KEGG   ORTHOLOGY: K10132
Entry
K10132                      KO                                     
Symbol
BBC3, PUMA
Name
Bcl-2-binding component 3
Pathway
map01524  Platinum drug resistance
map04115  p53 signaling pathway
map04210  Apoptosis
map04215  Apoptosis - multiple species
map04390  Hippo signaling pathway
map05016  Huntington disease
map05162  Measles
map05200  Pathways in cancer
map05210  Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K10132  BBC3, PUMA; Bcl-2-binding component 3
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K10132  BBC3, PUMA; Bcl-2-binding component 3
   04215 Apoptosis - multiple species
    K10132  BBC3, PUMA; Bcl-2-binding component 3
   04115 p53 signaling pathway
    K10132  BBC3, PUMA; Bcl-2-binding component 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10132  BBC3, PUMA; Bcl-2-binding component 3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K10132  BBC3, PUMA; Bcl-2-binding component 3
  09172 Infectious disease: viral
   05162 Measles
    K10132  BBC3, PUMA; Bcl-2-binding component 3
  09164 Neurodegenerative disease
   05016 Huntington disease
    K10132  BBC3, PUMA; Bcl-2-binding component 3
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K10132  BBC3, PUMA; Bcl-2-binding component 3
Genes
HSA: 27113(BBC3)
PTR: 107969772(BBC3)
PPS: 100974112(BBC3)
GGO: 101125453(BBC3)
PON: 100452429(BBC3)
PPYG: 129020809(BBC3)
NLE: 100588342(BBC3)
HMH: 116478291(BBC3)
SSYN: 129461196(BBC3)
MCC: 717955(BBC3)
MCF: 102119825(BBC3)
MTHB: 126943534
MNI: 105478601(BBC3)
CSAB: 103234932(BBC3)
CATY: 105595200(BBC3)
PANU: 101021738(BBC3)
TGE: 112611835(BBC3)
MLEU: 105531978(BBC3)
RRO: 104673391(BBC3)
RBB: 108523458
TFN: 117091464(BBC3)
PTEH: 111520160
CANG: 105526954(BBC3)
CJC: 100387604(BBC3)
SBQ: 101034279 104653273
CIMI: 108283840(BBC3)
ANAN: 105713012(BBC3)
MMUR: 105869584(BBC3)
LCAT: 123623903(BBC3)
PCOQ: 105817577(BBC3)
OGA: 100945413(BBC3)
MMU: 170770(Bbc3)
MCAL: 110297909(Bbc3)
MPAH: 110336584(Bbc3)
RNO: 317673(Bbc3)
MCOC: 116101682(Bbc3)
ANU: 117700355(Bbc3)
MUN: 110561311(Bbc3)
CGE: 103164214(Bbc3)
MAUA: 101826940(Bbc3)
PROB: 127238352(Bbc3)
PLEU: 114681446(Bbc3)
MORG: 121449455(Bbc3)
MFOT: 126493343
AAMP: 119820729(Bbc3)
NGI: 103724866(Bbc3)
HGL: 101714844(Bbc3)
CCAN: 109697533(Bbc3)
DSP: 122125754(Bbc3)
PLOP: 125368306(Bbc3)
NCAR: 124966999
OCU: 100357703
OPI: 101534750(BBC3)
TUP: 102499950(BBC3)
GVR: 103599629(BBC3)
CFA: 612153(BBC3)
CLUD: 112645247(BBC3)
VVP: 112931366(BBC3)
VLG: 121485860(BBC3)
NPO: 129499660(BBC3)
AML: 100474559
UMR: 103657211(BBC3)
UAH: 113243380(BBC3)
UAR: 123776262(BBC3)
ELK: 111160670
LLV: 125089753
MPUF: 101692767(BBC3)
MNP: 132005253(BBC3)
MLK: 131818362(BBC3)
NVS: 122911902(BBC3)
ORO: 101366869(BBC3)
EJU: 114197191(BBC3)
ZCA: 113936070(BBC3)
MLX: 117998194(BBC3)
NSU: 110572803(BBC3)
LWW: 102750827(BBC3)
FCA: 111558033(BBC3)
PYU: 121024375
PBG: 122493878(BBC3)
PVIV: 125153679(BBC3)
LRUF: 124510983
PTG: 102955464(BBC3)
PPAD: 109252887(BBC3)
AJU: 106973568
HHV: 120244480(BBC3)
BTA: 782359(BBC3)
BOM: 102284902(BBC3)
BIU: 109571765(BBC3)
BBUB: 102415717(BBC3)
BBIS: 104997797(BBC3)
CHX: 102171367(BBC3)
OAS: 101123490(BBC3)
BTAX: 128064189(BBC3)
ODA: 120872234(BBC3)
CCAD: 122421529(BBC3)
MBEZ: 129546622(BBC3)
SSC: 100517403(BBC3)
CFR: 102512800(BBC3)
CBAI: 105062733(BBC3)
CDK: 105104049(BBC3)
VPC: 102535421(BBC3)
BACU: 103003912(BBC3)
BMUS: 118885834(BBC3)
LVE: 103087294(BBC3)
OOR: 101275681(BBC3)
DLE: 111180693(BBC3)
PCAD: 102976277
PSIU: 116744488(BBC3)
NASI: 112415658(BBC3)
ECB: 100146714(BBC3)
EPZ: 103560717(BBC3)
EAI: 106845162(BBC3)
MYB: 102253129(BBC3)
MYD: 102753249(BBC3)
MMYO: 118652805(BBC3)
MLF: 102430812(BBC3)
MDT: 132216674(BBC3)
PKL: 118706786(BBC3)
EFUS: 103297683(BBC3)
MNA: 107540044(BBC3)
DRO: 112312833(BBC3)
SHON: 118996119(BBC3)
AJM: 119056646(BBC3)
PDIC: 114511715(BBC3)
PHAS: 123823020(BBC3)
MMF: 118638685(BBC3)
PPAM: 129082775(BBC3)
HAI: 109372194(BBC3)
RFQ: 117035576(BBC3)
PALE: 102892591(BBC3)
PGIG: 120617900(BBC3)
PVP: 105297315(BBC3)
RAY: 107516010(BBC3)
MJV: 108398862(BBC3)
TOD: 119249484(BBC3)
SARA: 101554035(BBC3)
SETR: 126028261(BBC3)
LAV: 100671262(BBC3)
TMU: 101348022
ETF: 101659338(BBC3)
DNM: 101443069(BBC3)
MDO: 100020711(BBC3)
GAS: 123256076(BBC3)
SHR: 116423037(BBC3)
AFZ: 127556256
PCW: 110202397(BBC3)
TVP: 118839422(BBC3)
CMY: 114021291
CPIC: 101950846
 » show all
Reference
PMID:11463392
  Authors
Nakano K, Vousden KH
  Title
PUMA, a novel proapoptotic gene, is induced by p53.
  Journal
Mol Cell 7:683-94 (2001)
DOI:10.1016/s1097-2765(01)00214-3
  Sequence
[hsa:27113]
Reference
PMID:21127253
  Authors
Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH
  Title
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.
  Journal
Science 330:1390-3 (2010)
DOI:10.1126/science.1190217
  Sequence
[mmu:170770]

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (18)   
   KEGG PATHWAY (18)   
Gene (202)   
   KEGG GENES (150)   
   KEGG MGENES (50)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (223)   

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