KEGG   ORTHOLOGY: K08249
Entry
K08249                      KO                                     

Name
E4.1.2.11
Definition
hydroxymandelonitrile lyase [EC:4.1.2.11]
Pathway
ko00460  Cyanoamino acid metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00460 Cyanoamino acid metabolism
    K08249  E4.1.2.11; hydroxymandelonitrile lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.11  hydroxymandelonitrile lyase
     K08249  E4.1.2.11; hydroxymandelonitrile lyase
Other DBs
RN: R01409 R02676 R02811
GO: 0050419
Genes
SBI: 110435085 110435343 8066733
SITA: 101776721
Reference
PMID:7948927
  Authors
Wajant H, Mundry KW, Pfizenmaier K
  Title
Molecular cloning of hydroxynitrile lyase from Sorghum bicolor (L.). Homologies to serine carboxypeptidases.
  Journal
Plant Mol Biol 26:735-46 (1994)
DOI:10.1007/BF00013758

KEGG   ENZYME: 4.1.2.11
Entry
EC 4.1.2.11                 Enzyme                                 

Name
hydroxymandelonitrile lyase;
hydroxynitrile lyase;
oxynitrilase;
Sorghum hydroxynitrile lyase;
(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)
Reaction(IUBMB)
(S)-4-hydroxymandelonitrile = cyanide + 4-hydroxybenzaldehyde [RN:R02676]
Reaction(KEGG)
R02676;
(other) R01409 R02811
Substrate
(S)-4-hydroxymandelonitrile [CPD:C03742]
Product
cyanide [CPD:C00177];
4-hydroxybenzaldehyde [CPD:C00633]
Comment
Does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 (mandelonitrile lyase), EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile ketone-lyase (cyanide forming)].
History
EC 4.1.2.11 created 1965, modified 1999
Pathway
ec00460  Cyanoamino acid metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08249  hydroxymandelonitrile lyase
Genes
SBI: 110435085 110435343 8066733
SITA: 101776721
Reference
1
  Authors
Bove, C. and Conn, E.E.
  Title
Metabolism of aromatic compounds in higher plants. II. Purification and properties of the oxynitrilase of Sorghum vulgare.
  Journal
J Biol Chem 236:207-210 (1961)
Reference
2  [PMID:5922969]
  Authors
Seely MK, Criddle RS, Conn EE.
  Title
The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin.
  Journal
J Biol Chem 241:4457-62 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.11
IUBMB Enzyme Nomenclature: 4.1.2.11
ExPASy - ENZYME nomenclature database: 4.1.2.11
BRENDA, the Enzyme Database: 4.1.2.11
CAS: 9075-38-1

KEGG   REACTION: R02676
Entry
R02676                      Reaction                               

Name
4-hydroxymandelonitrile hydroxybenzaldehyde-lyase
Definition
(S)-4-Hydroxymandelonitrile <=> Hydrogen cyanide + 4-Hydroxybenzaldehyde
Equation
Reaction class
RC00597  C00633_C03742
RC00598  C01326_C03742
Enzyme
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K08249  hydroxymandelonitrile lyase [EC:4.1.2.11]
Other DBs
RHEA: 15980

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