KEGG   ORTHOLOGY: K08695
Entry
K08695                      KO                                     

Name
ANR
Definition
anthocyanidin reductase [EC:1.3.1.77]
Pathway
ko00941  Flavonoid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00941 Flavonoid biosynthesis
    K08695  ANR; anthocyanidin reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.77  anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]
     K08695  ANR; anthocyanidin reductase
Other DBs
RN: R06541 R06542 R06543
GO: 0033729
Genes
ATH: AT1G61720(BAN)
ALY: 9322580
CRB: 17894009
CSAT: 104703765 104714500 104752826
EUS: EUTSA_v10023567mg
BRP: 103831042 103838541
BNA: 106352233 106374812 106374840 106395425
BOE: 106302532 106323258 106341298
RSZ: 108810876
THJ: 104809521
CPAP: 110812199
CIT: 102618954
TCC: 18597033(ANR)
GRA: 105768219
GAB: 108452981
DZI: 111280787
GMX: 100805127(ANR1) 100817081(ANR2)
CAM: 101494604
LJA: Lj4g3v0423090.1(Lj4g3v0423090.1)
ADU: 107480609
AIP: 107626250
LANG: 109330732
FVE: 101297977
RCN: 112202296
PPER: 18778549
PMUM: 103324591
PAVI: 110768767
ZJU: 107421422
RCU: 8267420
JCU: 105649408
HBR: 110658083
MESC: 110602917
PEU: 105110148
JRE: 108979344
QSU: 111989132
SLY: 101263493
SPEN: 107012467
SOT: 102584577
NSY: 104233566
NTO: 104120432
NAU: 109243327
BVG: 104883056
DOSA: Os04t0630100-01(Os04g0630100) Os04t0630300-01(Os04g0630300) Os04t0630400-01(Os04g0630400) Os04t0630600-00(Os04g0630600) Os04t0630800-01(Os04g0630800) Os04t0630900-01(Os04g0630900) Os04t0631000-00(Os04g0631000)
ATS: 109733882(LOC109733882) 109736125(LOC109736125) 109736130 109736133 109738472(LOC109738472) 109750081(LOC109750081) 109766837(LOC109766837) 109778519(LOC109778519)
PDA: 103698208
EGU: 105035639
MUS: 103994101
AOF: 109821630
ATR: 18427888
AG: AAN77735(ANR)
 » show all
Reference
  Authors
Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA
  Title
Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis.
  Journal
Science 299:396-9 (2003)
DOI:10.1126/science.1078540
  Sequence

KEGG   ENZYME: 1.3.1.77
Entry
EC 1.3.1.77                 Enzyme                                 

Name
anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming];
ANR (gene name) (ambiguous);
flavan-3-ol:NAD(P)+ oxidoreductase;
anthocyanidin reductase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase
Reaction(IUBMB)
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction(KEGG)
Substrate
(2R,3R)-flavan-3-ol [CPD:C15598];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
anthocyanidin with a 3-hydroxy group [CPD:C21381];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].
History
EC 1.3.1.77 created 2004, modified 2016
Pathway
ec00941  Flavonoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08695  anthocyanidin reductase
Genes
ATH: AT1G61720(BAN)
ALY: 9322580
CRB: 17894009
CSAT: 104703765 104714500 104752826
EUS: EUTSA_v10023567mg
BRP: 103831042 103838541
BNA: 106352233 106374812 106374840 106395425
BOE: 106302532 106323258 106341298
RSZ: 108810876
THJ: 104809521
CPAP: 110812199
CIT: 102618954
TCC: 18597033(ANR)
GRA: 105768219
GAB: 108452981
DZI: 111280787
GMX: 100805127(ANR1) 100817081(ANR2)
CAM: 101494604
LJA: Lj4g3v0423090.1(Lj4g3v0423090.1)
ADU: 107480609
AIP: 107626250
LANG: 109330732
FVE: 101297977
RCN: 112202296
PPER: 18778549
PMUM: 103324591
PAVI: 110768767
ZJU: 107421422
RCU: 8267420
JCU: 105649408
HBR: 110658083
MESC: 110602917
PEU: 105110148
JRE: 108979344
QSU: 111989132
SLY: 101263493
SPEN: 107012467
SOT: 102584577
NSY: 104233566
NTO: 104120432
NAU: 109243327
BVG: 104883056
DOSA: Os04t0630100-01(Os04g0630100) Os04t0630300-01(Os04g0630300) Os04t0630400-01(Os04g0630400) Os04t0630600-00(Os04g0630600) Os04t0630800-01(Os04g0630800) Os04t0630900-01(Os04g0630900) Os04t0631000-00(Os04g0631000)
ATS: 109733882(LOC109733882) 109736125(LOC109736125) 109736130 109736133 109738472(LOC109738472) 109750081(LOC109750081) 109766837(LOC109766837) 109778519(LOC109778519)
PDA: 103698208
EGU: 105035639
MUS: 103994101
AOF: 109821630
ATR: 18427888
 » show all
Reference
1  [PMID:12532018]
  Authors
Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA.
  Title
Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis.
  Journal
Science 299:396-9 (2003)
DOI:10.1126/science.1078540
  Sequence
Reference
2  [PMID:14725861]
  Authors
Xie DY, Sharma SB, Dixon RA.
  Title
Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana.
  Journal
Arch Biochem Biophys 422:91-102 (2004)
DOI:10.1016/j.abb.2003.12.011
  Sequence
[ath:AT1G61720]
Reference
3  [PMID:23288883]
  Authors
Pang Y, Abeysinghe IS, He J, He X, Huhman D, Mewan KM, Sumner LW, Yun J, Dixon RA
  Title
Functional characterization of proanthocyanidin pathway enzymes from tea and their application for metabolic engineering.
  Journal
Plant Physiol 161:1103-16 (2013)
DOI:10.1104/pp.112.212050
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.77
IUBMB Enzyme Nomenclature: 1.3.1.77
ExPASy - ENZYME nomenclature database: 1.3.1.77
BRENDA, the Enzyme Database: 1.3.1.77
CAS: 93389-48-1

KEGG   REACTION: R06542
Entry
R06542                      Reaction                               

Name
flavan-3-ol:NADP+ oxidoreductase
Definition
(-)-Epicatechin + 2 NADP+ <=> Cyanidin + 2 NADPH + H+
Equation
Comment
anthocyanidin reductase
BANYULS
Reaction class
RC00001  C00005_C00006
RC01553  C05905_C09727
Enzyme
Pathway
rn00941  Flavonoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K08695  anthocyanidin reductase [EC:1.3.1.77]

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