KEGG ORTHOLOGY: K10138

ORTHOLOGY: K10138

Entry

K10138                      KO

Symbol

IGFBP3

Name

insulin-like growth factor-binding protein 3

Pathway

map04115

p53 signaling pathway

map04218

Cellular senescence

map04935

Growth hormone synthesis, secretion and action

map05202

Transcriptional misregulation in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
   04218 Cellular senescence
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
Membrane trafficking [BR:ko04131]
Endocytosis
  Others
   Insulin-like growth factor-binding proteins
    K10138  IGFBP3; insulin-like growth factor-binding protein 3
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other cancer cells
   K10138  IGFBP3; insulin-like growth factor-binding protein 3

Other DBs

GO:

0005520

Genes

HSA:	3486(IGFBP3)

PTR:	463396(IGFBP3)

PPS:	100970241(IGFBP3)

GGO:	101129439(IGFBP3)

PPYG:

129040357(IGFBP3)

NLE:	100603785(IGFBP3)

HMH:	116812466(IGFBP3)

SSYN:

129489942(IGFBP3)

MCC:	696868(IGFBP3)

MCF:	102144139(IGFBP3)

MTHB:

126950174

MNI:	105494236(IGFBP3)

CSAB:

103226113(IGFBP3)

CATY:

105588318(IGFBP3)

PANU:

101026054(IGFBP3)

TGE:	112620335(IGFBP3)

RRO:	104671167(IGFBP3)

RBB:	108534795(IGFBP3)

TFN:	117073335(IGFBP3)

PTEH:

111552313(IGFBP3)

CANG:

105515089(IGFBP3)

CJC:	100393906(IGFBP3)

CIMI:

108301430(IGFBP3)

ANAN:

105721491(IGFBP3)

MMUR:

105870670(IGFBP3)

LCAT:

123647498(IGFBP3)

PCOQ:

105812488(IGFBP3)

OGA:	100949697(IGFBP3)

MMU:	16009(Igfbp3)

MCAL:

110305209(Igfbp3)

MPAH:

110330706(Igfbp3)

RNO:	24484(Igfbp3)

MCOC:

116070218(Igfbp3)

ANU:	117713128(Igfbp3)

MUN:	110555170(Igfbp3)

CGE:	100764858(Igfbp3)

MAUA:

101838522(Igfbp3) 101839104

PROB:

127233858(Igfbp3)

PLEU:

114693961(Igfbp3)

MORG:

121459914(Igfbp3)

MFOT:

126500794

AAMP:

119803267(Igfbp3)

NGI:	103741431(Igfbp3)

HGL:	101710997(Igfbp3) 101721052

CPOC:

100714097(Igfbp3)

CCAN:

109694875(Igfbp3)

DORD:

105998267(Igfbp3) 106002924

DSP:	122100040 122100935 122108733 122121599 122127665 122128073(Igfbp3)

PLOP:

125346639(Igfbp3)

NCAR:

124991742

MMMA:

107146075(Igfbp3)

OCU:

127485419

OPI:	101533087(IGFBP3)

TUP:	102477021(IGFBP3)

GVR:	103599614(IGFBP3)

CFA:	100855619(IGFBP3)

CLUD:

112650981(IGFBP3)

VLG:	121490105(IGFBP3)

NPO:	129516210(IGFBP3)

AML:	105239315(IGFBP3)

UMR:	103674673(IGFBP3)

UAH:	113257692(IGFBP3)

UAR:	123789482(IGFBP3)

ELK:

111157077

LLV:

125081186

MPUF:

101679105(IGFBP3)

MNP:	132016090(IGFBP3)

MLK:	131829177(IGFBP3)

NVS:	122904660(IGFBP3)

ORO:	101376941(IGFBP3)

EJU:	114213702(IGFBP3)

ZCA:	113911843(IGFBP3)

FCA:	101080442(IGFBP3)

PYU:	121016980(IGFBP3)

PCOO:

112859777(IGFBP3)

PBG:	122487652(IGFBP3)

PVIV:

125161071(IGFBP3)

LRUF:

124522960

PTG:	102961146(IGFBP3)

PPAD:

109267951(IGFBP3)

PUC:

125930397

AJU:

106968195

HHV:	120238887(IGFBP3)

BTA:	282261(IGFBP3)

BOM:	102288361(IGFBP3)

BIU:	109557914(IGFBP3)

BBUB:

102395071(IGFBP3)

BBIS:

104980413(IGFBP3)

CHX:	102174541(IGFBP3)

OAS:	100286737(IGFBP3)

BTAX:

128046632(IGFBP3)

ODA:	120877471(IGFBP3)

CCAD:

122438512(IGFBP3)

MBEZ:

129552547(IGFBP3)

SSC:	448812(IGFBP3)

CFR:	102520723(IGFBP3)

CDK:	116150633(IGFBP3)

BACU:

102998097(IGFBP3)

BMUS:

118900960(IGFBP3)

LVE:	103082081(IGFBP3)

OOR:	101272404(IGFBP3)

DLE:	111184577(IGFBP3)

PCAD:

102973604(IGFBP3)

PSIU:

116759438(IGFBP3)

ECB:	100034155(IGFBP3)

EPZ:	103550432(IGFBP3)

EAI:	123289215(IGFBP3)

MYB:	102257375(IGFBP3)

MYD:	102760273(IGFBP3)

MMYO:

118665885(IGFBP3)

MLF:	106696100(IGFBP3)

MDT:	132211220(IGFBP3)

PKL:	118727846(IGFBP3)

EFUS:

103303614(IGFBP3)

MNA:	107526006(IGFBP3)

SHON:

118983487(IGFBP3)

AJM:	119057336(IGFBP3)

PDIC:

114490249(IGFBP3)

PHAS:

123812162(IGFBP3)

MMF:	118620088(IGFBP3)

PPAM:

129068926(IGFBP3)

HAI:	109373013(IGFBP3)

RFQ:	117012511(IGFBP3)

PALE:

102891216(IGFBP3)

PGIG:

120589582(IGFBP3)

PVP:	105308301 105311774

RAY:	107512409(IGFBP3)

MJV:	108403510(IGFBP3)

TOD:	119231497(IGFBP3)

SARA:

101554973(IGFBP3)

SETR:

126031385(IGFBP3)

LAV:	100674990(IGFBP3)

TMU:

101355131

ETF:	101660698(IGFBP3)

DNM:	101412435(IGFBP3)

MDO:	100618843(IGFBP3)

GAS:	123243797(IGFBP3)

SHR:	100921412(IGFBP3)

AFZ:

127553634

PCW:	110197536(IGFBP3)

TVP:	118831497(IGFBP3)

OAA:	100076387(IGFBP3)

GGA:	420790(IGFBP3)

PCOC:

116228272(IGFBP3)

MGP:	100539598(IGFBP3)

CJO:	107309787(IGFBP3)

TPAI:

128087793(IGFBP3)

LMUT:

125690892(IGFBP3)

NMEL:

110390830(IGFBP3)

APLA:

101803685(IGFBP3)

ACYG:

106046458(IGFBP3)

CATA:

118249661(IGFBP3)

AFUL:

116486000(IGFBP3)

TGU:	100220315(IGFBP3)

LSR:	110477392(IGFBP3)

SCAN:

103819376(IGFBP3)

PMOA:

120503534(IGFBP3)

OTC:	121333303(IGFBP3)

PRUF:

121356123(IGFBP3)

GFR:	102040735(IGFBP3)

FAB:	101814335(IGFBP3)

OMA:	130249929(IGFBP3)

PHI:	102109965(IGFBP3)

PMAJ:

107200870(IGFBP3)

CCAE:

111923695(IGFBP3)

CCW:	104689253(IGFBP3)

CBRC:

103622007

ETL:	114068393(IGFBP3)

ZAB:	102074776(IGFBP3)

ZLE:	135444020(IGFBP3)

ACHL:

103799654(IGFBP3)

SVG:	106853831(IGFBP3)

MMEA:

130574314(IGFBP3)

HRT:	120763034(IGFBP3)

SATI:

136363689(IGFBP3)

FPG:	101914410(IGFBP3)

FCH:	102056357(IGFBP3)

CCRI:

104166433(IGFBP3)

NNT:	104399198(IGFBP3)

SHAB:

115613560(IGFBP3)

ACUN:

113477277(IGFBP3)

TALA:

104356179(IGFBP3)

ACHC:

115353110(IGFBP3)

HLE:	104837757(IGFBP3)

AGEN:

126048596

GCL:

127013042

CSTI:

104549465(IGFBP3)

LDI:	104345759(IGFBP3)

MNB:	103773714(IGFBP3)

DPUB:

104298310(IGFBP3)

AVIT:

104267604

BRHI:

104488023(IGFBP3)

EGZ:	104125967(IGFBP3)

NNI:	104015392(IGFBP3)

PCRI:

104024281(IGFBP3)

PCAO:

104043690(IGFBP3)

PADL:

103916268(IGFBP3)

AFOR:

103904018(IGFBP3)

FGA:	104081576(IGFBP3)

GSTE:

104262179(IGFBP3)

CLV:	102098854(IGFBP3)

MUI:	104533880(IGFBP3)

PGUU:

104470206(IGFBP3)

PLET:

104618421(IGFBP3)

EHS:	104503136(IGFBP3)

CMAC:

104473157(IGFBP3)

CUCA:

104065927(IGFBP3)

TEO:	104382733(IGFBP3)

BREG:

104635724(IGFBP3)

OHA:	104334083(IGFBP3)

ACAR:

104519057(IGFBP3)

CPEA:

104392182(IGFBP3)

CVF:	104295317(IGFBP3)

RTD:	128906038(IGFBP3)

AAM:	106492834(IGFBP3)

AROW:

112965168(IGFBP3)

NPD:	112942701(IGFBP3)

TGT:	104573628(IGFBP3)

DNE:	112997508(IGFBP3)

SCAM:

104150332(IGFBP3)

ASN:	102372891(IGFBP3)

AMJ:	102573354(IGFBP3)

CPOO:

109313100(IGFBP3)

GGN:	109291656(IGFBP3)

PSS:	102445995(IGFBP3)

CMY:	102936213(IGFBP3)

CCAY:

125631859(IGFBP3)

DCC:	119851932(IGFBP3)

CPIC:

101934995(IGFBP3)

TST:	117872637(IGFBP3)

CABI:

116834613(IGFBP3)

MRV:	120399123(IGFBP3)

ACS:	100565907(igfbp3)

ASAO:

132778509(IGFBP3)

PVT:	110088740(IGFBP3)

PBI:	103052169(IGFBP3)

PMUR:

107295282(IGFBP3)

TSR:	106551681(IGFBP3)

PGUT:

117664956(IGFBP3)

APRI:

131197789(IGFBP3)

PTEX:

113437372(IGFBP3)

NSS:	113421049(IGFBP3)

VKO:	123035469(IGFBP3)

PMUA:

114607066

PRAF:

128398539(IGFBP3)

ZVI:	118077661(IGFBP3)

HCG:	128331974(IGFBP3)

GJA:	107105599(IGFBP3)

STOW:

125441337(IGFBP3)

EMC:	129337560(IGFBP3)

BBUF:

121001966(IGFBP3)

BGAR:

122938679(IGFBP3)

MUO:	115470307(IGFBP3)

GSH:	117353887(IGFBP3)

DRE:	403079(igfbp3)

SRX:	107712886 107755684

SANH:

107687177 107697441

SGH:	107559743 107581452

CCAR:

109113390 109113391

CAUA:

113063281 113121088

CGIB:

127938457 127983874

PTET:

122325179(igfbp3)

LROH:

127183434(igfbp3)

OMC:	131527755(igfbp3)

PPRM:

120493735(igfbp3)

RKG:	130096164(igfbp3)

MAMB:

125279130(igfbp3)

CIDE:

127502180

CERY:

137019403(igfbp3)

MASI:

127410401 127416443

TROS:

130566291(igfbp3)

TDW:	130434452(igfbp3)

MANU:

129429463(igfbp3)

IPU:	100305016(igfbp3) 108268023

IFU:	128601050(igfbp3) 128610435

PHYP:

113545296 113547291

SMEO:

124377352(igfbp3) 124387769

TFD:	113662305 113664019(igfbp3)

TVC:	132843369(igfbp3) 132849007

TRN:	134312446 134320661(igfbp3)

AMEX:

103027084(igfbp3) 111194341

CMAO:

118815471(igfbp3)

EEE:	113582983 113588642(igfbp3)

CHAR:

105898458 105910822(igfbp3)

TRU:	101075107(igfbp3) 115247245 115247338

TFS:	130528769 130538680(igfbp3)

TNG:	GSTEN00004782G001 GSTEN00012277G001

LCO:	104927720(igfbp3) 104929330

NCC:	104950566 104960607

TBEN:

117488867 117495959(igfbp3)

CGOB:

115007374 115022759

PGEO:

117445467(igfbp3) 117462513

GACU:

117558466 117560551(igfbp3)

EMAC:

134865994 134869792(igfbp3)

ELY:	117254459(igfbp3) 117272377

EFO:	125895337 125902035

PLEP:

121941129(igfbp3) 121951737

SLUC:

116038224(igfbp3) 116046041

ECRA:

117951099 117954819

ESP:	116695248 116699487

PFLV:

114561819 114565527

GAT:	120816582 120824119(igfbp3)

PPUG:

119209202 119217194

AFB:	129088934 129094584(igfbp3)

CLUM:

117729588(igfbp3)

PSWI:

130193636(igfbp3) 130197938

MSAM:

119900263 119902051

SCHU:

122878309(igfbp3) 122887422

CUD:	121512269(igfbp3) 121520437

ALAT:

119010995 119028604(igfbp3)

MZE:	101465250 101475198

ONL:	100702310 102082028

OAU:	116314525(igfbp3) 116318660

OLA:	101162674 101166253

OML:	112147859 112150763

CSAI:

133452759(igfbp3)

XMA:	102226624 102227338(igfbp3)

XCO:	114147198 114151072

XHE:	116722303 116725969(igfbp3)

PRET:

103463405(igfbp3) 103479557

PFOR:

103129638 103143000

PLAI:

106936141 106948623

PMEI:

106914435(igfbp6) 106925935

GAF:	122838014(igfbp3) 122841231

PPRL:

129362303 129376855(igfbp3)

CVG:	107083028 107092413

CTUL:

119787606(igfbp3) 119795715

GMU:	124870254 124874155

NFU:	107383917 107393047

KMR:	108239579 108248361(igfbp3)

ALIM:

106526014 106533982

NWH:	119407634(igfbp3) 119414206

AOCE:

111568688 111569879

MCEP:

125009199(igfbp3) 125011472

CSEM:

103396287 103399857

POV:	109639207 109641634 109643988

SSEN:

122777543 122780781

HHIP:

117760194(igfbp3) 117778085

HSP:	118118138 118120960

PPLT:

128455055(igfbp3)

SMAU:

118310527 118317720

LCF:	108879542(igfbp3) 108883419

SDU:	111227515 111231074

SLAL:

111670503 111671736

XGL:	120790603(igfbp3) 120799102

HCQ:	109521219 109524696

SSCV:

125970133 125985326

SBIA:

133503301 133510824

PEE:	133406700(igfbp3) 133411193

PTAO:

133480794(igfbp3) 133489519

BPEC:

110158832 110172249

MALB:

109957706 109961275

BSPL:

114845183 114854703

SJO:	128361512 128369211

SASA:

101448060(igfbp-3a1) 101448063(igfbp-3a2) 101448066(igfbp-3b1) 101448067(igfbp-3b2)

STRU:

115157128 115158654 115169642 115192277

OTW:	112226459 112248249 112251323(igfbp3) 112260576

OMY:	110508632 110521771 110524670(igfbp3) 110530431

OGO:	123996815(igfbp3) 124009764 124037163 124040909

ONE:	115101771 115114519 115145418

OKI:	109872345 109898102 116353052

OKE:	118372076 118381503(igfbp3) 118395122 118402010

SALP:

111956369 111971187 111979022 112070217

SNH:	120020194 120051896 120054303 120055572

CCLU:

121533870(igfbp3) 121535310 121540035 121581004

ELS:	105011949 105018684

SFM:	108937708 108939070(igfbp3)

PKI:	111845974(igfbp3) 111850180

AANG:

118225902(igfbp3) 118233164

LOC:	102688916(igfbp3)

PSPA:

121313143 121314512

ARUT:

117394456 117399925

PSEX:

120529516(igfbp3)

LCM:	102347870(IGFBP3)

CMK:	103190034(igfbp3)

RTP:	109910480(igfbp3)

CPLA:

122549911(igfbp3)

HOC:	132815736(igfbp3)

LERI:

129710303(igfbp3)

PMRN:

LRJ:

BBEL:

VDE:

VJA:

XEN:

Reference

PMID:12067807

Authors

Furstenberger G, Senn HJ

Title

Insulin-like growth factors and cancer.

Journal

Lancet Oncol 3:298-302 (2002)
DOI:10.1016/S1470-2045(02)00731-3

Reference

PMID:2464130

Authors

Wood WI, Cachianes G, Henzel WJ, Winslow GA, Spencer SA, Hellmiss R, Martin JL, Baxter RC

Title

Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein.

Journal

Mol Endocrinol 2:1176-85 (1988)
DOI:10.1210/mend-2-12-1176

Sequence

[hsa:3486]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (8)   
   KEGG PATHWAY (8)   
Gene (889)   
   KEGG GENES (517)   
   KEGG MGENES (280)   
   RefGene (90)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (903)   

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