KEGG   ORTHOLOGY: K08328
Entry
K08328                      KO                                     

Name
GUCA1
Definition
guanylate cyclase activator 1
Pathway
ko04744  Phototransduction
Disease
H00481  Cone-rod dystrophy and cone dystrophy
H00527  Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09157 Sensory system
   04744 Phototransduction
    K08328  GUCA1; guanylate cyclase activator 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K08328  GUCA1; guanylate cyclase activator 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   K08328  GUCA1; guanylate cyclase activator 1
Other DBs
GO: 0030250
Genes
HSA: 118142757(GUCA1A) 2978(GUCA1A) 2979(GUCA1B) 9626(GUCA1C)
PTR: 460572(GUCA1C) 472007(GUCA1B) 748651(GUCA1A)
PPS: 100969746(GUCA1B) 100970089(GUCA1A) 100991552(GUCA1C)
GGO: 101135017(GUCA1C) 101135053(GUCA1A) 101135896(GUCA1B)
PON: 100443825(GUCA1C) 100458663(GUCA1A) 100459513(GUCA1B)
NLE: 100604636(GUCA1C) 100606451(GUCA1B) 100607696(GUCA1A)
MCC: 695552(GUCA1A) 695658(GUCA1B) 706071(GUCA1C)
MCF: 102133371(GUCA1C) 102146296(GUCA1B) 102146663(GUCA1A)
CSAB: 103221499(GUCA1B) 103221501(GUCA1A) 103228360(GUCA1C)
RRO: 104667313(GUCA1A) 104667314(GUCA1B) 104680581(GUCA1C)
RBB: 108528860(GUCA1C) 108533496(GUCA1B) 108533497(GUCA1A)
CJC: 100387684(GUCA1C) 100397971(GUCA1B) 100408987(GUCA1A)
SBQ: 101029842(GUCA1B) 101041597(GUCA1C) 101048697(GUCA1A)
MMU: 107477(Guca1b) 14913(Guca1a)
MCAL: 110284221(Guca1a) 110284343(Guca1b)
MPAH: 110335787(Guca1b) 110335961(Guca1a)
RNO: 301233(Guca1a) 316218(Guca1b)
MUN: 110550227(Guca1b) 110550244(Guca1a)
CGE: 100766612(Guca1a) 100766902(Guca1b)
NGI: 103726014(Guca1a) 103726023(Guca1b)
HGL: 101705513(Guca1b) 101706235(Guca1a) 106009688(Guca1c)
CCAN: 109682088(Guca1b) 109682185(Guca1a)
OCU: 100351008(GUCA1B) 100359051(GUCA1A) 108177903(GUCA1C)
TUP: 102490015(GUCA1C) 102497234(GUCA1B) 102497651(GUCA1A)
CFA: 481801(GUCA1B) 487968(GUCA1C) 609180(GUCA1A)
VVP: 112913766(GUCA1C) 112913988(GUCA1A) 112913990(GUCA1B)
AML: 100464300 100468451(GUCA1C)
UMR: 103664089(GUCA1B) 103664162(GUCA1A) 103677334(GUCA1C)
UAH: 113256399(GUCA1C) 113261027(GUCA1B) 113261041(GUCA1A)
ORO: 101371140(GUCA1C) 101373845(GUCA1A) 101374139(GUCA1B)
FCA: 101080382(GUCA1A) 101080634(GUCA1B) 101084309(GUCA1C)
PTG: 102960621(GUCA1C) 102961020(GUCA1A) 102969272(GUCA1B)
PPAD: 109266362(GUCA1C) 109271619(GUCA1A) 109271620(GUCA1B)
AJU: 106972267(GUCA1C) 106973972(GUCA1A) 106973986(GUCA1B)
BTA: 282243(GUCA1A) 286851(GUCA1B)
BOM: 102266761(GUCA1B) 102267311(GUCA1A)
BIU: 109576519(GUCA1A) 109576812(GUCA1B)
BBUB: 102415506(GUCA1A) 102416056(GUCA1B)
CHX: 102171919(GUCA1C) 102191474(GUCA1A) 102191747(GUCA1B)
OAS: 101108346(GUCA1A) 101108609(GUCA1B) 101112447(GUCA1C)
SSC: 100739200(GUCA1A) 102167816(GUCA1B)
CFR: 102504037(GUCA1A) 102504285(GUCA1B) 102505485(GUCA1C)
CDK: 105086760(GUCA1A) 105086761(GUCA1B)
BACU: 103005818(GUCA1B) 103006674(GUCA1A) 103011567(GUCA1C)
LVE: 103073868(GUCA1A) 103074145(GUCA1B) 103084658(GUCA1C)
OOR: 101273450(GUCA1B) 101273697(GUCA1A)
DLE: 111178620(GUCA1A) 111178621(GUCA1B)
PCAD: 102986581(GUCA1C) 102988744(GUCA1A) 102989033(GUCA1B)
ECB: 100054522(GUCA1B) 100066702(GUCA1A) 100071815(GUCA1C)
EPZ: 103558056(GUCA1C) 103559454(GUCA1B) 103559457(GUCA1A)
EAI: 106824502(GUCA1A) 106824536(GUCA1B) 106842169(GUCA1C)
MYB: 102250623(GUCA1B) 102250921(GUCA1A)
MYD: 102757876(GUCA1B) 102761465(GUCA1A)
MNA: 107536682(GUCA1C) 107536831(GUCA1B) 107536863(GUCA1A)
HAI: 109382859(GUCA1B) 109382861(GUCA1A) 109387334(GUCA1C)
DRO: 112302294(GUCA1B) 112302485(GUCA1A) 112320451(GUCA1C)
PALE: 102881101(GUCA1B) 102881358(GUCA1A) 102884796(GUCA1C)
RAY: 107501933(GUCA1A) 107502010(GUCA1B) 107519611(GUCA1C)
MJV: 108390303(GUCA1B) 108390305(GUCA1A)
LAV: 100663471(GUCA1B) 100663755(GUCA1A)
MDO: 100010555(GUCA1C) 100030469(GUCA1A)
SHR: 100922216(GUCA1A) 100928880(GUCA1C)
PCW: 110203295(GUCA1A) 110217467(GUCA1C)
OAA: 100077039(GUCA1A) 100077076(GUCA1B) 100078217(GUCA1C) 100087568
GGA: 374216(GUCA1A) 419864(GUCA1B) 427960(GUCA1C) 430443
MGP: 100538407 100542560(GUCA1B) 100542718(GUCA1A) 100549040(GUCA1C) 109364357
CJO: 107317046 107321138(GUCA1C) 107324843(GUCA1A) 107324850(GUCA1B)
NMEL: 110388208(GUCA1B) 110388355(GUCA1A) 110392524 110400774(GUCA1C)
APLA: 101790159(GUCA1B) 101790355(GUCA1A) 101802566(GUCA1C)
ACYG: 106039205(GUCA1C) 106041253(GUCA1B) 106041259(GUCA1A) 106048151
TGU: 100221886(GUCA1C) 100225533 115492489(GUCA1B) 115492493(GUCA1A)
LSR: 110475379(GUCA1A) 110475391(GUCA1B) 110477027(GUCA1C) 110479583
SCAN: 103820732(GUCA1C) 103823271(GUCA1B) 103823327(GUCA1A)
GFR: 102035942(GUCA1B) 102036111(GUCA1A) 102039217 102042123(GUCA1C)
FAB: 101812265(GUCA1A) 101814628(GUCA1B) 101821699 101821964(GUCA1C)
PHI: 102100990(GUCA1A) 102106373(GUCA1C) 102107330 102113392(GUCA1B)
PMAJ: 107198753 107200044(GUCA1C) 107214848(GUCA1A) 107214849(GUCA1B)
CCAE: 111923203 111939806(GUCA1A) 111939807(GUCA1B) 111943909(GUCA1C)
ETL: 114057229(GUCA1C) 114063119(GUCA1B) 114063127(GUCA1A) 114069108
FPG: 101911639(GUCA1C) 101916831 101924247(GUCA1A) 101924422(GUCA1B)
FCH: 102052460(GUCA1B) 102052626(GUCA1A) 102052778(GUCA1C) 102059136
CLV: 102084773(GUCA1C) 102084960 102090494(GUCA1B) 102090680(GUCA1A)
EGZ: 104124389 104125037(GUCA1C) 104126795(GUCA1B) 104126796(GUCA1A)
NNI: 104010313(GUCA1B) 104010314(GUCA1A) 104014122(GUCA1C) 104019906
ACUN: 113488875(GUCA1B) 113488892(GUCA1A) 113489529 113489995(GUCA1C)
PADL: 103916827(GUCA1C) 103923562(GUCA1A) 103923563(GUCA1B) 103924102
AAM: 106486081 106490624(GUCA1C) 106490979(GUCA1B) 106496142
ASN: 102377349(GUCA1C) 102378112 102384385(GUCA1B) 102384639(GUCA1A)
AMJ: 102559358(GUCA1C) 102559646 102571576(GUCA1A) 102571805(GUCA1B)
PSS: 102455136 102457858(GUCA1C) 102461056(GUCA1A)
CMY: 102934841(GUCA1B) 102935074 102936745 102944507(GUCA1C)
CPIC: 101930852(GUCA1B) 101941126(GUCA1A) 101943437 101953086(GUCA1C)
ACS: 100555924(guca1b) 100556029 100558867(guca1a) 100560444(guca1c) 103279985
PVT: 110072362(GUCA1B) 110072382(GUCA1A) 110073516 110085847(GUCA1C)
PBI: 103057518 103064517(GUCA1B) 103065714(GUCA1A)
PMUR: 107292263(GUCA1A) 107292264(GUCA1B) 107293269(GUCA1C)
TSR: 106537599(GUCA1A) 106537699(GUCA1B)
PMUA: 114595905(GUCA1C) 114596599 114598365(GUCA1B) 114599359(GUCA1A) 114605850
GJA: 107109932(GUCA1A) 107109933(GUCA1B) 107123971(GUCA1C)
XLA: 108707686 108707701(guca1c.L) 108709108(guca1c.S) 108715065 444645(guca1a.L) 447368 447765 447777
XTR: 100124863(guca1a) 100379842 100489509(guca1b) 100497028(guca1c) 779962(guca1al)
NPR: 108787353(GUCA1C) 108789676(GUCA1B) 108789678(GUCA1A) 108793467
DRE: 100330921(si:ch211-103a14.5) 140430(guca1a) 140431(guca1b) 373099(guca1c) 393629(guca1e) 494572(guca1g) 494573(guca1d)
EEE: 113567615 113569676(guca1a) 113570036(guca1b)
KMR: 108231951(guca1b) 108233321(guca1a) 108234764 108236008(guca1c) 108243988
PKI: 111844732(guca1b) 111851212(guca1a) 111858063
LCM: 102350299(GUCA1A) 102357477(GUCA1B) 102362011 102366599
RTP: 109914002(guca1b) 109922765(guca1a)
 » show all
Reference
PMID:7983048
  Authors
Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W
  Title
Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene.
  Journal
J Biol Chem 269:31080-9 (1994)
  Sequence
[hsa:2978]
Reference
  Authors
Dizhoor AM, Hurley JB
  Title
Regulation of photoreceptor membrane guanylyl cyclases by guanylyl cyclase activator proteins.
  Journal
Methods 19:521-31 (1999)
DOI:10.1006/meth.1999.0894
Reference
  Authors
Peshenko IV, Dizhoor AM
  Title
Activation and inhibition of photoreceptor guanylyl cyclase by guanylyl cyclase activating protein 1 (GCAP-1): the functional role of Mg2+/Ca2+ exchange in EF-hand domains.
  Journal
J Biol Chem 282:21645-52 (2007)
DOI:10.1074/jbc.M702368200

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