KEGG   ORTHOLOGY: K09827Help
Entry
K09827                      KO                                     

Name
ERG27
Definition
3-keto steroid reductase [EC:1.1.1.270]
Pathway
ko00100  Steroid biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K09827  ERG27; 3-keto steroid reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.270  3beta-hydroxysteroid 3-dehydrogenase
     K09827  ERG27; 3-keto steroid reductase
BRITE hierarchy
Other DBs
RN: R07495 R12405
COG: COG1028
GO: 0050576
Genes
QSU: 111993502 112014247
SCE: YLR100W(ERG27)
AGO: AGOS_AGR068W
ERC: Ecym_4279
KLA: KLLA0_F19756g
KMX: KLMA_40163(ERG27)
LTH: KLTH0G13046g
VPO: Kpol_1033p20
ZRO: ZYRO0D06534g
CGR: CAGL0M11506g
NCS: NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: TPHA_0C01040(TPHA0C01040)
TBL: TBLA_0D04010(TBLA0D04010)
TDL: TDEL_0F04160(TDEL0F04160)
KAF: KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
PIC: PICST_61325(ERG27)
CAL: CAALFM_CR01140CA(ERG27)
CDU: CD36_26140(ERG27)
SLB: AWJ20_1569(ERG27)
NCR: NCU05991
NTE: NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SSCK: SPSK_07425
MAW: MAC_02683
MAJ: MAA_02120
CMT: CCM_05105
MBE: MBM_01041
ANI: AN5585.2
ANG: ANI_1_1880184(An04g05000)
ABE: ARB_02354
TVE: TRV_04668
PTE: PTT_11743
SPO: SPBC1709.07(erg27)
ABP: AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: AGABI2DRAFT202140(AGABI2DRAFT_202140)
MGL: MGL_2564
MRT: MRET_0524
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]

KEGG   ORTHOLOGY: K13373Help
Entry
K13373                      KO                                     

Name
HSD17B7
Definition
17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]
Pathway
ko00100  Steroid biosynthesis
ko00140  Steroid hormone biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
ko04913  Ovarian steroidogenesis
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
   00140 Steroid hormone biosynthesis
    K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
    1.1.1.270  3beta-hydroxysteroid 3-dehydrogenase
     K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
BRITE hierarchy
Other DBs
RN: R02352 R02353 R04681 R04682 R07495 R08945 R08980 R12405
GO: 0004303 0050576
Genes
HSA: 51478(HSD17B7)
PTR: 466046 747814(HSD17B7)
PPS: 100985156(HSD17B7)
GGO: 101137638(HSD17B7)
PON: 100446761(HSD17B7)
NLE: 100587120(HSD17B7)
MCC: 720399
MCF: 102127673(HSD17B7)
CSAB: 103223654(HSD17B7)
RRO: 104656967(HSD17B7)
RBB: 108535633
CJC: 100410416(HSD17B7)
SBQ: 101047238(HSD17B7)
MMU: 15490(Hsd17b7)
MCAL: 110292934(Hsd17b7)
MPAH: 110322287(Hsd17b7)
RNO: 29540(Hsd17b7)
MUN: 110550630(Hsd17b7)
CGE: 100767580(Hsd17b7)
NGI: 103746788(Hsd17b7)
HGL: 101712707(Hsd17b7)
CCAN: 109690973(Hsd17b7)
OCU: 100008778(HSD17B7) 100349261
TUP: 102473205(HSD17B7)
CFA: 609364(HSD17B7)
VVP: 112914306(HSD17B7)
AML: 100477716(HSD17B7)
UMR: 103658287(HSD17B7)
UAH: 113268675(HSD17B7)
ORO: 101368538(HSD17B7)
ELK: 111151061
FCA: 101083482(HSD17B7)
PTG: 102968316(HSD17B7)
PPAD: 109276652(HSD17B7)
AJU: 106986761(HSD17B7)
BTA: 505212(HSD17B7)
BOM: 102266348(HSD17B7)
BIU: 109577890(HSD17B7)
BBUB: 102389083(HSD17B7)
CHX: 102179058(HSD17B7)
OAS: 101110013(HSD17B7)
SSC: 100155418(HSD17B7)
CFR: 102512546(HSD17B7)
CDK: 105092702(HSD17B7)
BACU: 103014331(HSD17B7)
LVE: 103084050(HSD17B7)
OOR: 101286750(HSD17B7)
DLE: 111169243(HSD17B7)
PCAD: 102984493(HSD17B7)
ECB: 100059061(HSD17B7)
EPZ: 103559639(HSD17B7)
EAI: 106823694(HSD17B7)
MYB: 102251181(HSD17B7)
MYD: 102767046(HSD17B7)
MNA: 107535110(HSD17B7)
HAI: 109392309(HSD17B7)
DRO: 112298817(HSD17B7)
PALE: 102892079(HSD17B7)
RAY: 107502487(HSD17B7)
MJV: 108396655(HSD17B7)
LAV: 100676060 100676343(HSD17B7)
MDO: 100016071(HSD17B7)
SHR: 100926227(HSD17B7)
PCW: 110209887(HSD17B7)
OAA: 114817513(HSD17B7)
GGA: 424367(HSD17B7)
MGP: 100542640(HSD17B7)
CJO: 107317140(HSD17B7)
NMEL: 110402344(HSD17B7)
APLA: 101799136(HSD17B7)
ACYG: 106041628(HSD17B7)
TGU: 100222823(HSD17B7)
LSR: 110478897(HSD17B7)
SCAN: 103824326(HSD17B7)
GFR: 102042580(HSD17B7)
FAB: 101818521(HSD17B7)
PHI: 102107312(HSD17B7)
PMAJ: 107198613(HSD17B7)
CCAE: 111932684(HSD17B7)
CCW: 104695594(HSD17B7)
ETL: 114067481(HSD17B7)
FPG: 101919410(HSD17B7)
FCH: 102059217(HSD17B7)
CLV: 102097738(HSD17B7)
EGZ: 104132130(HSD17B7)
NNI: 104010459(HSD17B7)
ACUN: 113483111(HSD17B7)
PADL: 103914076(HSD17B7)
AAM: 106499711(HSD17B7)
ASN: 102374189(HSD17B7)
AMJ: 102565865(HSD17B7)
PSS: 102461698(HSD17B7)
CMY: 102944731(HSD17B7)
CPIC: 101953232(HSD17B7)
ACS: 100556465(hsd17b7)
PVT: 110081655(HSD17B7)
PBI: 103063132(HSD17B7)
PMUR: 107302880(HSD17B7)
PMUA: 114598525(HSD17B7)
GJA: 107121042(HSD17B7)
XLA: 108714499(hsd17b7.L) 734717(hsd17b7.S)
XTR: 548963(hsd17b7)
NPR: 108801354(HSD17B7)
DRE: 768185(hsd17b7)
SANH: 107684349(hsd17b7) 107692446
CCAR: 109091408
IPU: 108271889(hsd17b7)
PHYP: 113538418(hsd17b7)
AMEX: 103035681(hsd17b7)
EEE: 113570462(hsd17b7)
TRU: 101072277 101079626(hsd17b7)
NCC: 104948248(hsd17b7) 104967182
XMA: 102223080(hsd17b7) 102225591
ALIM: 106528419(hsd17b7)
POV: 109625649(hsd17b7) 109644359
BPEC: 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109966957
OTW: 112260221
SALP: 111957119(hsd17b7)
ELS: 105024805
SFM: 108935177(hsd17b7)
PKI: 111841069(hsd17b7)
LCM: 102348492(HSD17B7)
CMK: 103180036(hsd17b7)
RTP: 109925128(hsd17b7)
CIN: 100180521
SPU: 588363
APLC: 110976300
SKO: 102804082
PCAN: 112564142
CRG: 105338891
MYI: 110457107
LAK: 106150742
AQU: 100638506
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]

KEGG   ENZYME: 1.1.1.270Help
Entry
EC 1.1.1.270                Enzyme                                 

Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R12402]
Reaction(KEGG)
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K09827  3-keto steroid reductase
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 51478(HSD17B7) 79154(DHRS11)
PTR: 454598(DHRS11) 466046 747814(HSD17B7)
PPS: 100985156(HSD17B7) 100989828(DHRS11)
GGO: 101133645(DHRS11) 101137638(HSD17B7)
PON: 100446761(HSD17B7) 100450428(DHRS11)
NLE: 100580130(DHRS11) 100587120(HSD17B7)
MCC: 713823(DHRS11) 720399
MCF: 102127673(HSD17B7) 102133734(DHRS11)
CSAB: 103223654(HSD17B7) 103242795(DHRS11)
RRO: 104656967(HSD17B7) 104672997(DHRS11)
RBB: 108526295(DHRS11) 108535633
CJC: 100410416(HSD17B7) 100415468(DHRS11)
SBQ: 101047238(HSD17B7) 101049784(DHRS11)
MMU: 15490(Hsd17b7) 192970(Dhrs11)
MCAL: 110292934(Hsd17b7) 110304998(Dhrs11)
MPAH: 110322287(Hsd17b7) 110332326(Dhrs11)
RNO: 29540(Hsd17b7) 360583(Dhrs11)
MUN: 110550630(Hsd17b7) 110555253(Dhrs11)
CGE: 100763193(Dhrs11) 100767580(Hsd17b7)
NGI: 103732605(Dhrs11) 103746788(Hsd17b7)
HGL: 101704213(Dhrs11) 101712707(Hsd17b7)
CCAN: 109690973(Hsd17b7) 109691233(Dhrs11)
OCU: 100008778(HSD17B7) 100349261 100350282(DHRS11)
TUP: 102473205(HSD17B7) 102481007(DHRS11)
CFA: 491129(DHRS11) 609364(HSD17B7)
VVP: 112914306(HSD17B7) 112917964(DHRS11)
AML: 100477716(HSD17B7) 100483445(DHRS11)
UMR: 103658287(HSD17B7) 103667445(DHRS11)
UAH: 113268675(HSD17B7) 113268922(DHRS11)
ORO: 101368538(HSD17B7) 101372465(DHRS11)
FCA: 101083482(HSD17B7) 101083724(DHRS11)
PTG: 102953856(DHRS11) 102968316(HSD17B7)
PPAD: 109251987(DHRS11) 109276652(HSD17B7)
AJU: 106980443(DHRS11) 106986761(HSD17B7)
BTA: 505212(HSD17B7) 510264(DHRS11)
BOM: 102266348(HSD17B7) 102267490(DHRS11)
BIU: 109574096(DHRS11) 109577890(HSD17B7)
BBUB: 102389083(HSD17B7) 102414485(DHRS11)
CHX: 102176160(DHRS11) 102179058(HSD17B7)
OAS: 101109465(DHRS11) 101110013(HSD17B7)
SSC: 100155418(HSD17B7) 100513307(DHRS11)
CFR: 102507556(DHRS11) 102512546(HSD17B7)
CDK: 105092702(HSD17B7) 105097850(DHRS11)
BACU: 103011691(DHRS11) 103014331(HSD17B7)
LVE: 103069867(DHRS11) 103084050(HSD17B7)
OOR: 101278328(DHRS11) 101286750(HSD17B7)
DLE: 111163734(DHRS11) 111169243(HSD17B7)
PCAD: 102984493(HSD17B7) 102995379(DHRS11)
ECB: 100059061(HSD17B7) 100071416(DHRS11)
EPZ: 103554456(DHRS11) 103559639(HSD17B7)
EAI: 106823694(HSD17B7) 106844689(DHRS11)
MYB: 102251181(HSD17B7) 102262752(DHRS11)
MYD: 102765268(DHRS11) 102767046(HSD17B7)
MNA: 107530816(DHRS11) 107535110(HSD17B7)
HAI: 109379798(DHRS11) 109392309(HSD17B7)
DRO: 112298817(HSD17B7) 112316505(DHRS11)
PALE: 102892079(HSD17B7) 102894290(DHRS11)
RAY: 107502487(HSD17B7) 107510114(DHRS11)
MJV: 108383263(DHRS11) 108396655(HSD17B7)
LAV: 100676060 100676239(DHRS11) 100676343(HSD17B7)
MDO: 100016071(HSD17B7) 100618596(DHRS11)
SHR: 100926227(HSD17B7) 100933320(DHRS11)
PCW: 110209887(HSD17B7) 110212020(DHRS11)
OAA: 100077820(DHRS11) 114817513(HSD17B7)
GGA: 395172(DHRS11) 424367(HSD17B7)
MGP: 100542399(DHRS11) 100542640(HSD17B7)
CJO: 107317140(HSD17B7) 107322636(DHRS11)
NMEL: 110402344(HSD17B7)
APLA: 101796287(DHRS11) 101799136(HSD17B7)
ACYG: 106041628(HSD17B7) 106046860(DHRS11)
TGU: 100222823(HSD17B7) 100230987(DHRS11)
LSR: 110467717(DHRS11) 110478897(HSD17B7)
SCAN: 103820184(DHRS11) 103824326(HSD17B7)
GFR: 102031952(DHRS11) 102042580(HSD17B7)
FAB: 101806967(DHRS11) 101818521(HSD17B7)
PHI: 102107312(HSD17B7) 102113937(DHRS11)
PMAJ: 107198613(HSD17B7) 107213026(DHRS11)
CCAE: 111932684(HSD17B7) 111937859(DHRS11)
CCW: 104690988(DHRS11) 104695594(HSD17B7)
ETL: 114057489(DHRS11) 114067481(HSD17B7)
FPG: 101912846(DHRS11) 101919410(HSD17B7)
FCH: 102050282(DHRS11) 102059217(HSD17B7)
CLV: 102090168(DHRS11) 102097738(HSD17B7)
EGZ: 104121871(DHRS11) 104132130(HSD17B7)
NNI: 104010459(HSD17B7) 104016400(DHRS11)
ACUN: 113483111(HSD17B7) 113487258(DHRS11)
PADL: 103914076(HSD17B7) 103917037(DHRS11)
AAM: 106494687(DHRS11) 106499711(HSD17B7)
ASN: 102374189(HSD17B7) 112551119(DHRS11)
AMJ: 102561890(DHRS11) 102565865(HSD17B7)
PSS: 102452802(DHRS11) 102461698(HSD17B7)
CMY: 102944731(HSD17B7) 102944881(DHRS11)
CPIC: 101936463(DHRS11) 101953232(HSD17B7)
ACS: 100556465(hsd17b7)
PVT: 110075560(DHRS11) 110081655(HSD17B7)
PBI: 103063132(HSD17B7) 103065679(DHRS11)
PMUR: 107294873(DHRS11) 107302880(HSD17B7)
TSR: 106539066(DHRS11)
PMUA: 114585448(DHRS11) 114598525(HSD17B7)
GJA: 107108933(DHRS11) 107121042(HSD17B7)
XLA: 108714499(hsd17b7.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR: 496708(dhrs11) 548963(hsd17b7)
NPR: 108801354(HSD17B7)
DRE: 768185(hsd17b7) 791578(dhrs11a)
IPU: 108260417(dhrs11) 108271889(hsd17b7)
PHYP: 113531061(dhrs11) 113538418(hsd17b7)
EEE: 113570462(hsd17b7) 113577576(dhrs11)
NCC: 104948248(hsd17b7) 104963923(dhrs11) 104967182 104967580
POV: 109625649(hsd17b7) 109628284(dhrs11) 109644359
BPEC: 110163629 110165106(dhrs11) 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109960466(dhrs11) 109966957
SFM: 108921710(dhrs11) 108935177(hsd17b7) 108938265
PKI: 111841069(hsd17b7) 111854721(dhrs11) 111859701
LCM: 102348492(HSD17B7) 102362545(DHRS11)
CMK: 103180036(hsd17b7) 103180635(dhrs11)
RTP: 109920236(dhrs11) 109925128(hsd17b7)
BTER: 100648073
HST: 105183111
OBO: 105274796
PCF: 106791135
TNL: 113498949
BTAB: 109032727
PTEP: 107437425
MNG: MNEG_6911
SCE: YLR100W(ERG27)
ERC: Ecym_4279
KMX: KLMA_40163(ERG27)
NCS: NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: TPHA_0C01040(TPHA0C01040)
TBL: TBLA_0D04010(TBLA0D04010)
TDL: TDEL_0F04160(TDEL0F04160)
KAF: KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
PIC: PICST_61325(ERG27)
CAL: CAALFM_CR01140CA(ERG27)
CDU: CD36_26140(ERG27)
SLB: AWJ20_1569(ERG27)
NCR: NCU05991
NTE: NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SSCK: SPSK_07425
MAW: MAC_02683
MAJ: MAA_02120
CMT: CCM_05105
MBE: MBM_01041
ANI: AN5585.2
ANG: ANI_1_1880184(An04g05000)
ABE: ARB_02354
TVE: TRV_04668
PTE: PTT_11743
SPO: SPBC1709.07(erg27)
ABP: AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: AGABI2DRAFT202140(AGABI2DRAFT_202140)
MGL: MGL_2564
MRT: MRET_0524
 » show all
Taxonomy
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J Biol Chem 243:5546-55 (1968)
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch Biochem Biophys 211:430-8 (1981)
DOI:10.1016/0003-9861(81)90474-4
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.270
IUBMB Enzyme Nomenclature: 1.1.1.270
ExPASy - ENZYME nomenclature database: 1.1.1.270
BRENDA, the Enzyme Database: 1.1.1.270
CAS: 42616-29-5

KEGG   REACTION: R12405Help
Entry
R12405                      Reaction                               

Name
zymosterol:NADP+ 3-oxidoreductase
Definition
Zymosterone + NADPH + H+ <=> Zymosterol + NADP+
Equation
Reaction class
RC00144  C05437_C22136
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
Orthology
K09827  3-keto steroid reductase [EC:1.1.1.270]
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]

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