KEGG   ORTHOLOGY: K08893
Entry
K08893                      KO                                     

Name
HCK
Definition
hemopoietic cell kinase [EC:2.7.10.2]
Pathway
ko04062  Chemokine signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K08893  HCK; hemopoietic cell kinase
   04062 Chemokine signaling pathway
    K08893  HCK; hemopoietic cell kinase
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K08893  HCK; hemopoietic cell kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08893  HCK; hemopoietic cell kinase
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08893  HCK; hemopoietic cell kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08893  HCK; hemopoietic cell kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K08893  HCK; hemopoietic cell kinase
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K08893  HCK; hemopoietic cell kinase
Other DBs
GO: 0004715
Genes
HSA: 3055(HCK)
PTR: 458163(HCK)
PPS: 100975763(HCK)
GGO: 101149280(HCK)
PON: 100455620(HCK)
NLE: 100587780(HCK)
MCC: 715723(HCK)
MCF: 102115729(HCK)
CSAB: 103248155(HCK)
RRO: 104653712(HCK)
RBB: 108524139(HCK)
CJC: 100389637(HCK)
SBQ: 101032860(HCK)
MMU: 15162(Hck)
MCAL: 110309091(Hck)
MPAH: 110317518(Hck)
RNO: 25734(Hck)
MUN: 110550096(Hck)
CGE: 100773315(Hck)
NGI: 103731073(Hck)
HGL: 101709222(Hck)
CCAN: 109691761(Hck)
OCU: 100343961(HCK)
TUP: 102491330(HCK)
CFA: 485828(HCK)
VVP: 112909929(HCK)
AML: 100468494(HCK)
UMR: 103674340(HCK)
UAH: 113258471(HCK)
ORO: 101383723(HCK)
ELK: 111141509
FCA: 101101207(HCK)
PTG: 102953452(HCK)
PPAD: 109272582(HCK)
AJU: 106974647(HCK)
BTA: 280814(HCK)
BOM: 102274987(HCK)
BIU: 109567352(HCK)
BBUB: 102410643(HCK)
CHX: 102183977(HCK)
OAS: 101113167(HCK)
SSC: 100526085(HCK)
CFR: 102507677(HCK)
CDK: 105100829(HCK)
BACU: 103015546(HCK)
LVE: 103078130(HCK)
OOR: 101288667(HCK)
DLE: 111184309(HCK) 111184310
PCAD: 102977689(HCK)
ECB: 100068557(HCK)
EPZ: 103554273(HCK)
EAI: 106833726(HCK)
MYB: 102256952(HCK)
MYD: 102756136(HCK)
MNA: 107527783(HCK)
HAI: 109384426(HCK)
DRO: 112303915(HCK)
PALE: 102890019(HCK)
RAY: 107512878(HCK)
MJV: 108397287(HCK)
LAV: 100660288(HCK)
TMU: 101344005
MDO: 100010539(HCK)
SHR: 100913992(HCK)
PCW: 110211423(HCK)
OAA: 100085668(HCK)
GGA: 419280(HCK)
MGP: 100543739(HCK)
CJO: 107323072(HCK)
NMEL: 110408000(HCK)
APLA: 101792612(HCK)
ACYG: 106047123(HCK)
TGU: 100220059(HCK)
LSR: 110469018(HCK)
SCAN: 103818665(HCK)
GFR: 102036877(HCK)
FAB: 101812195(HCK)
PHI: 102101716(HCK)
PMAJ: 107213469(HCK)
CCAE: 111943147(HCK)
CCW: 104687710(HCK)
ETL: 114063045(HCK)
FPG: 101910593(HCK)
FCH: 102055899(HCK)
CLV: 102096776(HCK)
EGZ: 104127632(HCK)
NNI: 104018316(HCK)
ACUN: 113487683(HCK)
PADL: 103912489(HCK)
AAM: 106497371(HCK)
ASN: 102368801(HCK)
AMJ: 106737579(HCK)
PSS: 106732490(HCK)
CMY: 102941333(HCK)
CPIC: 101948814(HCK)
ACS: 100557519(hck)
PVT: 110086725(HCK)
PBI: 103054220(HCK)
PMUR: 107299503(HCK)
PMUA: 114599837(HCK)
GJA: 107123021(HCK)
XLA: 373700(hck.L)
XTR: 548439(hck)
NPR: 108786954(HCK)
DRE: 101885596(hck)
SGH: 107558239(hck) 107559464
IPU: 108275896(hck)
PHYP: 113530620(hck)
AMEX: 103036768(hck)
EEE: 113575473(hck)
TRU: 101067815(hck)
LCO: 104933734(hck)
MZE: 101483358(hck)
ONL: 100699435(hck)
OLA: 101163900(hck)
XMA: 102216930(hck)
XCO: 114145598(hck)
PRET: 103466927(hck)
CVG: 107098932
NFU: 107386929
KMR: 108246117(hck)
ALIM: 106523041(hck)
AOCE: 111570488(hck)
CSEM: 103384757(hck)
POV: 109630933(hck)
LCF: 108885037(hck)
SDU: 111237026(hck)
SLAL: 111651844
HCQ: 109511820(hck)
BPEC: 110169150(hck)
MALB: 109969986(hck)
SASA: 100136375(hck) 106572127
SALP: 111976955(hck) 112068453
ELS: 105013770
SFM: 108925655(hck) 108926451
LCM: 102352014
CMK: 103172176(hck)
RTP: 109911600(hck)
 » show all
Reference
PMID:9407116
  Authors
Warmuth M, Bergmann M, Priess A, Hauslmann K, Emmerich B, Hallek M
  Title
The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.
  Journal
J Biol Chem 272:33260-70 (1997)
DOI:10.1074/jbc.272.52.33260
Reference
PMID:3496523
  Authors
Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD
  Title
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.
  Journal
Mol Cell Biol 7:2267-75 (1987)
DOI:10.1128/MCB.7.6.2267
  Sequence
[hsa:3055]

KEGG   ORTHOLOGY: K05854
Entry
K05854                      KO                                     

Name
LYN
Definition
tyrosine-protein kinase Lyn [EC:2.7.10.2]
Pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04611  Platelet activation
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04730  Long-term depression
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05203  Viral carcinogenesis
ko05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05854  LYN; tyrosine-protein kinase Lyn
   04662 B cell receptor signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
   04664 Fc epsilon RI signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
   04666 Fc gamma R-mediated phagocytosis
    K05854  LYN; tyrosine-protein kinase Lyn
   04062 Chemokine signaling pathway
    K05854  LYN; tyrosine-protein kinase Lyn
  09156 Nervous system
   04730 Long-term depression
    K05854  LYN; tyrosine-protein kinase Lyn
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K05854  LYN; tyrosine-protein kinase Lyn
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05854  LYN; tyrosine-protein kinase Lyn
   05169 Epstein-Barr virus infection
    K05854  LYN; tyrosine-protein kinase Lyn
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05854  LYN; tyrosine-protein kinase Lyn
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K05854  LYN; tyrosine-protein kinase Lyn
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05854  LYN; tyrosine-protein kinase Lyn
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05854  LYN; tyrosine-protein kinase Lyn
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05854  LYN; tyrosine-protein kinase Lyn
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05854  LYN; tyrosine-protein kinase Lyn
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K05854  LYN; tyrosine-protein kinase Lyn
Other DBs
GO: 0004715 0004716
Genes
HSA: 4067(LYN)
PTR: 472771(LYN)
PPS: 100996017(LYN)
GGO: 101145340(LYN)
PON: 100447326(LYN)
NLE: 100593961(LYN)
MCC: 698553(LYN)
MCF: 102118154(LYN)
CSAB: 103236819(LYN)
RRO: 104661780(LYN)
RBB: 108521691(LYN)
CJC: 100390096(LYN)
SBQ: 101036887(LYN)
MMU: 17096(Lyn)
MPAH: 110338916(Lyn)
RNO: 81515(Lyn)
MUN: 110541812
CGE: 100754828(Lyn)
NGI: 103734185(Lyn)
HGL: 101696753(Lyn)
CCAN: 109696666(Lyn)
OCU: 100340056(LYN)
TUP: 102493585(LYN)
CFA: 477886(LYN)
VVP: 112929497(LYN)
AML: 100479606(LYN)
UMR: 103677438(LYN)
UAH: 113268089(LYN)
ORO: 101383639(LYN)
ELK: 111155370
FCA: 101096633(LYN)
PTG: 102957150(LYN)
PPAD: 109250302(LYN)
AJU: 106982528(LYN)
BTA: 534996(LYN)
BOM: 102276698(LYN)
BIU: 109568555(LYN)
BBUB: 102394691(LYN)
CHX: 102184639(LYN)
OAS: 100302103(LYN)
SSC: 100152890(LYN)
CFR: 102515625(LYN)
CDK: 105097055(LYN)
BACU: 103001606(LYN)
LVE: 103074440(LYN)
OOR: 101280666(LYN)
DLE: 111165865(LYN)
PCAD: 102984630(LYN)
ECB: 100053129(LYN)
EPZ: 103552502(LYN)
EAI: 106841654(LYN)
MYB: 102262917(LYN)
MYD: 102755397(LYN)
MNA: 107533160(LYN)
HAI: 109394449(LYN)
DRO: 112315403(LYN)
PALE: 102880204(LYN)
RAY: 107500716(LYN)
LAV: 100673903(LYN)
TMU: 101353037
MDO: 100616821(LYN)
SHR: 100929196(LYN)
PCW: 110221373(LYN)
OAA: 100079507(LYN)
GGA: 421127(LYN)
MGP: 100550537(LYN)
CJO: 107310194(LYN)
NMEL: 110393410(LYN)
APLA: 101803881(LYN)
ACYG: 106039045(LYN)
TGU: 100230728(LYN)
LSR: 110484761(LYN)
SCAN: 103812340(LYN)
GFR: 102032206(LYN)
FAB: 101812689(LYN)
PHI: 102103954(LYN)
PMAJ: 107200243(LYN)
CCAE: 111924719(LYN)
CCW: 104690380(LYN)
ETL: 114060207(LYN)
FPG: 101914020(LYN)
FCH: 102048730(LYN)
CLV: 102084226(LYN)
EGZ: 104127723(LYN)
NNI: 104019751(LYN)
ACUN: 113477137(LYN)
PADL: 103923663(LYN)
AAM: 106494468(LYN)
ASN: 102383816(LYN)
AMJ: 102566940(LYN)
PSS: 102462919(LYN)
CMY: 102931818(LYN)
CPIC: 101950325(LYN)
ACS: 100554372(lyn)
PVT: 110089695(LYN)
PBI: 103061071
PMUR: 107284322(LYN)
TSR: 106540519(LYN)
PMUA: 114600595(LYN)
GJA: 107113876(LYN)
XLA: 108695301(lyn.S) 373649(lyn.L)
XTR: 549989(lyn)
NPR: 108789967(LYN)
DRE: 447804(lyn)
SANH: 107674289
TRU: 101072875
LCO: 104929874
NCC: 104963253
MZE: 101477890
ONL: 100711419
OLA: 101167902
XMA: 102235662
XCO: 114145990
PRET: 103478918
CVG: 107091676
NFU: 107384206
KMR: 108238651(lyn)
ALIM: 106514931
AOCE: 111580728
POV: 109637092
LCF: 108883973
SDU: 111239118
SLAL: 111653435
HCQ: 109515497
BPEC: 110170453
MALB: 109962671
SASA: 100196779(lyn) 106569254
ELS: 105022707(lyn)
SFM: 108929639(lyn) 108937715
LCM: 102360998(LYN)
CMK: 103177046(lyn)
RTP: 109918542
 » show all
Reference
PMID:3561390
  Authors
Yamanashi Y, Fukushige S, Semba K, Sukegawa J, Miyajima N, Matsubara K, Yamamoto T, Toyoshima K
  Title
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
  Journal
Mol Cell Biol 7:237-43 (1987)
DOI:10.1128/MCB.7.1.237
  Sequence
[hsa:4067]
Reference
  Authors
Gaul BS, Harrison ML, Geahlen RL, Burton RA, Post CB
  Title
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor.
  Journal
J Biol Chem 275:16174-82 (2000)
DOI:10.1074/jbc.M909044199

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