KEGG   ORTHOLOGY: K09833
Entry
K09833                      KO                                     

Name
HPT, HGGT, ubiA
Definition
homogentisate phytyltransferase / homogentisate geranylgeranyltransferase [EC:2.5.1.115 2.5.1.116]
Pathway
ko00130  Ubiquinone and other terpenoid-quinone biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K09833  HPT, HGGT, ubiA; homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K09833  HPT, HGGT, ubiA; homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.115  homogentisate phytyltransferase
     K09833  HPT, HGGT, ubiA; homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
    2.5.1.116  homogentisate geranylgeranyltransferase
     K09833  HPT, HGGT, ubiA; homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
Prenyltransferases [BR:ko01006]
 Compound prenylation
  HGA prenyltransferase
   K09833  HPT, HGGT, ubiA; homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
Other DBs
RN: R07500 R10708
COG: COG0382
GO: 0010176 0010356
Genes
ATH: AT2G18950(HPT1)
ALY: 9322319
CRB: 17890967
CSAT: 104700961 104747741 104767264 104767267
EUS: EUTSA_v10022720mg
BRP: 103828352
BNA: 106357630 106435342
BOE: 106301964
RSZ: 108807240
THJ: 104819975
TCC: 18589276
GRA: 105783372
GAB: 108450426
EGR: 104437423
CAM: 101500582
LJA: Lj0g3v0082139.1(Lj0g3v0082139.1) Lj0g3v0207399.1(Lj0g3v0207399.1) Lj0g3v0207399.2(Lj0g3v0207399.2) Lj0g3v0271809.1(Lj0g3v0271809.1) Lj0g3v0361429.2(Lj0g3v0361429.2) Lj2g3v3133590.1(Lj2g3v3133590.1) Lj4g3v2120440.1(Lj4g3v2120440.1) Lj6g3v2116900.1(Lj6g3v2116900.1)
PXB: 103934858
ZJU: 107403648
CSV: 101221791
CMO: 103492819
MCHA: 111020832
RCU: 8287864
VVI: 100232967(HGGT) 100257787
CANN: 107850218
OEU: 111402203
CCAV: 112516610
DOSA: Os06t0658900-01(Os06g0658900)
ATS: 109738157(LOC109738157) 109751933(LOC109751933) 109781124(LOC109781124)
APRO: F751_6870
OLU: OSTLU_119481(hpt1)
SMIN: v1.2.025201.t1(symbB.v1.2.025201.t1)
FCY: FRACYDRAFT_291522(VTE2)
SYN: slr1736
SYY: SYNGTS_1198(ubiA)
SYT: SYNGTI_1198(ubiA)
SYS: SYNPCCN_1197(ubiA)
SYQ: SYNPCCP_1197(ubiA)
SYP: SYNPCC7002_A0703(hggT)
CYA: CYA_1788
CYB: CYB_2237
SYV: AWQ23_03665(ubiA)
AMR: AM1_4541
MAR: MAE_41250
MPK: VL20_3746
CYT: cce_0241
TER: Tery_3881
GVI: gll0283(ubiA)
GLJ: GKIL_2663(ubiA)
ANA: alr3448
NON: NOS3756_12030(ubiA_1)
NSH: GXM_00460
AVA: Ava_3472
NAZ: Aazo_3462
ANB: ANA_C20682(ubiA)
AWA: AA650_08020(ubiA)
CALH: IJ00_11015(ubiA)
CTHE: Chro_0306
CAU: Caur_3427(ubiA)
CAG: Cagg_0386
 » show all
Reference
  Authors
Collakova E, DellaPenna D
  Title
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
  Journal
Plant Physiol 127:1113-24 (2001)
DOI:10.1104/pp.010421
  Sequence
[syn:slr1736] [ath:AT2G18950]
Reference
  Authors
Cahoon EB, Hall SE, Ripp KG, Ganzke TS, Hitz WD, Coughlan SJ
  Title
Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content.
  Journal
Nat Biotechnol 21:1082-7 (2003)
DOI:10.1038/nbt853
  Sequence
[osa:4341663]

KEGG   ENZYME: 2.5.1.116
Entry
EC 2.5.1.116                Enzyme                                 

Name
homogentisate geranylgeranyltransferase;
HGGT;
slr1736 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranylgeranyl diphosphate:homogentisate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + homogentisate = diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 [RN:R10708]
Reaction(KEGG)
R10708
Substrate
geranylgeranyl diphosphate [CPD:C00353];
homogentisate [CPD:C00544]
Product
diphosphate [CPD:C00013];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
CO2 [CPD:C00011]
Comment
Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].
History
EC 2.5.1.116 created 2014
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09833  homogentisate phytyltransferase / homogentisate geranylgeranyltransferase
Genes
ATH: AT2G18950(HPT1)
ALY: 9322319
CRB: 17890967
CSAT: 104700961 104747741 104767264 104767267
EUS: EUTSA_v10022720mg
BRP: 103828352
BNA: 106357630 106435342
BOE: 106301964
RSZ: 108807240
THJ: 104819975
TCC: 18589276
GRA: 105783372
GAB: 108450426
EGR: 104437423
CAM: 101500582
LJA: Lj0g3v0082139.1(Lj0g3v0082139.1) Lj0g3v0207399.1(Lj0g3v0207399.1) Lj0g3v0207399.2(Lj0g3v0207399.2) Lj0g3v0271809.1(Lj0g3v0271809.1) Lj0g3v0361429.2(Lj0g3v0361429.2) Lj2g3v3133590.1(Lj2g3v3133590.1) Lj4g3v2120440.1(Lj4g3v2120440.1) Lj6g3v2116900.1(Lj6g3v2116900.1)
PXB: 103934858
ZJU: 107403648
CSV: 101221791
CMO: 103492819
MCHA: 111020832
RCU: 8287864
VVI: 100232967(HGGT) 100257787
CANN: 107850218
OEU: 111402203
CCAV: 112516610
DOSA: Os06t0658900-01(Os06g0658900)
ATS: 109738157(LOC109738157) 109751933(LOC109751933) 109781124(LOC109781124)
APRO: F751_6870
OLU: OSTLU_119481(hpt1)
SMIN: v1.2.025201.t1(symbB.v1.2.025201.t1)
FCY: FRACYDRAFT_291522(VTE2)
SYN: slr1736
SYY: SYNGTS_1198(ubiA)
SYT: SYNGTI_1198(ubiA)
SYS: SYNPCCN_1197(ubiA)
SYQ: SYNPCCP_1197(ubiA)
SYP: SYNPCC7002_A0703(hggT)
CYA: CYA_1788
CYB: CYB_2237
SYV: AWQ23_03665(ubiA)
AMR: AM1_4541
MAR: MAE_41250
MPK: VL20_3746
CYT: cce_0241
TER: Tery_3881
GVI: gll0283(ubiA)
GLJ: GKIL_2663(ubiA)
ANA: alr3448
NON: NOS3756_12030(ubiA_1)
NSH: GXM_00460
AVA: Ava_3472
NAZ: Aazo_3462
ANB: ANA_C20682(ubiA)
AWA: AA650_08020(ubiA)
CALH: IJ00_11015(ubiA)
CTHE: Chro_0306
CAU: Caur_3427(ubiA)
CAG: Cagg_0386
 » show all
Reference
1  [PMID:11706191]
  Authors
Collakova E, DellaPenna D
  Title
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis.
  Journal
Plant Physiol 127:1113-24 (2001)
DOI:10.1104/pp.010421
  Sequence
[ath:AT2G18950] [syn:slr1736]
Reference
2  [PMID:12897790]
  Authors
Cahoon EB, Hall SE, Ripp KG, Ganzke TS, Hitz WD, Coughlan SJ
  Title
Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content.
  Journal
Nat Biotechnol 21:1082-7 (2003)
DOI:10.1038/nbt853
  Sequence
[osa:4341663]
Reference
3  [PMID:21223386]
  Authors
Yang W, Cahoon RE, Hunter SC, Zhang C, Han J, Borgschulte T, Cahoon EB
  Title
Vitamin E biosynthesis: functional characterization of the monocot homogentisate  geranylgeranyl transferase.
  Journal
Plant J 65:206-17 (2011)
DOI:10.1111/j.1365-313X.2010.04417.x
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.116
IUBMB Enzyme Nomenclature: 2.5.1.116
ExPASy - ENZYME nomenclature database: 2.5.1.116
BRENDA, the Enzyme Database: 2.5.1.116

KEGG   REACTION: R10708
Entry
R10708                      Reaction                               

Name
geranylgeranyl-diphosphate:homogentisate geranylgeranyltransferase
Definition
Geranylgeranyl diphosphate + Homogentisate <=> Diphosphate + 6-Geranylgeranyl-2-methylbenzene-1,4-diol + CO2
Equation
Reaction class
RC01840  C00544_C20737
Enzyme
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Orthology
K09833  homogentisate phytyltransferase / homogentisate geranylgeranyltransferase [EC:2.5.1.115 2.5.1.116]
Other DBs
RHEA: 38006

DBGET integrated database retrieval system