KEGG   ORTHOLOGY: K08660
Entry
K08660                      KO                                     

Name
CNDP2
Definition
cytosolic nonspecific dipeptidase [EC:3.4.13.18]
Pathway
ko00330  Arginine and proline metabolism
ko00340  Histidine metabolism
ko00410  beta-Alanine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K08660  CNDP2; cytosolic nonspecific dipeptidase
   00340 Histidine metabolism
    K08660  CNDP2; cytosolic nonspecific dipeptidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K08660  CNDP2; cytosolic nonspecific dipeptidase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08660  CNDP2; cytosolic nonspecific dipeptidase
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K08660  CNDP2; cytosolic nonspecific dipeptidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.13  Dipeptidases
    3.4.13.18  cytosol nonspecific dipeptidase
     K08660  CNDP2; cytosolic nonspecific dipeptidase
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M20
   K08660  CNDP2; cytosolic nonspecific dipeptidase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast milk
   K08660  CNDP2; cytosolic nonspecific dipeptidase
Other DBs
RN: R01166 R01992
Genes
HSA: 55748(CNDP2)
PTR: 455473(CNDP2)
PPS: 100970514(CNDP2)
GGO: 101126755(CNDP2)
PON: 100174694(CNDP2)
NLE: 100583155(CNDP2)
MCC: 114675568 695080(CNDP2)
MCF: 101865174(CNDP2)
CSAB: 103244083(CNDP2)
RRO: 104656990(CNDP2)
RBB: 108525047(CNDP2)
CJC: 100393355(CNDP2)
SBQ: 101053821(CNDP2)
MMU: 66054(Cndp2)
MCAL: 110284520(Cndp2)
MPAH: 110332928(Cndp2)
RNO: 291394(Cndp2)
MUN: 110555521(Cndp2)
CGE: 100760626(Cndp2)
NGI: 103748118(Cndp2)
HGL: 101709694(Cndp2)
CCAN: 109700927(Cndp2)
OCU: 100347984(CNDP2)
TUP: 102489914(CNDP2)
CFA: 476166(CNDP2)
VVP: 112919332(CNDP2)
AML: 100466673(CNDP2)
UMR: 103658414(CNDP2)
UAH: 113253527(CNDP2)
ORO: 101378244(CNDP2)
ELK: 111154262
FCA: 101095774(CNDP2)
PTG: 102964722(CNDP2)
PPAD: 109251777(CNDP2)
AJU: 106982249(CNDP2)
BTA: 512626(CNDP2)
BOM: 102267439(CNDP2)
BIU: 109577882(CNDP2)
BBUB: 102400679(CNDP2)
CHX: 102189261(CNDP2)
OAS: 101111244(CNDP2)
SSC: 100158127(CNDP2)
CFR: 102510239(CNDP2)
CDK: 105105096(CNDP2)
BACU: 103016660(CNDP2)
LVE: 103085206(CNDP2)
OOR: 101280936(CNDP2)
DLE: 111167306(CNDP2)
PCAD: 102990839(CNDP2)
ECB: 100061697(CNDP2)
EPZ: 103561747(CNDP2)
EAI: 106832864
MYB: 102242032(CNDP2)
MYD: 102767302(CNDP2)
MNA: 107537573(CNDP2)
HAI: 109383204(CNDP2)
DRO: 112322720(CNDP2)
PALE: 102880342(CNDP2)
RAY: 107512646(CNDP2)
MJV: 108409041(CNDP2)
LAV: 100668146(CNDP2)
TMU: 101353090
MDO: 100016094(CNDP2)
SHR: 100920874(CNDP2)
PCW: 110215842(CNDP2)
OAA: 100076934
GGA: 421013(CNDP2)
MGP: 100541349(CNDP2)
CJO: 107309961(CNDP2)
NMEL: 110394204(CNDP2)
APLA: 101791366(CNDP2)
ACYG: 106036016(CNDP2)
TGU: 100229152(CNDP2)
LSR: 110470875(CNDP2)
SCAN: 103826354(CNDP2)
GFR: 102034558(CNDP2)
FAB: 101807367(CNDP2)
PHI: 102114713(CNDP2)
PMAJ: 107200307(CNDP2)
CCAE: 111925251(CNDP2)
CCW: 104685798(CNDP2)
ETL: 114057531(CNDP2)
FPG: 101914717(CNDP2)
FCH: 102052576(CNDP2)
CLV: 102092467(CNDP2)
EGZ: 104128656(CNDP2)
NNI: 104018185(CNDP2)
ACUN: 113477172(CNDP2)
PADL: 103924880(CNDP2)
AAM: 106484108(CNDP2)
ASN: 102368140
AMJ: 102560010 102563504(CNDP2)
PSS: 102446043(CNDP2)
CMY: 102938228(CNDP2)
CPIC: 101937378(CNDP2)
ACS: 100553967(cndp2) 100556028
PVT: 110083373 110083377(CNDP2)
PBI: 103052866(CNDP2)
PMUR: 107291689(CNDP2)
TSR: 106538260(CNDP2)
PMUA: 114600794(CNDP2)
GJA: 107115121(CNDP2)
XLA: 108695220 380001(cndp2.S) 398689(darmin.L) 446978(cndp2.L)
XTR: 394903(darmin) 394907(cndp2)
NPR: 108799251
DRE: 327288(cndp2)
IPU: 108257136(cndp2)
PHYP: 113536259(cndp2)
AMEX: 103024590(cndp2)
EEE: 113585121(cndp2)
TRU: 101066809
LCO: 104927574(cndp2)
NCC: 104962947(cndp2)
OLA: 101158501(cndp2)
XMA: 102232950
XCO: 114156569
PRET: 103472482 103472483(cndp2)
NFU: 107394616(cndp2)
KMR: 108237889(cndp2)
ALIM: 106536426
AOCE: 111585218(cndp2)
CSEM: 103394277(cndp2)
LCF: 108879475(cndp2)
SDU: 111223447(cndp2)
SLAL: 111657615(cndp2)
HCQ: 109512013(cndp2)
BPEC: 110161127(cndp2)
MALB: 109958636(cndp2)
ELS: 105012659(cndp2) 105019195
PKI: 111852260(cndp2)
LCM: 102355182(CNDP2)
CMK: 103184951(cndp2)
SPU: 594228
DME: Dmel_CG17337(Cndp2)
DSE: 6619122
DSI: Dsimw501_GD10382(Dsim_GD10382)
DAN: 6496679
DSR: 110189385
MDE: 101898638
AAG: 5571265
AALB: 109423371
AME: 412393
BIM: 100743679
BTER: 100648827
CCAL: 108633094
OBB: 114878059
SOC: 105196148
MPHA: 105834920
AEC: 105147021
ACEP: 105622856
PBAR: 105423960
VEM: 105564520
HST: 105184854
DQU: 106745289
CFO: 105259365
LHU: 105675762
PGC: 109859585
OBO: 105278212
PCF: 106789699
MDL: 103573504
BMOR: 101736010
BMAN: 114249371
PMAC: 106712293
PRAP: 111003138
HAW: 110371138
TNL: 113492664
API: 100166238
BTAB: 109044429
CLEC: 106663411
ZNE: 110827434
CSCU: 111636340
PTEP: 107451720
TSP: Tsp_11047
PCAN: 112560591
MYI: 110440951
LAK: 106176476
EGL: EGR_00983
NVE: 5515142
EPA: 110248653
ADF: 107348131
PDAM: 113664778
SPIS: 111320177
DGT: 114517120
 » show all
Reference
  Authors
Ahluwalia TS, Lindholm E, Groop LC
  Title
Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
  Journal
Diabetologia 54:2295-302 (2011)
DOI:10.1007/s00125-011-2178-5
  Sequence
[hsa:55748]

KEGG   ENZYME: 3.4.13.18
Entry
EC 3.4.13.18                Enzyme                                 

Name
cytosol nonspecific dipeptidase;
N2-beta-alanylarginine dipeptidase;
glycyl-glycine dipeptidase;
glycyl-leucine dipeptidase;
iminodipeptidase;
peptidase A;
Pro-X dipeptidase;
prolinase;
prolyl dipeptidase;
prolylglycine dipeptidase;
iminodipeptidase;
prolinase;
L-prolylglycine dipeptidase;
prolylglycine dipeptidase;
diglycinase;
Gly-Leu hydrolase;
glycyl-L-leucine dipeptidase;
glycyl-L-leucine hydrolase;
glycyl-L-leucine peptidase;
L-amino-acyl-L-amino-acid hydrolase;
glycylleucine peptidase;
glycylleucine hydrolase;
glycylleucine dipeptide hydrolase;
non-specific dipeptidase;
human cytosolic non-specific dipeptidase;
glycyl-L-leucine hydrolase;
glycyl-glycine dipeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
Reaction(IUBMB)
Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids
Reaction(KEGG)
(other) R01166 R01992
Comment
A zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine.
History
EC 3.4.13.18 created 1961 as EC 3.4.3.1 and EC 3.4.3.2, transferred 1972 to EC 3.4.13.1 and EC 3.4.13.2, transferred 1978 to EC 3.4.13.11, part transferred 1992 to EC 3.4.13.18, modified 2000 (EC 3.4.13.15 created 1989, incorporated 1992)
Pathway
ec00330  Arginine and proline metabolism
ec00340  Histidine metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K08660  cytosolic nonspecific dipeptidase
Genes
HSA: 55748(CNDP2)
PTR: 455473(CNDP2)
PPS: 100970514(CNDP2)
GGO: 101126755(CNDP2)
PON: 100174694(CNDP2)
NLE: 100583155(CNDP2)
MCC: 114675568 695080(CNDP2)
MCF: 101865174(CNDP2)
CSAB: 103244083(CNDP2)
RRO: 104656990(CNDP2)
RBB: 108525047(CNDP2)
CJC: 100393355(CNDP2)
SBQ: 101053821(CNDP2)
MMU: 66054(Cndp2)
MCAL: 110284520(Cndp2)
MPAH: 110332928(Cndp2)
RNO: 291394(Cndp2)
MUN: 110555521(Cndp2)
CGE: 100760626(Cndp2)
NGI: 103748118(Cndp2)
HGL: 101709694(Cndp2)
CCAN: 109700927(Cndp2)
OCU: 100347984(CNDP2)
TUP: 102489914(CNDP2)
CFA: 476166(CNDP2)
VVP: 112919332(CNDP2)
AML: 100466673(CNDP2)
UMR: 103658414(CNDP2)
UAH: 113253527(CNDP2)
ORO: 101378244(CNDP2)
ELK: 111154262
FCA: 101095774(CNDP2)
PTG: 102964722(CNDP2)
PPAD: 109251777(CNDP2)
AJU: 106982249(CNDP2)
BTA: 512626(CNDP2)
BOM: 102267439(CNDP2)
BIU: 109577882(CNDP2)
BBUB: 102400679(CNDP2)
CHX: 102189261(CNDP2)
OAS: 101111244(CNDP2)
SSC: 100158127(CNDP2)
CFR: 102510239(CNDP2)
CDK: 105105096(CNDP2)
BACU: 103016660(CNDP2)
LVE: 103085206(CNDP2)
OOR: 101280936(CNDP2)
DLE: 111167306(CNDP2)
PCAD: 102990839(CNDP2)
ECB: 100061697(CNDP2)
EPZ: 103561747(CNDP2)
EAI: 106832864
MYB: 102242032(CNDP2)
MYD: 102767302(CNDP2)
MNA: 107537573(CNDP2)
HAI: 109383204(CNDP2)
DRO: 112322720(CNDP2)
PALE: 102880342(CNDP2)
RAY: 107512646(CNDP2)
MJV: 108409041(CNDP2)
LAV: 100668146(CNDP2)
TMU: 101353090
MDO: 100016094(CNDP2)
SHR: 100920874(CNDP2)
PCW: 110215842(CNDP2)
OAA: 100076934
GGA: 421013(CNDP2)
MGP: 100541349(CNDP2)
CJO: 107309961(CNDP2)
NMEL: 110394204(CNDP2)
APLA: 101791366(CNDP2)
ACYG: 106036016(CNDP2)
TGU: 100229152(CNDP2)
LSR: 110470875(CNDP2)
SCAN: 103826354(CNDP2)
GFR: 102034558(CNDP2)
FAB: 101807367(CNDP2)
PHI: 102114713(CNDP2)
PMAJ: 107200307(CNDP2)
CCAE: 111925251(CNDP2)
CCW: 104685798(CNDP2)
ETL: 114057531(CNDP2)
FPG: 101914717(CNDP2)
FCH: 102052576(CNDP2)
CLV: 102092467(CNDP2)
EGZ: 104128656(CNDP2)
NNI: 104018185(CNDP2)
ACUN: 113477172(CNDP2)
PADL: 103924880(CNDP2)
AAM: 106484108(CNDP2)
ASN: 102368140
AMJ: 102560010 102563504(CNDP2)
PSS: 102446043(CNDP2)
CMY: 102938228(CNDP2)
CPIC: 101937378(CNDP2)
ACS: 100553967(cndp2) 100556028
PVT: 110083373 110083377(CNDP2)
PBI: 103052866(CNDP2)
PMUR: 107291689(CNDP2)
TSR: 106538260(CNDP2)
PMUA: 114600794(CNDP2)
GJA: 107115121(CNDP2)
XLA: 108695220 380001(cndp2.S) 398689(darmin.L) 446978(cndp2.L)
XTR: 394903(darmin) 394907(cndp2)
NPR: 108799251
DRE: 327288(cndp2)
IPU: 108257136(cndp2)
PHYP: 113536259(cndp2)
AMEX: 103024590(cndp2)
EEE: 113585121(cndp2)
TRU: 101066809
LCO: 104927574(cndp2)
NCC: 104962947(cndp2)
OLA: 101158501(cndp2)
XMA: 102232950
XCO: 114156569
PRET: 103472482 103472483(cndp2)
NFU: 107394616(cndp2)
KMR: 108237889(cndp2)
ALIM: 106536426
AOCE: 111585218(cndp2)
CSEM: 103394277(cndp2)
LCF: 108879475(cndp2)
SDU: 111223447(cndp2)
SLAL: 111657615(cndp2)
HCQ: 109512013(cndp2)
BPEC: 110161127(cndp2)
MALB: 109958636(cndp2)
ELS: 105012659(cndp2) 105019195
PKI: 111852260(cndp2)
LCM: 102355182(CNDP2)
CMK: 103184951(cndp2)
SPU: 594228
DME: Dmel_CG17337(Cndp2)
DSE: 6619122
DSI: Dsimw501_GD10382(Dsim_GD10382)
DAN: 6496679
DSR: 110189385
MDE: 101898638
AAG: 5571265
AALB: 109423371
AME: 412393
BIM: 100743679
BTER: 100648827
CCAL: 108633094
OBB: 114878059
SOC: 105196148
MPHA: 105834920
AEC: 105147021
ACEP: 105622856
PBAR: 105423960
VEM: 105564520
HST: 105184854
DQU: 106745289
CFO: 105259365
LHU: 105675762
PGC: 109859585
OBO: 105278212
PCF: 106789699
MDL: 103573504
BMOR: 101736010
BMAN: 114249371
PMAC: 106712293
PRAP: 111003138
HAW: 110371138
TNL: 113492664
API: 100166238
BTAB: 109044429
CLEC: 106663411
ZNE: 110827434
CSCU: 111636340
PTEP: 107451720
TSP: Tsp_11047
PCAN: 112560591
MYI: 110440951
LAK: 106176476
EGL: EGR_00983
NVE: 5515142
EPA: 110248653
ADF: 107348131
PDAM: 113664778
SPIS: 111320177
DGT: 114517120
 » show all
Reference
1
  Authors
Bauer, K.
  Title
Cytosol non-specific dipeptidase.
  Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1520-1522.
Other DBs
ExplorEnz - The Enzyme Database: 3.4.13.18
IUBMB Enzyme Nomenclature: 3.4.13.18
ExPASy - ENZYME nomenclature database: 3.4.13.18
BRENDA, the Enzyme Database: 3.4.13.18
CAS: 9025-31-4

KEGG   REACTION: R01992
Entry
R01992                      Reaction                               

Name
alpha-Aminobutyryl histidine hydrolase
Definition
Homocarnosine + H2O <=> 4-Aminobutanoate + L-Histidine
Equation
Reaction class
RC00064  C00135_C00884
RC00090  C00334_C00884
Enzyme
3.4.13.18       3.4.13.20
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K05604  beta-Ala-His dipeptidase [EC:3.4.13.20]
K08660  cytosolic nonspecific dipeptidase [EC:3.4.13.18]
Other DBs
RHEA: 59575

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