KEGG   ORTHOLOGY: K10131
Entry
K10131                      KO                                     
Symbol
PMAIP1, NOXA
Name
phorbol-12-myristate-13-acetate-induced protein 1
Pathway
map01524  Platinum drug resistance
map04115  p53 signaling pathway
map04210  Apoptosis
map04215  Apoptosis - multiple species
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05210  Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
   04215 Apoptosis - multiple species
    K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
   04115 p53 signaling pathway
    K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
   05203 Viral carcinogenesis
    K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K10131  PMAIP1, NOXA; phorbol-12-myristate-13-acetate-induced protein 1
Genes
HSA: 5366(PMAIP1)
PTR: 737247(PMAIP1)
PPS: 100979315
GGO: 101152154
PON: 100457415(PMAIP1)
PPYG: 129019115(PMAIP1)
NLE: 100593765(PMAIP1)
HMH: 116468506(PMAIP1)
SSYN: 129492317(PMAIP1)
MCC: 702789(PMAIP1)
MCF: 102120192(PMAIP1)
MTHB: 126941403
PANU: 101013691(PMAIP1)
MLEU: 105553919(PMAIP1)
RRO: 104673006(PMAIP1)
RBB: 108526400(PMAIP1)
TFN: 117099591(PMAIP1)
PTEH: 111546851(PMAIP1)
CANG: 105517066(PMAIP1)
CJC: 100404690(PMAIP1)
SBQ: 101044364(PMAIP1)
CIMI: 108304579(PMAIP1)
ANAN: 105712987
MMUR: 105881696(PMAIP1)
LCAT: 123621605(PMAIP1)
PCOQ: 105816366(PMAIP1)
OGA: 100957322(PMAIP1)
MMU: 58801(Pmaip1)
MCAL: 110285029(Pmaip1)
MPAH: 110333558(Pmaip1)
RNO: 492821(Pmaip1)
MCOC: 116087283(Pmaip1)
ANU: 117719540(Pmaip1)
MUN: 110555473(Pmaip1)
CGE: 100755393(Pmaip1)
MAUA: 101826532(Pmaip1)
PROB: 127234185(Pmaip1)
PLEU: 114685740(Pmaip1)
MORG: 121438816(Pmaip1)
MFOT: 126511110
AAMP: 119815786(Pmaip1)
NGI: 103739615(Pmaip1)
HGL: 106010564(Pmaip1)
CPOC: 100727696(Pmaip1)
CCAN: 109701119(Pmaip1)
DSP: 122098053(Pmaip1)
PLOP: 125363917(Pmaip1)
NCAR: 124965553 124980793 124990302
MMMA: 125617707(Pmaip1)
OCU: 103349392
OPI: 105942711(PMAIP1)
TUP: 102497162(PMAIP1)
GVR: 103607162(PMAIP1)
CFA: 100502558(PMAIP1)
CLUD: 112644049(PMAIP1)
VVP: 112919301(PMAIP1)
VLG: 121481985(PMAIP1)
NPO: 129495504 129514545
AML: 100474991(PMAIP1)
UMR: 103676254(PMAIP1)
UAH: 113253468(PMAIP1)
UAR: 123787524(PMAIP1)
ELK: 111154272
LLV: 125082638
MPUF: 101694272(PMAIP1)
MNP: 132023965(PMAIP1)
MLK: 131811605(PMAIP1)
NVS: 122902845(PMAIP1)
ORO: 101362130(PMAIP1)
EJU: 114208937(PMAIP1)
ZCA: 113913342(PMAIP1)
MLX: 118004507(PMAIP1)
NSU: 110577139(PMAIP1)
LWW: 102729920(PMAIP1)
FCA: 102900397(PMAIP1)
PYU: 121032861(PMAIP1)
PBG: 122470816(PMAIP1)
PVIV: 125149678(PMAIP1)
LRUF: 124517009
PTG: 102958923(PMAIP1)
PPAD: 109275651(PMAIP1)
PUC: 125917270 125918157
AJU: 106978896
HHV: 120230786(PMAIP1)
BTA: 100296226(PMAIP1)
BOM: 102285398(PMAIP1)
BIU: 109577992(PMAIP1)
BBUB: 102396135(PMAIP1)
BBIS: 104999240(PMAIP1)
CHX: 102175063(PMAIP1) 108633288
OAS: 101102359(PMAIP1)
BTAX: 128067549(PMAIP1)
ODA: 120856907 120880879(PMAIP1)
CCAD: 122425792(PMAIP1)
MBEZ: 129539258(PMAIP1)
SSC: 397278(PMAIP1)
CFR: 106729352(PMAIP1)
CBAI: 105073910(PMAIP1)
CDK: 105089011(PMAIP1)
VPC: 102545461(PMAIP1)
BACU: 103009672(PMAIP1)
BMUS: 118880334(PMAIP1)
OOR: 101269536(PMAIP1)
DLE: 111180211(PMAIP1)
PCAD: 102980477(PMAIP1)
PSIU: 116739138(PMAIP1)
NASI: 112406199(PMAIP1)
ECB: 100629496(PMAIP1)
EPZ: 103563750(PMAIP1)
EAI: 106842499(PMAIP1)
MYB: 102246714(PMAIP1)
MYD: 102767454(PMAIP1)
MMYO: 118663460(PMAIP1)
MLF: 102427214(PMAIP1)
MDT: 132239643(PMAIP1)
PKL: 118708068(PMAIP1)
EFUS: 103293277(PMAIP1)
MNA: 107545406(PMAIP1)
SHON: 118979233(PMAIP1)
AJM: 119054137(PMAIP1)
PDIC: 114507019(PMAIP1)
PHAS: 123826163(PMAIP1)
MMF: 118618593(PMAIP1)
PPAM: 129078902(PMAIP1)
HAI: 109381726(PMAIP1)
RFQ: 117011794(PMAIP1)
PALE: 102894490(PMAIP1)
PGIG: 120584607(PMAIP1)
PVP: 105292725(PMAIP1)
RAY: 107516202(PMAIP1)
MJV: 108390232(PMAIP1)
TOD: 119243768(PMAIP1)
SARA: 101547642(PMAIP1)
SETR: 126020801(PMAIP1)
LAV: 100677531(PMAIP1)
TMU: 101345213
ETF: 101657818(PMAIP1)
DNM: 101414712(PMAIP1)
OAA: 114810052(PMAIP1)
GGA: 770077(PMAIP1)
PCOC: 116239702(PMAIP1)
MGP: 104914820(PMAIP1)
CJO: 107305837(PMAIP1)
TPAI: 128074595(PMAIP1)
LMUT: 125686766(PMAIP1)
NMEL: 110390170(PMAIP1)
APLA: 119714528(PMAIP1)
ACYG: 106036301(PMAIP1)
CATA: 118256678(PMAIP1)
AFUL: 116500719(PMAIP1)
TGU: 105760854(PMAIP1)
LSR: 110484205(PMAIP1)
SCAN: 103822915(PMAIP1)
PMOA: 120502526(PMAIP1)
OTC: 121343792(PMAIP1)
PRUF: 121365766(PMAIP1)
GFR: 102043659(PMAIP1)
FAB: 107604289(PMAIP1)
OMA: 130264960(PMAIP1)
PHI: 102110157(PMAIP1)
PMAJ: 107216430(PMAIP1)
CCW: 104686752
CBRC: 103611721(PMAIP1)
ETL: 114070069(PMAIP1)
ZAB: 106629476(PMAIP1)
ZLE: 135459967(PMAIP1)
SVG: 106852706(PMAIP1)
MMEA: 130575579(PMAIP1)
HRT: 120765710(PMAIP1)
SATI: 136373750(PMAIP1)
FPG: 106112088(PMAIP1)
NNT: 104408103(PMAIP1)
SHAB: 115601122(PMAIP1)
ACUN: 113489803(PMAIP1)
TALA: 116961381(PMAIP1)
ACHC: 115337331(PMAIP1)
HLE: 104829628(PMAIP1)
AGEN: 126036366
GCL: 127027812
CSTI: 104557121(PMAIP1)
LDI: 104353448(PMAIP1)
DPUB: 104302363(PMAIP1)
AVIT: 104275579(PMAIP1)
BRHI: 104498380(PMAIP1)
EGZ: 104133908(PMAIP1)
NNI: 104009099 104021592
PCAO: 104047414(PMAIP1)
PADL: 103912216(PMAIP1)
AFOR: 103903921(PMAIP1)
CLV: 102097231(PMAIP1)
MUI: 104544145(PMAIP1)
EHS: 104507455(PMAIP1)
CMAC: 104487159(PMAIP1)
CUCA: 104061057(PMAIP1)
ACAR: 104521081(PMAIP1)
CPEA: 104398641(PMAIP1)
CVF: 104294610(PMAIP1)
RTD: 128902528(PMAIP1)
AAM: 106499501(PMAIP1)
AROW: 112976205(PMAIP1)
NPD: 112952189(PMAIP1)
TGT: 104578757
DNE: 112982164(PMAIP1)
SCAM: 104147770(PMAIP1)
ASN: 112549505(PMAIP1)
PSS: 102454201(PMAIP1)
CMY: 102936530(PMAIP1)
CCAY: 125637328(PMAIP1)
DCC: 119856415(PMAIP1)
CPIC: 101953262(PMAIP1)
TST: 117879579(PMAIP1)
CABI: 116822341(PMAIP1)
MRV: 120408423(PMAIP1)
ACS: 103280258(pmaip1)
ASAO: 132766902(PMAIP1)
SUND: 121923468(PMAIP1)
PBI: 103049002(PMAIP1)
PMUR: 107290866(PMAIP1)
APRI: 131190746(PMAIP1)
VKO: 123024069(PMAIP1)
PMUA: 114606656(PMAIP1)
PRAF: 128423376(PMAIP1)
ZVI: 118077339(PMAIP1)
HCG: 128341908(PMAIP1)
GJA: 107105807(PMAIP1)
STOW: 125436303(PMAIP1)
NPR: 108798740(PMAIP1)
RTEM: 120927320(PMAIP1)
BBUF: 120992235(PMAIP1)
BGAR: 122937312(PMAIP1)
MUO: 115462913(PMAIP1)
DRE: 751765(pmaip1)
CGIB: 127966656
PTET: 122352570(pmaip1)
LROH: 127172063(pmaip1)
OMC: 131548719(pmaip1)
PPRM: 120481732(pmaip1)
RKG: 130087053(pmaip1)
MAMB: 125257284(pmaip1)
CIDE: 127520913
CERY: 137027490(pmaip1)
TROS: 130546007(pmaip1)
TDW: 130411981(pmaip1)
MANU: 129447352(pmaip1)
IPU: 108276988
IFU: 128620898(pmaip1)
TFD: 125139716(pmaip1)
TVC: 132863508(pmaip1)
TRN: 134332594(pmaip1)
CMAO: 118825109(pmaip1)
CHAR: 122133350(pmaip1)
TNG: GSTEN00014459G001
KMR: 119617657(pmaip1)
NWH: 119424919(pmaip1)
BSPL: 121202651(pmaip1)
SNH: 120053464(pmaip1)
CCLU: 121584054(pmaip1)
AANG: 118237153(pmaip1)
PSPA: 121299781(pmaip1)
ARUT: 117403657(pmaip1)
 » show all
Reference
PMID:2398525
  Authors
Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K
  Title
Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line.
  Journal
J Virol 64:4632-9 (1990)
DOI:10.1128/JVI.64.10.4632-4639.1990
  Sequence
[hsa:5366]
Reference
PMID:19641509
  Authors
Ploner C, Kofler R, Villunger A
  Title
Noxa: at the tip of the balance between life and death.
  Journal
Oncogene 27 Suppl 1:S84-92 (2008)
DOI:10.1038/onc.2009.46
Reference
PMID:15705586
  Authors
Sun Y, Leaman DW
  Title
Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.
  Journal
J Biol Chem 280:15561-8 (2005)
DOI:10.1074/jbc.M412630200
  Sequence
[hsa:5366]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (14)   
   KEGG PATHWAY (14)   
Gene (271)   
   KEGG GENES (267)   
   RefGene (1)   
   OC (3)   
Literature (3)   
   PubMed (3)   
All databases (289)   

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