KEGG ORTHOLOGY: K08732

ORTHOLOGY: K08732

Entry

K08732                      KO

Symbol

RALGDS

Name

ral guanine nucleotide dissociation stimulator

Pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04072

Phospholipase D signaling pathway

map05200

Pathways in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05231

Choline metabolism in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K08732  RALGDS; ral guanine nucleotide dissociation stimulator
   04015 Rap1 signaling pathway
    K08732  RALGDS; ral guanine nucleotide dissociation stimulator
   04072 Phospholipase D signaling pathway
    K08732  RALGDS; ral guanine nucleotide dissociation stimulator
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08732  RALGDS; ral guanine nucleotide dissociation stimulator
   05231 Choline metabolism in cancer
    K08732  RALGDS; ral guanine nucleotide dissociation stimulator
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08732  RALGDS; ral guanine nucleotide dissociation stimulator
   05212 Pancreatic cancer
    K08732  RALGDS; ral guanine nucleotide dissociation stimulator

Other DBs

GO:

0008321

Genes

HSA:	5900(RALGDS)

PTR:	458697(RGL4) 464824(RALGDS)

PPS:	100969771 100977720(RALGDS) 117977520(RGL4) 117978709

GGO:	101144743(RALGDS)

PON:	100434751(RGL4) 100451493(RALGDS)

PPYG:

129022987(RGL4) 129043972(RALGDS)

NLE:	100579487 100589231(RALGDS) 115835869

HMH:	116459240 116475810(RALGDS)

SSYN:

129467510 129478732(RALGDS)

MCC:	100426259 106992479 106995478 106995524 114670406 710293 710997 711158 713249 714436(RALGDS)

MCF:	102121408(RALGDS) 102124288 102125458 135965465 135965503 135965504

MTHB:

126929238 126929502 126929506 126929550 126929580 126929584 126929625 126929778 126929779 126929780 126936899 126947346 126964069

MNI:	105464075(RALGDS) 105464191 105464203 105480640 105497377 105497421 112422941

CSAB:

103223583 103239705(RALGDS)

CATY:

105575634 105575857 105594177(RALGDS) 105599414

PANU:

100997587 101006888(RALGDS)

TGE:	112607916(RALGDS) 112632401 112632635 112632636 112632868 112632869

MLEU:

105530438 105533469 105537592 105542946(RALGDS) 105546073(RGL4) 105552366

RRO:	104669737(RALGDS) 104674726

RBB:	108513486(RALGDS) 108528764

TFN:	117073836(RALGDS) 117087293

PTEH:

111524003(RALGDS) 111530411

CANG:

105504139(RALGDS) 105514932 105519370

CJC:	100409316(RALGDS)

SBQ:	101029174(RALGDS)

CIMI:

108295416(RALGDS)

ANAN:

105721084(RALGDS)

CSYR:

103250925(RALGDS)

MMUR:

105859871(RALGDS)

LCAT:

123646555(RALGDS)

PCOQ:

105806629(RALGDS)

OGA:	100953476(RALGDS)

MMU:	19730(Ralgds)

MCAL:

110286147(Ralgds)

MPAH:

110317707(Ralgds)

RNO:	29622(Ralgds)

MCOC:

116089898(Ralgds)

ANU:	117703478(Ralgds)

ASYL:

127685131(Ralgds)

MUN:	110549995(Ralgds)

CGE:	100771841(Ralgds)

MAUA:

101833106(Ralgds)

PROB:

127222676(Ralgds)

PLEU:

114702785(Ralgds)

MORG:

121462907(Ralgds)

MFOT:

126509280

AAMP:

119819393(Ralgds)

NGI:	103742830(Ralgds)

HGL:	101700047(Ralgds)

CPOC:

100722725(Ralgds)

CCAN:

109677013 109677869 109678448 109683009 109690895 109690997(Ralgds) 109699717 109701306 109701840

DORD:

105987223 105989429(Ralgds) 105993771

DSP:	122109018(Ralgds) 122114492 122114847 122120732 122120746 122120747 122120774 122120806 122120809 122120812 122120814 122120818 122120862 122120901 122120903 122120905 122124476

DMER:

138822249(Ralgds) 138831822 138836801

PLOP:

125344534 125344567 125344605 125350781(Ralgds) 125352435 125352446 125352469 125364257

NCAR:

124964488 124973713 124973758 124973773 124973926 124974333

MMMA:

107151971(Ralgds)

ITI:	101964927(Ralgds)

OCU:	103345957 103345959 103346586 103346760

OPI:	101534158(RALGDS)

TUP:	102479691(RALGDS)

GVR:	103581819 103582164(RALGDS)

CFA:	100855428 480686(RALGDS) 611891

CLUD:

112662313 112674653 112677375(RALGDS) 118354211 118355030 118355031

VVP:	112928009(RALGDS)

VLG:	121473707(RALGDS)

NPO:	129513831(RALGDS)

AML:

100472281

UMR:	103670397(RALGDS)

UAR:	123775706(RALGDS) 123779677 123784908 123784911 123803286 123803339

ELK:

111145587

LLV:	125083157 125109844 125109847

MPUF:

101672726(RALGDS)

MNP:	132024291(RALGDS)

MLK:	131813170(RALGDS)

NVS:	122917134(RALGDS)

ORO:	101386629(RALGDS)

EJU:	114198818(RALGDS)

ZCA:	113934764(RALGDS) 113938139

MLX:	118018104(RALGDS)

NSU:	110581484(RALGDS)

LWW:	102737721(RALGDS)

FCA:	101090558(RALGDS) 102899245

PYU:	121035155(RALGDS)

PBG:	122474949(RALGDS) 122478535 122478537 122497556 122497557

PVIV:

125150456(RALGDS) 125162371

LRUF:

124503890 124525632

LGF:	123592422(RALGDS)

AJU:	106985322 106989551 113597310

PTG:	102965767(RALGDS)

PPAD:

109249977(RALGDS)

PUC:

125922835

PLEZ:

122204750(RALGDS)

HHV:	120230137(RALGDS)

BTA:	513723(RALGDS)

BOM:	102284256(RALGDS)

BIU:	109565671(RALGDS) 109565672

BBUB:

102404125(RALGDS)

BBIS:

105000869(RALGDS)

CHX:	102187410(RALGDS)

OAS:	101118864(RALGDS)

BTAX:

128055089(RALGDS)

CSUM:

138086271(RALGDS)

ODA:	120852130(RALGDS)

CCAD:

122442306(RALGDS)

MREE:

136163668(RALGDS)

OVR:	110148781(RALGDS)

MBEZ:

129539155(RALGDS)

SSC:	100513970(RALGDS)

CFR:	102503669(RALGDS)

CBAI:

105069723(RALGDS)

CDK:	105085184(RALGDS)

VPC:

102528835

BACU:

103008135(RALGDS)

BMUS:

118896780(RALGDS)

LVE:	103086535(RALGDS)

OOR:	101280055(RALGDS)

LALB:

132523244

GMF:	115842950(RALGDS)

DDP:	132426967(RALGDS)

DLE:	111177083(RALGDS)

PCAD:

102992808(RALGDS)

PSIU:

116755498(RALGDS)

PPHC:

136124379(RALGDS)

NASI:

112411278(RALGDS)

ECB:	100052576 100054137 100056032 100063871 100069402(RALGDS) 102147367 102148588 102149317 102149416 102149785 102150685 106780978 106781089 106781151 106781162

EPZ:	103544676 103553681(RALGDS)

EAI:	106835340 106839449 106841638 106845364(RALGDS) 106848366 123275672 123283947 123285599 123286146 123286149 123286150 123286238

MYB:	102240340(RALGDS)

MYD:	102766224(RALGDS) 102771781

MMYO:

118660540 118666917(RALGDS)

MLF:

102418938

MDT:	132212522(RALGDS) 132241561

MYUM:

139020657(RALGDS)

PKL:	118708879(RALGDS)

EFUS:

103305000(RALGDS)

MNA:	107524673(RALGDS)

DRO:	112306313(RALGDS)

SHON:

118980105(RALGDS)

AJM:	119036094(RALGDS)

PDIC:

114504710(RALGDS)

PHAS:

123823464(RALGDS)

MMF:	118629545(RALGDS) 118630659

PPAM:

129079186(RALGDS)

HAI:	109382359(RALGDS)

RFQ:	117032148(RALGDS)

PALE:

102880177(RALGDS)

PGIG:

120602747(RALGDS)

PVP:	105298674(RALGDS)

RAY:	107504584(RALGDS)

MJV:	108388220(RALGDS)

TOD:	119231221(RALGDS)

SARA:

101554760(RALGDS)

SFUM:

130040809(RALGDS)

SETR:

126009524(RALGDS)

LAV:	100659236(RALGDS) 100674091

TMU:	101348205 101348938 101349734 101351825

ETF:	101654227(RALGDS)

MDO:	100017777(RALGDS)

GAS:	123233620(RALGDS)

SHR:	100917637(RALGDS)

AFZ:

127550939

PCW:	110205393(RALGDS)

TVP:	118843760(RALGDS)

PBRV:

138147084(RALGDS)

MLAO:

141505206(RALGDS)

OAA:	100080818(RALGDS)

TACU:

119927126(RALGDS)

GGA:	427758(RALGDS)

PCOC:

116234287(RALGDS)

MGP:	100543539(RALGDS)

CJO:	107321879(RALGDS)

TPAI:

128073234(RALGDS)

LMUT:

125702495(RALGDS)

NMEL:

110406742(RALGDS)

APLA:

101799472(RALGDS)

ACYG:

106044092(RALGDS)

CATA:

118252191(RALGDS)

AFUL:

116497077(RALGDS)

TGU:	100221484(RALGDS)

LSR:	110477613(RALGDS)

SCAN:

103819134(RALGDS)

PMOA:

120512409(RALGDS)

OTC:	121336923(RALGDS)

PRUF:

121362421(RALGDS)

ATRC:

139603454(RALGDS)

GFR:	102043791(RALGDS)

FAB:	101807597(RALGDS)

OMA:	130260256(RALGDS)

PHI:	102103696(RALGDS)

PMAJ:

107212012(RALGDS)

CCAE:

111937026(RALGDS)

CCW:	104688325(RALGDS)

CBRC:

103623254(RALGDS)

ACOE:

138119531(RALGDS)

ETL:	114059093(RALGDS)

ZAB:	102073433(RALGDS)

ZLE:	135454865(RALGDS)

ACHL:

103805569(RALGDS)

SVG:	106851363(RALGDS)

MMEA:

130576703(RALGDS)

HRT:	120761664(RALGDS)

SATI:

136369765(RALGDS)

CCIC:

134051875(RALGDS)

FPG:	101924202(RALGDS)

FCH:	102056619(RALGDS)

CCRI:

104162329(RALGDS)

NNT:	104404233(RALGDS)

SHAB:

115617115(RALGDS)

ACUN:

113486640(RALGDS)

TALA:

104369586(RALGDS)

ACHC:

115335131(RALGDS)

HALD:

104320308

HLE:	104834023(RALGDS)

AGEN:

126052274

HHAR:

128154819(RALGDS)

GCL:

127023803

CSTI:

104563525(RALGDS)

LDI:

104352375

DPUB:

104296402(RALGDS)

PPUS:

135190217(RALGDS)

AVIT:

104280478(RALGDS)

BRHI:

104496246(RALGDS)

EGZ:	104129348(RALGDS)

NNI:	104023281(RALGDS)

PCRI:

104028822(RALGDS)

PCAO:

104051685(RALGDS)

PADL:

103915354(RALGDS)

AFOR:

103905390(RALGDS)

FGA:	104077412(RALGDS)

GSTE:

104256088

CBOY:

140661372(RALGDS)

CLV:	102088221(RALGDS)

CNIC:

135996402(RALGDS)

PGUU:

104466327(RALGDS)

PLET:

104619603(RALGDS)

EHS:	104509521(RALGDS)

CMAC:

104486089(RALGDS)

CUCA:

104066933(RALGDS)

TEO:

104382134

BREG:

104643247

OHA:	104329600(RALGDS)

ACAR:

104532250(RALGDS)

CPEA:

104389914(RALGDS)

CVF:	104292882(RALGDS)

RTD:	128917434(RALGDS)

CRID:

134523692(RALGDS)

AAM:	106483747(RALGDS)

AROW:

112964231(RALGDS)

NPD:	112956025(RALGDS)

TGT:	104565742(RALGDS)

DNE:	112979940(RALGDS)

SCAM:

104138247(RALGDS)

ASN:	102367792(RALGDS)

AMJ:	102566192(RALGDS)

CPOO:

109313973(RALGDS)

GGN:	109292995(RALGDS)

PSS:	102455196(RALGDS)

CMY:	102937874(RALGDS)

CCAY:

125623479(RALGDS)

DCC:	119844372(RALGDS)

CPIC:

101945651(RALGDS)

TST:	117889323(RALGDS)

CABI:

116824023(RALGDS)

MRV:	120386787(RALGDS)

ACS:	100562121(ralgds)

ASAO:

132763541(RALGDS)

PVT:	110079654(RALGDS)

SUND:

121936280(RALGDS)

PBI:	103059380(RALGDS)

PMUR:

107299323(RALGDS)

CTIG:

120298892(RALGDS)

PGUT:

117656268(RALGDS)

PCAE:

139325822(RALGDS)

APRI:

131186027(RALGDS)

PTEX:

113443804(RALGDS)

VKO:	123028321(RALGDS)

PMUA:

114588787(RALGDS)

PRAF:

128406198(RALGDS)

ZVI:	118078366(RALGDS)

HCG:	128338951(RALGDS)

GJA:	107112792(RALGDS)

STOW:

125441553(RALGDS)

EMC:	129342122(RALGDS)

XLA:	108698864(ralgds.L) 108699930(ralgds.S)

XTR:	100135084(ralgds)

NPR:	108793321(RALGDS)

RTEM:

120914018(RALGDS)

ACAT:

141108696(RALGDS)

BBUF:

120977960(RALGDS)

BGAR:

122945969(RALGDS)

DTC:	141059844(RALGDS)

PWL:	138299111(RALGDS)

MUO:	115473100(RALGDS)

GSH:	117367968(RALGDS)

DRE:	101885008 103909384 799483(ralgds)

SRX:	107711877 107717753 107724899 107734393

SANH:

107667531 107667907 107694528 107696901

SGH:	107573634 107574105 107600003 107602853

CCAR:

109046316 109084264 109084268(ralgds) 109097850

CAUA:

113083586 113088324 113090384 113090385 113096342

CGIB:

127941931 127962889 127986295 128018520

PTET:

122341023 122350504(ralgds)

LROH:

127162120 127169508(ralgds)

GRF:	141286668(ralgds) 141292340

OMC:	131528497 131545229(ralgds)

PPRM:

120461894 120484897(si:ch211-251j10.3)

RKG:	130072364(ralgds) 130079720

MAMB:

125252397 125279683(ralgds)

CIDE:

127504009 127517961

CERY:

137012554 137027070(ralgds)

MASI:

127415079 127424165 127428971 127430452 127446396

TROS:

130550199 130568140(ralgds)

TDW:	130407950 130440091(ralgds)

MANU:

129413858(ralgds) 129424331

PDAB:

135721381 135729520(ralgds)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:	113584565(ralgds)

CHAR:

105891580 105909371

SPIL:

134088401 134100540

TRU:	101067502(ralgds)

TFS:

130526276

TNG:	GSTEN00031001G001

LCO:	104934922(ralgds)

NCC:

104955348

TBEN:

117472362(si:ch211-251j10.3)

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:	125890778(ralgds)

SLUC:

116054237(si:ch211-251j10.3)

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

132974809(ralgds)

ALAT:

119019381

ASTR:

137592404

MZE:	101479161(ralgds)

ONL:	100693157(ralgds)

OAU:

116316301

OLA:	101164630(ralgds)

OML:

112158957

CSAI:

133451520

XMA:	102237107(ralgds)

XCO:	114154167(ralgds)

XHE:	116730409(ralgds)

PRET:

103469838(ralgds)

PFOR:

103134913(ralgds)

PLAI:

106955954(ralgds)

PMEI:

106933326(ralgds)

GAF:

122828206

PPRL:

129365796

CVG:	107103647(ralgds)

CTUL:

119797460

GMU:

124877345

NFU:	107386081(rgl4)

KMR:

108242791

ALIM:

106521867(ralgds)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103397014 103397399(rgl4)

POV:	109640300(ralgds)

SSEN:

122769758

SSOE:

131463614

HHIP:

117768474

HSP:	118114604(ralgds)

PPLT:

128437657

SMAU:

118314631

LCF:

108881628

SDU:	111238528(ralgds)

SLAL:

111645675(ralgds)

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110162079(ralgds)

ENY:

140346616

MALB:

109957320(ralgds)

BSPL:

114861525(ralgds)

SJO:

128365492

SSCO:

133978513

GMH:

115545407

SASA:

106562829 106570436 106579966 106585456

STRU:

115159992 115164678 115199955 115203760

OTW:	112220069 112234556 112248341 112263063

OMY:	110509485 110523253 110525507 110535052

OGO:	123989409 124016638 124034428 124036173

ONE:	115111474 115119137 115139900 115147093

OKI:	109868317 109873521 109878069 109895772

OKE:	118358206 118385547 118388058 118393058

OMM:	135514230 135518280 135539756 135544732

OCLA:

139388417 139389706 139408389 139410799

SALP:

111957831 111963773 111975184 112080611

SNH:	120021291 120026074 120060258 120063146

CCLU:

121541417 121550239 121582061 121584722

ELS:	105007891 105014171

OEP:	134015068 134038586

SFM:	108921911 108932954

PKI:	111842082 111858727

AANG:

118212773 118237553

AROT:

135238946 135265044

CCOG:

133140777 133142367

LOC:	102694251(ralgds)

PSPA:

121309690

ARUT:

117396931 117422410

PSEX:

120536021

LCM:	102354527(RGL2) 102360981(RALGDS)

CMK:

103183072

RTP:	109916669 109919061

CPLA:

122541250 122564935

HOC:	132825901 132832895

LERI:

HAKA:

RSAN:

Reference

PMID:20478380

Authors

Ferro E, Trabalzini L

Title

RalGDS family members couple Ras to Ral signalling and that's not all.

Journal

Cell Signal 22:1804-10 (2010)
DOI:10.1016/j.cellsig.2010.05.010

Reference

PMID:7972015

Authors

Hofer F, Fields S, Schneider C, Martin GS

Title

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

Journal

Proc Natl Acad Sci U S A 91:11089-93 (1994)
DOI:10.1073/pnas.91.23.11089

Sequence

[hsa:5900]

All links

Ontology (1)   
   GO (1)   
Gene (400)   
   MGENES (272)   
   RefGene (123)   
   OC (5)   
All databases (401)   

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