KEGG ORTHOLOGY: K08014

ORTHOLOGY: K08014

Entry

K08014                      KO

Symbol

RAPGEF3, EPAC1

Name

Rap guanine nucleotide exchange factor 3

Pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04072

Phospholipase D signaling pathway

map04261

Adrenergic signaling in cardiomyocytes

map04670

Leukocyte transendothelial migration

map04720

Long-term potentiation

map04726

Serotonergic synapse

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04072 Phospholipase D signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04024 cAMP signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  09156 Nervous system
   04726 Serotonergic synapse
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04720 Long-term potentiation
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3

Genes

HSA:	10411(RAPGEF3)

PTR:	467198(RAPGEF3)

PPS:	100979763(RAPGEF3)

GGO:	101153785(RAPGEF3)

PON:	100174087(RAPGEF3)

PPYG:

129009692(RAPGEF3)

NLE:	100592347(RAPGEF3)

HMH:

116461620

SSYN:

129491169(RAPGEF3)

MCC:	703967(RAPGEF3)

MCF:	101865707(RAPGEF3)

MTHB:

126930152

MNI:	105470060(RAPGEF3)

CSAB:

103238211(RAPGEF3)

CATY:

105580438(RAPGEF3)

PANU:

101025773 116268864(RAPGEF3) 116273061

TGE:	112635556(RAPGEF3)

MLEU:

105544948(RAPGEF3)

RRO:	104654834(RAPGEF3)

RBB:	108515949(RAPGEF3)

TFN:	117090223(RAPGEF3)

PTEH:

111555300(RAPGEF3)

CANG:

105507675(RAPGEF3)

CJC:	100399583(RAPGEF3)

SBQ:	101043933(RAPGEF3)

CIMI:

108304876(RAPGEF3)

ANAN:

105721841(RAPGEF3)

CSYR:

103255783(RAPGEF3)

MMUR:

105864995(RAPGEF3)

LCAT:

123640470(RAPGEF3)

PCOQ:

105805565(RAPGEF3)

OGA:	100962179(RAPGEF3)

MMU:	223864(Rapgef3)

MCAL:

110310170(Rapgef3)

MPAH:

110334708(Rapgef3)

RNO:	59326(Rapgef3)

MCOC:

116078746(Rapgef3)

ANU:	117719035(Rapgef3)

MUN:	110546167(Rapgef3)

CGE:	100767619(Rapgef3)

MAUA:

101828520(Rapgef3)

PROB:

127226010(Rapgef3)

PLEU:

114708554(Rapgef3)

MORG:

121441440(Rapgef3)

MFOT:

126493026

AAMP:

119823360(Rapgef3)

NGI:	103740631(Rapgef3)

HGL:	101711127(Rapgef3)

CPOC:

100723672(Rapgef3)

CCAN:

109691611(Rapgef3)

DORD:

105987528(Rapgef3)

DSP:	122106262(Rapgef3)

PLOP:

125365569(Rapgef3)

NCAR:

124982354

MMMA:

107148572(Rapgef3)

OCU:

100356363

OPI:	101523807(RAPGEF3)

TUP:	102502265(RAPGEF3)

GVR:

103595451

CFA:	486591(RAPGEF3)

CLUD:

112678240(RAPGEF3)

VVP:	112921075(RAPGEF3)

VLG:	121479984(RAPGEF3)

NPO:	129505637(RAPGEF3)

AML:	100473947(RAPGEF3)

UMR:	103675595(RAPGEF3)

UAH:	113257686(RAPGEF3)

UAR:	123794811(RAPGEF3)

ELK:

111157928

LLV:

125107069

MPUF:

101682435(RAPGEF3)

MNP:	132019619(RAPGEF3)

MLK:	131838837(RAPGEF3)

NVS:	122891124(RAPGEF3)

ORO:	101371953(RAPGEF3)

EJU:	114224104(RAPGEF3)

ZCA:	113922250(RAPGEF3)

MLX:	118008918(RAPGEF3)

NSU:	110593498(RAPGEF3)

LWW:	102749024(RAPGEF3)

FCA:	101085387(RAPGEF3)

PYU:	121038668(RAPGEF3)

PCOO:

112867519(RAPGEF3)

PBG:	122473326(RAPGEF3)

PVIV:

125169634(RAPGEF3)

LRUF:

124502372

PTG:	102966186(RAPGEF3)

PPAD:

109249020(RAPGEF3)

PUC:

125919002

AJU:

106969310

HHV:	120239023(RAPGEF3)

BTA:	535383(RAPGEF3)

BOM:	102282215(RAPGEF3)

BIU:	109559177(RAPGEF3)

BBUB:

102407658(RAPGEF3)

BBIS:

104986831(RAPGEF3)

CHX:	102178145(RAPGEF3)

OAS:	101109786(RAPGEF3)

BTAX:

128049033(RAPGEF3)

ODA:	120858453 120861325

CCAD:

122427721(RAPGEF3)

MBEZ:

129536287(RAPGEF3)

SSC:	100620989(RAPGEF3)

CFR:	102524040(RAPGEF3)

CBAI:

105076166(RAPGEF3)

CDK:	105103807(RAPGEF3)

VPC:	102527378(RAPGEF3)

BACU:

103005728(RAPGEF3)

BMUS:

118902169(RAPGEF3)

LVE:	103080613(RAPGEF3)

OOR:	101278657(RAPGEF3)

DLE:	111174075(RAPGEF3)

PCAD:

102987186

PSIU:

116761070(RAPGEF3)

NASI:

112394063(RAPGEF3)

ECB:	100050541(RAPGEF3)

EPZ:	103546793(RAPGEF3)

EAI:	106836844(RAPGEF3)

MYB:	102257237(RAPGEF3)

MYD:	102768579(RAPGEF3)

MMYO:

118651234(RAPGEF3)

MLF:	102423490(RAPGEF3)

MDT:	132227498(RAPGEF3)

PKL:	118729444(RAPGEF3)

EFUS:

103285230(RAPGEF3)

MNA:	107528219(RAPGEF3)

DRO:	112318292(RAPGEF3)

SHON:

118997444(RAPGEF3)

AJM:	119041969(RAPGEF3)

PDIC:

114513019(RAPGEF3)

PHAS:

123812417(RAPGEF3)

MMF:	118623856(RAPGEF3)

PPAM:

129084894(RAPGEF3)

HAI:

109372517

RFQ:	117028527(RAPGEF3)

PALE:

102895678(RAPGEF3)

PVP:	105297498(RAPGEF3)

RAY:	107499884(RAPGEF3)

MJV:	108392459(RAPGEF3)

TOD:	119247598(RAPGEF3)

SARA:

101540127(RAPGEF3)

SETR:

126022758(RAPGEF3)

LAV:	100655802(RAPGEF3)

TMU:

101344659

ETF:	101663954(RAPGEF3)

DNM:	101417819(RAPGEF3)

GAS:	123249342(RAPGEF3)

SHR:	100925807(RAPGEF3)

AFZ:

127537825

PCW:	110201486(RAPGEF3)

TVP:	118850582(RAPGEF3)

OAA:	100680839(RAPGEF3)

GGA:	426888(RAPGEF3)

PCOC:

116239648(RAPGEF3)

MGP:	100539538(RAPGEF3)

CJO:	107325717(RAPGEF3)

TPAI:

128091845(RAPGEF3)

LMUT:

125685547(RAPGEF3)

NMEL:

110389221(RAPGEF3)

APLA:

101791788(RAPGEF3)

ACYG:

106047705(RAPGEF3)

CATA:

118260218(RAPGEF3)

AFUL:

116499913(RAPGEF3)

TGU:	115491504(RAPGEF3)

LSR:	110481646(RAPGEF3)

SCAN:

115483875

PMOA:

120500674(RAPGEF3)

OTC:	121333700(RAPGEF3)

PRUF:

121353961(RAPGEF3)

GFR:	102039560(RAPGEF3)

FAB:	101814980(RAPGEF3)

OMA:	130265849(RAPGEF3)

PHI:	102110109(RAPGEF3)

PMAJ:

107198895

CBRC:

103613210

ZLE:	135459209(RAPGEF3)

HRT:	120764425(RAPGEF3)

FPG:	101924930(RAPGEF3)

FCH:	102048878(RAPGEF3)

SHAB:

115618683(RAPGEF3)

ACUN:

113491036(RAPGEF3)

TALA:

116964163(RAPGEF3)

ACHC:

115351213(RAPGEF3)

HLE:	104831163(RAPGEF3)

AGEN:

126046519

GCL:

127028385

EGZ:	104132693(RAPGEF3)

NNI:	104011982(RAPGEF3)

PADL:

103914893(RAPGEF3)

AFOR:

103894937(RAPGEF3)

CLV:	102094087(RAPGEF3)

MUI:	104535844(RAPGEF3)

CUCA:

104055138(RAPGEF3)

OHA:

104336076

CVF:	104284838(RAPGEF3)

RTD:	128901349(RAPGEF3)

AAM:	106485098(RAPGEF3)

AROW:

112975385(RAPGEF3)

NPD:	112950330(RAPGEF3)

TGT:	104574250(RAPGEF3)

DNE:	112991008(RAPGEF3)

SCAM:

104144388(RAPGEF3)

ASN:	102381678(RAPGEF3)

AMJ:	102574517(RAPGEF3)

CPOO:

109324408(RAPGEF3)

GGN:	109293213(RAPGEF3)

PSS:	102443863(RAPGEF3)

CMY:	102939607(RAPGEF3)

CCAY:

125629135(RAPGEF3)

DCC:	119845965(RAPGEF3)

CPIC:

101931835(RAPGEF3)

TST:	117889092(RAPGEF3)

CABI:

116826941(RAPGEF3)

MRV:	120391129(RAPGEF3)

ACS:	100560594(rapgef3)

ASAO:

132768165(RAPGEF3)

PVT:	110071318(RAPGEF3)

SUND:

121920804(RAPGEF3)

PBI:	103063904(RAPGEF3)

PMUR:

107288970(RAPGEF3)

CTIG:

120312211(RAPGEF3)

TSR:

106556124

PGUT:

117666559(RAPGEF3)

APRI:

131191262(RAPGEF3)

PTEX:

113444818(RAPGEF3)

NSS:	113416153(RAPGEF3)

VKO:	123024026(RAPGEF3)

PMUA:

114592897(RAPGEF3)

PRAF:

128404243(RAPGEF3)

ZVI:	118077695(RAPGEF3)

HCG:	128346368(RAPGEF3)

GJA:	107109551(RAPGEF3)

STOW:

125429966(RAPGEF3)

EMC:	129346376(RAPGEF3)

XLA:	108708626(rapgef3.L) 108709885

XTR:	100491495(rapgef3)

NPR:	108800976(RAPGEF3)

RTEM:

120929384(RAPGEF3)

BGAR:

122930866(RAPGEF3)

MUO:	115466785(RAPGEF3)

GSH:	117357024(RAPGEF3)

DRE:	101886094(rapgef3)

SRX:	107723737 107756413

SANH:

107671875 107697977

SGH:	107594040 107598495

CCAR:

109047993 109048004

CAUA:

113041515 113065575

CGIB:

127945124 128011334

PTET:

122328968(rapgef3) 122333675

LROH:

127154573(rapgef3)

OMC:	131532333(rapgef3)

PPRM:

120462943(rapgef3) 120463796

RKG:	130090498(rapgef3)

MAMB:

125259848(rapgef3)

CIDE:

127504743

CERY:

137009190(rapgef3)

MASI:

127418663 127419898

TROS:

130571899(rapgef3)

TDW:	130409242(rapgef3)

MANU:

129430871(rapgef3)

IPU:	108275659(rapgef3)

IFU:	128618979(rapgef3)

PHYP:

113530617

SMEO:

124398619(rapgef3)

TFD:	113641742(rapgef3)

TVC:	132862155(rapgef3)

TRN:	134333116(rapgef3)

AMEX:

103025506(rapgef3)

CMAO:

118822570(rapgef3)

EEE:	113576412(rapgef3)

CHAR:

105906747(rapgef3)

TRU:

101068679

TFS:	130529794(rapgef3)

TNG:	GSTEN00023559G001

LCO:

104919939

TBEN:

117484371(rapgef3)

CGOB:

115004794

PGEO:

117449045(rapgef3)

GACU:

117542226(rapgef3)

EMAC:

134866624(rapgef3)

ELY:	117257965(rapgef3)

EFO:	125891149(rapgef3)

PLEP:

121946557(rapgef3)

SLUC:

116043746(rapgef3)

ECRA:

117946996(rapgef3)

ESP:

116692193

PFLV:

114558191

GAT:	120828846(rapgef3)

PPUG:

119221891(rapgef3)

AFB:	129100281(rapgef3)

CLUM:

117733002(rapgef3)

PSWI:

130198926(rapgef3)

MSAM:

119905182(rapgef3)

SCHU:

122883673(rapgef3)

CUD:	121517284(rapgef3)

ALAT:

119022621(rapgef3)

MZE:

101480994

ONL:

100711715

OAU:	116322009(rapgef3)

OLA:

101158525

OML:	112158872(rapgef3)

CSAI:

133456771(rapgef3)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122829278(rapgef3)

PPRL:

129376979(rapgef3)

CVG:

107091899

CTUL:

119799402(rapgef3)

GMU:	124866665(rapgef3)

NFU:

107390402

KMR:	108237632(rapgef3)

ALIM:

106522985

NWH:	119416619(rapgef3)

AOCE:

111581117

MCEP:

125005434(rapgef3)

CSEM:

103385263

POV:

109643141

SSEN:

122777200(rapgef3)

HHIP:

117764433(rapgef3)

HSP:	118111533(rapgef3)

PPLT:

128442196(rapgef3)

SMAU:

118316234(rapgef3)

LCF:	108886373(rapgef3)

SDU:

111235101

SLAL:

111661896

XGL:	120803283(rapgef3)

HCQ:	109513787(rapgef3)

SSCV:

125989075

SBIA:

133511041(rapgef3)

PEE:	133407501(rapgef3)

PTAO:

133485671(rapgef3)

BPEC:

110164588

MALB:

109970308

BSPL:

114858485(rapgef3)

SJO:	128357085(rapgef3)

SASA:

106567164 106572513

STRU:

115165650 115167990

OTW:	112216258 112221521

OMY:	110492097(rapgef3) 110532567

OGO:	124032166 124045982(rapgef3)

ONE:	115102440 115132407

OKI:	109869277 109908218

OKE:	118360324 118360768

SALP:

111966719 111977003

SNH:	120059261 120061105

CCLU:

121537424 121545735

ELS:

105022286

SFM:

108939388

PKI:	111840326(rapgef3)

AANG:

118208262(rapgef3)

LOC:	102696564(rapgef3)

PSPA:

121308884(rapgef3)

ARUT:

117401125 117967082

PSEX:

120524956(rapgef3)

» show all

Reference

PMID:20055708

Authors

Gloerich M, Bos JL

Title

Epac: defining a new mechanism for cAMP action.

Journal

Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714

Reference

PMID:9856955

Authors

Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM

Title

A family of cAMP-binding proteins that directly activate Rap1.

Journal

Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275

Sequence

[hsa:10411]

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (14)   
   KEGG PATHWAY (14)   
Gene (687)   
   KEGG GENES (384)   
   KEGG MGENES (194)   
   RefGene (108)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (704)   

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