| Entry |
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| Name |
(5-formylfuran-3-yl)methyl phosphate synthase;
mfnB (gene name);
4-HFC-P synthase;
4-(hydroxymethyl)-2-furaldehyde phosphate synthase
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| Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
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| Sysname |
D-glyceraldehyde-3-phosphate phosphate-lyase [D-glyceraldehyde-3-phosphate-adding; (5-formylfuran-3-yl)methyl-phosphate-forming]
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| Reaction(IUBMB) |
2 D-glyceraldehyde 3-phosphate = (5-formylfuran-3-yl)methyl phosphate + phosphate + 2 H2O [RN: R10935]
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| Reaction(KEGG) |
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| Substrate |
D-glyceraldehyde 3-phosphate [CPD: C00118]
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| Product |
(5-formylfuran-3-yl)methyl phosphate [CPD: C20954];
phosphate [CPD: C00009];
H2O [CPD: C00001]
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| Comment |
The enzyme catalyses the reaction in the direction of producing (5-formylfuran-3-yl)methyl phosphate, an intermediate in the biosynthesis of methanofuran. The sequence of events starts with the removal of a phosphate group, followed by aldol condensation and cyclization. Methanofuran is a carbon-carrier cofactor involved in the first step of the methanogenic reduction of carbon dioxide by methanogenic archaea.
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| History |
EC 4.2.3.153 created 2015 as EC 4.1.99.21, transferred 2015 to EC 4.2.3.153
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| Pathway |
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| Orthology |
| K09733 | (5-formylfuran-3-yl)methyl phosphate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Miller D, Wang Y, Xu H, Harich K, White RH |
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| Title |
Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Bobik TA, Morales EJ, Shin A, Cascio D, Sawaya MR, Arbing M, Yeates TO, Rasche ME |
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| Title |
Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Wang Y, Jones MK, Xu H, Ray WK, White RH |
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| Title |
Mechanism of the Enzymatic Synthesis of 4-(Hydroxymethyl)-2- furancarboxaldehyde-phosphate (4-HFC-P) from Glyceraldehyde-3-phosphate Catalyzed by 4-HFC-P Synthase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.3.153 |
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