KEGG   ORTHOLOGY: K09953
Entry
K09953                      KO                                     

Name
lpxR
Definition
lipid A 3-O-deacylase [EC:3.1.1.-]
Pathway
ko00540  Lipopolysaccharide biosynthesis
ko01100  Metabolic pathways
Module
M00867  KDO2-lipid A modification pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00540 Lipopolysaccharide biosynthesis
    K09953  lpxR; lipid A 3-O-deacylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01005 Lipopolysaccharide biosynthesis proteins
    K09953  lpxR; lipid A 3-O-deacylase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.-  
     K09953  lpxR; lipid A 3-O-deacylase
Lipopolysaccharide biosynthesis proteins [BR:ko01005]
 Lipid A
  K09953  lpxR; lipid A 3-O-deacylase
Other DBs
RN: R12196 R12204
COG: COG3528
Genes
ECE: Z0955
ECS: ECs0814
ECF: ECH74115_0887
ETW: ECSP_0836
ELX: CDCO157_0794
EOI: ECO111_0793
EOJ: ECO26_0856
EOH: ECO103_0766
ECOO: ECRM13514_0819
ECOH: ECRM13516_0772
STY: STY1783
STT: t1208
STM: STM1328
SENI: CY43_06765
SPT: SPA1516
SEK: SSPA1407
SEI: SPC_2402
SEC: SCH_1349
SHB: SU5_01947
SENS: Q786_08615
SED: SeD_A2016
SEG: SG1788
SEL: SPUL_1145
SET: SEN1715
SENA: AU38_08880
SENO: AU37_08885
SENV: AU39_08890
SENQ: AU40_09920
SENL: IY59_09085
SEEP: I137_05265
SENE: IA1_06555
SBG: SBG_1182
SBZ: A464_1283
YEN: YE3039
YEY: Y11_05741
YEW: CH47_2405
YET: CH48_4101
XAX: XACM_0669
XAC: XAC0665
XPH: XppCFBP6546_08250(XppCFBP6546P_08250)
SMZ: SMD_3637
LEZ: GLE_4584
VTA: A1697
PSTT: CH92_07320
SWP: swp_1413
SVO: SVI_1332
CPS: CPS_1463
MAD: HP15_1124
MVS: MVIS_2549
HMAR: HVMH_0067
TKM: TK90_2256
TVR: TVD_01160
HEL: HELO_2700
HAM: HALO3462
APAC: S7S_00175
KGE: TQ33_1871
TIN: Tint_1115
TCL: Tchl_1300
HPJ: jhp_0634
HPG: HPG27_650
HPL: HPB8_894
HPZ: HPKB_0653
HPD: KHP_0628
HEY: MWE_0811
HPYR: K747_07570
HPYI: K750_05750
HPYU: K751_03910
HPYM: K749_02190
HEB: U063_0998
HEZ: U064_1002
HAC: Hac_0953
HMS: HMU07990
HCE: HCW_04490
HCM: HCD_05150
SUA: Saut_0436
SULC: CVO_04060
AELL: AELL_1028
AAQI: AAQM_0913
APAI: APAC_2391
PACO: AACT_1144
ARC: ABLL_1117
SDL: Sdel_1743
SMUL: SMUL_2438
SHAL: SHALO_2184
DFL: DFE_0057
DALK: DSCA_03110
PLA: Plav_3457
RBM: TEF_05900
HBA: Hbal_0436
GOH: B932_2467
ASZ: ASN_3667
MGRY: MSR1_15820
TMO: TMO_2910
TXI: TH3_15550
MAGQ: MGMAQ_2461
BBAT: Bdt_1937
BBW: BDW_00890
BBAC: EP01_05875
BEX: A11Q_364
CAA: Caka_2181
AGL: PYTT_1082
LBF: LBF_2670
FLN: FLA_0228
MUC: MuYL_1422
FAE: FAES_3145
FLM: MY04_0439
FJO: Fjoh_0633
ZPR: ZPR_4201
DDO: I597_0024
NDO: DDD_2920
TMAR: MARIT_1197
 » show all
Reference
  Authors
Reynolds CM, Ribeiro AA, McGrath SC, Cotter RJ, Raetz CR, Trent MS
  Title
An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid A.
  Journal
J Biol Chem 281:21974-87 (2006)
DOI:10.1074/jbc.M603527200
Reference
  Authors
Cullen TW, Giles DK, Wolf LN, Ecobichon C, Boneca IG, Trent MS
  Title
Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa.
  Journal
PLoS Pathog 7:e1002454 (2011)
DOI:10.1371/journal.ppat.1002454
  Sequence
[hpj:jhp_0634]

KEGG   REACTION: R12204
Entry
R12204                      Reaction                               

Name
4'-dephosphorylated-1-PEtN-KDO-lipid-A acyloxyacylhydrolase
Definition
4'-Dephosphorylated 1-PEtN-KDO-lipid A + H2O <=> H. pylori KDO-lipid A + (R)-3-(Tetradecanoyloxy)hexadecanoic acid
Equation
Enzyme
3.1.1.-
Pathway
rn00540  Lipopolysaccharide biosynthesis
rn01100  Metabolic pathways
Module
M00867  KDO2-lipid A modification pathway
Orthology
K09953  lipid A 3-O-deacylase [EC:3.1.1.-]

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