobtb2)

SLAL:

111651575 111663939(rhobtb2)

HCQ:	109525359(rhobtb2) 109530709

BPEC:

110164577 110169913(rhobtb2)

MALB:

109956907(rhobtb2) 109956932

SASA:

106579856 106580155 106585588 106585803 106604002

OTW:	112240643 112246921 112248459 112263394 112263991

SALP:

111957690 111957764 111974051 111974746

ELS:	105014033(rhobtb2) 105026303 105031178

SFM:	108925057 108929453(rhobtb2) 108932784 108938624(rhobtb3) 108939451(rhobtb1)

PKI:	111838933(rhobtb2) 111847069 111847281 111853732(rhobtb1)

LCM:	102358015 102365356(RHOBTB1) 102365816(RHOBTB2)

CMK:	103180966(rhobtb1) 103190310(rhobtb2)

RTP:	109910405(rhobtb2) 109911523(rhobtb1) 109913732

BFO:	118414091 118429992 118429994

CIN:

100185717

SPU:	115924096 575159 752289

APLC:

110977126

SKO:	100367936 100370762

DME:	Dmel_CG5701(RhoBTB)

DER:

6544554

DSE:

6616290

DSI:	Dsimw501_GD14882(Dsim_GD14882)

DYA:	Dyak_GE19673

DAN:

6493207

DSR:

110184659

DPO:	Dpse_GA19068

DPE:

6603354

DMN:

108152652

DWI:

6638787

DGR:	Dgri_GH16972

DMO:	Dmoj_GI11838

DNV:

DHE:

DVI:

MDE:

LCQ:

AGA:	AgaP_AGAP006474

AAG:

5564816

AALB:

109402732 115270028

CQU:	CpipJ_CPIJ012218

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:	109596175 109608028

NVL:

108561226

BMOR:

105841626

BMAN:

114253057

DPL:	KGM_210262

PMAC:

PRAP:

HAW:

TNL:

PXY:	105390202 105392852

BTAB:

109039295

CLEC:

106668406

PHU:	Phum_PHUM025340

ZNE:

110839233

FCD:

110856644

DPX:	DAPPUDRAFT_225906

PVM:	113822427 113822428

ISC:	IscW_ISCW010048

DPTE:

113788563

CSCU:

111618480

PTEP:

107448369 107456640

LGI:	LOTGIDRAFT_117662 LOTGIDRAFT_119223

PCAN:

112563647

CRG:	105319862 105326416

MYI:	110443079 110445073 110445074 110445082 110455403

OBI:

106872317

LAK:	106159540 106169343

NVE:	5508001 5508604 5514052

EPA:	110234058 110236946

ADF:	107333107 107343919 107348414

AMIL:

114958489 114964815 114965962 114970827

PDAM:

113675069 113675864 113680049 113681638

SPIS:

111328030 111329963 111341302

DGT:

114516371

HMG:

100202873

TAD:	TRIADDRAFT_31248

» show all

Reference

PMID:18835386

Authors

Berthold J, Schenkova K, Ramos S, Miura Y, Furukawa M, Aspenstrom P, Rivero F

Title

Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.

Journal

Exp Cell Res 314:3453-65 (2008)
DOI:10.1016/j.yexcr.2008.09.005

Sequence

[hsa:9886 23221]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (2106)   
   KEGG GENES (480)   
   KEGG MGENES (344)   
   RefGene (1273)   
   OC (9)   
Literature (1)   
   PubMed (1)   
All databases (2113)   

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