KEGG   ORTHOLOGY: K08155
Entry
K08155                      KO                                     
Symbol
SLC18A1_2, VMAT
Name
MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
Pathway
map04721  Synaptic vesicle cycle
map04726  Serotonergic synapse
map04728  Dopaminergic synapse
map05012  Parkinson disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   04726 Serotonergic synapse
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   04721 Synaptic vesicle cycle
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
  09165 Substance dependence
   05030 Cocaine addiction
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   05031 Amphetamine addiction
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   05034 Alcoholism
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
Transporters [BR:ko02000]
 Solute carrier family (SLC)
  SLC18: Vesicular amine transporter
   K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
 Major facilitator superfamily (MFS)
  Drug transporters
   Drug:H+ antiporter-1 (12 spanner) (DHA1) family
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
Other DBs
GO: 0008504
TC: 2.A.1.2.11 2.A.1.2.12 2.A.1.2.29
Genes
HSA: 6570(SLC18A1) 6571(SLC18A2)
PTR: 464032(SLC18A1) 466213(SLC18A2)
PPS: 100967958(SLC18A2) 100986598(SLC18A1)
GGO: 101124622(SLC18A1) 101132348(SLC18A2)
PON: 100444121(SLC18A1) 100447972(SLC18A2)
NLE: 100586312(SLC18A2) 100592997(SLC18A1)
MCC: 701133(SLC18A2) 705489(SLC18A1)
MCF: 102119311(SLC18A2) 102131054(SLC18A1)
CSAB: 103215416(SLC18A1) 103216582(SLC18A2)
CATY: 105577951(SLC18A2) 105579256(SLC18A1)
PANU: 101015017(SLC18A1) 101019672(SLC18A2)
TGE: 112630291(SLC18A1) 112631529(SLC18A2)
RRO: 104672557(SLC18A1) 104682306(SLC18A2)
RBB: 108529152(SLC18A2) 108532608(SLC18A1)
TFN: 117066183(SLC18A2) 117092877(SLC18A1)
PTEH: 111545765(SLC18A1) 111550703(SLC18A2)
CJC: 100395730(SLC18A2) 100405909(SLC18A1)
SBQ: 101044005(SLC18A2) 101050367(SLC18A1)
CSYR: 103263556(SLC18A2) 103276578(SLC18A1)
MMUR: 105876900(SLC18A2) 105882560(SLC18A1)
OGA: 100947676(SLC18A1) 100960769(SLC18A2)
MMU: 110877(Slc18a1) 214084(Slc18a2)
MCAL: 110285258(Slc18a2) 110300754(Slc18a1)
MPAH: 110333946(Slc18a2) 110336763(Slc18a1)
RNO: 25549(Slc18a2) 25693(Slc18a1)
MCOC: 116071446(Slc18a1) 116104058(Slc18a2)
MUN: 110552258(Slc18a2) 110557633(Slc18a1)
CGE: 100755842(Slc18a1) 100774860(Slc18a2)
PLEU: 114701064(Slc18a2) 114703116(Slc18a1)
NGI: 103729298(Slc18a2) 103747655(Slc18a1)
HGL: 101703356(Slc18a1) 101725597(Slc18a2)
CPOC: 100719098(Slc18a2) 100726249(Slc18a1)
CCAN: 109700669(Slc18a2)
DORD: 105986707(Slc18a2) 105992356(Slc18a1)
DSP: 122115706(Slc18a2) 122127176(Slc18a1)
OCU: 100340936(SLC18A1) 100351780(SLC18A2)
OPI: 101522326(SLC18A1) 101535906(SLC18A2)
TUP: 102492742(SLC18A1) 102494965(SLC18A2)
CFA: 486138(SLC18A1) 486908(SLC18A2)
VVP: 112916463(SLC18A2) 112925441(SLC18A1)
VLG: 121484057(SLC18A2) 121497831(SLC18A1)
AML: 100463950(SLC18A1) 100473870(SLC18A2)
UMR: 103657567(SLC18A2) 103676704(SLC18A1)
UAH: 113251976(SLC18A2) 113270073(SLC18A1)
UAR: 123789908(SLC18A1) 123795992(SLC18A2)
MPUF: 101671502(SLC18A2) 101691449(SLC18A1)
ORO: 101379977(SLC18A1) 101381057(SLC18A2)
EJU: 114200801(SLC18A1) 114223104(SLC18A2)
ZCA: 113918955(SLC18A2) 113925181(SLC18A1)
MLX: 118022364(SLC18A1) 118026872(SLC18A2)
FCA: 101086507(SLC18A2) 101094843(SLC18A1)
PYU: 121037280(SLC18A2) 121039995(SLC18A1)
PBG: 122472678(SLC18A1) 122493295(SLC18A2)
PTG: 102970532(SLC18A2) 102970567(SLC18A1)
PPAD: 109272958(SLC18A2) 109277413(SLC18A1)
AJU: 106971854(SLC18A1) 106974109(SLC18A2)
HHV: 120234024(SLC18A1) 120235149(SLC18A2)
BTA: 282471(SLC18A2) 617708(SLC18A1)
BOM: 102271632(SLC18A2) 102274678
BIU: 109562706(SLC18A1) 109579167(SLC18A2)
BBUB: 102408717(SLC18A2) 102409259(SLC18A1)
CHX: 102187453(SLC18A2) 102190515(SLC18A1)
OAS: 101104796(SLC18A2) 101121491(SLC18A1)
ODA: 120862974(SLC18A1) 120873825(SLC18A2)
CCAD: 122432085(SLC18A1) 122445885(SLC18A2)
SSC: 100154435(SLC18A1) 100154950(SLC18A2)
CFR: 102523059(SLC18A1) 102523925(SLC18A2)
CBAI: 105069001(SLC18A1) 105080762(SLC18A2)
CDK: 105095097(SLC18A2) 105102901(SLC18A1)
VPC: 102528246(SLC18A1) 102534389(SLC18A2)
BACU: 103000979(SLC18A2) 103003968(SLC18A1)
LVE: 103075046(SLC18A2) 103084206(SLC18A1)
OOR: 101279274(SLC18A2) 101285599(SLC18A1)
DLE: 111168991(SLC18A1) 111172270(SLC18A2)
PCAD: 102978728(SLC18A1) 102994134(SLC18A2)
PSIU: 116741221(SLC18A2) 116755694(SLC18A1)
ECB: 100055485(SLC18A1) 100058805(SLC18A2)
EPZ: 103554413(SLC18A2) 103561143(SLC18A1)
EAI: 106831222(SLC18A1) 106836377(SLC18A2)
MYB: 102246774(SLC18A1)
MYD: 102757123(SLC18A1) 102764776(SLC18A2)
MMYO: 118658601(SLC18A1) 118669705(SLC18A2)
MLF: 102438871(SLC18A1) 102438995(SLC18A2)
MNA: 107535441(SLC18A1) 107536429(SLC18A2)
PKL: 118719524(SLC18A2) 118726092(SLC18A1)
HAI: 109382401(SLC18A1) 109383017(SLC18A2)
DRO: 112300293(SLC18A2) 112305205(SLC18A1)
SHON: 118975168(SLC18A1) 118996317(SLC18A2)
AJM: 119040044(SLC18A2) 119054713(SLC18A1)
PDIC: 114497436(SLC18A2) 114503941(SLC18A1)
PHAS: 123828380(SLC18A1) 123828675(SLC18A2)
MMF: 118615752(SLC18A1) 118632491(SLC18A2)
RFQ: 117036440(SLC18A2) 117038047(SLC18A1)
PALE: 102892885(SLC18A1) 102896474(SLC18A2)
PGIG: 120606608(SLC18A1) 120609047(SLC18A2)
PVP: 105291491(SLC18A2) 105296664(SLC18A1)
RAY: 107503755(SLC18A1) 107509743(SLC18A2)
MJV: 108383434(SLC18A2) 108384238(SLC18A1)
TOD: 119233542(SLC18A1) 119233869(SLC18A2)
SARA: 101542593(SLC18A2) 101555547(SLC18A1)
LAV: 100667118(SLC18A1) 100668348(SLC18A2)
DNM: 101428255(SLC18A2) 101431703(SLC18A1)
MDO: 100020699(SLC18A2) 100033069(SLC18A1)
GAS: 123234838(SLC18A1) 123238186(SLC18A2)
SHR: 100916325(SLC18A2) 100933876(SLC18A1)
PCW: 110196419(SLC18A1) 110209553(SLC18A2)
OAA: 100073866(SLC18A1) 100081376(SLC18A2)
GGA: 423921(SLC18A2) 431330(SLC18A1)
PCOC: 116231594(SLC18A2) 116234553(SLC18A1)
CJO: 107316210(SLC18A2) 107323772(SLC18A1)
NMEL: 110387020(SLC18A1) 110400070(SLC18A2)
APLA: 101802757(SLC18A2) 101805341(SLC18A1)
ACYG: 106044367(SLC18A1) 106045203(SLC18A2)
AFUL: 116491646(SLC18A2) 116499331(SLC18A1)
TGU: 100228266(SLC18A2)
LSR: 110478521(SLC18A2)
SCAN: 103813802(SLC18A2) 103824520
PMOA: 120502197(SLC18A2) 120504874(SLC18A1)
OTC: 121341726(SLC18A2) 121346702(SLC18A1)
PRUF: 121350167(SLC18A2) 121355870(SLC18A1)
GFR: 102034248(SLC18A2)
FAB: 101814308(SLC18A1) 101816900(SLC18A2)
PHI: 102100715(SLC18A2) 102113147(SLC18A1)
PMAJ: 107206905(SLC18A2) 107213830(SLC18A1)
CCAE: 111931348(SLC18A2) 111938761(SLC18A1)
CCW: 104694889(SLC18A1) 104694947(SLC18A2)
ETL: 114064382(SLC18A1) 114069973(SLC18A2)
ZAB: 102068934(SLC18A2)
FPG: 101917215(SLC18A1) 101917491(SLC18A2)
FCH: 102049236(SLC18A1) 102059762(SLC18A2)
CLV: 102096441(SLC18A2) 102097425(SLC18A1)
EGZ: 104127841(SLC18A1) 104128609(SLC18A2)
NNI: 104016044(SLC18A1) 104022351(SLC18A2)
ACUN: 113481785(SLC18A2) 113488101(SLC18A1)
TALA: 104360672(SLC18A2) 104360997(SLC18A1)
PADL: 103912381(SLC18A1) 103918556(SLC18A2)
ACHC: 115348509(SLC18A2) 115350053(SLC18A1)
AAM: 106489486(SLC18A2) 106498832(SLC18A1)
AROW: 112966698(SLC18A2) 112973644(SLC18A1)
NPD: 112949966(SLC18A1) 112956999(SLC18A2)
DNE: 112980928(SLC18A2) 112996713(SLC18A1)
ASN: 102368779(SLC18A2) 102377559(SLC18A1)
AMJ: 102565966(SLC18A2) 102575216(SLC18A1)
CPOO: 109317441(SLC18A1) 109324090(SLC18A2)
GGN: 109287651(SLC18A2) 109295572(SLC18A1)
PSS: 102458866(SLC18A2) 102464018(SLC18A1)
CMY: 102933350(SLC18A1) 102940972(SLC18A2)
CPIC: 101931537(SLC18A1) 101932022(SLC18A2)
TST: 117871604(SLC18A1) 117879902(SLC18A2)
CABI: 116825082(SLC18A2) 116839834(SLC18A1)
MRV: 120398381(SLC18A1) 120409273(SLC18A2)
ACS: 100555086(slc18a1) 100555672(slc18a2)
PVT: 110071993(SLC18A2) 110089340
SUND: 121925191(SLC18A2) 121934672(SLC18A1)
PBI: 103057330(SLC18A2) 103062718(SLC18A1)
PMUR: 107286798(SLC18A2) 107297451(SLC18A1)
TSR: 106556071(SLC18A1)
PGUT: 117677031(SLC18A1) 117678742(SLC18A2)
VKO: 123028113(SLC18A2) 123029755(SLC18A1)
PMUA: 114585851(SLC18A1) 114597448(SLC18A2)
ZVI: 118096154(SLC18A2) 118097189(SLC18A1)
GJA: 107110450(SLC18A2) 107115370(SLC18A1)
STOW: 125438607(SLC18A2) 125441961(SLC18A1)
NPR: 108795038(SLC18A1)
RTEM: 120933120 120946795(SLC18A2)
DRE: 553304(slc18a2) 571483(slc18a1)
PPRM: 120466822(slc18a2) 120474859
MAMB: 125268758(slc18a2) 125280566
IPU: 108265875 108270156(slc18a2)
PHYP: 113544961(slc18a2) 113546107(slc18a1)
SMEO: 124390382(slc18a2) 124400486
TFD: 113640568(slc18a2) 113645259
AMEX: 103028146(slc18a1) 103032219
EEE: 113586455(slc18a2) 113590243(slc18a1)
TRU: 101066290(slc18a1) 101069336(slc18a2)
LCO: 104929391(slc18a2)
NCC: 104957734(slc18a2)
CGOB: 115005129 115011850 115013989(slc18a1)
PLEP: 121954986(slc18a2) 121956198
ECRA: 117944852 117960199(slc18a2)
GAT: 120820930(slc18a2)
PPUG: 119214648(slc18a2) 119220574 119225242
MSAM: 119891615 119916798(slc18a2)
MZE: 101478189(slc18a1) 101481739(slc18a2)
ONL: 100699691(slc18a2) 100703472(slc18a1)
OAU: 116328432 116332162(slc18a2)
OLA: 101158793(slc18a2) 101172172(slc18a1)
OML: 112138438 112162217(slc18a2)
XMA: 102230760(slc18a1) 102236350(slc18a2)
XCO: 114137716(slc18a2) 114144799(slc18a1)
XHE: 116713276(slc18a2) 116730364(slc18a1)
PRET: 103470757(slc18a1) 103476537(slc18a2)
PFOR: 103129634(slc18a1) 103153110(slc18a2)
PLAI: 106953392 106964380(slc18a2)
PMEI: 106904248(slc18a1) 106910893
GAF: 122828588 122842864(slc18a2)
CVG: 107095083(slc18a2) 107097909
CTUL: 119791369 119796158(slc18a2)
GMU: 124858776(slc18a2) 124878083
NFU: 107375486(slc18a2) 107386158
KMR: 108239127(slc18a2) 108241525
ALIM: 106513871(slc18a2) 106527823
NWH: 119407573(slc18a2) 119413112
AOCE: 111579962 111586787(slc18a2)
CSEM: 103376790 103387791(slc18a2) 103398054(slc18a1)
POV: 109631469(slc18a2)
SSEN: 122760081(slc18a2) 122769048
HHIP: 117768360 117775720(slc18a2)
LCF: 108875429(slc18a1) 108884808(slc18a2)
SDU: 111236433(slc18a2) 111236962(slc18a1)
SLAL: 111646053(slc18a1) 111672959(slc18a2)
XGL: 120796123(slc18a2) 120805430
HCQ: 109523233(slc18a2)
BPEC: 110171919(slc18a2) 110173987
MALB: 109957424(slc18a1) 109960073(slc18a2)
SASA: 106576939 106587027 106606532(slc18a2)
ELS: 105014047(slc18a1) 105023227(slc18a2)
SFM: 108940370(slc18a1) 108942709(slc18a2)
PKI: 111839782(slc18a2) 111857492(slc18a1)
AANG: 118206453 118217655(slc18a2)
LOC: 102692401(slc18a2) 102695707(slc18a1)
LCM: 102351318(SLC18A2)
CMK: 103185206(slc18a2)
SKO: 100367975
DME: Dmel_CG10251(prt) Dmel_CG33528(Vmat)
DSI: Dsimw501_GD18364(Dsim_GD18364) Dsimw501_GD25754(Dsim_GD25754)
AGIF: 122848854
APLN: 108741234
PPOT: 106110671
HAW: 110380111
HAZT: 108675630
EAF: 111707656
DSV: 119460943
RSAN: 119379076
RMP: 119175945
VDE: 111251934
PTEP: 107437267
CEL: CELE_W01C8.6(cat-1)
CBR: CBG_14734(Cbr-cat-1)
BMY: BM_BM4975(Bma-cat-1)
TSP: Tsp_06252
MMER: 123546682
EGL: EGR_02979
ADF: 107337828
AMIL: 114962503
PDAM: 113686527
SPIS: 111324422
BMYC: DJ92_4764
BFD: NCTC4823_00502(tetA_1)
PPO: PPM_1213(M1_1438)
CGV: CGLAU_03610(tetA1)
CCYS: SAMEA4530656_2223(emrB_3)
PAUS: NCTC13651_02180(tetA_2)
RCI: RRC10
 » show all
Reference
  Authors
Eiden LE, Schafer MK, Weihe E, Schutz B
  Title
The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine.
  Journal
Pflugers Arch 447:636-40 (2004)
DOI:10.1007/s00424-003-1100-5
Reference
  Authors
Gasnier B
  Title
The loading of neurotransmitters into synaptic vesicles.
  Journal
Biochimie 82:327-37 (2000)
DOI:10.1016/S0300-9084(00)00221-2
Reference
PMID:8643547
  Authors
Erickson JD, Schafer MK, Bonner TI, Eiden LE, Weihe E
  Title
Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.
  Journal
Proc Natl Acad Sci U S A 93:5166-71 (1996)
DOI:10.1073/pnas.93.10.5166
  Sequence
[hsa:6570]

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