KEGG ORTHOLOGY: K09708

ORTHOLOGY: K09708

Entry

K09708                      KO

Symbol

ACE2, ACEH

Name

angiotensin-converting enzyme 2 [EC:3.4.17.23]

Pathway

map03262

Virion - Coronavirus

map04614

Renin-angiotensin system

map04974

Protein digestion and absorption

map05171

Coronavirus disease - COVID-19

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03262 Virion - Coronavirus
    K09708  ACE2, ACEH; angiotensin-converting enzyme 2
09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    K09708  ACE2, ACEH; angiotensin-converting enzyme 2
  09154 Digestive system
   04974 Protein digestion and absorption
    K09708  ACE2, ACEH; angiotensin-converting enzyme 2
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K09708  ACE2, ACEH; angiotensin-converting enzyme 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K09708  ACE2, ACEH; angiotensin-converting enzyme 2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K09708  ACE2, ACEH; angiotensin-converting enzyme 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.17  Metallocarboxypeptidases
    3.4.17.23  angiotensin-converting enzyme 2
     K09708  ACE2, ACEH; angiotensin-converting enzyme 2
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M2
   K09708  ACE2, ACEH; angiotensin-converting enzyme 2
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K09708  ACE2, ACEH; angiotensin-converting enzyme 2

Other DBs

GO:

0004180

Genes

HSA:	59272(ACE2)

PTR:	465511(ACE2)

PPS:	100970340(ACE2)

GGO:	101142534(ACE2)

PON:	100171441(ACE2)

PPYG:

129024770(ACE2)

NLE:	100602708(ACE2)

HMH:	116811532(ACE2)

SSYN:

129476374(ACE2)

MCC:	712790(ACE2)

MCF:	102130864(ACE2)

MTHB:

126946901

MNI:	105478157(ACE2)

CSAB:

103231639(ACE2)

CATY:

105574684(ACE2)

PANU:

101008749(ACE2)

TGE:	112615413(ACE2)

MLEU:

105550583(ACE2)

RRO:	104664530(ACE2)

RBB:	108539696(ACE2)

TFN:	117077264(ACE2)

PTEH:

111531712(ACE2)

CANG:

105510462

CJC:	100408882(ACE2)

SBQ:	101045190(ACE2)

CIMI:

108291904(ACE2)

ANAN:

105705080(ACE2)

CSYR:

103267011(ACE2)

MMUR:

105882317(ACE2)

LCAT:

123628560(ACE2)

PCOQ:

105805773(ACE2)

OGA:	100951881(ACE2)

MMU:	70008(Ace2)

MCAL:

110286854(Ace2)

MPAH:

110313851(Ace2)

RNO:	302668(Ace2)

MCOC:

116090418(Ace2)

ANU:	117695200(Ace2)

MUN:	110542541(Ace2)

CGE:	100772552(Ace2)

MAUA:

101823817(Ace2)

PROB:

127218185(Ace2)

PLEU:

114705723(Ace2)

MORG:

121439480(Ace2)

MFOT:

126512736

AAMP:

119804711(Ace2)

NGI:	103740288(Ace2)

HGL:	101697829(Ace2)

CPOC:

100302675(Ace2)

DORD:

105997641(Ace2)

DSP:	122108549(Ace2)

PLOP:

125344172(Ace2)

NCAR:

124971823

MMMA:

107144246(Ace2)

OCU:	100327258(ACE2)

OPI:	101526767(ACE2)

TUP:	102484728(ACE2)

GVR:

103607293

CFA:	480847(ACE2)

CLUD:

112653200(ACE2)

VVP:	112910549(ACE2)

VLG:	121483384(ACE2)

NPO:	129518830(ACE2)

AML:	100465802(ACE2)

UMR:	103668146(ACE2)

UAH:	113240702(ACE2)

UAR:	123797272(ACE2)

ELK:

111157129

LLV:

125091709

MPUF:

101673097(ACE2)

MNP:	132006914(ACE2)

MLK:	131821656(ACE2)

NVS:	122897655(ACE2)

ORO:	101373514(ACE2)

EJU:	114218071(ACE2)

ZCA:	113931501(ACE2)

MLX:	118004949(ACE2)

NSU:	110572485(ACE2)

LWW:

102726269

FCA:	554349(ACE2)

PYU:	121025614(ACE2)

PCOO:

112871621(ACE2)

PBG:	122476826(ACE2)

PVIV:

125157818(ACE2)

LRUF:

124509367

PTG:	102965716(ACE2)

PPAD:

109248320(ACE2)

PUC:

125931501

AJU:

106974224

HHV:	120232915(ACE2)

BTA:	509235(ACE2)

BOM:	102274886(ACE2)

BIU:	109555348(ACE2)

BBUB:

102409199(ACE2)

BBIS:

104984774(ACE2)

CHX:	102184608(ACE2)

OAS:	101103622(ACE2)

BTAX:

128070268(ACE2)

ODA:	120882560(ACE2)

CCAD:

122434819(ACE2)

MBEZ:

129564307(ACE2)

SSC:	100144303(ACE2)

CFR:	102523304(ACE2)

CBAI:

105079297(ACE2)

CDK:	105100402(ACE2)

VPC:	102526063(ACE2)

BACU:

103009000(ACE2)

BMUS:

118888930(ACE2)

LVE:	103086585(ACE2)

OOR:	101283738(ACE2)

DLE:	111168887(ACE2)

PCAD:

102996907(ACE2)

PSIU:

116747656(ACE2)

NASI:

112399149(ACE2)

ECB:	100055952(ACE2)

EPZ:	103568003(ACE2)

EAI:	106841569(ACE2)

MYB:	102259026(ACE2)

MYD:	102763166(ACE2)

MMYO:

118654484(ACE2)

MLF:	102419076(ACE2)

MDT:	132224863(ACE2)

PKL:	118719785(ACE2)

EFUS:

103298184(ACE2)

MNA:	107529512(ACE2)

DRO:	112313373(ACE2)

SHON:

118987251(ACE2)

AJM:	119058376(ACE2)

PDIC:

114504693(ACE2)

PHAS:

123829997(ACE2)

MMF:	118636490(ACE2)

PPAM:

129076971(ACE2)

HAI:	109395939(ACE2)

RFQ:	117022979(ACE2)

PALE:

102888407(ACE2)

PGIG:

120611083(ACE2)

PVP:	105294000(ACE2)

RAY:	107497263(ACE2)

MJV:	108390919(ACE2)

TOD:	119246786(ACE2)

SARA:

101538370(ACE2)

SETR:

125998723(ACE2)

LAV:	100663153(ACE2)

TMU:

101343545

ETF:	101656395(ACE2)

DNM:	101429092(ACE2)

MDO:	100031783(ACE2)

GAS:	123241705(ACE2)

SHR:	100917420(ACE2)

AFZ:

127553615

PCW:	110222490(ACE2)

TVP:	118837758(ACE2)

OAA:	100085223(ACE2)

GGA:	418623(ACE2)

PCOC:

116230727(ACE2)

MGP:	100541186(ACE2)

CJO:	107325566(ACE2)

TPAI:

128076552(ACE2)

LMUT:

125687963(ACE2)

NMEL:

110392736(ACE2)

APLA:

101792697(ACE2)

ACYG:

106037784(ACE2)

CATA:

118245768(ACE2)

AFUL:

116498237(ACE2)

TGU:	100232752(ACE2)

LSR:	110471619(ACE2)

SCAN:

103815821(ACE2)

PMOA:

120504620(ACE2)

OTC:	121342248(ACE2)

PRUF:

121356213(ACE2)

GFR:	102037445(ACE2)

FAB:	101814772(ACE2)

OMA:	130252717(ACE2)

PHI:	102108306(ACE2)

PMAJ:

107206020(ACE2)

CCAE:

111922841(ACE2)

CCW:	104686166(ACE2)

CBRC:

103611746(ACE2)

ETL:	114066567(ACE2)

ZAB:	102067801(ACE2)

ZLE:	135445434(ACE2)

ACHL:

103810970(ACE2)

SVG:	106852915(ACE2)

MMEA:

130578770(ACE2)

HRT:	120748819(ACE2)

SATI:

136358072(ACE2)

FPG:	101911905(ACE2)

FCH:	102045810(ACE2)

CCRI:

104165694(ACE2)

NNT:	104405453(ACE2)

SHAB:

115604077(ACE2)

ACUN:

113480767(ACE2)

TALA:

104364304(ACE2)

ACHC:

115334679(ACE2)

HALD:

104310355(ACE2)

HLE:	104840548(ACE2)

AGEN:

126052875

GCL:

127026027

CSTI:

104561893(ACE2)

LDI:	104350299(ACE2)

MNB:	103771950(ACE2)

AVIT:

104273417(ACE2)

BRHI:

104495535(ACE2)

EGZ:	104127303(ACE2)

NNI:	104022575(ACE2)

PCRI:

104029332(ACE2)

PCAO:

104049988(ACE2)

PADL:

103918227(ACE2)

AFOR:

103896937(ACE2)

FGA:	104075932(ACE2)

GSTE:

104261683(ACE2)

CLV:	102095592(ACE2)

MUI:	104537500(ACE2)

PGUU:

104470941(ACE2)

PLET:

104624367(ACE2)

EHS:	104502443(ACE2)

CMAC:

104481125(ACE2)

CUCA:

104063399(ACE2)

TEO:	104374083(ACE2)

BREG:

104636426

OHA:	104334989(ACE2)

ACAR:

104527265(ACE2)

CPEA:

104385382(ACE2)

CVF:	104289986(ACE2)

RTD:	128915154(ACE2)

AAM:	106490772(ACE2)

AROW:

112976192(ACE2)

NPD:	112943996(ACE2)

TGT:	104572141(ACE2)

DNE:	112995661(ACE2)

SCAM:

104140442(ACE2)

ASN:	102388701(ACE2)

AMJ:	102570994(ACE2)

CPOO:

109306030(ACE2)

GGN:	109303314(ACE2)

PSS:	102452742(ACE2)

CMY:	102938941(ACE2)

CCAY:

125641506(ACE2)

DCC:	119843507(ACE2)

CPIC:

101950848(ACE2)

TST:	117869503(ACE2)

CABI:

116821846(ACE2)

MRV:	120375732(ACE2)

ACS:	100565298(ace2)

ASAO:

132771692(ACE2)

PVT:	110075460(ACE2)

SUND:

121925094(ACE2)

PBI:	103068164(ACE2)

PMUR:

107290068(ACE2)

CTIG:

120306512(ACE2)

TSR:	106541239 106553039(ACE2)

PGUT:

117675857(ACE2)

APRI:

131199951(ACE2)

PTEX:

113445202(ACE2)

NSS:	113416856(ACE2)

VKO:	123033092(ACE2)

PRAF:

128413188(ACE2)

ZVI:	118085306(ACE2)

HCG:	128351280(ACE2)

GJA:	107115822(ACE2)

STOW:

125431331(ACE2)

EMC:	129325501(ACE2)

XLA:	100037182(ace2.S) 108707435(ace2.L)

XTR:	100486137(ace2)

NPR:	108792313(ACE2)

RTEM:

120927763(ACE2)

BBUF:

120994623(ACE2)

BGAR:

122927935 122930372(ACE2)

MUO:	115469546(ACE2)

GSH:	117363038(ACE2)

DRE:	492331(ace2)

SRX:	107737258 107751135

SANH:

107691301(ace2) 107695051

SGH:	107555905 107569674

CCAR:

109101192 109101497

CAUA:

113055292 113111073(ace2)

CGIB:

127968584 128022223

PTET:

122354480(ace2)

LROH:

127172960(ace2)

OMC:	131549029(ace2)

PPRM:

120480577(ace2)

RKG:	130085545(ace2)

MAMB:

125256625(ace2)

CIDE:

127522319

CERY:

137021491(ace2)

MASI:

127426183 127428003

TROS:

130571431(ace2)

TDW:	130410350(ace2)

MANU:

129427964(ace2)

IPU:

108259124

IFU:	128603044(ace2)

PHYP:

113547458(ace2)

SMEO:

124380062(ace2)

TFD:	113657143(ace2)

TVC:	132838731(ace2)

TRN:	134304225(ace2)

AMEX:

103030208(ace2)

CMAO:

118800932(ace2)

EEE:	113578258(ace2)

CHAR:

105893318(ace2) 105893961

TRU:	101066589(ace2)

TFS:	130517506(ace2)

TNG:	GSTEN00018041G001

LCO:	104919764(ace2)

NCC:	104963551(ace2)

TBEN:

117471608(ace2)

CGOB:

115005777(ace2)

PGEO:

117465461(ace2)

GACU:

117549374(ace2)

EMAC:

134863466(ace2)

ELY:	117263329(ace2)

EFO:	125878828(ace2)

PLEP:

121945388(ace2)

SLUC:

116054689(ace2)

ECRA:

117947475(ace2)

ESP:	116669656(ace2)

PFLV:

114560278(ace2)

GAT:	120808741(ace2)

PPUG:

119225508(ace2)

AFB:	129106465(ace2)

CLUM:

117727424(ace2)

PSWI:

130192921(ace2)

MSAM:

119890262(ace2)

SCHU:

122874501(ace2)

CUD:	121521168(ace2)

ALAT:

119018333(ace2)

MZE:	101480744(ace2)

ONL:	100699386(ace2)

OAU:	116311736(ace2)

OML:	112160389(ace2)

CSAI:

133460181(ace2)

XMA:	102218691(ace2)

XCO:	114143639(ace2)

XHE:	116719116(ace2)

PRET:

103462028(ace2)

PFOR:

103143561(ace2)

PLAI:

106952008(ace2)

PMEI:

106914635(ace2)

GAF:	122820294(ace2)

PPRL:

129369427(ace2)

CVG:	107082518(ace2)

CTUL:

119782330(ace2)

GMU:	124867441(ace2)

NFU:	107381688(ace2)

KMR:	108250149(ace2)

ALIM:

106536269(ace2)

NWH:	119429166(ace2)

AOCE:

111567340(ace2)

MCEP:

125005739(ace2)

CSEM:

103378664(ace2)

POV:	109624773(ace2)

SSEN:

122771881(ace2)

HHIP:

117759282(ace2)

HSP:	118113077(ace2)

PPLT:

128434631(ace2)

SMAU:

118302191(ace2)

LCF:

108887946

SDU:	111224725(ace2)

SLAL:

111651666(ace2)

XGL:	120794742(ace2)

HCQ:	109526010(ace2)

SSCV:

125966797

SBIA:

133497730(ace2)

PEE:	133399314(ace2)

PTAO:

133467595(ace2)

BPEC:

110161222(ace2)

MALB:

109965722(ace2)

BSPL:

114851880(ace2)

SJO:	128360392(ace2)

SASA:

106595857 106609069(ace2)

STRU:

115188686 115188791

OTW:	112239661(ace2)

OMY:	110496986 110500299

OGO:

124028887

OKI:	109879259 109887010

OKE:	118382156(ace2)

SALP:

112076415(ace2)

SNH:	120042338 120042431(ace2)

CCLU:

121562841(ace2)

ELS:	105019921(ace2)

SFM:	108920456(ace2)

PKI:	111850234(ace2)

AANG:

118213842(ace2)

LOC:	102690232(ace2)

PSPA:

121320626(ace2) 121328027

ARUT:

117406081 117407347(ace2)

PSEX:

120523603(ace2)

LCM:	102362771(ACE2)

CMK:	103177482(ace2)

HOC:	132820893(ace2)

LERI:

129702785(ace2)

PMRN:

116957162(ACE2)

BBEL:

LPIC:

ARUN:

AJC:

SKO:	100375272 100375575 102806594

OBB:

CGIG:

SOC:

MPHA:

HST:

DQU:

LHU:

OBO:

DPX:	DAPPUDRAFT_65345

DMK:	116922098 116928362

DPZ:	124312323 124328503 124328504 124340502

HAME:

CQD:

MNZ:

TCF:

Reference

PMID:10969042

Authors

Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S

Title

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.

Journal

Circ Res 87:E1-9 (2000)
DOI:10.1161/01.RES.87.5.e1

Sequence

[hsa:59272]

All links

Ontology (5)   
   KEGG BRITE (4)   
   GO (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1078)   
   KEGG GENES (438)   
   KEGG MGENES (240)   
   RefGene (395)   
   OC (5)   
Literature (1)   
   PubMed (1)   
All databases (1093)   

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