KEGG   ORTHOLOGY: K08018
Entry
K08018                      KO                                     
Symbol
RAPGEF2, PDZGEF1
Name
Rap guanine nucleotide exchange factor 2
Pathway
map04010  MAPK signaling pathway
map04015  Rap1 signaling pathway
map04530  Tight junction
Disease
H02213  Familial adult myoclonic epilepsy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
   04015 Rap1 signaling pathway
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
Genes
HSA: 9693(RAPGEF2)
PTR: 461577(RAPGEF2)
PPS: 100972977(RAPGEF2)
GGO: 101154294(RAPGEF2)
PON: 100444094(RAPGEF2)
NLE: 100594311(RAPGEF2)
MCC: 704717(RAPGEF2)
MCF: 102145680(RAPGEF2)
CSAB: 103236456(RAPGEF2)
CATY: 105597871(RAPGEF2)
PANU: 101004196(RAPGEF2)
TGE: 112624756(RAPGEF2)
RRO: 104677918(RAPGEF2)
RBB: 108520366
PTEH: 111553506(RAPGEF2)
CJC: 100388886(RAPGEF2)
SBQ: 101033151(RAPGEF2)
CSYR: 103250500(RAPGEF2)
MMUR: 105854966(RAPGEF2)
OGA: 100941053(RAPGEF2)
MMU: 76089(Rapgef2)
MCAL: 110290848(Rapgef2)
RNO: 310533(Rapgef2)
MCOC: 116093009(Rapgef2)
CGE: 100754995(Rapgef2)
PLEU: 114700477(Rapgef2)
NGI: 103751016(Rapgef2)
HGL: 101718791(Rapgef2)
CCAN: 109689106
DORD: 105995908(Rapgef2)
DSP: 122097797(Rapgef2)
OCU: 100346752(RAPGEF2)
OPI: 101532068(RAPGEF2)
TUP: 102476593(RAPGEF2)
CFA: 100856359(RAPGEF2)
VVP: 112926924(RAPGEF2)
VLG: 121481097(RAPGEF2)
AML: 100484273(RAPGEF2)
UMR: 103658068(RAPGEF2)
UAH: 113255808(RAPGEF2)
UAR: 123793179(RAPGEF2)
ELK: 111155074
LLV: 125093089
MPUF: 101684904(RAPGEF2)
ORO: 101373494(RAPGEF2)
EJU: 114210141(RAPGEF2)
ZCA: 113924290(RAPGEF2)
MLX: 118022195(RAPGEF2)
FCA: 101084954(RAPGEF2)
PYU: 121027743(RAPGEF2)
PBG: 122474939(RAPGEF2)
PTG: 102950679(RAPGEF2)
PPAD: 109262464(RAPGEF2)
AJU: 106967455(RAPGEF2)
HHV: 120220354(RAPGEF2)
BTA: 100139484(RAPGEF2)
BOM: 102275520(RAPGEF2)
BIU: 109571167(RAPGEF2)
BBUB: 102405471(RAPGEF2)
CHX: 102187973(RAPGEF2)
OAS: 101111578(RAPGEF2)
ODA: 120870997(RAPGEF2)
CCAD: 122453356(RAPGEF2)
SSC: 100517409(RAPGEF2)
CFR: 102510135(RAPGEF2)
CBAI: 105069401(RAPGEF2)
CDK: 105094767(RAPGEF2)
VPC: 102546108(RAPGEF2)
BACU: 103005459
LVE: 103076487(RAPGEF2)
OOR: 101274731(RAPGEF2)
DLE: 111179022(RAPGEF2)
PCAD: 102982227(RAPGEF2)
PSIU: 116753860(RAPGEF2)
ECB: 100069003(RAPGEF2)
EPZ: 103545519(RAPGEF2)
EAI: 106823789(RAPGEF2)
MYB: 102244394(RAPGEF2)
MYD: 102762387(RAPGEF2)
MMYO: 118658949(RAPGEF2)
MLF: 102436397(RAPGEF2)
MNA: 107527478(RAPGEF2)
PKL: 118711384(RAPGEF2)
HAI: 109395998(RAPGEF2)
DRO: 112312369(RAPGEF2)
SHON: 118995360(RAPGEF2)
AJM: 119034621(RAPGEF2)
PDIC: 114503947(RAPGEF2)
PHAS: 123813684(RAPGEF2)
MMF: 118615237(RAPGEF2)
RFQ: 117037655(RAPGEF2)
PALE: 102879764(RAPGEF2)
PGIG: 120613457(RAPGEF2)
PVP: 105294479(RAPGEF2)
RAY: 107511410(RAPGEF2)
MJV: 108392300(RAPGEF2)
TOD: 119234576(RAPGEF2)
SARA: 101538440(RAPGEF2)
LAV: 100670174(RAPGEF2)
TMU: 101340649
DNM: 101415624(RAPGEF2)
MDO: 100023159(RAPGEF2)
GAS: 123252097(RAPGEF2)
SHR: 100923893(RAPGEF2)
PCW: 110196451(RAPGEF2)
OAA: 100079239(RAPGEF2)
GGA: 422418(RAPGEF2)
PCOC: 116243180(RAPGEF2)
MGP: 100549357(RAPGEF2)
CJO: 107313022(RAPGEF2)
NMEL: 110398765(RAPGEF2)
APLA: 101802476(RAPGEF2)
ACYG: 106032300
AFUL: 116488451(RAPGEF2)
TGU: 100224541(RAPGEF2)
LSR: 110473752(RAPGEF2)
SCAN: 103825944(RAPGEF2)
PMOA: 120497914(RAPGEF2)
OTC: 121348413(RAPGEF2)
PRUF: 121360217(RAPGEF2)
GFR: 102042003(RAPGEF2)
FAB: 101805788(RAPGEF2)
PHI: 102109398(RAPGEF2)
PMAJ: 107203090(RAPGEF2)
CCAE: 111927874(RAPGEF2)
CCW: 104697194(RAPGEF2)
ETL: 114057051(RAPGEF2)
ZAB: 102072245(RAPGEF2)
FPG: 101920342(RAPGEF2)
FCH: 102060194(RAPGEF2)
CLV: 102086538(RAPGEF2)
EGZ: 104124157(RAPGEF2)
NNI: 104021249(RAPGEF2)
ACUN: 113479525(RAPGEF2)
TALA: 104360745(RAPGEF2)
PADL: 103917939(RAPGEF2)
ACHC: 115340706(RAPGEF2)
AAM: 106491974
AROW: 112963819(RAPGEF2)
NPD: 112949231(RAPGEF2)
DNE: 112995323(RAPGEF2)
ASN: 102382228(RAPGEF2)
AMJ: 102563879(RAPGEF2)
CPOO: 109309712(RAPGEF2)
GGN: 109300859(RAPGEF2)
PSS: 102457114(RAPGEF2)
CMY: 102941224(RAPGEF2)
CPIC: 101940840(RAPGEF2)
TST: 117878482(RAPGEF2)
CABI: 116838340(RAPGEF2)
MRV: 120405555(RAPGEF2)
ACS: 100561833(rapgef2)
PVT: 110072791(RAPGEF2)
SUND: 121931376(RAPGEF2)
PBI: 103066867
PMUR: 107286040(RAPGEF2)
TSR: 106550917(RAPGEF2)
PGUT: 117674702(RAPGEF2)
VKO: 123023712(RAPGEF2)
PMUA: 114603804(RAPGEF2)
ZVI: 118083321(RAPGEF2)
GJA: 107109403
XLA: 108706643 447229(rapgef2.L)
XTR: 100145659(rapgef2)
NPR: 108791705(RAPGEF2)
RTEM: 120920381(RAPGEF2)
BBUF: 120990082(RAPGEF2)
BGAR: 122942349(RAPGEF2)
DRE: 557693(rapgef2) 793952(si:dkey-253i9.4)
PPRM: 120460755(rapgef2) 120493821(si:dkey-253i9.4)
IPU: 108260802(rapgef2a) 108263426 108269045(rapgef2b)
PHYP: 113542715(rapgef2) 113544331
SMEO: 124381348(rapgef2a) 124385808(rapgef2b)
TFD: 113647706(rapgef2b) 113660687(rapgef2a)
AMEX: 103034322(rapgef2) 103036243
EEE: 113570740(rapgef2) 113586113
TRU: 101068626(rapgef2)
LCO: 104932582(rapgef2)
NCC: 104941952(rapgef2)
CGOB: 115015125(rapgef2)
ELY: 117260729(rapgef2)
PLEP: 121948211(rapgef2b)
SLUC: 116062486(rapgef2)
ECRA: 117951280(rapgef2)
PFLV: 114562530(rapgef2)
GAT: 120817001(rapgef2b)
PPUG: 119210090(rapgef2)
MSAM: 119888255(rapgef2)
CUD: 121515938(rapgef2b)
MZE: 101469290(rapgef2)
ONL: 100709689(rapgef2)
OAU: 116335306(rapgef2)
OLA: 101158677(rapgef2)
OML: 112139725(rapgef2)
XMA: 102216833(rapgef2)
XCO: 114139721(rapgef2)
XHE: 116714923(rapgef2)
PRET: 103471849(rapgef2)
PFOR: 103137325(rapgef2)
PLAI: 106937380
PMEI: 106932496
GAF: 122836816(rapgef2b)
CVG: 107095759
CTUL: 119793629(rapgef2)
GMU: 124860141(rapgef2b)
NFU: 107380014(rapgef2)
KMR: 108236655(rapgef2)
ALIM: 106513263(rapgef2)
NWH: 119408352(rapgef2b)
AOCE: 111574983(rapgef2)
CSEM: 103390684(rapgef2)
POV: 109640036(rapgef2)
SSEN: 122778263(rapgef2b)
HHIP: 117769843(rapgef2)
LCF: 108885198(rapgef2)
SDU: 111232429(rapgef2)
SLAL: 111655148(rapgef2)
XGL: 120785147(rapgef2b)
HCQ: 109526251(rapgef2)
BPEC: 110153676(rapgef2)
MALB: 109973331(rapgef2)
SASA: 106604533(rapgef2) 106611555
ONE: 115129556(rapgef2) 115130821
ELS: 105027765(rapgef2)
SFM: 108924469(rapgef2) 108930833
PKI: 111833211 111837306(rapgef2)
AANG: 118228077 118231908(rapgef2)
LOC: 102687483(rapgef2)
PSPA: 121322860(rapgef2b) 121326444
LCM: 102349377(RAPGEF2)
CMK: 103182258(rapgef2b)
RTP: 109927844(rapgef2)
BFO: 118411352
BBEL: 109466768
SCLV: 120347508
SPU: 591190
APLC: 110987331
DME: Dmel_CG9491(PDZ-GEF)
DER: 6542976
DSE: 6613608
DSI: Dsimw501_GD23402(Dsim_GD23402)
DAN: 6497338
DSR: 110185630
DPE: 6593934
DMN: 108161852
DWI: 6642759
DGR: 6561668
DAZ: 108610898
DNV: 115563719
DHE: 111602206
DVI: 6628617
CCAT: 101460390
BOD: 106625199
MDE: 101891421
SCAC: 106093634
LCQ: 111687387
ACOZ: 120956643
AARA: 120900834
AAG: 5566803
CPII: 120418602
CNS: 116339352
AME: 408810
ACER: 107995623
ALAB: 122719920
BIM: 100745022
BBIF: 117208452
BVAN: 117164860
BTER: 100648358
BPYO: 122567103
OBB: 114872640
MGEN: 117218896
NMEA: 116432792
CGIG: 122395020
SOC: 105203629
MPHA: 105831101
AEC: 105143272
ACEP: 105623391
PBAR: 105426200
VEM: 105569329
HST: 105185384
DQU: 106746305
CFO: 105248938
FEX: 115243675
LHU: 105678707
PGC: 109856330
OBO: 105276339
PCF: 106785252
PFUC: 122526461
VPS: 122631810
NVI: 100119820
CSOL: 105363782
TPRE: 106656063
MDL: 103578822
FAS: 105270463
DAM: 107040237
AGIF: 122854553
CCIN: 107265226
TCA: 655931
DPA: 109534373
SOY: 115879850
CSET: 123322864
AGB: 108908271
LDC: 111512176
NVL: 108564103
APLN: 108744268
PPYR: 116180119
OTU: 111415419
BMOR: 101747113
BMAN: 114240391
MSEX: 115443389
BANY: 112044305
PMAC: 106721665
PPOT: 106101097
PXU: 106120182
PRAP: 110997433
ZCE: 119828630
HAW: 110373392
TNL: 113504713
SLIU: 111350252
OFU: 114352253
PXY: 105382413
API: 100162402
DNX: 107163614
AGS: 114123378
RMD: 113550608
BTAB: 109034095
CLEC: 106668129
HHAL: 106679069
NLU: 111054557
FOC: 113213159
ZNE: 110841549
CSEC: 111866119
FCD: 110845730
DMK: 116932695
PJA: 122260311
PCHN: 125038191
HAME: 121875198
PTRU: 123499249
HAZT: 108680204
DSV: 119437141
RSAN: 119379545
RMP: 119161094
VDE: 111243353
VJA: 111262007
TUT: 107371050
DPTE: 113793219
DFR: 124492113
CEL: CELE_T14G10.2(pxf-1)
CBR: CBG_03403(Cbr-pxf-1)
BMY: BM_BM5795(Bma-pxf-1)
PCAN: 112563321
BGT: 106054959
GAE: 121378901
HRF: 124152032
HRJ: 124286450
CRG: 105329799
MYI: 110447077
PMAX: 117339109
MMER: 123563404
OBI: 106881120
EGL: EGR_03501
EPA: 110254157
ATEN: 116300410
AMIL: 114954505
PDAM: 113666422
SPIS: 111328912
DGT: 114530055
 » show all
Reference
  Authors
Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ
  Title
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
  Journal
Biochim Biophys Acta 1593:141-9 (2003)
DOI:10.1016/S0167-4889(02)00365-8
Reference
  Authors
de Rooij J, Boenink NM, van Triest M, Cool RH, Wittinghofer A, Bos JL
  Title
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.
  Journal
J Biol Chem 274:38125-30 (1999)
DOI:10.1074/jbc.274.53.38125
  Sequence
[hsa:9693]

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