KEGG   ORTHOLOGY: K09834
Entry
K09834                      KO                                     

Name
VTE1, SXD1
Definition
tocopherol cyclase [EC:5.5.1.24]
Pathway
ko00130  Ubiquinone and other terpenoid-quinone biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K09834  VTE1, SXD1; tocopherol cyclase
Enzymes [BR:ko01000]
 5. Isomerases
  5.5  Intramolecular lyases
   5.5.1  Intramolecular lyases (only sub-subclass identified to date)
    5.5.1.24  tocopherol cyclase
     K09834  VTE1, SXD1; tocopherol cyclase
Other DBs
RN: R07502 R07503 R10623 R10624
GO: 0009976
Genes
ATH: AT4G32770(VTE1)
ALY: 9305317
CRB: 17877607
CSAT: 104716894 104720514 104721549 104729992
EUS: EUTSA_v10025006mg
BRP: 103862197
BNA: 106411207 106423312 106423394
BOE: 106301700
RSZ: 108851396
THJ: 104803808
CPAP: 110822117
CIT: 102615028
TCC: 18587955
DZI: 111302940
EGR: 104437768
VRA: 106762339
VAR: 108318687
VUN: 114164033
CCAJ: 109801639
CAM: 101502250
ADU: 107470774
AIP: 107623139
LANG: 109339295
FVE: 101304641
RCN: 112173193
PPER: 18791199
PMUM: 103320200
PAVI: 110761173
CSV: 101206720
CMO: 103488188
MCHA: 111004926
CMAX: 111496186
CMOS: 111454510
CPEP: 111799319
RCU: 8271188
JCU: 105638244
HBR: 110669879
MESC: 110603804
PEU: 105127155
QSU: 112016280
VVI: 100268095
SLY: 101263925
SPEN: 107026784
SOT: 102577462(SXD1)
CANN: 107839135
NSY: 104221249
NTO: 104098970
NAU: 109234037
INI: 109178717
SIND: 105164753
OEU: 111385234
HAN: 110873807
LSV: 111907085
DCR: 108225390
BVG: 104885180
SOE: 110775274
CQI: 110705597
NNU: 104595147
OSA: 4329007
DOSA: Os02t0276500-01(Os02g0276500)
OBR: 102712058
BDI: 100846924
ATS: 109734383(LOC109734383)
SBI: 8060379
ZMA: 541877(sxd1)
SITA: 101764913
PDA: 103702550
EGU: 105040851
MUS: 103995049
DCT: 110106522
PEQ: 110025563
AOF: 109821288
ATR: 18426679
APRO: F751_1103
PTI: PHATRDRAFT_bd1025(VTE1)
FCY: FRACYDRAFT_242143(VTE1)
EHR: EHR_02320
ECAS: ECBG_00190
EMU: EMQU_0164
CARC: NY10_1012
AMT: Amet_3459
AOE: Clos_0174
CCE: Ccel_1994
CCEL: CCDG5_0731
BPB: bpr_I1006
BHU: bhn_I1975
CPY: Cphy_1141
ACL: ACL_1398
ABRA: BN85314670
MUL: MUL_2705
MMI: MMAR_3430
MGI: Mflv_4428
CEF: CE1100
RER: RER_16120
REY: O5Y_07695
SYN: slr1737
SYY: SYNGTS_1199(slr1737)
SYT: SYNGTI_1199(slr1737)
SYS: SYNPCCN_1198(slr1737)
SYQ: SYNPCCP_1198(slr1737)
CYB: CYB_0605
AMR: AM1_2430
MAR: MAE_59750
MPK: VL20_741
CYT: cce_3689
TER: Tery_1802
GVI: glr3089
GLJ: GKIL_0805
ANA: all0245
NSH: GXM_05592
AVA: Ava_2735
NAZ: Aazo_3505
CALH: IJ00_12110
CTHE: Chro_1644
TAF: THA_709
ASAC: ATHSA_1559
MRU: mru_0432
MMIL: sm9_0735
MEYE: TL18_03560
MOL: YLM1_0103
MBAK: MSBR3_0408
MMA: MM_0519
MMAC: MSMAC_0766
MTHR: MSTHT_0418
MTHE: MSTHC_0303
 » show all
Reference
  Authors
Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D
  Title
Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.
  Journal
Plant Physiol 132:2184-95 (2003)
DOI:10.1104/pp.900086
  Sequence
[ath:AT4G32770] [zma:541877] [syn:slr1737]

KEGG   ENZYME: 5.5.1.24
Entry
EC 5.5.1.24                 Enzyme                                 

Name
tocopherol cyclase;
VTE1 (gene name);
SXD1 (gene name);
delta/gamma-tocopherol lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
delta/gamma-tocopherol lyase (ring-opening)
Reaction(IUBMB)
(1) delta-tocopherol = 2-methyl-6-phytylbenzene-1,4-diol  [RN:R07503];
(2) gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol  [RN:R07502];
(3) delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol  [RN:R10623];
(4) gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [RN:R10624]
Reaction(KEGG)
Substrate
delta-tocopherol [CPD:C14151];
gamma-tocopherol [CPD:C02483];
delta-tocotrienol [CPD:C14156];
gamma-tocotrienol [CPD:C14155]
Product
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
2,3-dimethyl-6-phytylbenzene-1,4-diol [CPD:C15883];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [CPD:C20738]
Comment
The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols).
History
EC 5.5.1.24 created 2013
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09834  tocopherol cyclase
Genes
ATH: AT4G32770(VTE1)
ALY: 9305317
CRB: 17877607
CSAT: 104716894 104720514 104721549 104729992
EUS: EUTSA_v10025006mg
BRP: 103862197
BNA: 106411207 106423312 106423394
BOE: 106301700
RSZ: 108851396
THJ: 104803808
CPAP: 110822117
CIT: 102615028
TCC: 18587955
DZI: 111302940
EGR: 104437768
VRA: 106762339
VAR: 108318687
VUN: 114164033
CCAJ: 109801639
CAM: 101502250
ADU: 107470774
AIP: 107623139
LANG: 109339295
FVE: 101304641
RCN: 112173193
PPER: 18791199
PMUM: 103320200
PAVI: 110761173
CSV: 101206720
CMO: 103488188
MCHA: 111004926
CMAX: 111496186
CMOS: 111454510
CPEP: 111799319
RCU: 8271188
JCU: 105638244
HBR: 110669879
MESC: 110603804
PEU: 105127155
QSU: 112016280
VVI: 100268095
SLY: 101263925
SPEN: 107026784
SOT: 102577462(SXD1)
CANN: 107839135
NSY: 104221249
NTO: 104098970
NAU: 109234037
INI: 109178717
SIND: 105164753
OEU: 111385234
HAN: 110873807
LSV: 111907085
DCR: 108225390
BVG: 104885180
SOE: 110775274
CQI: 110705597
NNU: 104595147
OSA: 4329007
DOSA: Os02t0276500-01(Os02g0276500)
OBR: 102712058
BDI: 100846924
ATS: 109734383(LOC109734383)
SBI: 8060379
ZMA: 541877(sxd1)
SITA: 101764913
PDA: 103702550
EGU: 105040851
MUS: 103995049
DCT: 110106522
PEQ: 110025563
AOF: 109821288
ATR: 18426679
APRO: F751_1103
PTI: PHATRDRAFT_bd1025(VTE1)
FCY: FRACYDRAFT_242143(VTE1)
EHR: EHR_02320
ECAS: ECBG_00190
EMU: EMQU_0164
CARC: NY10_1012
AMT: Amet_3459
AOE: Clos_0174
CCE: Ccel_1994
CCEL: CCDG5_0731
BPB: bpr_I1006
BHU: bhn_I1975
CPY: Cphy_1141
ACL: ACL_1398
ABRA: BN85314670
MUL: MUL_2705
MMI: MMAR_3430
MGI: Mflv_4428
CEF: CE1100
RER: RER_16120
REY: O5Y_07695
SYN: slr1737
SYY: SYNGTS_1199(slr1737)
SYT: SYNGTI_1199(slr1737)
SYS: SYNPCCN_1198(slr1737)
SYQ: SYNPCCP_1198(slr1737)
CYB: CYB_0605
AMR: AM1_2430
MAR: MAE_59750
MPK: VL20_741
CYT: cce_3689
TER: Tery_1802
GVI: glr3089
GLJ: GKIL_0805
ANA: all0245
NSH: GXM_05592
AVA: Ava_2735
NAZ: Aazo_3505
CALH: IJ00_12110
CTHE: Chro_1644
TAF: THA_709
ASAC: ATHSA_1559
MRU: mru_0432
MMIL: sm9_0735
MEYE: TL18_03560
MOL: YLM1_0103
MBAK: MSBR3_0408
MMA: MM_0519
MMAC: MSMAC_0766
MTHR: MSTHT_0418
MTHE: MSTHC_0303
 » show all
Reference
1  [PMID:12213958]
  Authors
Porfirova S, Bergmuller E, Tropf S, Lemke R, Dormann P.
  Title
Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis.
  Journal
Proc Natl Acad Sci U S A 99:12495-500 (2002)
DOI:10.1073/pnas.182330899
  Sequence
[ath:AT4G32770]
Reference
2  [PMID:12913173]
  Authors
Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D
  Title
Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.
  Journal
Plant Physiol 132:2184-95 (2003)
DOI:10.1104/pp.103.024257
  Sequence
[ath:AT4G32770] [zma:541877] [syn:slr1737]
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.24
IUBMB Enzyme Nomenclature: 5.5.1.24
ExPASy - ENZYME nomenclature database: 5.5.1.24
BRENDA, the Enzyme Database: 5.5.1.24

KEGG   REACTION: R10623
Entry
R10623                      Reaction                               

Name
delta-tocotrienol lyase (decyclizing)
Definition
delta-Tocotrienol <=> 6-Geranylgeranyl-2-methylbenzene-1,4-diol
Equation
Reaction class
RC01911  C14156_C20737
Enzyme
Pathway
rn00130  Ubiquinone and other terpenoid-quinone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00112  Tocopherol/tocotorienol biosynthesis
Orthology
K09834  tocopherol cyclase [EC:5.5.1.24]
Other DBs
RHEA: 38018

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