KEGG ORTHOLOGY: K08009

ORTHOLOGY: K08009

Entry

K08009                      KO

Symbol

CYBA, P22PHOX

Name

cytochrome b-245, alpha polypeptide

Pathway

map04145

Phagosome

map04380

Osteoclast differentiation

map04613

Neutrophil extracellular trap formation

map04621

NOD-like receptor signaling pathway

map04670

Leukocyte transendothelial migration

map05020

Prion disease

map05140

Leishmaniasis

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Disease

H00098

Chronic granulomatous disease

H01167

Granulibacter infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
   04621 NOD-like receptor signaling pathway
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
   04670 Leukocyte transendothelial migration
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
  09164 Neurodegenerative disease
   05020 Prion disease
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
   05418 Fluid shear stress and atherosclerosis
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
   05415 Diabetic cardiomyopathy
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
Membrane trafficking [BR:ko04131]
Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide

Other DBs

TC:

5.B.1.1.1

Genes

HSA:	1535(CYBA)

PTR:	468068(CYBA)

PPS:

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:

MTHB:

MNI:

CSAB:

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100414967(CYBA)

SBQ:

CIMI:

ANAN:

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13057(Cyba)

MCAL:

110300473

MPAH:

110337603

RNO:	79129(Cyba)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:	100008800(CYBA)

OPI:

105941756

TUP:

102471991

GVR:

103585024

CFA:	489664(CYBA)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101091745(CYBA)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PPAD:

PUC:

AJU:

HHV:

BTA:	281111(CYBA)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	397507(CYBA)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100049843(CYBA)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

GGA:	100859840(CYBA)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

136791769(CYBA)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136366423(CYBA)

FPG:

SHAB:

TALA:

ACHC:

HLE:

AGEN:

GCL:

DPUB:

NNI:

CLV:

MUI:

CUCA:

RTD:

AAM:

AROW:

NPD:

TGT:

DNE:

ASN:

AMJ:

CPOO:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

EMC:

XLA:	108704084(cyba.S) 446853(cyba.L)

XTR:	549234(cyba)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	393551(cyba)

SRX:	107715044 107755553

SANH:

107661987 107698019

SGH:	107550118 107571231

CCAR:

109047843 109077080 109092367

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137022640(cyba)

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:	445889(p22phox)

TFS:

130518254

TNG:	GSTEN00017657G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

STRU:

OTW:	112249245 112263759

OMY:	100301566(p22-phox)

OGO:	124033697 124035679

ONE:	115112360 115112380

OKI:	109888400 109895367

OKE:	118372440 118393926

SALP:

111969440 111975110

SNH:	120024964 120056328

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133339012 133349792

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

PTEP:

UDV:

SDM:

LPOL:

HRO:	HELRODRAFT_165935

LGI:	LOTGIDRAFT_86582

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_52448

AQU:

100637130

MBR:	MONBRDRAFT_3080

SRE:	PTSG_04597

DDI:	DDB_G0267460(cybA)

DPP:	DICPUDRAFT_30041

DFA:	DFA_07591(cybA)

» show all

Reference

PMID:17583407

Authors

Miyano K, Sumimoto H

Title

Role of the small GTPase Rac in p22phox-dependent NADPH oxidases.

Journal

Biochimie 89:1133-44 (2007)
DOI:10.1016/j.biochi.2007.05.003

Reference

PMID:3368442

Authors

Parkos CA, Dinauer MC, Walker LE, Allen RA, Jesaitis AJ, Orkin SH

Title

Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.

Journal

Proc Natl Acad Sci U S A 85:3319-23 (1988)
DOI:10.1073/pnas.85.10.3319

Sequence

[hsa:1535]

All links

Ontology (3)   
   KEGG BRITE (2)   
   TC (1)   
Pathway (22)   
   KEGG PATHWAY (22)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (579)   
   KEGG GENES (441)   
   KEGG MGENES (26)   
   RefGene (109)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (608)   

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