KEGG   ORTHOLOGY: K08097
Entry
K08097                      KO                                     

Name
comA
Definition
phosphosulfolactate synthase [EC:4.4.1.19]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01240  Biosynthesis of cofactors
Module
M00358  Coenzyme M biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K08097  comA; phosphosulfolactate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.19  phosphosulfolactate synthase
     K08097  comA; phosphosulfolactate synthase
Other DBs
RN: R07476
COG: COG1809
GO: 0043817
Genes
LOK: Loa_02096
BGM: CAL15_12810
DPG: DESPIGER_2203
BSU: BSU10950(yitD)
BSR: I33_1230(yitD)
BSL: A7A1_0911
BSH: BSU6051_10950(yitD)
BSY: I653_05540
BSUT: BSUB_01192(yitD)
BSUL: BSUA_01192(yitD)
BSUS: Q433_06185
BSN: BSn5_17370
BSQ: B657_10950(slpS)
BSX: C663_1118(comA)
BSP: U712_05605
BSS: BSUW23_05550(yitD)
BST: GYO_1401(yitD)
BLI: BL02005(yitD)
BLD: BLi02155(yitD)
BLH: BaLi_c22300(yitD)
BAE: BATR1942_03110
BSON: S101395_02481(comA)
BHT: DIC78_04125
BCO: Bcell_3136
BCK: BCO26_1398(yitD)
BAG: Bcoa_3122
BCOA: BF29_414(yitD)
BJS: MY9_1193
BACI: B1NLA3E_03505
GST: HW35_17420
BACY: QF06_04410
BACL: BS34A_12090(yitD)
BALM: BsLM_1140
BGY: BGLY_2293(yitD)
BGI: BGM20_20755
BIT: BIS30_16185
BTHV: CQJ30_09390
BFD: NCTC4823_02234(yitD)
AQT: FN924_04655
NMK: CHR53_10645
BBE: BBR47_23190(comA)
BLR: BRLA_c016650
BFM: BP422_06795
BAGR: BA6348_17500
BRW: GOP56_01235
PJD: Pjdr2_2292
PMS: KNP414_02661
PMQ: PM3016_2903
PMW: B2K_14740
PLV: ERIC2_c33000(comA)
PBJ: VN24_25310
PNP: IJ22_24320
POW: IJ21_30190
PSWU: SY83_19300
PIB: BBD41_01685
PCX: LPB68_18080
PLEN: EIM92_09255
PPSC: EHS13_20600
PALB: EJC50_13865
PCHI: PC41400_11100
PBK: Back11_24680
PRZ: GZH47_05160
TCO: Theco_1988
ANX: ACH33_09010
COH: EAV92_09850
COHN: KCTCHS21_24650
AAC: Aaci_1301 Aaci_2433
AAD: TC41_1228 TC41_2723(comA)
BTS: Btus_1783
KYR: CVV65_07600
TUM: CBW65_20240
TAB: CIG75_09285
EFF: skT53_03360
NTR: B0W44_13255
LFB: C1X05_06540
TVU: AB849_012595
KPUL: GXN76_06790
KEB: GXN75_07905
LHW: BSQ49_02940
LMAL: LM596_03095
LOL: LACOL_1489
LPD: AYR62_02825
LMAE: FGL90_02275
OOE: OEOE_0441
OEN: DSM07_07720
STH: STH2643
DRM: Dred_1677
DCA: Desca_1257
DRU: Desru_2345
DFG: B0537_07980
DAE: Dtox_2359
DKU: Desku_1279
DGI: Desgi_3259
PTH: PTH_1816
DAU: Daud_1309
TJR: TherJR_1470
TFR: BR63_07920
HMO: HM1_0946
HCV: FTV88_0865(comA)
TMR: Tmar_1045
THEF: E1B22_08890
THEP: DYI95_005195
SAY: TPY_1196(comA)
SAP: Sulac_2457
STHR: BXT84_11625
MTA: Moth_0118
MTHO: MOTHE_c01240(yitD)
MTHZ: MOTHA_c01240(yitD)
ADG: Adeg_1603
HOR: Hore_21790
HALS: D7D81_00820
AAR: Acear_1343
HHL: Halha_1510
AFT: BBF96_13960
LPIL: LIP_0779
MSA: Mycsm_01875
MCB: Mycch_5452 Mycch_5966
MRH: MycrhN_2934
NTP: CRH09_05130
SALS: SLNWT_0539
HUW: FPZ11_11375
NCA: Noca_4816 Noca_4839
FRI: FraEuI1c_5954
AMQ: AMETH_2056
PDX: Psed_1619 Psed_6288
PAUT: Pdca_54820
BSOL: FSW04_04285
CWO: Cwoe_0088
SYD: Syncc9605_1170
SYNK: KR100_08215
HAU: Haur_1567
SUS: Acid_4865
TTZ: FHG85_06135
SRU: SRU_0020
SRM: SRM_00021(comA)
RMR: Rmar_0022
RMG: Rhom172_0022
RBAR: AWN76_012815
CPI: Cpin_1670 Cpin_5589
CBAE: COR50_10035 COR50_19515
CHIT: FW415_17205 FW415_22305
CHIH: GWR21_08495 GWR21_23760
NKO: Niako_4703
NSO: NIASO_11290
NIA: A8C56_02190 A8C56_07490
FLA: SY85_06285
FGG: FSB75_08920 FSB75_11205
ARB: A9P82_00090
ARK: D6B99_09500
AGI: FSB73_00150 FSB73_02050
ARAC: E0W69_019830
FLN: FLA_0115
PSEG: D3H65_14745
PGIN: FRZ67_08215
PGO: FSB84_29760
FLS: GLV81_14000
LACS: H4075_14410
PHE: Phep_4158
PEP: AQ505_01190
PCM: AY601_4372
PSTY: BFS30_06080
PGS: CPT03_17685
PEJ: FYC62_13355
PEK: FFJ24_020435
PROE: H9L23_21340
PSN: Pedsa_3036
SHG: Sph21_1338
SCN: Solca_4247
MUP: A0256_08050
MUC: MuYL_0731
MGOT: MgSA37_00444(yitD)
MUH: HYN43_025745
MGIN: FRZ54_05565
MGK: FSB76_15775
MRUB: DEO27_026680
MGOS: DIU38_023370
OLI: FKG96_03635
SBX: CA265_19750
CMR: Cycma_1455
CAMU: CA2015_1351
BBD: Belba_0911
EVI: Echvi_1147
EST: DN752_12365
ECHI: FKX85_04590
ALM: AO498_02300
CHU: CHU_0004
DFE: Dfer_4445
SLI: Slin_0707
SRD: SD10_06655
SMON: AWR27_12200
SPIR: CWM47_32745
SPIK: EXU85_09435
SPIB: G8759_16150
LBY: Lbys_3154
RSI: Runsl_3058
RUN: DR864_10290
RUP: DTQ70_17910
EOL: Emtol_2406
FAE: FAES_0308
FIB: A6C57_14855
PSEZ: HME7025_00418(comA)
ALS: DJ013_06600
RHOZ: GXP67_16360
FLI: Fleli_2960
HSW: Hsw_3670
HYM: N008_11020
HYD: PK28_15930
HYE: AM218_00550
HYG: AUC43_05885
HYP: A0257_15910
HYZ: AXW84_18180
HNV: DDQ68_13060
HYH: D3Y59_15825
HYJ: FHG12_11365
HQI: H9L05_09945
HRS: HER32_08165
PKO: PKOR_08170
PACT: CA264_19065
RUF: TH63_00780
RTI: DC20_11260
RUD: TH61_09245
NIB: GU926_15000
ADD: HUW48_26315
ASWU: HUW51_10645
MTT: Ftrac_2674
FPF: DCC35_19385
FLM: MY04_3220
FLL: EI427_18430
FBT: D770_13430
CHK: D4L85_01040
FTE: Fluta_3660
FLU: CHH17_09260
BBAU: AEM51_13675
MJA: MJ_0255
MFE: Mefer_0102
MVU: Metvu_1522
MFS: MFS40622_0491
MIF: Metin_1007
MJH: JH146_0170
MIG: Metig_0856
MMP: MMP0273(comA)
MMQ: MmarC5_1399
MMX: MmarC6_0679
MMZ: MmarC7_1277
MMD: GYY_01400
MMAK: MMKA1_02800(comA)
MMAO: MMOS7_03070(comA)
MMAD: MMJJ_07850(yitD)
MAE: Maeo_0153
MVN: Mevan_1285
MVO: Mvol_1330
MOK: Metok_0167
METF: CFE53_04670(comA)
MTH: MTH_1674
MMG: MTBMA_c02530(comA)
METC: MTCT_1527
MWO: MWSIV6_0212(comA)
METE: tca_01621(yitD)
METZ: METMT2_1504
METK: FVF72_03295(comA)
MTHM: FZP57_00950(comA)
MST: Msp_1270(comA)
METB: AW729_09300
MSI: Msm_0086
MEB: Abm4_0691(comA)
MMIL: sm9_0980(comA)
MEYE: TL18_05470
MOL: YLM1_0878
MEL: Metbo_2244
MEW: MSWAN_0399
METH: MBMB1_0449(comA)
MFC: BRM9_1809(comA)
MFI: DSM1535_2450(comA)
MCUB: MCBB_0411(comA)
MSUB: BK009_00305
METN: BK008_08110
METT: CIT01_07045(comA)
METO: CIT02_04555(comA)
MFV: Mfer_1060
MKA: MK0394(comA)
FAC: FACI_IFERC01G1194
NGA: Ngar_c10400(comA) Ngar_c26460
NVN: NVIE_024140(comA) NVIE_028040
NEV: NTE_01035 NTE_03133
TAA: NMY3_01362(yitD_1) NMY3_02409(yitD_2)
NFN: NFRAN_2269(yitD) NFRAN_3066(yitD)
 » show all
Reference
  Authors
Graham DE, Xu H, White RH
  Title
Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes.
  Journal
J Biol Chem 277:13421-9 (2002)
DOI:10.1074/jbc.M201011200
  Sequence
[mja:MJ_0255]

  All links  
Ontology (4)   
   KEGG BRITE (2)   
   GO (1)   
   COG (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3494)   
   KEGG GENES (303)   
   KEGG MGENES (2439)   
   RefGene (739)   
   OC (13)   
Literature (1)   
   PubMed (1)   
All databases (3511)   

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KEGG   ENZYME: 4.4.1.19
Entry
EC 4.4.1.19                 Enzyme                                 

Name
phosphosulfolactate synthase;
(2R)-phospho-3-sulfolactate synthase;
(2R)-O-phospho-3-sulfolactate sulfo-lyase
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
(2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming)
Reaction(IUBMB)
(2R)-2-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite [RN:R07476]
Reaction(KEGG)
R07476
Substrate
(2R)-2-O-phospho-3-sulfolactate
Product
phosphoenolpyruvate [CPD:C00074];
sulfite [CPD:C00094]
Comment
Requires Mg2+. The enzyme from the archaeon Methanococcus jannaschii catalyses the Michael addition of sulfite to phosphoenolpyruvate. It specifically requires phosphoenolpyruvate and its broad alkaline pH optimum suggests that it uses sulfite rather than hydrogensulfite.
History
EC 4.4.1.19 created 2003
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08097  phosphosulfolactate synthase
Genes
LOK: Loa_02096
BGM: CAL15_12810
DPG: DESPIGER_2203
BSU: BSU10950(yitD)
BSR: I33_1230(yitD)
BSL: A7A1_0911
BSH: BSU6051_10950(yitD)
BSY: I653_05540
BSUT: BSUB_01192(yitD)
BSUL: BSUA_01192(yitD)
BSUS: Q433_06185
BSN: BSn5_17370
BSQ: B657_10950(slpS)
BSX: C663_1118(comA)
BSP: U712_05605
BSS: BSUW23_05550(yitD)
BST: GYO_1401(yitD)
BLI: BL02005(yitD)
BLD: BLi02155(yitD)
BLH: BaLi_c22300(yitD)
BAE: BATR1942_03110
BSON: S101395_02481(comA)
BHT: DIC78_04125
BCO: Bcell_3136
BCK: BCO26_1398(yitD)
BAG: Bcoa_3122
BCOA: BF29_414(yitD)
BJS: MY9_1193
BACI: B1NLA3E_03505
GST: HW35_17420
BACY: QF06_04410
BACL: BS34A_12090(yitD)
BALM: BsLM_1140
BGY: BGLY_2293(yitD)
BGI: BGM20_20755
BIT: BIS30_16185
BTHV: CQJ30_09390
BFD: NCTC4823_02234(yitD)
AQT: FN924_04655
NMK: CHR53_10645
BBE: BBR47_23190(comA)
BLR: BRLA_c016650
BFM: BP422_06795
BAGR: BA6348_17500
BRW: GOP56_01235
PJD: Pjdr2_2292
PMS: KNP414_02661
PMQ: PM3016_2903
PMW: B2K_14740
PLV: ERIC2_c33000(comA)
PBJ: VN24_25310
PNP: IJ22_24320
POW: IJ21_30190
PSWU: SY83_19300
PIB: BBD41_01685
PCX: LPB68_18080
PLEN: EIM92_09255
PPSC: EHS13_20600
PALB: EJC50_13865
PCHI: PC41400_11100
PBK: Back11_24680
PRZ: GZH47_05160
TCO: Theco_1988
ANX: ACH33_09010
COH: EAV92_09850
COHN: KCTCHS21_24650
AAC: Aaci_1301 Aaci_2433
AAD: TC41_1228 TC41_2723(comA)
BTS: Btus_1783
KYR: CVV65_07600
TUM: CBW65_20240
TAB: CIG75_09285
EFF: skT53_03360
NTR: B0W44_13255
LFB: C1X05_06540
TVU: AB849_012595
KPUL: GXN76_06790
KEB: GXN75_07905
LHW: BSQ49_02940
LMAL: LM596_03095
LOL: LACOL_1489
LPD: AYR62_02825
LMAE: FGL90_02275
OOE: OEOE_0441
OEN: DSM07_07720
STH: STH2643
DRM: Dred_1677
DCA: Desca_1257
DRU: Desru_2345
DFG: B0537_07980
DAE: Dtox_2359
DKU: Desku_1279
DGI: Desgi_3259
PTH: PTH_1816
DAU: Daud_1309
TJR: TherJR_1470
TFR: BR63_07920
HMO: HM1_0946
HCV: FTV88_0865(comA)
TMR: Tmar_1045
THEF: E1B22_08890
THEP: DYI95_005195
SAY: TPY_1196(comA)
SAP: Sulac_2457
STHR: BXT84_11625
MTA: Moth_0118
MTHO: MOTHE_c01240(yitD)
MTHZ: MOTHA_c01240(yitD)
ADG: Adeg_1603
HOR: Hore_21790
HALS: D7D81_00820
AAR: Acear_1343
HHL: Halha_1510
AFT: BBF96_13960
LPIL: LIP_0779
MSA: Mycsm_01875
MCB: Mycch_5452 Mycch_5966
MRH: MycrhN_2934
NTP: CRH09_05130
SALS: SLNWT_0539
HUW: FPZ11_11375
NCA: Noca_4816 Noca_4839
FRI: FraEuI1c_5954
AMQ: AMETH_2056
PDX: Psed_1619 Psed_6288
PAUT: Pdca_54820
BSOL: FSW04_04285
CWO: Cwoe_0088
SYD: Syncc9605_1170
SYNK: KR100_08215
HAU: Haur_1567
SUS: Acid_4865
TTZ: FHG85_06135
SRU: SRU_0020
SRM: SRM_00021(comA)
RMR: Rmar_0022
RMG: Rhom172_0022
RBAR: AWN76_012815
CPI: Cpin_1670 Cpin_5589
CBAE: COR50_10035 COR50_19515
CHIT: FW415_17205 FW415_22305
CHIH: GWR21_08495 GWR21_23760
NKO: Niako_4703
NSO: NIASO_11290
NIA: A8C56_02190 A8C56_07490
FLA: SY85_06285
FGG: FSB75_08920 FSB75_11205
ARB: A9P82_00090
ARK: D6B99_09500
AGI: FSB73_00150 FSB73_02050
ARAC: E0W69_019830
FLN: FLA_0115
PSEG: D3H65_14745
PGIN: FRZ67_08215
PGO: FSB84_29760
FLS: GLV81_14000
LACS: H4075_14410
PHE: Phep_4158
PEP: AQ505_01190
PCM: AY601_4372
PSTY: BFS30_06080
PGS: CPT03_17685
PEJ: FYC62_13355
PEK: FFJ24_020435
PROE: H9L23_21340
PSN: Pedsa_3036
SHG: Sph21_1338
SCN: Solca_4247
MUP: A0256_08050
MUC: MuYL_0731
MGOT: MgSA37_00444(yitD)
MUH: HYN43_025745
MGIN: FRZ54_05565
MGK: FSB76_15775
MRUB: DEO27_026680
MGOS: DIU38_023370
OLI: FKG96_03635
SBX: CA265_19750
CMR: Cycma_1455
CAMU: CA2015_1351
BBD: Belba_0911
EVI: Echvi_1147
EST: DN752_12365
ECHI: FKX85_04590
ALM: AO498_02300
CHU: CHU_0004
DFE: Dfer_4445
SLI: Slin_0707
SRD: SD10_06655
SMON: AWR27_12200
SPIR: CWM47_32745
SPIK: EXU85_09435
SPIB: G8759_16150
LBY: Lbys_3154
RSI: Runsl_3058
RUN: DR864_10290
RUP: DTQ70_17910
EOL: Emtol_2406
FAE: FAES_0308
FIB: A6C57_14855
PSEZ: HME7025_00418(comA)
ALS: DJ013_06600
RHOZ: GXP67_16360
FLI: Fleli_2960
HSW: Hsw_3670
HYM: N008_11020
HYD: PK28_15930
HYE: AM218_00550
HYG: AUC43_05885
HYP: A0257_15910
HYZ: AXW84_18180
HNV: DDQ68_13060
HYH: D3Y59_15825
HYJ: FHG12_11365
HQI: H9L05_09945
HRS: HER32_08165
PKO: PKOR_08170
PACT: CA264_19065
RUF: TH63_00780
RTI: DC20_11260
RUD: TH61_09245
NIB: GU926_15000
ADD: HUW48_26315
ASWU: HUW51_10645
MTT: Ftrac_2674
FPF: DCC35_19385
FLM: MY04_3220
FLL: EI427_18430
FBT: D770_13430
CHK: D4L85_01040
FTE: Fluta_3660
FLU: CHH17_09260
BBAU: AEM51_13675
MJA: MJ_0255
MFE: Mefer_0102
MVU: Metvu_1522
MFS: MFS40622_0491
MIF: Metin_1007
MJH: JH146_0170
MIG: Metig_0856
MMP: MMP0273(comA)
MMQ: MmarC5_1399
MMX: MmarC6_0679
MMZ: MmarC7_1277
MMD: GYY_01400
MMAK: MMKA1_02800(comA)
MMAO: MMOS7_03070(comA)
MMAD: MMJJ_07850(yitD)
MAE: Maeo_0153
MVN: Mevan_1285
MVO: Mvol_1330
MOK: Metok_0167
METF: CFE53_04670(comA)
MTH: MTH_1674
MMG: MTBMA_c02530(comA)
METC: MTCT_1527
MWO: MWSIV6_0212(comA)
METE: tca_01621(yitD)
METZ: METMT2_1504
METK: FVF72_03295(comA)
MTHM: FZP57_00950(comA)
MST: Msp_1270(comA)
METB: AW729_09300
MSI: Msm_0086
MEB: Abm4_0691(comA)
MMIL: sm9_0980(comA)
MEYE: TL18_05470
MOL: YLM1_0878
MEL: Metbo_2244
MEW: MSWAN_0399
METH: MBMB1_0449(comA)
MFC: BRM9_1809(comA)
MFI: DSM1535_2450(comA)
MCUB: MCBB_0411(comA)
MSUB: BK009_00305
METN: BK008_08110
METT: CIT01_07045(comA)
METO: CIT02_04555(comA)
MFV: Mfer_1060
MKA: MK0394(comA)
FAC: FACI_IFERC01G1194
NGA: Ngar_c10400(comA) Ngar_c26460
NVN: NVIE_024140(comA) NVIE_028040
NEV: NTE_01035 NTE_03133
TAA: NMY3_01362(yitD_1) NMY3_02409(yitD_2)
NFN: NFRAN_2269(yitD) NFRAN_3066(yitD)
 » show all
Reference
1  [PMID:11830598]
  Authors
Graham DE, Xu H, White RH
  Title
Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes.
  Journal
J Biol Chem 277:13421-9 (2002)
DOI:10.1074/jbc.M201011200
  Sequence
[mja:MJ_0255]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.19
IUBMB Enzyme Nomenclature: 4.4.1.19
ExPASy - ENZYME nomenclature database: 4.4.1.19
BRENDA, the Enzyme Database: 4.4.1.19
CAS: 473575-53-0

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Pathway (7)   
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Gene (3482)   
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Protein sequence (335)   
   UniProt (250)   
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DNA sequence (451)   
   RefSeq(nuc) (134)   
   GenBank (163)   
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3D Structure (1)   
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Protein domain (4)   
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KEGG   REACTION: R07476
Entry
R07476                      Reaction                               

Name
(2R)-O-phospho-3-sulfolactate sulfo-lyase
Definition
(2R)-O-Phospho-3-sulfolactate <=> Sulfite + Phosphoenolpyruvate
Equation
Reaction class
RC01799  C00074_C11536
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Module
M00358  Coenzyme M biosynthesis
Orthology
K08097  phosphosulfolactate synthase [EC:4.4.1.19]
Other DBs
RHEA: 22787

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG RCLASS (1)   
Gene (304)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (303)   
All databases (319)   

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