Entry
Symbol
ERN1
Name
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1 3.1.26.-]
Pathway
map04141 Protein processing in endoplasmic reticulum
map04932 Non-alcoholic fatty liver disease
map05022 Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
09143 Cell growth and death
04210 Apoptosis
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
05012 Parkinson disease
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
05014 Amyotrophic lateral sclerosis
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
05016 Huntington disease
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
05017 Spinocerebellar ataxia
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
05022 Pathways of neurodegeneration - multiple diseases
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
Enzymes [BR:ko01000 ]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
Protein kinases [BR:ko01001 ]
Serine/threonine kinases: Other
IRE family
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
BRITE hierarchy
Genes
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Taxonomy UniProt
Reference
Authors
Liu CY, Xu Z, Kaufman RJ
Title
Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.
Journal
Sequence
Reference
Authors
Tirasophon W, Welihinda AA, Kaufman RJ
Title
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.
Journal
Sequence