KEGG ORTHOLOGY: K08536

ORTHOLOGY: K08536

Entry

K08536                      KO

Symbol

NR1H3, LXRA

Name

liver X receptor alpha

Pathway

map03320

PPAR signaling pathway

map04148

Efferocytosis

map04931

Insulin resistance

map04932

Non-alcoholic fatty liver disease

map05160

Hepatitis C

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K08536  NR1H3, LXRA; liver X receptor alpha
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K08536  NR1H3, LXRA; liver X receptor alpha
09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K08536  NR1H3, LXRA; liver X receptor alpha
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08536  NR1H3, LXRA; liver X receptor alpha
   04931 Insulin resistance
    K08536  NR1H3, LXRA; liver X receptor alpha
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08536  NR1H3, LXRA; liver X receptor alpha
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08536  NR1H3, LXRA; liver X receptor alpha
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08536  NR1H3, LXRA; liver X receptor alpha
Nuclear receptors [BR:ko03310]
1. Thyroid hormone like
  1H. Liver X receptor like receptor
   K08536  NR1H3, LXRA; liver X receptor alpha

Genes

HSA:	10062(NR1H3)

PTR:	466507(NR1H3)

PPS:	100971327(NR1H3)

GGO:	101126697(NR1H3)

PON:	100453246(NR1H3)

PPYG:

129008018(NR1H3)

NLE:	100605954(NR1H3)

HMH:	116476281(NR1H3)

SSYN:

129484152(NR1H3)

MCC:	713679(NR1H3)

MCF:	102122176(NR1H3)

MTHB:

126936383

MNI:	105471680(NR1H3)

CSAB:

103236235(NR1H3)

CATY:

105592814(NR1H3)

PANU:

100997292(NR1H3)

TGE:	112606093(NR1H3)

MLEU:

105554814(NR1H3)

RRO:	104668406(NR1H3)

RBB:	108521961(NR1H3)

TFN:	117080144(NR1H3)

PTEH:

111544892(NR1H3)

CANG:

105527125(NR1H3)

CJC:	100388967(NR1H3)

SBQ:	101027381(NR1H3)

CIMI:

108304849(NR1H3)

ANAN:

105717346(NR1H3)

CSYR:

103261207(NR1H3)

MMUR:

105884841(NR1H3)

LCAT:

123642670(NR1H3)

PCOQ:

105811098(NR1H3)

OGA:	100963453(NR1H3)

MMU:	22259(Nr1h3)

MCAL:

110290092(Nr1h3)

MPAH:

110319594(Nr1h3)

RNO:	58852(Nr1h3)

MCOC:

116090464(Nr1h3)

ANU:	117703799(Nr1h3)

MUN:	110550752(Nr1h3)

CGE:	100756988(Nr1h3)

MAUA:

101844164(Nr1h3)

PROB:

127222250(Nr1h3)

PLEU:

114699685(Nr1h3)

MORG:

121437670(Nr1h3)

MFOT:

126489768

AAMP:

119815699(Nr1h3)

NGI:	103742506(Nr1h3)

HGL:	101709627(Nr1h3)

CPOC:

100725013(Nr1h3)

CCAN:

109696188(Nr1h3)

DORD:

105996055(Nr1h3)

DSP:	122104986(Nr1h3)

PLOP:

125362235(Nr1h3)

NCAR:

124960239

MMMA:

107135811(Nr1h3)

OCU:	100352900(NR1H3)

OPI:	101526478(NR1H3)

TUP:	102470906(NR1H3)

GVR:	103592095(NR1H3)

CFA:	483625(NR1H3)

CLUD:

112663309(NR1H3)

VVP:	112924074(NR1H3)

VLG:	121472219(NR1H3)

NPO:	129499069(NR1H3)

AML:	100474551(NR1H3)

UMR:	103672313(NR1H3)

UAH:	113264967(NR1H3)

UAR:	123785017(NR1H3)

ELK:

111150112

LLV:

125078753

MPUF:

101692562(NR1H3)

MNP:	132008231 132008426

MLK:	131812350(NR1H3)

NVS:	122912893(NR1H3)

ORO:	101378256(NR1H3)

EJU:	114215361(NR1H3)

ZCA:	113913862(NR1H3)

MLX:	118015829(NR1H3)

NSU:	110575771(NR1H3)

LWW:	102739263(NR1H3)

FCA:	101092889(NR1H3)

PYU:	121043456(NR1H3)

PCOO:

112866158(NR1H3)

PBG:	122484437(NR1H3)

PVIV:

125176369(NR1H3)

LRUF:

124504923

PTG:	102961389(NR1H3)

PPAD:

109245119(NR1H3)

PUC:

125934009

AJU:

106978022

HHV:	120228478(NR1H3)

BTA:	507176(NR1H3)

BOM:	102273526(NR1H3)

BIU:	109569543(NR1H3)

BBIS:

104990349(NR1H3)

CHX:	100860906(NR1H3)

OAS:	101116762(NR1H3)

BTAX:

128060316(NR1H3)

ODA:	120876948(NR1H3)

CCAD:

122450467(NR1H3)

MBEZ:

129554814(NR1H3)

SSC:	397553(NR1H3)

CFR:	102524294(NR1H3)

CBAI:

105076451(NR1H3)

CDK:	105106874(NR1H3)

VPC:	102531242(NR1H3)

BACU:

103020980(NR1H3)

BMUS:

118899131(NR1H3)

LVE:	103078468(NR1H3)

OOR:	101270749(NR1H3)

DLE:	111183967(NR1H3)

PCAD:

102993698(NR1H3)

PSIU:

116757746(NR1H3)

NASI:

112402081(NR1H3)

ECB:	100051253(NR1H3)

EPZ:	103566773(NR1H3)

EAI:	106844011(NR1H3)

MYB:	102256806(NR1H3)

MYD:	102755020(NR1H3)

MMYO:

118665063(NR1H3)

MLF:	102423593(NR1H3)

MDT:	132241201(NR1H3)

PKL:	118713532(NR1H3)

EFUS:

103290835(NR1H3)

MNA:	107530308(NR1H3)

DRO:	112303327(NR1H3)

SHON:

118974480(NR1H3)

AJM:	119064433(NR1H3)

PDIC:

114499559(NR1H3)

PHAS:

123810168(NR1H3)

MMF:	118627553(NR1H3)

PPAM:

129081432(NR1H3)

HAI:

109390175

RFQ:	117029992(NR1H3)

PALE:

102879732(NR1H3)

PGIG:

120607208(NR1H3)

PVP:	105290031(NR1H3)

RAY:	107511849(NR1H3)

MJV:	108388644(NR1H3)

TOD:	119255300(NR1H3)

SARA:

101547453(NR1H3)

SETR:

126017928(NR1H3)

LAV:	100673961(NR1H3)

TMU:

101350241

ETF:	101646597(NR1H3)

DNM:	101426093(NR1H3)

MDO:	100124291(NR1H3)

GAS:	123251084(NR1H3)

SHR:	100916753(NR1H3)

AFZ:

127540913

PCW:	110223918(NR1H3)

TVP:	118853907(NR1H3)

OAA:	100088231(NR1H3)

GGA:	395221(NR1H3)

PCOC:

116229157(NR1H3)

MGP:	100548441 104911104

CJO:	107314747(NR1H3)

TPAI:

128086328(NR1H3)

LMUT:

125694605(NR1H3)

NMEL:

110400977(NR1H3)

APLA:

101789691(NR1H3)

ACYG:

106043679(NR1H3)

CATA:

118249906(NR1H3)

AFUL:

116489839(NR1H3)

TGU:	100224796(NR1H3)

LSR:	110472063(NR1H3)

SCAN:

103826694(NR1H3)

PMOA:

120500412(NR1H3)

OTC:	121335095(NR1H3)

PRUF:

121349391(NR1H3)

GFR:	102035443(NR1H3)

FAB:	101814161(NR1H3)

OMA:	130253746(NR1H3)

PHI:	102113251(NR1H3)

PMAJ:

107205450(NR1H3)

CCAE:

111930174(NR1H3)

CCW:	104697919(NR1H3)

CBRC:

103620738(NR1H3)

ETL:	114058903(NR1H3)

ZAB:	102069499(NR1H3)

ZLE:	135448336(NR1H3)

ACHL:

103798656(NR1H3)

SVG:	106856518(NR1H3)

MMEA:

130572845(NR1H3)

HRT:	120754536(NR1H3)

SATI:

136362514(NR1H3)

FPG:	101910810(NR1H3)

FCH:	102048486(NR1H3)

CCRI:

104162181(NR1H3)

NNT:	104400667(NR1H3)

SHAB:

115606120(NR1H3)

ACUN:

113480619(NR1H3)

TALA:

104356472(NR1H3)

ACHC:

115334352(NR1H3)

HALD:

104321648(NR1H3)

HLE:	104839699(NR1H3)

AGEN:

126049443

GCL:

127016452

CSTI:

104554091(NR1H3)

LDI:	104344530(NR1H3)

MNB:	103780833(NR1H3)

DPUB:

104297430(NR1H3)

AVIT:

104275732(NR1H3)

BRHI:

104496259(NR1H3)

EGZ:	104134070(NR1H3)

NNI:	104020385(NR1H3)

PCRI:

104032592(NR1H3)

PCAO:

104047836(NR1H3)

PADL:

103921703(NR1H3)

AFOR:

103897474(NR1H3)

FGA:	104071254(NR1H3)

GSTE:

104262588(NR1H3)

CLV:	102086773(NR1H3)

MUI:	104541027(NR1H3)

PGUU:

104471742(NR1H3)

PLET:

104623830(NR1H3)

EHS:	104504250(NR1H3)

CMAC:

104474697(NR1H3)

CUCA:

104067303(NR1H3)

TEO:	104384218(NR1H3)

BREG:

104639495(NR1H3)

OHA:	104328087(NR1H3)

ACAR:

104528076

CPEA:

104390408(NR1H3)

CVF:	104295852(NR1H3)

RTD:	128908464(NR1H3)

AAM:	106498279(NR1H3)

AROW:

112973929(NR1H3)

NPD:	112943804(NR1H3)

TGT:	104574987(NR1H3)

DNE:	112979212(NR1H3)

SCAM:

104149239(NR1H3)

ASN:	102372676(NR1H3)

AMJ:	102570390(NR1H3)

CPOO:

109321387(NR1H3)

GGN:	109298893(NR1H3)

PSS:	102462146(NR1H3)

CMY:	102941155(NR1H3)

CCAY:

125637541(NR1H3)

DCC:	119857836(NR1H3)

CPIC:

101942487(NR1H3)

TST:	117876920(NR1H3)

CABI:

116825875(NR1H3)

MRV:	120403279(NR1H3)

ACS:	100567692(nr1h3)

ASAO:

132767940(NR1H3)

PVT:	110082017(NR1H3)

SUND:

121922620(NR1H3)

PBI:	103059096(NR1H3)

PMUR:

107289838(NR1H3)

CTIG:

120314639(NR1H3)

TSR:	106552441(NR1H3)

PGUT:

117665533(NR1H3)

APRI:

131187480(NR1H3)

PTEX:

113441139(NR1H3)

NSS:	113414344(NR1H3)

VKO:	123026301(NR1H3)

PMUA:

114595776(NR1H3)

PRAF:

128413004(NR1H3)

ZVI:	118084837(NR1H3)

HCG:	128340430(NR1H3)

GJA:	107123209(NR1H3)

STOW:

125425967(NR1H3)

EMC:	129324312(NR1H3)

MUO:	115468847(NR1H3)

GSH:	117352172(NR1H3)

DRE:	548341(nr1h3)

SRX:	107740482 107755109

SANH:

107664377 107689968

SGH:	107553099 107563452

CCAR:

109063142 109063146

CAUA:

113051496 113106024

CGIB:

127961992 128016889

PTET:

122349293(nr1h3)

LROH:

127168398(nr1h3)

OMC:	131544398(nr1h3)

PPRM:

120490960(nr1h3)

RKG:	130099649(nr1h3)

MAMB:

125264803(nr1h3)

CIDE:

127515544

CERY:

137031371(nr1h3)

MASI:

127446661 127455588

TDW:	130430103(nr1h3)

MANU:

129444385(nr1h3)

IPU:

108259587

IFU:	128602922(nr1h3)

PHYP:

113540920(nr1h3)

SMEO:

124380029(nr1h3)

TFD:	113636740(nr1h3)

TVC:	132838863(nr1h3)

TRN:	134303977(nr1h3)

AMEX:

103030650(nr1h3)

CMAO:

118817506(nr1h3)

EEE:	113574111(nr1h3)

CHAR:

105906540(nr1h3)

TRU:	101071817(nr1h3)

TFS:	130521764(nr1h3)

LCO:	104920625(nr1h3)

NCC:	104955310(nr1h3)

TBEN:

117471313(nr1h3)

CGOB:

115025058(nr1h3)

PGEO:

117464281(nr1h3)

GACU:

117549429(nr1h3)

EMAC:

134862608(nr1h3)

ELY:	117255500(nr1h3)

EFO:	125902405(nr1h3)

PLEP:

121946124(nr1h3)

SLUC:

116043386(nr1h3)

ECRA:

117944866(nr1h3)

ESP:	116691766(nr1h3)

PFLV:

114553848(nr1h3)

GAT:	120835797(nr1h3)

PPUG:

119229114(nr1h3)

AFB:	129101707(nr1h3)

CLUM:

117747531(nr1h3)

PSWI:

130192725(nr1h3)

MSAM:

119889711(nr1h3)

SCHU:

122878755(nr1h3)

CUD:	121510751(nr1h3)

ALAT:

119017958(nr1h3)

MZE:	101487674(nr1h3)

ONL:	100702741(nr1h3)

OAU:	116324024(nr1h3)

OLA:	101163474(nr1h3)

OML:	112160647(nr1h3)

CSAI:

133459208(nr1h3)

XMA:	102221658(nr1h3)

XCO:	114143060(nr1h3)

XHE:	116718298(nr1h3)

PRET:

103462712(nr1h3)

PFOR:

103149704(nr1h3)

PLAI:

106938308(nr1h3)

PMEI:

106911832(nr1h3)

GAF:	122845880(nr1h3)

PPRL:

129364293(nr1h3)

CVG:	107095562(nr1h3)

CTUL:

119773585(nr1h3)

GMU:	124867022(nr1h3)

NFU:	107381957(nr1h3)

KMR:	108234799(nr1h3)

ALIM:

106523554(nr1h3)

NWH:	119430236(nr1h3)

AOCE:

111571031

MCEP:

125005302(nr1h3)

CSEM:

103398631(nr1h3)

POV:	109637258(nr1h3)

SSEN:

122772301(nr1h3)

HHIP:

117759195(nr1h3)

HSP:	118112735(nr1h3)

PPLT:

128449291(nr1h3)

SMAU:

118302037(nr1h3)

LCF:

108887816

SDU:	111223407(nr1h3)

SLAL:

111644318(nr1h3)

XGL:	120791626(nr1h3)

HCQ:	109525775(nr1h3)

SSCV:

125967245

SBIA:

133498421(nr1h3)

PEE:	133399122(nr1h3)

PTAO:

133471869(nr1h3)

BPEC:

110162465(nr1h3)

MALB:

109965075(nr1h3)

BSPL:

114851792(nr1h3)

SJO:	128379575(nr1h3)

SASA:

100270809(nr1h3) 106561932

STRU:

115167550 115202857

OTW:	112248987 112263485

OMY:	100286817(nr1h3) 110506299

OGO:	124033933(nr1h3) 124035905

ONE:	115112058 115113472

OKI:	109885055 109895544

OKE:	118357526 118393657

SALP:

111969202 111974002

SNH:	120024726 120045480

CCLU:

121534848 121573295

ELS:	105025968(nr1h3)

SFM:	108938803 108940795

PKI:	111843355(nr1h3) 111851925

AANG:

118227325(nr1h3)

LOC:	102684692(nr1h3)

PSPA:

121294502 121329926

ARUT:

117432029 117434977

PSEX:

120529906(nr1h3)

LCM:	102349225(NR1H3)

CPLA:

HOC:

LERI:

PMRN:

BFO:

BBEL:

CIN:

SPU:	574588(Ecr/Fxr)

LPIC:

129282874 129283091

APLC:

110990097

ARUN:

117291254

SKO:	100313647 102800686

ACOO:

HVI:

MQU:

FCD:

DPZ:

TCF:	131882656 131884821

LPOL:

106457829 106461441 106467738 106472442 106475416

PMEO:

129580766

CBR:

CBG_01321

LGI:	LOTGIDRAFT_122846

BGT:

106052335

GAE:	121380533 121386287

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MMER:

RPHI:

DPOL:

MAEA:

OSN:

LAK:

LLON:

Reference

PMID:19520913

Authors

Zelcer N, Hong C, Boyadjian R, Tontonoz P

Title

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

Journal

Science 325:100-4 (2009)
DOI:10.1126/science.1168974

Sequence

[mmu:22259]

Reference

PMID:7744246

Authors

Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ

Title

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

Journal

Genes Dev 9:1033-45 (1995)
DOI:10.1101/gad.9.9.1033

Sequence

[hsa:10062]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (10)   
Drug (2)   
   KEGG DRUG (2)   
Gene (823)   
   KEGG GENES (455)   
   KEGG MGENES (78)   
   RefGene (287)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (840)   

Download RDF

DBGET integrated database retrieval system