KEGG   ORTHOLOGY: K08061
Entry
K08061                      KO                                     

Name
RFX5
Definition
regulatory factor X 5
Pathway
ko04612  Antigen processing and presentation
ko05152  Tuberculosis
ko05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
H00985  Bare lymphocyte syndrome type2
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K08061  RFX5; regulatory factor X 5
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K08061  RFX5; regulatory factor X 5
  09163 Immune disease
   05340 Primary immunodeficiency
    K08061  RFX5; regulatory factor X 5
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08061  RFX5; regulatory factor X 5
Transcription factors [BR:ko03000]
 Eukaryotic type
  Other basic domains
   RF-X
    K08061  RFX5; regulatory factor X 5
Genes
HSA: 5993(RFX5)
PTR: 457292(RFX5)
PPS: 100992078(RFX5)
GGO: 101125622(RFX5)
PON: 100171696(RFX5)
NLE: 100591494(RFX5)
MCC: 710369(RFX5)
MCF: 101866363(RFX5)
CSAB: 103224037(RFX5)
RRO: 104681042(RFX5)
RBB: 108533234(RFX5)
CJC: 100386724(RFX5)
SBQ: 101038197(RFX5)
MMU: 53970(Rfx5)
MCAL: 110291777(Rfx5)
MPAH: 110320214(Rfx5)
RNO: 310659(Rfx5)
MUN: 110555091(Rfx5)
CGE: 100770896(Rfx5)
NGI: 103730067(Rfx5)
HGL: 101698005(Rfx5)
CCAN: 109681226(Rfx5)
OCU: 100328902(RFX5)
TUP: 102490053(RFX5)
CFA: 483197(RFX5)
VVP: 112907705(RFX5)
AML: 100477566(RFX5)
UMR: 103667516(RFX5)
UAH: 113246224(RFX5)
ORO: 101381083(RFX5)
ELK: 111162046
FCA: 101099317(RFX5)
PTG: 102955141(RFX5)
PPAD: 109257004(RFX5)
AJU: 106979587(RFX5)
BTA: 539884(RFX5)
BOM: 102272455(RFX5)
BIU: 109555052(RFX5)
BBUB: 102393259(RFX5)
CHX: 102171562(RFX5)
OAS: 101115494(RFX5)
SSC: 100517711(RFX5)
CFR: 102518041(RFX5)
CDK: 105103216(RFX5)
BACU: 103019018(RFX5)
LVE: 103083879(RFX5)
OOR: 101278537(RFX5)
DLE: 111169773(RFX5)
PCAD: 102990464(RFX5)
ECB: 100055472(RFX5)
EPZ: 103547660(RFX5)
EAI: 106846509(RFX5)
MYB: 102263683(RFX5)
MYD: 102757377(RFX5)
MNA: 107539146(RFX5)
HAI: 109372299(RFX5)
DRO: 112313958(RFX5)
PALE: 102890997(RFX5)
RAY: 107499051(RFX5)
MJV: 108406308(RFX5)
LAV: 100674427(RFX5)
TMU: 101343924
MDO: 100018161(RFX5)
SHR: 100931506(RFX5)
PCW: 110220851(RFX5)
OAA: 114808063(RFX5)
GGA: 100857912(RFX5)
MGP: 100543120(RFX5)
CJO: 107324582(RFX5)
NMEL: 110387892(RFX5)
APLA: 101799074(RFX5)
SCAN: 103824741(RFX5)
PHI: 102109455(RFX5)
ETL: 114072181
FPG: 101921769(RFX5)
CLV: 102098560(RFX5)
EGZ: 104130569(RFX5)
NNI: 104014453(RFX5)
AAM: 106484832(RFX5)
ASN: 102368905(RFX5)
AMJ: 102560794(RFX5)
PSS: 102451312(RFX5)
CMY: 102932684(RFX5)
CPIC: 101939826(RFX5)
ACS: 100556550(rfx5)
PVT: 110081521(RFX5)
PBI: 103057032(RFX5)
PMUR: 107292904(RFX5)
TSR: 106540616(RFX5)
PMUA: 114586455(RFX5)
GJA: 107120553(RFX5)
XLA: 108700439 414633(rfx5.S)
XTR: 395025(rfx5)
NPR: 108797690(RFX5)
DRE: 101884332(rfx5)
CCAR: 109052792(rfx5) 109052795
IPU: 108257285(rfx5)
PHYP: 113546239(rfx5)
AMEX: 103044951(rfx5)
EEE: 113582902(rfx5)
TRU: 101069988(rfx5)
LCO: 104934320
ONL: 102082745(rfx5)
OLA: 101161817(rfx5)
XMA: 102236852(rfx5)
XCO: 114156547(rfx5)
PRET: 103472543(rfx5)
CVG: 107084978(rfx5)
NFU: 107394459(rfx5)
KMR: 108243906(rfx5)
ALIM: 106529687(rfx5)
AOCE: 111563416(rfx5)
CSEM: 103393855(rfx5)
POV: 109647869
LCF: 108892777(rfx5)
SDU: 111223148
SLAL: 111647350(rfx5)
HCQ: 109528002(rfx5)
BPEC: 110156508(rfx5)
MALB: 109972585(rfx5)
ELS: 105012699(rfx5)
SFM: 108938857(rfx5)
PKI: 111854281(rfx5)
LCM: 102353739(RFX5)
 » show all
Reference
  Authors
Villard J, Peretti M, Masternak K, Barras E, Caretti G, Mantovani R, Reith W
  Title
A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.
  Journal
Mol Cell Biol 20:3364-76 (2000)
DOI:10.1128/mcb.20.10.3364-3376.2000
  Sequence
[mmu:53970]

KEGG   ORTHOLOGY: K08062
Entry
K08062                      KO                                     

Name
RFXANK
Definition
regulatory factor X-associated ankyrin-containing protein
Pathway
ko04612  Antigen processing and presentation
ko05152  Tuberculosis
ko05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
H00985  Bare lymphocyte syndrome type2
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K08062  RFXANK; regulatory factor X-associated ankyrin-containing protein
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K08062  RFXANK; regulatory factor X-associated ankyrin-containing protein
  09163 Immune disease
   05340 Primary immunodeficiency
    K08062  RFXANK; regulatory factor X-associated ankyrin-containing protein
Genes
HSA: 8625(RFXANK)
PTR: 455872(RFXANK)
PPS: 100992419(RFXANK)
GGO: 101147831(RFXANK)
PON: 100452179(RFXANK)
NLE: 100607068(RFXANK)
MCC: 719706(RFXANK)
MCF: 102139597(RFXANK)
CSAB: 103234207(RFXANK)
RRO: 104680647(RFXANK)
RBB: 108515646(RFXANK)
CJC: 100387462(RFXANK)
SBQ: 101044361(RFXANK)
MMU: 19727(Rfxank)
MCAL: 110300447(Rfxank)
MPAH: 110336546(Rfxank)
RNO: 306353(Rfxank)
MUN: 110549170(Rfxank)
CGE: 100768124(Rfxank)
NGI: 103726843(Rfxank)
HGL: 101712628(Rfxank)
CCAN: 109699147(Rfxank)
OCU: 103346995(RFXANK)
TUP: 102498441(RFXANK)
CFA: 476662(RFXANK)
VVP: 112912912(RFXANK)
AML: 100481805(RFXANK)
UMR: 103674922(RFXANK)
UAH: 113256743(RFXANK)
ORO: 101384521(RFXANK)
ELK: 111144209
FCA: 101098525(RFXANK)
PTG: 102963393(RFXANK)
PPAD: 109247657(RFXANK)
AJU: 106969067(RFXANK)
BTA: 100125917(RFXANK)
BOM: 102287152(RFXANK)
BIU: 109561381(RFXANK)
BBUB: 102393919(RFXANK)
CHX: 102189385(RFXANK)
OAS: 101105568(RFXANK)
SSC: 100628226(RFXANK)
CFR: 102505204(RFXANK)
CDK: 105103715(RFXANK)
BACU: 102998324(RFXANK)
LVE: 103071769(RFXANK)
OOR: 101269571(RFXANK)
DLE: 111166539(RFXANK)
PCAD: 102981790(RFXANK)
ECB: 100069652(RFXANK)
EPZ: 103563800(RFXANK)
EAI: 106825456(RFXANK)
MYB: 102251243(RFXANK)
MYD: 102764236(RFXANK)
MNA: 107535352(RFXANK)
HAI: 109382506(RFXANK)
DRO: 112305217(RFXANK)
PALE: 102888781(RFXANK)
RAY: 107503727(RFXANK)
MJV: 108385012(RFXANK)
LAV: 100676802(RFXANK)
TMU: 101357405
MDO: 100011447(RFXANK)
SHR: 100916785(RFXANK)
PCW: 110196129(RFXANK)
OAA: 100082668(RFXANK)
GGA: 426623(RFXANK)
MGP: 100544210(RFXANK)
CJO: 107325613(RFXANK)
NMEL: 110388900(RFXANK)
APLA: 101803643(RFXANK)
ACYG: 106047961(RFXANK)
TGU: 101234131(RFXANK)
LSR: 110478338(RFXANK)
GFR: 102044271(RFXANK)
FAB: 101806980(RFXANK)
PHI: 102099541(RFXANK)
PMAJ: 107198801(RFXANK)
CCAE: 111940374(RFXANK)
ETL: 114071831(RFXANK)
FPG: 101917433(RFXANK)
FCH: 102057659(RFXANK)
CLV: 102094480(RFXANK)
EGZ: 104129791(RFXANK)
NNI: 104013680(RFXANK)
ACUN: 113489352(RFXANK)
PADL: 103923280(RFXANK)
AAM: 106482273(RFXANK)
ASN: 102373493(RFXANK)
AMJ: 102574996(RFXANK)
PSS: 102460705(RFXANK)
CMY: 102936777(RFXANK)
CPIC: 101931598(RFXANK)
PVT: 110072547(RFXANK)
PBI: 103056565(RFXANK)
PMUR: 107282891(RFXANK)
TSR: 106553649(RFXANK)
PMUA: 114588384(RFXANK)
GJA: 107124869(RFXANK)
XLA: 734461(rfxank.S)
XTR: 100490142(rfxank)
NPR: 108796867(RFXANK)
DRE: 100170804(rfxank)
SANH: 107655236(rfxank) 107687741
IPU: 108271273(rfxank)
PHYP: 113525944(rfxank)
AMEX: 103042807(rfxank)
EEE: 113576196(rfxank)
TRU: 101069318(rfxank)
LCO: 104918765(rfxank)
NCC: 104950596(rfxank)
MZE: 101484601(rfxank)
ONL: 100695630(rfxank)
OLA: 101167861(rfxank)
XMA: 102228421(rfxank)
XCO: 114151142(rfxank)
PRET: 103463703(rfxank)
CVG: 107100789(rfxank)
NFU: 107396482(rfxank)
KMR: 108230587(rfxank)
ALIM: 106536825(rfxank)
AOCE: 111570682(rfxank)
CSEM: 103376772(rfxank)
POV: 109625705(rfxank)
LCF: 108879135(rfxank)
SDU: 111231944(rfxank)
SLAL: 111653545(rfxank)
HCQ: 109532144(rfxank)
BPEC: 110174069(rfxank)
MALB: 109966982(rfxank)
SASA: 100195944(rfxank)
OTW: 112244778(rfxank)
SALP: 111952527
ELS: 105011511(rfxank)
SFM: 108919951(rfxank)
PKI: 111860488(rfxank)
LCM: 102361098(RFXANK)
CMK: 103181982(rfxank)
RTP: 109927677
 » show all
Reference
PMID:9806546
  Authors
Masternak K, Barras E, Zufferey M, Conrad B, Corthals G, Aebersold R, Sanchez JC, Hochstrasser DF, Mach B, Reith W
  Title
A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.
  Journal
Nat Genet 20:273-7 (1998)
DOI:10.1038/3081
  Sequence
[hsa:8625]

KEGG   ORTHOLOGY: K08063
Entry
K08063                      KO                                     

Name
RFXAP
Definition
regulatory factor X-associated protein
Pathway
ko04612  Antigen processing and presentation
ko05152  Tuberculosis
ko05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
H00985  Bare lymphocyte syndrome type2
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K08063  RFXAP; regulatory factor X-associated protein
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K08063  RFXAP; regulatory factor X-associated protein
  09163 Immune disease
   05340 Primary immunodeficiency
    K08063  RFXAP; regulatory factor X-associated protein
Genes
HSA: 5994(RFXAP)
PTR: 100610983(RFXAP)
PPS: 100984854(RFXAP)
GGO: 101138043(RFXAP)
PON: 100450280(RFXAP)
NLE: 100582394(RFXAP)
MCC: 694441(RFXAP)
MCF: 102138204(RFXAP)
CSAB: 103214283(RFXAP)
RRO: 104677939(RFXAP)
RBB: 108516591(RFXAP)
CJC: 100393775(RFXAP)
SBQ: 101027776(RFXAP)
MMU: 170767(Rfxap)
MCAL: 110291319(Rfxap)
MPAH: 110320546(Rfxap)
RNO: 499617(Rfxap)
MUN: 110554912(Rfxap)
CGE: 100774659(Rfxap)
NGI: 103752221(Rfxap)
HGL: 101719989(Rfxap)
CCAN: 109699608(Rfxap)
OCU: 100338019(RFXAP)
TUP: 102484630(RFXAP)
CFA: 607367(RFXAP)
VVP: 112918543(RFXAP)
AML: 100475849(RFXAP)
UMR: 103664419(RFXAP)
UAH: 113251009(RFXAP)
ORO: 101375274(RFXAP)
ELK: 111158537
FCA: 101088294(RFXAP)
PTG: 102967387(RFXAP)
PPAD: 109265816(RFXAP)
AJU: 106973843(RFXAP)
BTA: 540760(RFXAP)
BIU: 109566774(RFXAP)
BBUB: 102412691(RFXAP)
CHX: 102185753(RFXAP)
OAS: 105612445(RFXAP)
SSC: 100155648(RFXAP)
CFR: 102520757(RFXAP)
CDK: 105100832(RFXAP)
BACU: 103020095(RFXAP)
LVE: 103077390(RFXAP)
OOR: 101287764(RFXAP)
DLE: 111175071(RFXAP)
PCAD: 102974203(RFXAP)
EPZ: 103559383(RFXAP)
EAI: 106844942(RFXAP)
MYB: 102243528(RFXAP) 106725997
MYD: 102753562(RFXAP)
MNA: 107525164(RFXAP)
HAI: 109388472(RFXAP)
DRO: 112313590(RFXAP)
PALE: 102898769(RFXAP)
RAY: 107503949(RFXAP)
LAV: 100658303(RFXAP)
TMU: 101345853
MDO: 100027231(RFXAP)
SHR: 100920977(RFXAP)
PCW: 110195160(RFXAP)
OAA: 100080809
GGA: 418899(RFXAP)
CJO: 107306771(RFXAP)
NMEL: 110402808(RFXAP)
TGU: 101234225(RFXAP)
LSR: 110476700(RFXAP)
SCAN: 103812558(RFXAP)
FAB: 101806274(RFXAP)
PMAJ: 107209746(RFXAP)
ETL: 114060971(RFXAP)
AMJ: 102570327(RFXAP)
CMY: 114022150
CPIC: 101937694(RFXAP)
ACS: 103278417(rfxap)
PVT: 110074023(RFXAP)
PBI: 103048639(RFXAP)
PMUR: 107287661(RFXAP)
TSR: 106545914(RFXAP)
PMUA: 114595806(RFXAP)
GJA: 107106040(RFXAP)
XLA: 108709940(rfxap.S)
XTR: 100379771(rfxap)
NPR: 108785355(RFXAP)
DRE: 100006212(rfxap)
SANH: 107686162(rfxap) 107697413
IPU: 108276696(rfxap)
PHYP: 113543604(rfxap)
AMEX: 103039202(rfxap)
EEE: 113572180(rfxap)
TRU: 101075394(rfxap)
LCO: 104928218(rfxap)
NCC: 104964550(rfxap)
MZE: 101471661(rfxap)
ONL: 100704569(rfxap)
OLA: 101167388(rfxap)
XMA: 102218213(rfxap)
XCO: 114153306(rfxap)
PRET: 103475560(rfxap)
CVG: 107088285(rfxap)
NFU: 107391187(rfxap)
KMR: 108236909
ALIM: 106514161(rfxap)
AOCE: 111566079(rfxap)
CSEM: 103395221(rfxap) 103399480
POV: 109635807(rfxap)
LCF: 108893716(rfxap)
SDU: 111217127(rfxap)
SLAL: 111662677(rfxap)
HCQ: 109515632(rfxap)
BPEC: 110158608(rfxap)
MALB: 109971886(rfxap)
SASA: 106563855(rfxap) 106604035
OTW: 112238481
ELS: 105029978(rfxap)
SFM: 108936053(rfxap)
PKI: 111840452(rfxap)
LCM: 102346053(RFXAP)
CMK: 103177191(rfxap)
BFO: 118418918
SPU: 582158
APLC: 110989795
SKO: 100371473
PCAN: 112559892
MYI: 110442777
DGT: 114521538
 » show all
Reference
PMID:9118943
  Authors
Durand B, Sperisen P, Emery P, Barras E, Zufferey M, Mach B, Reith W
  Title
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.
  Journal
EMBO J 16:1045-55 (1997)
DOI:10.1093/emboj/16.5.1045
  Sequence
[hsa:5994]
Reference
  Authors
Bushway M, Cycon KA, Mulvaney K, Murphy SP
  Title
Coordinate loss of MHC class II expression in the diffuse large B cell lymphoma cell line OCI-Ly2 is due to a novel mutation in RFX-AP.
  Journal
Immunogenetics 62:109-16 (2010)
DOI:10.1007/s00251-009-0418-3
  Sequence
[hsa:5994]

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