KEGG   ORTHOLOGY: K07966
Entry
K07966                      KO                                     

Name
B4GALT1
Definition
beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
Pathway
ko00052  Galactose metabolism
ko00510  N-Glycan biosynthesis
ko00513  Various types of N-glycan biosynthesis
ko00514  Other types of O-glycan biosynthesis
ko00515  Mannose type O-glycan biosynthesis
ko00533  Glycosaminoglycan biosynthesis - keratan sulfate
ko00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ko01100  Metabolic pathways
Module
M00071  Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer
M00075  N-glycan biosynthesis, complex type
Disease
H00119  Congenital disorders of glycosylation type II
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00052 Galactose metabolism
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00513 Various types of N-glycan biosynthesis
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00515 Mannose type O-glycan biosynthesis
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00514 Other types of O-glycan biosynthesis
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00533 Glycosaminoglycan biosynthesis - keratan sulfate
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.22  lactose synthase
     K07966  B4GALT1; beta-1,4-galactosyltransferase 1
    2.4.1.38  beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
     K07966  B4GALT1; beta-1,4-galactosyltransferase 1
    2.4.1.90  N-acetyllactosamine synthase
     K07966  B4GALT1; beta-1,4-galactosyltransferase 1
    2.4.1.-  
     K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Glycosyltransferases [BR:ko01003]
 Glycan extension
  Type 2 chain/Poly-N-acetyllactosamine
   K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Acrosomal exocytosis proteins
    K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast milk
   K07966  B4GALT1; beta-1,4-galactosyltransferase 1
Other DBs
RN: R00503 R05977 R05989 R06033 R06067 R07617 R09299
GO: 0004461 0003945 0003831
CAZy: GT7
Genes
HSA: 2683(B4GALT1)
PTR: 100613700(B4GALT1)
PPS: 100974756(B4GALT1)
GGO: 101138982(B4GALT1)
PON: 100438031(B4GALT1)
NLE: 100597531(B4GALT1)
MCC: 703541(B4GALT1)
MCF: 102131044(B4GALT1)
CSAB: 103219294(B4GALT1)
RRO: 104674271(B4GALT1)
RBB: 108518246(B4GALT1)
CJC: 100385157(B4GALT1)
SBQ: 101054125(B4GALT1)
MMU: 14595(B4galt1)
MCAL: 110292819(B4galt1)
MPAH: 110338771(B4galt1)
RNO: 24390(B4galt1)
MUN: 110561670(B4galt1)
CGE: 100689430(B4galt1)
NGI: 103741594(B4galt1)
HGL: 101698779 101721414(B4galt1)
CCAN: 109681413
OCU: 100345726(B4GALT1)
TUP: 102470655(B4GALT1)
CFA: 481579(B4GALT1)
VVP: 112927554(B4GALT1)
AML: 100477164(B4GALT1)
UMR: 103667105(B4GALT1)
UAH: 113260528(B4GALT1)
ORO: 101362571(B4GALT1)
ELK: 111146253
FCA: 101100927(B4GALT1)
PTG: 102959538(B4GALT1)
PPAD: 109252046(B4GALT1)
AJU: 106976144(B4GALT1)
BTA: 281781(B4GALT1)
BOM: 102269762(B4GALT1)
BIU: 109563168(B4GALT1)
BBUB: 102389487(B4GALT1)
CHX: 100860927(B4GALT1)
OAS: 100620048(B4GALT1)
SSC: 100511655(B4GALT1)
CFR: 102517623(B4GALT1)
CDK: 105085573(B4GALT1)
BACU: 102999260(B4GALT1)
LVE: 103086401(B4GALT1)
OOR: 101285364(B4GALT1)
DLE: 111163203(B4GALT1)
PCAD: 102981888(B4GALT1)
ECB: 100068209(B4GALT1)
EPZ: 103555031(B4GALT1)
EAI: 106841463(B4GALT1)
MYB: 102240062(B4GALT1)
MYD: 102751484(B4GALT1)
MNA: 107544980(B4GALT1)
HAI: 109371790(B4GALT1)
DRO: 112304428(B4GALT1)
PALE: 102878748(B4GALT1)
RAY: 107502798(B4GALT1)
MJV: 108404111(B4GALT1)
LAV: 100659897(B4GALT1)
TMU: 101341812
MDO: 100010600(B4GALT1)
SHR: 100929465(B4GALT1)
PCW: 110194785(B4GALT1)
OAA: 100075703(B4GALT1)
GGA: 396121(B4GALT1)
MGP: 100543545(B4GALT1)
CJO: 107306674(B4GALT1)
NMEL: 110389893(B4GALT1)
APLA: 101792817(B4GALT1)
ACYG: 106040136(B4GALT1)
TGU: 100223650(B4GALT1)
LSR: 110474049(B4GALT1)
SCAN: 103821842(B4GALT1)
GFR: 102041517(B4GALT1)
FAB: 101807052(B4GALT1)
PHI: 102109081(B4GALT1)
PMAJ: 107198186(B4GALT1)
CCAE: 111941228(B4GALT1)
CCW: 104689823(B4GALT1)
ETL: 114057877(B4GALT1)
FPG: 101918852(B4GALT1)
FCH: 102046112(B4GALT1)
CLV: 102088289(B4GALT1)
NNI: 104022647(B4GALT1)
ACUN: 113490200(B4GALT1)
PADL: 103921076(B4GALT1)
AAM: 106486901(B4GALT1)
ASN: 102372956(B4GALT1)
AMJ: 102559129(B4GALT1)
PSS: 102459690(B4GALT1)
CMY: 102942662(B4GALT1)
CPIC: 101932379(B4GALT1)
ACS: 100561064(b4galt1)
PVT: 110087350(B4GALT1)
PBI: 103065477(B4GALT1)
PMUR: 107285615(B4GALT1)
TSR: 106557055(B4GALT1)
PMUA: 114587454(B4GALT1)
GJA: 107110573(B4GALT1)
XLA: 108704693 108706812(b4galt1.1.S) 108706813(b4galt1.2.S) 108712215(b4galt1.1.L) 108712216(b4galt1.2.L) 108712940 108712957
XTR: 100145518(b4galt1.1) 100485024(b4galt1l) 549418(b4galt1.2)
DRE: 550425(b4galt1) 768123(b4galt1l)
IPU: 108260689 108277608(B4galt1)
PHYP: 113540104(b4galt1)
NCC: 104951664
MZE: 101472320(b4galt1) 101486761
OLA: 101171148(b4galt1)
XCO: 114137012 114139607(b4galt1)
KMR: 108248973(b4galt1) 108249546
ALIM: 106517566 106533299(b4galt1)
CSEM: 103390794(b4galt1)
SDU: 111233512(b4galt1) 111237265
SLAL: 111662869 111665610(b4galt1)
HCQ: 109508336
BPEC: 110161009 110168019(b4galt1)
PKI: 111848718(b4galt1)
LCM: 102357329
CMK: 103177647
RTP: 109917086
AME: 552141
BIM: 100740998
BTER: 100646215
CCAL: 108623214
OBB: 114879791
SOC: 105204470
MPHA: 105828743
AEC: 105147678
ACEP: 105625179
PBAR: 105428016
VEM: 105568351
HST: 105182815
DQU: 106747702
CFO: 105253646
LHU: 105676090
PGC: 109852267
OBO: 105276803
PCF: 106786585
NVI: 100119383
MDL: 103573666
TCA: 660633
DPA: 109535724
ATD: 109601349
BMOR: 101738885
HAW: 110377712
API: 100165374 100302475(NV135)
DNX: 107166054
AGS: 114128088
RMD: 113554920
CLEC: 112128463
ZNE: 110831915
FCD: 110863018
CSCU: 111638060
PTEP: 107439945
BMY: Bm1_02770
PCAN: 112557792
OBI: 106877819
LAK: 106166688
ADF: 107350754
AMIL: 114976753
PDAM: 113679114
SPIS: 111338386
HMG: 101235348
PCU: pc1394
PNL: PNK_0340
 » show all
Reference
PMID:3091013
  Authors
Appert HE, Rutherford TJ, Tarr GE, Thomford NR, McCorquodale DJ
  Title
Isolation of galactosyltransferase from human milk and the determination of its N-terminal amino acid sequence.
  Journal
Biochem Biophys Res Commun 138:224-9 (1986)
DOI:10.1016/0006-291X(86)90269-X

KEGG   ORTHOLOGY: K07967
Entry
K07967                      KO                                     

Name
B4GALT2
Definition
beta-1,4-galactosyltransferase 2 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
Pathway
ko00052  Galactose metabolism
ko00510  N-Glycan biosynthesis
ko00513  Various types of N-glycan biosynthesis
ko00514  Other types of O-glycan biosynthesis
ko00515  Mannose type O-glycan biosynthesis
ko00533  Glycosaminoglycan biosynthesis - keratan sulfate
ko00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ko01100  Metabolic pathways
Module
M00071  Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer
M00075  N-glycan biosynthesis, complex type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00052 Galactose metabolism
    K07967  B4GALT2; beta-1,4-galactosyltransferase 2
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K07967  B4GALT2; beta-1,4-galactosyltransferase 2
   00513 Various types of N-glycan biosynthesis
    K07967  B4GALT2; beta-1,4-galactosyltransferase 2
   00515 Mannose type O-glycan biosynthesis
    K07967  B4GALT2; beta-1,4-galactosyltransferase 2
   00514 Other types of O-glycan biosynthesis
    K07967  B4GALT2; beta-1,4-galactosyltransferase 2
   00533 Glycosaminoglycan biosynthesis - keratan sulfate
    K07967  B4GALT2; beta-1,4-galactosyltransferase 2
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K07967  B4GALT2; beta-1,4-galactosyltransferase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K07967  B4GALT2; beta-1,4-galactosyltransferase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.22  lactose synthase
     K07967  B4GALT2; beta-1,4-galactosyltransferase 2
    2.4.1.38  beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
     K07967  B4GALT2; beta-1,4-galactosyltransferase 2
    2.4.1.90  N-acetyllactosamine synthase
     K07967  B4GALT2; beta-1,4-galactosyltransferase 2
    2.4.1.-  
     K07967  B4GALT2; beta-1,4-galactosyltransferase 2
Glycosyltransferases [BR:ko01003]
 Glycan extension
  Type 2 chain/Poly-N-acetyllactosamine
   K07967  B4GALT2; beta-1,4-galactosyltransferase 2
Other DBs
RN: R00503 R05977 R05989 R06067 R09299
GO: 0004461 0003945 0003831
CAZy: GT7
Genes
HSA: 8704(B4GALT2)
PTR: 456522(B4GALT2)
PPS: 100980267(B4GALT2)
GGO: 101133326(B4GALT2)
PON: 100437696(B4GALT2)
NLE: 100598306(B4GALT2)
MCC: 704038(B4GALT2)
MCF: 102115300(B4GALT2)
CSAB: 103224947(B4GALT2)
RRO: 104669045(B4GALT2)
RBB: 108535685(B4GALT2)
CJC: 100896540(B4GALT2)
SBQ: 101039415(B4GALT2)
MMU: 53418(B4galt2)
MCAL: 110292610(B4galt2)
MPAH: 110322866(B4galt2)
RNO: 313536(B4galt2)
MUN: 110552917(B4galt2)
CGE: 100689434(B4galt2)
NGI: 103743868(B4galt2)
HGL: 101718811(B4galt2)
CCAN: 109695495(B4galt2)
OCU: 100351419(B4GALT2)
TUP: 102489782(B4GALT2)
CFA: 482527(B4GALT2)
VVP: 112914817(B4GALT2)
AML: 100471634(B4GALT2)
UMR: 103670800(B4GALT2)
UAH: 113254774(B4GALT2)
ORO: 101364688(B4GALT2)
ELK: 111143515
FCA: 101084809(B4GALT2)
PTG: 102955088(B4GALT2)
PPAD: 109254800(B4GALT2)
AJU: 106970225(B4GALT2)
BTA: 100125390(B4GALT2)
BOM: 102283249(B4GALT2)
BIU: 109556391(B4GALT2)
BBUB: 102408682(B4GALT2)
CHX: 102191101(B4GALT2)
OAS: 101114825(B4GALT2)
SSC: 100736821(B4GALT2)
CFR: 102516080(B4GALT2)
CDK: 105090897(B4GALT2)
BACU: 103001417(B4GALT2)
LVE: 103086978(B4GALT2)
OOR: 101285582(B4GALT2)
DLE: 111175715(B4GALT2)
PCAD: 102991108(B4GALT2)
ECB: 100066149(B4GALT2)
EPZ: 103548278(B4GALT2)
EAI: 106847911(B4GALT2)
MYB: 102248727(B4GALT2)
MYD: 102774860(B4GALT2)
MNA: 107526700(B4GALT2)
HAI: 109383427(B4GALT2)
DRO: 112314589(B4GALT2)
PALE: 102884318(B4GALT2)
RAY: 107499511(B4GALT2)
MJV: 108404461(B4GALT2)
LAV: 100657659(B4GALT2)
TMU: 101358819
MDO: 100617718(B4GALT2)
SHR: 100918732(B4GALT2)
PCW: 110200216(B4GALT2)
OAA: 100092000(B4GALT2)
GGA: 396122(B4GALT2)
MGP: 100543680(B4GALT2)
CJO: 107317480(B4GALT2)
NMEL: 110402248(B4GALT2)
ACYG: 106049039(B4GALT2)
TGU: 100230857(B4GALT2)
LSR: 110469509(B4GALT2)
SCAN: 103815164(B4GALT2)
GFR: 102036032(B4GALT2)
FAB: 101805871(B4GALT2)
PHI: 102106294(B4GALT2)
PMAJ: 107208264(B4GALT2)
CCAE: 111933140(B4GALT2)
CCW: 104695261(B4GALT2)
ETL: 114061818(B4GALT2)
FPG: 101916596(B4GALT2)
FCH: 102056545(B4GALT2)
CLV: 102088677(B4GALT2)
EGZ: 104125508(B4GALT2)
NNI: 104015428(B4GALT2)
ACUN: 113483103(B4GALT2)
AAM: 106484931(B4GALT2)
ASN: 102376584(B4GALT2)
AMJ: 102558168(B4GALT2)
CMY: 102941864(B4GALT2)
CPIC: 101945883(B4GALT2)
ACS: 100557558(b4galt2)
PVT: 110073738(B4GALT2)
PBI: 103068203(B4GALT2)
PMUR: 107283468(B4GALT2)
TSR: 106546760(B4GALT2)
PMUA: 114599120(B4GALT2)
GJA: 107120293(B4GALT2)
XLA: 100190782(b4galt2.S) 108714282(b4galt2.L)
XTR: 100492356(b4galt2)
NPR: 108802209
DRE: 100148828(b4galt2)
SRX: 107713046 107730805(b4galt2)
CCAR: 109046140 109113239(b4galt2)
IPU: 108267387(b4galt2)
PHYP: 113540513(b4galt2)
AMEX: 103033307(b4galt2)
EEE: 113584665(b4galt2)
TRU: 101072068(b4galt2)
LCO: 104917723(b4galt2)
ONL: 100711524(b4galt2)
OLA: 100301598(b4galt2)
XMA: 102223611 102231933(b4galt2)
PRET: 103479896
CVG: 107081704(b4galt2)
KMR: 108241697(b4galt2) 108250944
ALIM: 106531648 106532850(b4galt2)
AOCE: 111579296(b4galt2)
CSEM: 103396367(b4galt2)
POV: 109629466 109647156(b4galt2)
LCF: 108883305(b4galt2)
SDU: 111230961(b4galt2)
SLAL: 111656997(b4galt2)
HCQ: 109524074(b4galt2)
BPEC: 110164179(b4galt2)
MALB: 109955445(b4galt2) 109963721
ELS: 105022694(b4galt2)
SFM: 108935233(b4galt2)
PKI: 111846077(b4galt2)
LCM: 102350195(B4GALT2)
CMK: 103181973 103182791(b4galt2)
RTP: 109923637
DSI: Dsimw501_GD18000(Dsim_GD18000)
LCQ: 111677328
AAG: 110677016
BIM: 100744402
BTER: 100652024
CCAL: 108628792
OBB: 114877587
SOC: 105195967
MPHA: 105837604
AEC: 105148790
ACEP: 105619925
PBAR: 105423830
VEM: 105559205
CFO: 105253066
LHU: 105670187
PGC: 109856896
OBO: 105285158
MDL: 103580462
NVL: 108560872
BMOR: 101742217
HAW: 110384583
TNL: 113492584
DNX: 107163209
AGS: 114121594
RMD: 113553073
BTAB: 109039552
TUT: 107361940
DPTE: 113789586
BMY: Bm1_02765
NVE: 5521186
DGT: 114517454
 » show all
Reference
  Authors
Guo S, Sato T, Shirane K, Furukawa K
  Title
Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.
  Journal
Glycobiology 11:813-20 (2001)
DOI:10.1093/glycob/11.10.813
  Sequence
[hsa:8704]

KEGG   ORTHOLOGY: K07968
Entry
K07968                      KO                                     

Name
B4GALT3
Definition
beta-1,4-galactosyltransferase 3 [EC:2.4.1.90 2.4.1.38 2.4.1.-]
Pathway
ko00510  N-Glycan biosynthesis
ko00513  Various types of N-glycan biosynthesis
ko00514  Other types of O-glycan biosynthesis
ko00515  Mannose type O-glycan biosynthesis
ko00533  Glycosaminoglycan biosynthesis - keratan sulfate
ko00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ko01100  Metabolic pathways
Module
M00071  Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer
M00075  N-glycan biosynthesis, complex type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K07968  B4GALT3; beta-1,4-galactosyltransferase 3
   00513 Various types of N-glycan biosynthesis
    K07968  B4GALT3; beta-1,4-galactosyltransferase 3
   00515 Mannose type O-glycan biosynthesis
    K07968  B4GALT3; beta-1,4-galactosyltransferase 3
   00514 Other types of O-glycan biosynthesis
    K07968  B4GALT3; beta-1,4-galactosyltransferase 3
   00533 Glycosaminoglycan biosynthesis - keratan sulfate
    K07968  B4GALT3; beta-1,4-galactosyltransferase 3
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K07968  B4GALT3; beta-1,4-galactosyltransferase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K07968  B4GALT3; beta-1,4-galactosyltransferase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.38  beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
     K07968  B4GALT3; beta-1,4-galactosyltransferase 3
    2.4.1.90  N-acetyllactosamine synthase
     K07968  B4GALT3; beta-1,4-galactosyltransferase 3
    2.4.1.-  
     K07968  B4GALT3; beta-1,4-galactosyltransferase 3
Glycosyltransferases [BR:ko01003]
 Glycan extension
  Type 2 chain/Poly-N-acetyllactosamine
   K07968  B4GALT3; beta-1,4-galactosyltransferase 3
  Glycolipid
   K07968  B4GALT3; beta-1,4-galactosyltransferase 3
Other DBs
RN: R05977 R05989 R06033 R09299
GO: 0003945 0003831
CAZy: GT7
Genes
HSA: 8703(B4GALT3)
PTR: 457451(B4GALT3)
PPS: 100980499(B4GALT3)
GGO: 101152694(B4GALT3)
PON: 100174763(B4GALT3) 100442932
NLE: 100600657(B4GALT3)
MCC: 719920(B4GALT3)
MCF: 102123574(B4GALT3)
CSAB: 103223692(B4GALT3)
RRO: 104665338(B4GALT3)
RBB: 108521170(B4GALT3)
CJC: 100413633(B4GALT3)
SBQ: 101048901(B4GALT3)
MMU: 57370(B4galt3)
MCAL: 110300448(B4galt3)
MPAH: 110321517(B4galt3)
RNO: 494342(B4galt3)
MUN: 110554442(B4galt3)
CGE: 100689346(B4galt3)
NGI: 103745954(B4galt3)
HGL: 101702700(B4galt3)
CCAN: 109689965 109693205(B4galt3)
OCU: 100358436(B4GALT3)
TUP: 102501629(B4GALT3)
CFA: 476397 488650(B4GALT3)
VVP: 112910047(B4GALT3) 112931239
AML: 100479119 100482718(B4GALT3)
UMR: 103657308 103672017(B4GALT3)
UAH: 113246729(B4GALT3) 113247273
ORO: 101366805(B4GALT3)
ELK: 111138937
FCA: 101089738(B4GALT3)
PTG: 102965736(B4GALT3)
PPAD: 109257290(B4GALT3)
AJU: 106978533(B4GALT3)
BTA: 515771(B4GALT3)
BOM: 102273575(B4GALT3)
BIU: 109578355(B4GALT3)
BBUB: 102398964(B4GALT3)
CHX: 102191287(B4GALT3)
OAS: 101103686(B4GALT3)
SSC: 100154856(B4GALT3) 100514465
CFR: 102510375 102523348(B4GALT3)
CDK: 105100111(B4GALT3)
BACU: 103014433(B4GALT3)
LVE: 103083911(B4GALT3)
OOR: 101278293(B4GALT3)
DLE: 111167059(B4GALT3) 111181131
PCAD: 102991770(B4GALT3)
ECB: 100065936 100066144(B4GALT3)
EPZ: 103540622 103559988(B4GALT3)
EAI: 106822347 106827571(B4GALT3)
MYB: 102245477(B4GALT3)
MYD: 102755410 102770964(B4GALT3)
MNA: 107531762 107535094(B4GALT3)
HAI: 109376935(B4GALT3)
DRO: 112298941(B4GALT3)
PALE: 102897413(B4GALT3)
RAY: 107504675(B4GALT3)
MJV: 108385572 108394555(B4GALT3)
LAV: 100666904 100671768(B4GALT3)
TMU: 101348830
MDO: 100028240 100032749(B4GALT3)
SHR: 100917085(B4GALT3) 100934965
PCW: 110197965(B4GALT3) 110220169
OAA: 100075607 114807990(B4GALT3)
GGA: 107049101(B4GALT3) 418342(B4GALT3)
MGP: 100548019
APLA: 101792630(B4GALT3)
ACYG: 106037599(B4GALT3)
TGU: 100219809 100223491(B4GALT3)
LSR: 110479050(B4GALT3) 110480886
SCAN: 103827099
GFR: 102034619
FAB: 101809643
PHI: 102104795(B4GALT3) 102108330
PMAJ: 107206030(B4GALT3)
CCAE: 111939118
CCW: 104687054
ETL: 114055095 114072102(B4GALT3)
FPG: 101910439(B4GALT3) 101915824
FCH: 102051290 102057757(B4GALT3)
CLV: 102093948 102094059(B4GALT3)
EGZ: 104126496(B4GALT3)
NNI: 104008640 104012591(B4GALT3)
ACUN: 113485122(B4GALT3)
PADL: 103922311(B4GALT3)
AAM: 106490693 106500494(B4GALT3)
CMY: 102937222(B4GALT3)
CPIC: 101933315 101952944 101953612(B4GALT3)
PMUR: 107287654 107288004 107300024(B4GALT3)
PMUA: 114587210(B4GALT3) 114595808
XLA: 108696936 108709275 379106(MGC52827) 414540 446718(b4galt3.S) 496041
XTR: 100486704(b4galt3) 116406683 448369(b4galt3l1) 733985(b4galt3l2)
DRE: 556544(si:dkey-199f5.8) 561756(b4galt3)
PHYP: 113530669(b4galt3)
AMEX: 103022975(b4galt3) 103031892
EEE: 113570039(b4galt3) 113574431
ONL: 100690937 100694871(b4galt3)
OLA: 101159351(b4galt3) 101162708
SASA: 106566510(b4galt3) 106582539 106605235
SALP: 111959078 111965171 111976535(b4galt3)
PKI: 111838658 111842288(b4galt3)
RTP: 109922940 109926608(b4galt3)
CIN: 100177052
PRAP: 111002374
API: 100159313
DNX: 107166964
AGS: 114120142
RMD: 113549579
PTEP: 107437815
CEL: CELE_Y73E7A.7(bre-4)
CBR: CBG22165(Cbr-bre-4)
OBI: 106871325
SHX: MS3_07047
 » show all
Reference
  Authors
Guo S, Sato T, Shirane K, Furukawa K
  Title
Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells.
  Journal
Glycobiology 11:813-20 (2001)
DOI:10.1093/glycob/11.10.813
  Sequence
[hsa:8703]

KEGG   ENZYME: 2.4.1.38
Entry
EC 2.4.1.38                 Enzyme                                 

Name
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase;
UDP-galactose---glycoprotein galactosyltransferase;
glycoprotein 4-beta-galactosyl-transferase;
beta-N-acetyl-beta1-4-galactosyltransferase;
thyroid glycoprotein beta-galactosyltransferase;
glycoprotein beta-galactosyltransferase;
thyroid galactosyltransferase;
uridine diphosphogalactose-glycoprotein galactosyltransferase;
beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase;
GalT;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide [RN:R04495]
Reaction(KEGG)
R04495 > R05989(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminylglycopeptide
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Comment
Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. High activity is shown towards such residues in branched-chain polysaccharides when these are linked by beta-1,6-links to galactose residues; lower activity towards residues linked to galactose by beta-1,3-links. A component of EC 2.4.1.22 (lactose synthase).
History
EC 2.4.1.38 created 1972, modified 1976, modified 1980, modified 1986
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec00533  Glycosaminoglycan biosynthesis - keratan sulfate
ec01100  Metabolic pathways
Orthology
K07966  beta-1,4-galactosyltransferase 1
K07967  beta-1,4-galactosyltransferase 2
K07968  beta-1,4-galactosyltransferase 3
Genes
HSA: 2683(B4GALT1) 8703(B4GALT3) 8704(B4GALT2)
PTR: 100613700(B4GALT1) 456522(B4GALT2) 457451(B4GALT3)
PPS: 100974756(B4GALT1) 100980267(B4GALT2) 100980499(B4GALT3)
GGO: 101133326(B4GALT2) 101138982(B4GALT1) 101152694(B4GALT3)
PON: 100174763(B4GALT3) 100437696(B4GALT2) 100438031(B4GALT1) 100442932
NLE: 100597531(B4GALT1) 100598306(B4GALT2) 100600657(B4GALT3)
MCC: 703541(B4GALT1) 704038(B4GALT2) 719920(B4GALT3)
MCF: 102115300(B4GALT2) 102123574(B4GALT3) 102131044(B4GALT1)
CSAB: 103219294(B4GALT1) 103223692(B4GALT3) 103224947(B4GALT2)
RRO: 104665338(B4GALT3) 104669045(B4GALT2) 104674271(B4GALT1)
RBB: 108518246(B4GALT1) 108521170(B4GALT3) 108535685(B4GALT2)
CJC: 100385157(B4GALT1) 100413633(B4GALT3) 100896540(B4GALT2)
SBQ: 101039415(B4GALT2) 101048901(B4GALT3) 101054125(B4GALT1)
MMU: 14595(B4galt1) 53418(B4galt2) 57370(B4galt3)
MCAL: 110292610(B4galt2) 110292819(B4galt1) 110300448(B4galt3)
MPAH: 110321517(B4galt3) 110322866(B4galt2) 110338771(B4galt1)
RNO: 24390(B4galt1) 313536(B4galt2) 494342(B4galt3)
MUN: 110552917(B4galt2) 110554442(B4galt3) 110561670(B4galt1)
CGE: 100689346(B4galt3) 100689430(B4galt1) 100689434(B4galt2)
NGI: 103741594(B4galt1) 103743868(B4galt2) 103745954(B4galt3)
HGL: 101698779 101702700(B4galt3) 101718811(B4galt2) 101721414(B4galt1)
CCAN: 109681413 109689965 109693205(B4galt3) 109695495(B4galt2)
OCU: 100345726(B4GALT1) 100351419(B4GALT2) 100358436(B4GALT3)
TUP: 102470655(B4GALT1) 102489782(B4GALT2) 102501629(B4GALT3)
CFA: 476397 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3)
VVP: 112910047(B4GALT3) 112914817(B4GALT2) 112927554(B4GALT1) 112931239
AML: 100471634(B4GALT2) 100477164(B4GALT1) 100479119 100482718(B4GALT3)
UMR: 103657308 103667105(B4GALT1) 103670800(B4GALT2) 103672017(B4GALT3)
UAH: 113246729(B4GALT3) 113247273 113254774(B4GALT2) 113260528(B4GALT1)
ORO: 101362571(B4GALT1) 101364688(B4GALT2) 101366805(B4GALT3)
FCA: 101084809(B4GALT2) 101089738(B4GALT3) 101100927(B4GALT1)
PTG: 102955088(B4GALT2) 102959538(B4GALT1) 102965736(B4GALT3)
PPAD: 109252046(B4GALT1) 109254800(B4GALT2) 109257290(B4GALT3)
AJU: 106970225(B4GALT2) 106976144(B4GALT1) 106978533(B4GALT3)
BTA: 100125390(B4GALT2) 281781(B4GALT1) 515771(B4GALT3)
BOM: 102269762(B4GALT1) 102273575(B4GALT3) 102283249(B4GALT2)
BIU: 109556391(B4GALT2) 109563168(B4GALT1) 109578355(B4GALT3)
BBUB: 102389487(B4GALT1) 102398964(B4GALT3) 102408682(B4GALT2)
CHX: 100860927(B4GALT1) 102191101(B4GALT2) 102191287(B4GALT3)
OAS: 100620048(B4GALT1) 101103686(B4GALT3) 101114825(B4GALT2)
SSC: 100154856(B4GALT3) 100511655(B4GALT1) 100514465 100736821(B4GALT2)
CFR: 102510375 102516080(B4GALT2) 102517623(B4GALT1) 102523348(B4GALT3)
CDK: 105085573(B4GALT1) 105090897(B4GALT2) 105100111(B4GALT3)
BACU: 102999260(B4GALT1) 103001417(B4GALT2) 103014433(B4GALT3)
LVE: 103083911(B4GALT3) 103086401(B4GALT1) 103086978(B4GALT2)
OOR: 101278293(B4GALT3) 101285364(B4GALT1) 101285582(B4GALT2)
DLE: 111163203(B4GALT1) 111167059(B4GALT3) 111175715(B4GALT2) 111181131
PCAD: 102981888(B4GALT1) 102991108(B4GALT2) 102991770(B4GALT3)
ECB: 100065936 100066144(B4GALT3) 100066149(B4GALT2) 100068209(B4GALT1)
EPZ: 103540622 103548278(B4GALT2) 103555031(B4GALT1) 103559988(B4GALT3)
EAI: 106822347 106827571(B4GALT3) 106841463(B4GALT1) 106847911(B4GALT2)
MYB: 102240062(B4GALT1) 102245477(B4GALT3) 102248727(B4GALT2)
MYD: 102751484(B4GALT1) 102755410 102770964(B4GALT3) 102774860(B4GALT2)
MNA: 107526700(B4GALT2) 107531762 107535094(B4GALT3) 107544980(B4GALT1)
HAI: 109371790(B4GALT1) 109376935(B4GALT3) 109383427(B4GALT2)
DRO: 112298941(B4GALT3) 112304428(B4GALT1) 112314589(B4GALT2)
PALE: 102878748(B4GALT1) 102884318(B4GALT2) 102897413(B4GALT3)
RAY: 107499511(B4GALT2) 107502798(B4GALT1) 107504675(B4GALT3)
MJV: 108385572 108394555(B4GALT3) 108404111(B4GALT1) 108404461(B4GALT2)
LAV: 100657659(B4GALT2) 100659897(B4GALT1) 100666904 100671768(B4GALT3)
MDO: 100010600(B4GALT1) 100028240 100032749(B4GALT3) 100617718(B4GALT2)
SHR: 100917085(B4GALT3) 100918732(B4GALT2) 100929465(B4GALT1) 100934965
PCW: 110194785(B4GALT1) 110197965(B4GALT3) 110200216(B4GALT2) 110220169
OAA: 100075607 100075703(B4GALT1) 100092000(B4GALT2) 114807990(B4GALT3)
GGA: 107049101(B4GALT3) 396121(B4GALT1) 396122(B4GALT2) 418342(B4GALT3)
MGP: 100543545(B4GALT1) 100543680(B4GALT2) 100548019
CJO: 107306674(B4GALT1) 107307393 107317480(B4GALT2) 107320437
NMEL: 110389893(B4GALT1) 110390460 110399414 110402248(B4GALT2)
APLA: 101792630(B4GALT3) 101792817(B4GALT1)
ACYG: 106037599(B4GALT3) 106040136(B4GALT1) 106049039(B4GALT2)
TGU: 100219809 100223491(B4GALT3) 100223650(B4GALT1) 100230857(B4GALT2)
LSR: 110469509(B4GALT2) 110474049(B4GALT1) 110479050(B4GALT3) 110480886
SCAN: 103815164(B4GALT2) 103821842(B4GALT1) 103827099
GFR: 102034619 102036032(B4GALT2) 102041517(B4GALT1)
FAB: 101805871(B4GALT2) 101807052(B4GALT1) 101809643
PHI: 102104795(B4GALT3) 102106294(B4GALT2) 102108330 102109081(B4GALT1)
PMAJ: 107198186(B4GALT1) 107206030(B4GALT3) 107208264(B4GALT2)
CCAE: 111933140(B4GALT2) 111939118 111941228(B4GALT1)
CCW: 104687054 104689823(B4GALT1) 104695261(B4GALT2)
ETL: 114055095 114057877(B4GALT1) 114061818(B4GALT2) 114072102(B4GALT3)
FPG: 101910439(B4GALT3) 101915824 101916596(B4GALT2) 101918852(B4GALT1)
FCH: 102046112(B4GALT1) 102051290 102056545(B4GALT2) 102057757(B4GALT3)
CLV: 102088289(B4GALT1) 102088677(B4GALT2) 102093948 102094059(B4GALT3)
EGZ: 104125508(B4GALT2) 104126496(B4GALT3)
NNI: 104008640 104012591(B4GALT3) 104015428(B4GALT2) 104022647(B4GALT1)
ACUN: 113483103(B4GALT2) 113485122(B4GALT3) 113490200(B4GALT1)
PADL: 103921076(B4GALT1) 103922311(B4GALT3)
AAM: 106484931(B4GALT2) 106486901(B4GALT1) 106490693 106500494(B4GALT3)
ASN: 102370415 102371026 102372956(B4GALT1) 102376584(B4GALT2) 102388067(B4GALT3)
AMJ: 102558168(B4GALT2) 102559129(B4GALT1) 102572436 102575172 106737239(B4GALT3)
PSS: 102448865(B4GALT3) 102450039 102459690(B4GALT1) 102461193
CMY: 102937222(B4GALT3) 102941864(B4GALT2) 102942662(B4GALT1)
CPIC: 101932379(B4GALT1) 101933315 101945883(B4GALT2) 101952944 101953612(B4GALT3)
ACS: 100553459 100557158 100557558(b4galt2) 100558708(b4galt3) 100561064(b4galt1)
PVT: 110073738(B4GALT2) 110074017 110081027(B4GALT3) 110087350(B4GALT1) 110089672
PBI: 103050267 103063173(B4GALT3) 103065477(B4GALT1) 103068003 103068203(B4GALT2)
PMUR: 107283468(B4GALT2) 107285615(B4GALT1) 107287654 107288004 107300024(B4GALT3)
TSR: 106544528 106546760(B4GALT2) 106549006 106550798(B4GALT3) 106557055(B4GALT1)
PMUA: 114587210(B4GALT3) 114587454(B4GALT1) 114595808 114599120(B4GALT2)
GJA: 107106046 107110573(B4GALT1) 107120293(B4GALT2) 107121751(B4GALT3) 107122018
XLA: 100190782(b4galt2.S) 108696936 108704693 108706812(b4galt1.1.S) 108706813(b4galt1.2.S) 108709275 108712215(b4galt1.1.L) 108712216(b4galt1.2.L) 108712940 108712957 108714282(b4galt2.L) 379106(MGC52827) 414540 446718(b4galt3.S) 496041
XTR: 100145518(b4galt1.1) 100485024(b4galt1l) 100486704(b4galt3) 100492356(b4galt2) 116406683 448369(b4galt3l1) 549418(b4galt1.2) 733985(b4galt3l2)
DRE: 100148828(b4galt2) 550425(b4galt1) 556544(si:dkey-199f5.8) 561756(b4galt3) 768123(b4galt1l)
PHYP: 113530669(b4galt3) 113540104(b4galt1) 113540513(b4galt2)
OLA: 100301598(b4galt2) 101159351(b4galt3) 101162708 101171148(b4galt1)
SDU: 111219126 111219224(b4galt3) 111230961(b4galt2) 111233512(b4galt1) 111235761 111237265
PKI: 111838658 111842288(b4galt3) 111846077(b4galt2) 111848718(b4galt1)
DSI: Dsimw501_GD18000(Dsim_GD18000)
LCQ: 111677328
AAG: 110677016
AME: 552141
HST: 105182815
DQU: 106747702
PCF: 106786585
NVI: 100119383
TCA: 660633
DPA: 109535724
ATD: 109601349
NVL: 108560872
PRAP: 111002374
BTAB: 109039552
ZNE: 110831915
FCD: 110863018
TUT: 107361940
CEL: CELE_Y73E7A.7(bre-4)
CBR: CBG22165(Cbr-bre-4)
SHX: MS3_07047
NVE: 5521186
ADF: 107350754
AMIL: 114976753
PDAM: 113679114
SPIS: 111338386
HMG: 101235348
PCU: pc1394
PNL: PNK_0340
 » show all
Reference
1  [PMID:6784450]
  Authors
Beyer TA, Sadler JE, Rearick JI, Paulson JC, Hill RL.
  Title
Glycosyltransferases and their use in assessing oligosaccharide structure and structure-function relationships.
  Journal
Adv Enzymol Relat Areas Mol Biol 52:23-175 (1981)
DOI:10.1002/9780470122976.ch2
Reference
2  [PMID:6816588]
  Authors
Blanken WM, Hooghwinkel GJ, Van Den Eijnden DH.
  Title
Biosynthesis of blood-group I and i substances. Specificity of bovine colostrum beta-N-acetyl-D-glucosaminide beta 1 leads to 4 galactosyltransferase.
  Journal
Eur J Biochem 127:547-52 (1982)
DOI:10.1111/j.1432-1033.1982.tb06906.x
Reference
3  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J Biol Chem 260:12927-34 (1985)
Reference
4  [PMID:5726898]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid galactosyltransferase.
  Journal
J Biol Chem 243:6529-37 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.38
IUBMB Enzyme Nomenclature: 2.4.1.38
ExPASy - ENZYME nomenclature database: 2.4.1.38
BRENDA, the Enzyme Database: 2.4.1.38
CAS: 37237-43-7

KEGG   REACTION: R05989
Entry
R05989                      Reaction                               

Name
UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase
Definition
2 UDP-D-galactose + G00016 <=> 2 UDP + G00017
Equation
2 G10609 + G00016 <=> 2 G10619 + G00017
Enzyme
Pathway
rn00510  N-Glycan biosynthesis
rn00513  Various types of N-glycan biosynthesis
rn01100  Metabolic pathways
Module
M00075  N-glycan biosynthesis, complex type
Orthology
K07966  beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
K07967  beta-1,4-galactosyltransferase 2 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]
K07968  beta-1,4-galactosyltransferase 3 [EC:2.4.1.90 2.4.1.38 2.4.1.-]

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