KEGG ORTHOLOGY: K07989

ORTHOLOGY: K07989

Entry

K07989                      KO

Symbol

SH2D1B, EAT2

Name

SH2 domain-containing protein 1B

Pathway

map04650

Natural killer cell mediated cytotoxicity

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K07989  SH2D1B, EAT2; SH2 domain-containing protein 1B
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K07989  SH2D1B, EAT2; SH2 domain-containing protein 1B
Domain-containing proteins not elsewhere classified [BR:ko04990]
Src homology (SH) domain-containing proteins
  Other SH2 and SH3-containing proteins
   K07989  SH2D1B, EAT2; SH2 domain-containing protein 1B

Genes

HSA:	117157(SH2D1B)

PTR:	457464(SH2D1B)

PPS:	100984836(SH2D1B)

PON:	100450772(SH2D1B)

PPYG:

129019110(SH2D1B)

NLE:	100585207(SH2D1B)

HMH:	116473316(SH2D1B)

SSYN:

134734506(SH2D1B)

MCC:	720097(SH2D1B)

MCF:	102132319(SH2D1B)

MNI:	105498230(SH2D1B)

CSAB:

103223659(SH2D1B)

CATY:

105589224(SH2D1B)

PANU:

101016361(SH2D1B)

TGE:	112604866(SH2D1B)

MLEU:

105550999(SH2D1B)

RRO:	104663734(SH2D1B)

RBB:	108535492(SH2D1B)

TFN:	117075220(SH2D1B)

PTEH:

111525048(SH2D1B)

CANG:

105519592(SH2D1B)

CJC:	100408363(SH2D1B)

SBQ:	101045348(SH2D1B)

CIMI:

108293574(SH2D1B)

ANAN:

105728482(SH2D1B)

CSYR:

103274632(SH2D1B)

MMUR:

105873576(SH2D1B)

LCAT:

123635238(SH2D1B)

PCOQ:

105806431(SH2D1B)

OGA:	100958244(SH2D1B)

MMU:	26904(Sh2d1b1) 545378(Sh2d1b2)

MCAL:

110300975 110304430

MPAH:

110322583 110322657

RNO:	102556681(Sh2d1b2) 501869(Sh2d1b)

MCOC:

116103209(Sh2d1b)

ANU:	117712945 117716605

ASYL:

127697329(Sh2d1b)

MUN:	110550632(Sh2d1b)

CGE:	100768725(Sh2d1b)

MAUA:

101843044(Sh2d1b)

PROB:

127223550(Sh2d1b)

PLEU:

114689899(Sh2d1b)

MORG:

121441971 121455462

MFOT:

126511228

AAMP:

119828089(Sh2d1b)

NGI:	103746784(Sh2d1b)

HGL:	101701557(Sh2d1b)

CCAN:

109690976(Sh2d1b)

DORD:

106001739(Sh2d1b)

DSP:	122109664(Sh2d1b)

DMER:

138812105(Sh2d1b)

PLOP:

125360155(Sh2d1b)

NCAR:

124983178

MMMA:

107147451(Sh2d1b)

ITI:	101960545(Sh2d1b)

OCU:

103350022

OPI:	101524490(SH2D1B)

TUP:	102470340(SH2D1B)

GVR:	103607480(SH2D1B)

CFA:	609474(SH2D1B)

CLUD:

112643053(SH2D1B)

VVP:	112914302(SH2D1B)

VLG:	121471746(SH2D1B)

NPO:	129515155(SH2D1B)

AML:	100480679(SH2D1B)

UMR:	103658244(SH2D1B)

UAH:	113268669(SH2D1B)

UAR:	123800159(SH2D1B)

ELK:

111151140

LLV:

125086276

MPUF:

101687317(SH2D1B)

MNP:	132026217(SH2D1B)

MLK:	131814804(SH2D1B)

NVS:	122918087(SH2D1B)

ORO:	101366789(SH2D1B)

EJU:	114210413(SH2D1B)

ZCA:	113931755(SH2D1B)

MLX:	118013643(SH2D1B)

NSU:	110588186(SH2D1B)

LWW:	102746641(SH2D1B)

FCA:	101083998(SH2D1B)

PYU:	121020890(SH2D1B)

PCOO:

112864835(SH2D1B)

PBG:	122475935(SH2D1B)

PVIV:

125155422(SH2D1B)

LRUF:

124509912

LGF:	123586952(SH2D1B)

AJU:

106986768

PTG:	102960871(SH2D1B)

PPAD:

109276659(SH2D1B)

PUC:

125925961

PLEZ:

122211665(SH2D1B)

HHV:	120241070(SH2D1B)

BTA:	617485(SH2D1B)

BOM:	102264831(SH2D1B)

BIU:	109577968(SH2D1B)

BBUB:

102413772(SH2D1B)

BBIS:

104999173(SH2D1B)

CHX:	102181175(SH2D1B)

OAS:	101108790(SH2D1B)

BTAX:

128045750(SH2D1B)

CSUM:

138096203(SH2D1B)

ODA:	120855526(SH2D1B)

CCAD:

122430042(SH2D1B)

MREE:

136160819(SH2D1B)

OVR:	110125754(SH2D1B)

MBEZ:

129541302(SH2D1B)

SSC:	100620669(SH2D1B)

CFR:	102513279(SH2D1B)

CBAI:

105068033(SH2D1B)

CDK:	105092695(SH2D1B)

VPC:	102545314(SH2D1B)

BACU:

103005134(SH2D1B)

BMUS:

118906222(SH2D1B)

LVE:	103085710(SH2D1B)

OOR:	101285633(SH2D1B)

LALB:

132515875(SH2D1B)

GMF:	115847497(SH2D1B)

DDP:	132423353(SH2D1B)

DLE:	111170405(SH2D1B)

PCAD:

102986358(SH2D1B)

PSIU:

116742424(SH2D1B)

PPHC:

136136158(SH2D1B)

NASI:

112403913(SH2D1B)

ECB:	100058250(SH2D1B)

EPZ:	103561276(SH2D1B)

EAI:	106823692(SH2D1B)

MNA:	107535138(SH2D1B)

DRO:	112297386(SH2D1B)

SHON:

118979282(SH2D1B)

AJM:	119052357(SH2D1B)

PDIC:

114489399(SH2D1B)

PHAS:

123818553(SH2D1B)

MMF:	118637865(SH2D1B)

PPAM:

129081921(SH2D1B)

HAI:	109392297(SH2D1B)

RFQ:	117014379(SH2D1B)

PALE:

102893316(SH2D1B)

PGIG:

120584179(SH2D1B)

PVP:	105303428(SH2D1B)

MJV:	108398476(SH2D1B)

TOD:	119240087(SH2D1B)

SARA:

101557359(SH2D1B)

SFUM:

130045061(SH2D1B)

SETR:

126014303(SH2D1B)

LAV:	100675491(SH2D1B)

TMU:

101354708

ETF:	101664336(SH2D1B)

DNM:	101444441(SH2D1B)

MDO:	100015719(SH2D1B)

GAS:	123247403(SH2D1B)

SHR:	100925702(SH2D1B)

AFZ:

127562990

PCW:	110209894(SH2D1B)

TVP:	118845302(SH2D1B)

PBRV:

138166203(SH2D1B)

TACU:

119937999(SH2D1B)

GGA:	418411(SH2D1B)

PCOC:

116242396(SH2D1B)

CJO:	107321169(SH2D1B)

TPAI:

128091913(SH2D1B)

LMUT:

125702745(SH2D1B)

NMEL:

110400733(SH2D1B)

APLA:

101803185(SH2D1B)

ACYG:

106039199(SH2D1B)

CATA:

118244947(SH2D1B)

AFUL:

116492909(SH2D1B)

TGU:	100229574(SH2D1B)

LSR:	110477025(SH2D1B)

SCAN:

103820729(SH2D1B)

PMOA:

120513389(SH2D1B)

OTC:	121345475(SH2D1B)

PRUF:

121351700(SH2D1B)

ATRC:

139592985(SH2D1B)

GFR:	102045419(SH2D1B)

FAB:	101805712(SH2D1B)

OMA:	130257371(SH2D1B)

PHI:

102105987

PMAJ:

107202079(SH2D1B)

CCAE:

111940432(SH2D1B)

CCW:

104687003

CBRC:

103613990(SH2D1B)

ACOE:

138113757(SH2D1B)

ETL:	114057231(SH2D1B)

ZAB:	102073590(SH2D1B)

ZLE:	135442851(SH2D1B)

ACHL:

103801117(SH2D1B)

SVG:	106862941(SH2D1B)

MMEA:

130578093(SH2D1B)

HRT:

120749371

SATI:

136373660(SH2D1B)

CCIC:

134055652(SH2D1B)

FPG:	101911982(SH2D1B)

FCH:

102053121

CCRI:

104157596(SH2D1B)

NNT:	104410947(SH2D1B)

SHAB:

115601592(SH2D1B)

ACUN:

113484411(SH2D1B)

TALA:

104357735(SH2D1B)

ACHC:

115343817(SH2D1B)

HALD:

104321256(SH2D1B)

HLE:	104831621(SH2D1B)

AGEN:

126048849

HHAR:

128144785(SH2D1B)

GCL:

127029529

CSTI:

104560405(SH2D1B)

LDI:	104349151(SH2D1B)

MNB:	103780399(SH2D1B)

DPUB:

104297102(SH2D1B)

PPUS:

135175641(SH2D1B)

AVIT:

104270541(SH2D1B)

BRHI:

104498126(SH2D1B)

EGZ:	104125034(SH2D1B)

NNI:	104014120(SH2D1B)

PCRI:

104038952(SH2D1B)

PCAO:

104052403

PADL:

103916824(SH2D1B)

AFOR:

103901918(SH2D1B)

FGA:	104081402(SH2D1B)

GSTE:

104254658(SH2D1B)

CBOY:

140647064(SH2D1B)

CLV:	102084395(SH2D1B)

CNIC:

136002849(SH2D1B)

MUI:	104536026(SH2D1B)

PGUU:

104460269

PLET:

104623944(SH2D1B)

EHS:	104505981(SH2D1B)

CMAC:

104485718(SH2D1B)

CUCA:

104055958(SH2D1B)

BREG:

104641783(SH2D1B)

OHA:	104335492(SH2D1B)

ACAR:

104526068(SH2D1B)

CPEA:

104384967(SH2D1B)

CVF:	104289531(SH2D1B)

RTD:	128904091(SH2D1B)

CRID:

134521995(SH2D1B)

AAM:	106490626(SH2D1B)

AROW:

112962318(SH2D1B)

NPD:	112949441(SH2D1B)

TGT:	104576525(SH2D1B)

DNE:	112990496(SH2D1B)

SCAM:

104144217(SH2D1B)

ASN:	102378466(SH2D1B)

AMJ:	102575227(SH2D1B)

CPOO:

109305613(SH2D1B)

GGN:	109303550(SH2D1B)

PSS:	102457346(SH2D1B)

CMY:	102944061(SH2D1B)

CCAY:

125645379(SH2D1B)

DCC:	119846973(SH2D1B)

CPIC:

101952363(SH2D1B)

TST:	117887930(SH2D1B)

CABI:

116816203(SH2D1B)

MRV:	120398025(SH2D1B)

ACS:

100560639

ASAO:

132770040

PVT:	110085860(SH2D1B)

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108707522(sh2d1b.L)

XTR:	100486929(sh2d1b)

NPR:

108794721

RTEM:

120928587(SH2D1B)

ACAT:

141127986(SH2D1B)

BBUF:

BGAR:

DTC:

MUO:

GSH:	117359196(SH2D1B)

DRE:	100000923(si:ch73-264p11.1)

SRX:	107705207 107721835

SANH:

107663674 107671353

SGH:	107576911 107586726 107586778

CCAR:

109077063 109084385(si:ch73-264p11.1)

CAUA:

113042488 113066190

CGIB:

127946589 128013484

PTET:

122329507(si:ch73-264p11.1)

LROH:

127156120(si:ch73-264p11.1)

GRF:

141300795

OMC:	131532898(si:ch73-264p11.1)

PPRM:

120488013(si:ch73-264p11.1)

RKG:	130084178(si:ch73-264p11.1)

MAMB:

125258345(si:ch73-264p11.1)

CIDE:

127506331(si:ch73-264p11.1)

CERY:

137014266(si:ch73-264p11.1)

MASI:

127431487(si:ch73-264p11.1) 127434369

TROS:

130547074(si:ch73-264p11.1)

TDW:	130413567(si:ch73-264p11.1)

MANU:

129425406

PDAB:

135740209

IPU:	100528723(si:ch73-264p11.1)

IFU:	128600023(si:ch73-264p11.1)

PHYP:

113541294

SMEO:

124403865(si:ch73-264p11.1)

TFD:	113646353(si:ch73-264p11.1)

TVC:	132840344(si:ch73-264p11.1)

CGAR:

128513920(si:ch73-264p11.1)

NGRA:

132867844(si:ch73-264p11.1)

TRN:	134301239(si:ch73-264p11.1)

AMEX:

103047291(si:ch73-264p11.1)

CMAO:

118799020(si:ch73-264p11.1)

EEE:

113567865

CHAR:

116224336(si:ch73-264p11.1)

SPIL:

134065939(si:ch73-264p11.1)

TRU:

101071277

TFS:	130513845(si:ch73-264p11.1)

LCO:

104938246

NCC:	104958447(sh2d1b)

TBEN:

117498495(si:ch73-264p11.1)

CGOB:

115004692

PGEO:

117465798

GACU:

117539755(si:ch73-264p11.1)

EMAC:

134884158(si:ch73-264p11.1)

ELY:	117265119(si:ch73-264p11.1)

EFO:	125882253(si:ch73-264p11.1)

SLUC:

116040035(si:ch73-264p11.1)

ECRA:

117937636(si:ch73-264p11.1)

ESP:

116672633

PFLV:

114549227

GAT:	120811482(si:ch73-264p11.1)

PPUG:

119198351(si:ch73-264p11.1)

AFB:	129110903(si:ch73-264p11.1)

CLUM:

117749489(si:ch73-264p11.1)

PSWI:

130206272(si:ch73-264p11.1)

CANA:

137789005(si:ch73-264p11.1)

CVE:	137871667(si:ch73-264p11.1)

MSAM:

119913197(si:ch73-264p11.1) 119916729

SCHU:

122866403(si:ch73-264p11.1)

CUD:	121527480(si:ch73-264p11.1)

SPUL:

138596288

LMIX:

132994199(si:ch73-264p11.1)

ALAT:

119009104(si:ch73-264p11.1)

MZE:

101464785

ONL:

100689879

OAU:	116309926(si:ch73-264p11.1)

OLA:

101167248

OML:	112142279(si:ch73-264p11.1)

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122824468(si:ch73-264p11.1)

PPRL:

129354364 129378982

CVG:

107103374

CTUL:

119796055(si:ch73-264p11.1)

GMU:	124858175(si:ch73-264p11.1)

KMR:	108250619(si:ch73-264p11.1)

ALIM:

106531849

NWH:	119426422(si:ch73-264p11.1)

AOCE:

111570979(si:ch73-264p11.1)

EJA:

BFRE:

MCEP:

CSEM:

POV:

SSEN:

122769479(si:ch73-264p11.1)

SSOE:

131464627(si:ch73-264p11.1)

HHIP:

117753587(si:ch73-264p11.1)

HSP:	118098347(si:ch73-264p11.1)

PPLT:

128425758(si:ch73-264p11.1)

SMAU:

118290926(si:ch73-264p11.1)

LCF:	108885031(si:ch73-264p11.1)

SDU:

111238288

SLAL:

111647297

XGL:	120789552(si:ch73-264p11.1)

BPEC:

110158660

ENY:

140364948

MALB:

109951071

BSPL:

114853533(si:ch73-264p11.1)

SJO:	128382171(si:ch73-264p11.1)

SSCO:

134002492(si:ch73-264p11.1)

GMH:	115537386(sh2d1b)

SASA:

106579497 106590498

STRU:

115151793 115195193

OTW:	112236900(si:ch73-264p11.1)

OMY:	110535388(si:ch73-264p11.1)

OGO:	123990238(si:ch73-264p11.1)

ONE:

115104569

OKI:

109908744

OKE:	118360527(si:ch73-264p11.1)

OMM:	135518520 135523189

OCLA:

139420651

SALP:

111973238 112071123

SNH:	120028113 120050594

CCLU:

121549621 121570472

ELS:

105022002

OEP:	134034998(si:ch73-264p11.1)

SFM:

108939543

PKI:

111838079

AANG:

118234896(si:ch73-264p11.1)

AROT:

135263134(si:ch73-264p11.1)

CCOG:

133132640(si:ch73-264p11.1)

LOC:

102682628

PSPA:

121302577(si:ch73-264p11.1)

ARUT:

117405637 117406990

PSEX:

120523859(si:ch73-264p11.1)

LCM:

102355450

RTP:	109924445(si:ch73-264p11.1)

CPLA:

122550908 122555257(si:ch73-264p11.1)

HOC:	132816864 132821099

LERI:

129703101

HAKA:

140727663

» show all

Reference

PMID:11689425

Authors

Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C

Title

Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.

Journal

EMBO J 20:5840-52 (2001)
DOI:10.1093/emboj/20.21.5840

Sequence

[hsa:117157]

All links

Gene (16)   
   MGENES (11)   
   RefGene (2)   
   OC (3)   
All databases (16)   

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