KEGG   ORTHOLOGY: K08352Help
Entry
K08352                      KO                                     

Name
phsA, psrA
Definition
thiosulfate reductase / polysulfide reductase chain A [EC:1.8.5.5]
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K08352  phsA, psrA; thiosulfate reductase / polysulfide reductase chain A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K08352  phsA, psrA; thiosulfate reductase / polysulfide reductase chain A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.8  Acting on a sulfur group of donors
   1.8.5  With a quinone or similar compound as acceptor
    1.8.5.5  thiosulfate reductase (quinone)
     K08352  phsA, psrA; thiosulfate reductase / polysulfide reductase chain A
Transporters [BR:ko02000]
 Other transporters
  Transmembrane electron carriers
   K08352  phsA, psrA; thiosulfate reductase / polysulfide reductase chain A
BRITE hierarchy
Other DBs
RN: R10149
COG: COG0243
TC: 5.A.3.5
Genes
ECY: ECSE_P3-0024
STY: STY2271(phsA)
STT: t0809(phsA)
SEX: STBHUCCB_8630
SENT: TY21A_04105
STM: STM2065(phsA)
SEO: STM14_2555(phsA)
SEV: STMMW_20951
SEY: SL1344_2041(phsA)
SEM: STMDT12_C20870
SEJ: STMUK_2095(phsA)
SEB: STM474_2150(phsA)
SEF: UMN798_2231(phsA)
SENR: STMDT2_20381(phsA)
SEND: DT104_21221(phsA)
SENI: CY43_11140
SEI: SPC_1649(phsA)
SEC: SCH_2074(phsA)
SHB: SU5_02659
SENS: Q786_10195
SED: SeD_A2401(phsA)
SEG: SG2094(phsA)
SEL: SPUL_0835(phsA)
SEGA: SPUCDC_0835(phsA)
SET: SEN2063(phsA)
SENA: AU38_10410
SENO: AU37_10420
SENV: AU39_10420
SENQ: AU40_11665
SENL: IY59_10705
SENB: BN855_21500(phsA)
SENE: IA1_10305
SBG: SBG_1889(phsA)
SBZ: A464_2189
SALZ: EOS98_08685(phsA)
PMR: PMI1814(phsA)
PMIB: BB2000_1921(phsA)
PHAU: PH4a_01215
ETR: ETAE_1845(phsA)
ETD: ETAF_1665
ETE: ETEE_3891
LRI: NCTC12151_02197(psrA)
SON: SO_4062(phsA)
SFR: Sfri_1999
SAZ: Sama_3177
SLO: Shew_0608
SSE: Ssed_4047
SWP: swp_1238
SLJ: EGC82_11685(phsA)
FBL: Fbal_3636
AEH: Mlg_0633
HHA: Hhal_1166
WSU: WS0116(fdhA) WS0709(fdhA)
CGRA: CGRAC_0560
CURE: CUREO_1061
CHYO: CHH_0519
CSPF: CSF_0471
NAM: NAMH_1518
GLO: Glov_1164
DEU: DBW_0837
DVU: DVU0173
DVL: Dvul_2794
DDS: Ddes_1667
DMA: DMR_08220(phaA)
DGG: DGI_0241
DPI: BN4_20079
DRT: Dret_0895
DML: Dmul_02650(phsA)
DTO: TOL2_C03980(phsA)
ADE: Adeh_2632
DBR: Deba_2842
ACR: Acry_0345
AMV: ACMV_03760(psrA)
BBEV: BBEV_1018(psrA-1)
BSE: Bsel_1476
STH: STH109
DSY: DSY3896
DHD: Dhaf_1509
CHY: CHY_2574
MTA: Moth_0450
TACI: TDSAC_1714
LPIL: LIP_1347
GPA: GPA_25490
TTH: TT_C0155
OTE: Oter_1466
MBAS: ALGA_3219
CCH: Cag_0620
CLI: Clim_2400
PPH: Ppha_0912
PAA: Paes_2139
PROC: Ptc2401_02170(psrA)
IAL: IALB_1663
MRO: MROS_1774
CABY: Cabys_1269
CTHI: THC_0921
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hinsley AP, Berks BC
  Title
Specificity of respiratory pathways involved in the reduction of sulfur compounds by Salmonella enterica.
  Journal
Microbiology 148:3631-8 (2002)
DOI:10.1099/00221287-148-11-3631
Reference
PMID:7607234
  Authors
Krafft T, Gross R, Kroger A
  Title
The function of Wolinella succinogenes psr genes in electron transport with polysulphide as the terminal electron acceptor.
  Journal
Eur J Biochem 230:601-6 (1995)
DOI:10.1111/j.1432-1033.1995.0601h.x
Reference
PMID:7751291
  Authors
Heinzinger NK, Fujimoto SY, Clark MA, Moreno MS, Barrett EL
  Title
Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism.
  Journal
J Bacteriol 177:2813-20 (1995)
DOI:10.1128/JB.177.10.2813-2820.1995
  Sequence
[stm:STM2065]

KEGG   ORTHOLOGY: K08353Help
Entry
K08353                      KO                                     

Name
phsB
Definition
thiosulfate reductase electron transport protein
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K08353  phsB; thiosulfate reductase electron transport protein
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K08353  phsB; thiosulfate reductase electron transport protein
Transporters [BR:ko02000]
 Other transporters
  Transmembrane electron carriers
   K08353  phsB; thiosulfate reductase electron transport protein
BRITE hierarchy
Other DBs
RN: R10149
COG: COG0437
TC: 5.A.3.5
Genes
ECY: ECSE_P3-0025
STY: STY2270(phsB)
STT: t0810(phsB)
SEX: STBHUCCB_8640
SENT: TY21A_04110
STM: STM2064(phsB)
SEO: STM14_2554(phsB)
SEV: STMMW_20941
SEY: SL1344_2040(phsB)
SEM: STMDT12_C20860
SEJ: STMUK_2094(phsB)
SEB: STM474_2149(phsB)
SEF: UMN798_2230(phsB)
SENR: STMDT2_20371(phsB)
SEND: DT104_21211(phsB)
SENI: CY43_11135
SPT: SPA0807(phsB)
SEK: SSPA0755
SEI: SPC_1650(phsB)
SEC: SCH_2073(phsB)
SHB: SU5_02658
SENS: Q786_10190
SED: SeD_A2400
SEG: SG2093(phsB)
SEL: SPUL_0836(phsB)
SEGA: SPUCDC_0836(phsB)
SET: SEN2062(phsB)
SENA: AU38_10405
SENO: AU37_10415
SENV: AU39_10415
SENQ: AU40_11660
SENL: IY59_10700
SENE: IA1_10300
SBG: SBG_1888(phsB)
SBZ: A464_2188
CRO: ROD_13831
CBRA: A6J81_00995(phsB)
CIF: AL515_09930(phsB)
CIE: AN232_13870(phsB)
CPAR: CUC49_05305(phsB)
PHAU: PH4a_01220
ETR: ETAE_1844(phsB)
ETD: ETAF_1664(phsB)
ETE: ETEE_3890(phsB)
LRI: NCTC12151_02196(dmsB_2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hinsley AP, Berks BC
  Title
Specificity of respiratory pathways involved in the reduction of sulfur compounds by Salmonella enterica.
  Journal
Microbiology 148:3631-8 (2002)
DOI:10.1099/00221287-148-11-3631
Reference
PMID:7751291
  Authors
Heinzinger NK, Fujimoto SY, Clark MA, Moreno MS, Barrett EL
  Title
Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism.
  Journal
J Bacteriol 177:2813-20 (1995)
DOI:10.1128/JB.177.10.2813-2820.1995
  Sequence
[stm:STM2064]

KEGG   ORTHOLOGY: K08354Help
Entry
K08354                      KO                                     

Name
phsC
Definition
thiosulfate reductase cytochrome b subunit
Pathway
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K08354  phsC; thiosulfate reductase cytochrome b subunit
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K08354  phsC; thiosulfate reductase cytochrome b subunit
Transporters [BR:ko02000]
 Other transporters
  Transmembrane electron carriers
   K08354  phsC; thiosulfate reductase cytochrome b subunit
BRITE hierarchy
Other DBs
RN: R10149
COG: COG4117
TC: 5.A.3.5
Genes
ECO: b1670(ydhU)
ECJ: JW1660(ydhU)
ECD: ECDH10B_1804(ydhU)
EBW: BWG_1484(ydhU)
ECOK: ECMDS42_1341(ydhU)
ECE: Z2697(ydhU)
ECS: ECs2377
ECF: ECH74115_2383
ETW: ECSP_2237(ydhU)
ELX: CDCO157_2211
EOJ: ECO26_2398(ydhU)
EOI: ECO111_2139(ydhU)
EOH: ECO103_1810(ydhU)
ECOO: ECRM13514_2165(ydhU)
ECOH: ECRM13516_2067(ydhU)
ECG: E2348C_1755(ydhU)
EOK: G2583_2065(ydhU)
ESO: O3O_13750
ESM: O3M_11850
ESL: O3K_11885
ELH: ETEC_1703
ECC: c2064(ydhU)
ECP: ECP_1617
ECI: UTI89_C1862(ydhU)
ECV: APECO1_749(ydhU)
ECR: ECIAI1_1721(ydhU)
ECQ: ECED1_1868(ydhU)
ECK: EC55989_1837(ydhU)
ECT: ECIAI39_1387(ydhU)
EOC: CE10_1943(ydhU)
EUM: ECUMN_1959(ydhU)
ECZ: ECS88_1718(ydhU)
ESE: ECSF_1530
EBR: ECB_01639(ydhU)
EBD: ECBD_1975
EKF: KO11_14395(ydhU)
EAB: ECABU_c19240(ydhU)
EDJ: ECDH1ME8569_1614(ydhU)
ENA: ECNA114_1716(ydhU)
ELW: ECW_m1837(ydhU)
ELL: WFL_09000(ydhU)
ELC: i14_1886(ydhU)
ELD: i02_1886(ydhU)
ELP: P12B_c1412(ydhU)
EBL: ECD_01639(ydhU)
EBE: B21_01629(ydhU)
ELF: LF82_2863(ydhU)
ECOJ: P423_08925
ECOS: EC958_1890(ydhU)
STY: STY2269(phsC)
STT: t0811(phsC)
STM: STM2063(phsC)
SEO: STM14_2553(phsC)
SEY: SL1344_2039(phsC)
SEJ: STMUK_2093(phsC)
SEB: STM474_2148(phsC)
SEF: UMN798_2229(phsC)
SENR: STMDT2_20361(phsC)
SEND: DT104_21201(phsC)
SENI: CY43_11130
SPT: SPA0808(phsC)
SEK: SSPA0756
SEI: SPC_1651(phsC)
SEC: SCH_2072
SHB: SU5_02657
SENS: Q786_10185
SED: SeD_A2399
SEG: SG2092(phsC)
SEL: SPUL_0837(phsC)
SEGA: SPUCDC_0837(phsC)
SET: SEN2061(phsC)
SENA: AU38_10400
SENO: AU37_10410
SENV: AU39_10410
SENQ: AU40_11655
SENL: IY59_10695
SEEP: I137_03770
SENE: IA1_10295
SBG: SBG_1887(phsC)
SBZ: A464_2187
SFL: SF1698(ydhU)
SFX: S1830(ydhU)
SFV: SFV_1692(ydhU)
SFE: SFxv_1904
SFN: SFy_2432
SFS: SFyv_2486
SSN: SSON_1486(ydhU)
SBO: SBO_1462(ydhU)
SDY: SDY_1898(ydhU)
CKO: CKO_01695
CRO: ROD_13841
PMR: PMI0066 PMI1816(phsC)
ETR: ETAE_1843(phsC)
ETD: ETAF_1663
ETE: ETEE_3889
MAGQ: MGMAQ_1684
DORI: FH5T_16955
MBAS: ALGA_3877
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hinsley AP, Berks BC
  Title
Specificity of respiratory pathways involved in the reduction of sulfur compounds by Salmonella enterica.
  Journal
Microbiology 148:3631-8 (2002)
DOI:10.1099/00221287-148-11-3631
Reference
PMID:7751291
  Authors
Heinzinger NK, Fujimoto SY, Clark MA, Moreno MS, Barrett EL
  Title
Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism.
  Journal
J Bacteriol 177:2813-20 (1995)
DOI:10.1128/JB.177.10.2813-2820.1995
  Sequence
[stm:STM2063]

KEGG   ENZYME: 1.8.5.5Help
Entry
EC 1.8.5.5                  Enzyme                                 

Name
thiosulfate reductase (quinone);
phsABC (gene names)
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
sulfite,hydrogen sulfide:quinone oxidoreductase
Reaction(IUBMB)
sulfite + hydrogen sulfide + a quinone = thiosulfate + a quinol [RN:R11488]
Reaction(KEGG)
Substrate
sulfite [CPD:C00094];
hydrogen sulfide [CPD:C00283];
quinone [CPD:C15602]
Product
thiosulfate [CPD:C00320];
quinol [CPD:C15603]
Comment
The enzyme, characterized from the bacterium Salmonella enterica, is similar to EC 1.17.5.3, formate dehydrogenase-N. It contains a molybdopterin-guanine dinucleotide, five [4Fe-4S] clusters and two heme b groups. The reaction occurs in vivo in the direction of thiosulfate disproportionation, which is highly endergonic. It is driven by the proton motive force that occurs across the cytoplasmic membrane.
History
EC 1.8.5.5 created 2016, modified 2017
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08352  thiosulfate reductase / polysulfide reductase chain A
Genes
ECY: ECSE_P3-0024
STY: STY2271(phsA)
STT: t0809(phsA)
SEX: STBHUCCB_8630
SENT: TY21A_04105
STM: STM2065(phsA)
SEO: STM14_2555(phsA)
SEV: STMMW_20951
SEY: SL1344_2041(phsA)
SEM: STMDT12_C20870
SEJ: STMUK_2095(phsA)
SEB: STM474_2150(phsA)
SEF: UMN798_2231(phsA)
SENR: STMDT2_20381(phsA)
SEND: DT104_21221(phsA)
SENI: CY43_11140
SEI: SPC_1649(phsA)
SEC: SCH_2074(phsA)
SHB: SU5_02659
SENS: Q786_10195
SED: SeD_A2401(phsA)
SEG: SG2094(phsA)
SEL: SPUL_0835(phsA)
SEGA: SPUCDC_0835(phsA)
SET: SEN2063(phsA)
SENA: AU38_10410
SENO: AU37_10420
SENV: AU39_10420
SENQ: AU40_11665
SENL: IY59_10705
SENB: BN855_21500(phsA)
SENE: IA1_10305
SBG: SBG_1889(phsA)
SBZ: A464_2189
SALZ: EOS98_08685(phsA)
PMR: PMI1814(phsA)
PMIB: BB2000_1921(phsA)
PHAU: PH4a_01215
ETR: ETAE_1845(phsA)
ETD: ETAF_1665
ETE: ETEE_3891
LRI: NCTC12151_02197(psrA)
SON: SO_4062(phsA)
SFR: Sfri_1999
SAZ: Sama_3177
SLO: Shew_0608
SSE: Ssed_4047
SWP: swp_1238
SLJ: EGC82_11685(phsA)
FBL: Fbal_3636
AEH: Mlg_0633
HHA: Hhal_1166
WSU: WS0116(fdhA) WS0709(fdhA)
CGRA: CGRAC_0560
CURE: CUREO_1061
CHYO: CHH_0519
CSPF: CSF_0471
NAM: NAMH_1518
GLO: Glov_1164
DEU: DBW_0837
DVU: DVU0173
DVL: Dvul_2794
DDS: Ddes_1667
DMA: DMR_08220(phaA)
DGG: DGI_0241
DPI: BN4_20079
DRT: Dret_0895
DML: Dmul_02650(phsA)
DTO: TOL2_C03980(phsA)
ADE: Adeh_2632
DBR: Deba_2842
ACR: Acry_0345
AMV: ACMV_03760(psrA)
BBEV: BBEV_1018(psrA-1)
BSE: Bsel_1476
STH: STH109
DSY: DSY3896
DHD: Dhaf_1509
CHY: CHY_2574
MTA: Moth_0450
TACI: TDSAC_1714
LPIL: LIP_1347
GPA: GPA_25490
TTH: TT_C0155
OTE: Oter_1466
MBAS: ALGA_3219
CCH: Cag_0620
CLI: Clim_2400
PPH: Ppha_0912
PAA: Paes_2139
PROC: Ptc2401_02170(psrA)
IAL: IALB_1663
MRO: MROS_1774
CABY: Cabys_1269
CTHI: THC_0921
 » show all
Taxonomy
Reference
1  [PMID:6384182]
  Authors
Kwan HS, Barrett EL
  Title
Map locations and functions of Salmonella typhimurium men genes.
  Journal
J Bacteriol 159:1090-2 (1984)
Reference
2  [PMID:3108233]
  Authors
Clark MA, Barrett EL
  Title
The phs gene and hydrogen sulfide production by Salmonella typhimurium.
  Journal
J Bacteriol 169:2391-7 (1987)
DOI:10.1128/JB.169.6.2391-2397.1987
Reference
3  [PMID:7737516]
  Authors
Alami N, Hallenbeck PC
  Title
Cloning and characterization of a gene cluster, phsBCDEF, necessary for the production of hydrogen sulfide from thiosulfate by Salmonella typhimurium.
  Journal
Gene 156:53-7 (1995)
DOI:10.1016/0378-1119(94)00930-Q
  Sequence
Reference
4  [PMID:7751291]
  Authors
Heinzinger NK, Fujimoto SY, Clark MA, Moreno MS, Barrett EL
  Title
Sequence analysis of the phs operon in Salmonella typhimurium and the contribution of thiosulfate reduction to anaerobic energy metabolism.
  Journal
J Bacteriol 177:2813-20 (1995)
DOI:10.1128/JB.177.10.2813-2820.1995
  Sequence
Reference
5  [PMID:22081391]
  Authors
Stoffels L, Krehenbrink M, Berks BC, Unden G
  Title
Thiosulfate reduction in Salmonella enterica is driven by the proton motive force.
  Journal
J Bacteriol 194:475-85 (2012)
DOI:10.1128/JB.06014-11
Other DBs
ExplorEnz - The Enzyme Database: 1.8.5.5
IUBMB Enzyme Nomenclature: 1.8.5.5
ExPASy - ENZYME nomenclature database: 1.8.5.5
BRENDA, the Enzyme Database: 1.8.5.5

KEGG   REACTION: R10149Help
Entry
R10149                      Reaction                               

Definition
Thiosulfate + Menaquinol <=> HSO3- + Hydrogen sulfide + Menaquinone
Equation
Comment
thiosulfate reductase
Reaction class
RC00819  C00828_C05819
RC02823  C00283_C00320
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K08352  thiosulfate reductase / polysulfide reductase chain A [EC:1.8.5.5]
K08353  thiosulfate reductase electron transport protein
K08354  thiosulfate reductase cytochrome b subunit

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