KEGG ORTHOLOGY: K10140

ORTHOLOGY: K10140

Entry

K10140                      KO

Symbol

DDB2

Name

DNA damage-binding protein 2

Pathway

map03420

Nucleotide excision repair

map04115

p53 signaling pathway

map04120

Ubiquitin mediated proteolysis

map05161

Hepatitis B

map05169

Epstein-Barr virus infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05213

Endometrial cancer

map05214

Glioma

map05216

Thyroid cancer

map05217

Basal cell carcinoma

map05218

Melanoma

map05220

Chronic myeloid leukemia

map05222

Small cell lung cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Disease

H00403

Disorders of nucleotide excision repair

H01428

Xeroderma pigmentosum

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10140  DDB2; DNA damage-binding protein 2
  09124 Replication and repair
   03420 Nucleotide excision repair
    K10140  DDB2; DNA damage-binding protein 2
09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K10140  DDB2; DNA damage-binding protein 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10140  DDB2; DNA damage-binding protein 2
   05202 Transcriptional misregulation in cancer
    K10140  DDB2; DNA damage-binding protein 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K10140  DDB2; DNA damage-binding protein 2
   05212 Pancreatic cancer
    K10140  DDB2; DNA damage-binding protein 2
   05225 Hepatocellular carcinoma
    K10140  DDB2; DNA damage-binding protein 2
   05226 Gastric cancer
    K10140  DDB2; DNA damage-binding protein 2
   05214 Glioma
    K10140  DDB2; DNA damage-binding protein 2
   05216 Thyroid cancer
    K10140  DDB2; DNA damage-binding protein 2
   05220 Chronic myeloid leukemia
    K10140  DDB2; DNA damage-binding protein 2
   05217 Basal cell carcinoma
    K10140  DDB2; DNA damage-binding protein 2
   05218 Melanoma
    K10140  DDB2; DNA damage-binding protein 2
   05213 Endometrial cancer
    K10140  DDB2; DNA damage-binding protein 2
   05224 Breast cancer
    K10140  DDB2; DNA damage-binding protein 2
   05222 Small cell lung cancer
    K10140  DDB2; DNA damage-binding protein 2
   05223 Non-small cell lung cancer
    K10140  DDB2; DNA damage-binding protein 2
  09172 Infectious disease: viral
   05161 Hepatitis B
    K10140  DDB2; DNA damage-binding protein 2
   05169 Epstein-Barr virus infection
    K10140  DDB2; DNA damage-binding protein 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10140  DDB2; DNA damage-binding protein 2
   03400 DNA repair and recombination proteins
    K10140  DDB2; DNA damage-binding protein 2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul4 complex
    Target recognizing subunit (DCAF)
     K10140  DDB2; DNA damage-binding protein 2
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K10140  DDB2; DNA damage-binding protein 2

Genes

HSA:	1643(DDB2)

PTR:	451165(DDB2)

GGO:	101128036(DDB2)

PON:	100454099(DDB2)

PPYG:

129008019(DDB2)

NLE:	100605065(DDB2)

HMH:	116476282(DDB2)

SSYN:

129484153(DDB2)

MCC:	114672263 713813(DDB2)

MCF:	102124623(DDB2)

MTHB:

126936385

MNI:	105471678(DDB2)

CSAB:

103236219(DDB2)

CATY:

105592813(DDB2)

PANU:

100998564(DDB2)

TGE:	112606094(DDB2)

MLEU:

105554817(DDB2)

RRO:	104668405(DDB2)

RBB:	108521962(DDB2)

TFN:	117080146(DDB2)

PTEH:

111544893(DDB2)

CANG:

105527128(DDB2)

CJC:	100390419(DDB2)

SBQ:	101027903(DDB2)

CIMI:

108304850(DDB2)

ANAN:

105717347(DDB2)

CSYR:

103261208(DDB2)

MMUR:

105884857(DDB2)

LCAT:

123642672(DDB2)

PCOQ:

105811078(DDB2)

OGA:	100962402(DDB2)

MMU:	107986(Ddb2)

MCAL:

110290093(Ddb2)

MPAH:

110319597(Ddb2)

RNO:	100362121(Ddb2)

MCOC:

116090466(Ddb2)

ANU:	117703801(Ddb2)

MUN:	110550733(Ddb2)

CGE:	100756705(Ddb2)

MAUA:

101843985(Ddb2)

PROB:

127222248(Ddb2)

PLEU:

114699687(Ddb2)

MORG:

121437671(Ddb2) 121437682

MFOT:

126489766

AAMP:

119815700(Ddb2)

NGI:	103742505(Ddb2)

HGL:	101715591(Ddb2)

CPOC:

100726538(Ddb2)

CCAN:

109696190(Ddb2)

DORD:

105996079(Ddb2)

DSP:	122104989(Ddb2)

PLOP:

125362234(Ddb2)

NCAR:

124960240

MMMA:

107135807(Ddb2)

OCU:

100352386

OPI:	101527969(DDB2)

TUP:	102472614(DDB2)

GVR:	103592096(DDB2)

CFA:	483626(DDB2)

CLUD:

112663311(DDB2)

VVP:	112924073(DDB2)

VLG:	121472218(DDB2)

NPO:	129499055(DDB2)

AML:	100479738(DDB2)

UMR:	103672315(DDB2)

UAH:	113264969(DDB2)

UAR:	123785020(DDB2)

ELK:

111150113

LLV:

125078755

MPUF:

101691261(DDB2)

MNP:	132008234 132008429

MLK:	131812400(DDB2)

NVS:	122912895(DDB2)

ORO:	101378738(DDB2)

EJU:	114215282(DDB2)

ZCA:	113913864(DDB2)

MLX:	118015830(DDB2)

NSU:	110575769(DDB2)

LWW:	102739956(DDB2)

FCA:	101092211(DDB2)

PYU:	121043455(DDB2)

PCOO:

112866046(DDB2)

PBG:	122484438(DDB2)

PVIV:

125176371(DDB2)

LRUF:

124504922

PTG:	102961097(DDB2)

PPAD:

109245111(DDB2)

PUC:

125933993

AJU:

106978021

HHV:	120228475(DDB2)

BTA:	519357(DDB2)

BOM:	102272760(DDB2)

BIU:	109569541(DDB2)

BBUB:

102390671(DDB2)

BBIS:

104990347(DDB2)

CHX:	102171356(DDB2)

OAS:	101116344(DDB2)

BTAX:

128059803(DDB2)

ODA:	120876950(DDB2)

CCAD:

122450465(DDB2)

MBEZ:

129554816(DDB2)

SSC:	100513197(DDB2)

CFR:	102523860(DDB2)

CBAI:

105076453(DDB2)

CDK:	105106872(DDB2)

VPC:	102532209(DDB2)

BACU:

103017537(DDB2)

BMUS:

118899128(DDB2)

LVE:	103079116(DDB2)

OOR:	101270094(DDB2)

DLE:	111183968(DDB2)

PCAD:

102974256(DDB2)

PSIU:

116757742(DDB2)

NASI:

112402084(DDB2)

ECB:	100051180(DDB2)

EPZ:	103566732(DDB2)

EAI:	106844006(DDB2)

MYB:	102256502(DDB2)

MYD:	102756511(DDB2)

MMYO:

118665064(DDB2)

MLF:	102422583(DDB2)

MDT:	132241202(DDB2)

PKL:	118713534(DDB2)

EFUS:

103291020(DDB2)

MNA:	107530310(DDB2)

DRO:	112303349(DDB2)

SHON:

118974481(DDB2)

AJM:	119064434(DDB2)

PDIC:

114499000(DDB2)

PHAS:

123810170(DDB2)

MMF:	118627554(DDB2)

PPAM:

129081434(DDB2)

HAI:	109390202(DDB2)

RFQ:	117029994(DDB2)

PALE:

102879479(DDB2)

PGIG:

120607230(DDB2)

PVP:	105290030(DDB2)

RAY:	107511851(DDB2)

MJV:	108388647(DDB2)

TOD:	119255301(DDB2)

SARA:

101555848(DDB2)

SETR:

126017658(DDB2)

LAV:	100665802(DDB2)

TMU:

101349998

ETF:	101659849(DDB2)

DNM:	101412187(DDB2)

MDO:	100016157(DDB2) 100021792

GAS:	123253069(DDB2) 123253673

SHR:	100916232(DDB2)

AFZ:

127541912

PCW:	110223919(DDB2)

TVP:	118853234(DDB2)

OAA:	100088212(DDB2)

GGA:	423185(DDB2)

PCOC:

116229153(DDB2)

MGP:	100548596(DDB2)

CJO:	107314743(DDB2)

TPAI:

128086324(DDB2)

LMUT:

125695416(DDB2)

NMEL:

110400968(DDB2)

APLA:

101791096(DDB2)

ACYG:

106043656(DDB2)

CATA:

118244787(DDB2)

AFUL:

116490407(DDB2)

TGU:	100221888(DDB2)

LSR:	110472060(DDB2)

SCAN:

103826693(DDB2)

PMOA:

120500408(DDB2)

OTC:	121335031(DDB2)

PRUF:

121349387(DDB2)

GFR:	102035276(DDB2)

FAB:	101813959(DDB2)

OMA:	130253742(DDB2)

PHI:	102113625(DDB2)

PMAJ:

107205447(DDB2)

CCAE:

111930172(DDB2)

CCW:	104697960(DDB2)

CBRC:

103620739(DDB2)

ETL:	114058833(DDB2)

ZAB:	102069315(DDB2)

ZLE:	135448334(DDB2)

ACHL:

103808261(DDB2)

SVG:	106856506(DDB2)

MMEA:

130572823(DDB2)

HRT:	120754533(DDB2)

SATI:

136362518(DDB2)

FPG:	101911160(DDB2)

FCH:	102048021(DDB2)

CCRI:

104167922(DDB2)

NNT:	104403721(DDB2)

SHAB:

115606117(DDB2)

ACUN:

113480499(DDB2)

TALA:

104359024(DDB2)

ACHC:

115334295(DDB2)

HALD:

104317689(DDB2)

HLE:	104839698(DDB2)

AGEN:

126049439

GCL:

127016714

CSTI:

104555752(DDB2)

LDI:

104341105

MNB:	103773491(DDB2)

DPUB:

104297431(DDB2)

AVIT:

104273255

BRHI:

104495989(DDB2)

EGZ:	104134072(DDB2)

NNI:	104020384(DDB2)

PCRI:

104025346(DDB2)

PCAO:

104040121(DDB2)

PADL:

103921706(DDB2)

AFOR:

103897476(DDB2)

FGA:	104070766(DDB2)

GSTE:

104255028(DDB2)

CLV:	102087151(DDB2)

MUI:	104534597(DDB2)

PGUU:

104465277(DDB2)

PLET:

104625110(DDB2)

EHS:	104509419(DDB2)

CMAC:

104480689(DDB2)

CUCA:

104067301(DDB2)

TEO:	104379744(DDB2)

BREG:

104630420(DDB2)

OHA:	104328089(DDB2)

ACAR:

104518947(DDB2)

CPEA:

104390410(DDB2)

CVF:	104295853(DDB2)

RTD:	128909544(DDB2)

AAM:	106498364(DDB2)

AROW:

112973926(DDB2)

NPD:	112943809(DDB2)

TGT:	104574985(DDB2)

DNE:	112979222(DDB2)

SCAM:

104149238(DDB2)

ASN:	102374438(DDB2)

AMJ:	102570152(DDB2)

CPOO:

109320949(DDB2)

GGN:	109298895(DDB2)

PSS:	102461762(DDB2)

CMY:	102941615(DDB2)

CCAY:

125637539(DDB2)

DCC:	119857834(DDB2)

CPIC:

101941863(DDB2)

TST:	117876923(DDB2)

CABI:

116825871(DDB2)

MRV:	120403276(DDB2)

ACS:	100554400(ddb2)

ASAO:

132767978(DDB2)

PVT:	110081991(DDB2)

SUND:

121927602(DDB2)

PBI:	103059573(DDB2)

PMUR:

107289836(DDB2)

CTIG:

120314670(DDB2)

TSR:	106552427(DDB2)

PGUT:

117665529(DDB2)

APRI:

131187476(DDB2)

PTEX:

113441052(DDB2)

NSS:	113414346(DDB2)

VKO:	123026299(DDB2)

PMUA:

114595784(DDB2)

PRAF:

128412943(DDB2)

ZVI:	118084855(DDB2)

HCG:	128327518(DDB2)

GJA:	107123208(DDB2)

STOW:

125425961(DDB2)

EMC:	129324963(DDB2)

XLA:	108713786(ddb2.L) 108715228(ddb2.S)

XTR:	493565(ddb2)

NPR:	108791609(DDB2)

RTEM:

120917151(DDB2)

BBUF:

120980229(DDB2)

BGAR:

122920544(DDB2)

MUO:	115468843(DDB2)

GSH:	117352072(DDB2)

DRE:	100004133(ddb2)

SRX:	107708220 107738696

SANH:

107686311(ddb2)

SGH:	107583755 107596991

CCAR:

109109984 109110490

CAUA:

113118377(ddb2)

CGIB:

127977554

PTET:

122363151(ddb2)

LROH:

127180602(ddb2)

OMC:	131524820(ddb2)

PPRM:

120487867(ddb2)

RKG:	130087958(ddb2)

MAMB:

125253987(ddb2)

CIDE:

127500154

CERY:

137022829(ddb2)

MASI:

127416687

TROS:

130562738(ddb2)

TDW:	130435140(ddb2)

MANU:

129419125(ddb2)

AMEX:

103036503(ddb2)

CMAO:

118817897(ddb2)

EEE:	113585066(ddb2)

CHAR:

122131763(ddb2)

TRU:	101074409(ddb2)

TFS:	130535744(ddb2)

TNG:	GSTEN00012482G001

LCO:	104922334(ddb2)

NCC:	104945738(ddb2)

TBEN:

117491248(ddb2)

CGOB:

115009134(ddb2)

PGEO:

117447520(ddb2)

GACU:

117538908(ddb2)

EMAC:

134873103(ddb2)

ELY:	117262827(ddb2)

EFO:	125887890(ddb2)

PLEP:

121950322(ddb2)

SLUC:

116038653(ddb2)

ECRA:

117948999(ddb2)

ESP:	116694797(ddb2)

PFLV:

114560042(ddb2)

GAT:	120809393(ddb2)

PPUG:

119196094(ddb2)

AFB:	129108586(ddb2)

CLUM:

117732268(ddb2)

PSWI:

130195540(ddb2)

MSAM:

119893989(ddb2)

SCHU:

122875443(ddb2)

CUD:	121515051(ddb2)

ALAT:

119024438(ddb2)

MZE:	101480006(ddb2)

ONL:	100709229(ddb2)

OAU:	116326282(ddb2)

OLA:	101159499(ddb2)

OML:	112151711(ddb2)

CSAI:

133444184(ddb2)

XMA:	102226772(ddb2)

XCO:	114134296(ddb2)

XHE:	116737520(ddb2)

PRET:

103466527(ddb2)

PFOR:

103141280(ddb2)

PLAI:

106955817(ddb2)

PMEI:

106921844(ddb2)

GAF:	122835988(ddb2)

PPRL:

129365707(ddb2)

CVG:	107097841(ddb2)

CTUL:

119780374(ddb2)

GMU:	124882015(ddb2)

NFU:	107388695(ddb2)

KMR:	108230198(ddb2)

ALIM:

106534715(ddb2)

NWH:	119416455(ddb2)

AOCE:

111582143(ddb2)

MCEP:

125015444(ddb2)

CSEM:

103380265(ddb2)

POV:	109624175(ddb2)

SSEN:

122760516(ddb2)

HHIP:

117763457(ddb2)

HSP:	118109197(ddb2)

PPLT:

128445074(ddb2)

SMAU:

118314907(ddb2)

LCF:

108886614

SDU:	111228602(ddb2)

SLAL:

111666992(ddb2)

XGL:	120793553(ddb2)

HCQ:	109519449(ddb2)

SSCV:

125970244

SBIA:

133502003(ddb2)

PEE:	133402369(ddb2)

PTAO:

133478478(ddb2)

BPEC:

110160813(ddb2)

MALB:

109971222(ddb2)

BSPL:

114856820(ddb2)

SJO:	128359343(ddb2)

SASA:

106584815(ddb2)

STRU:

115192953

OTW:	112241207(ddb2)

OMY:	110515488(ddb2)

OGO:	124036968(ddb2)

OKI:	109885077(ddb2)

OKE:	118381105(ddb2)

SALP:

112077473(ddb2)

SNH:	120035709 120035710

CCLU:

121540101(ddb2) 121540776

ELS:	105029687(ddb2)

SFM:	108941276(ddb2)

PKI:	111858235(ddb2)

AANG:

118227701(ddb2)

LOC:	102693465(ddb2)

PSPA:

121294299(ddb2)

ARUT:

117432036(ddb2)

PSEX:

120530394(ddb2)

PMRN:

116942798(DDB2)

LRJ:	133343094 133343095

BFO:

118430317

BBEL:

109479763

SPU:	100892716 115924834

LPIC:

APLC:

ARUN:

AJC:

SKO:	100376707 100377457

BTAB:

109038745

CLEC:

106666549

HHAL:

106683541

HVI:	124364607 124364609

MQU:

128992812

PHU:	Phum_PHUM473480

CSEC:

111871881

IEL:

124158771

FCD:

110853733

DPX:	DAPPUDRAFT_39221

DPZ:

PVM:

PJA:

PCHN:

PCLA:

CQD:

EAF:

LSM:

TCF:

DSV:	119435771 119435776

RSAN:

119389520

RMP:	119164124 119182121

TUT:

107359138

ABRU:

129988071

UDV:	129229392 129230345

SDM:

118197059

LPOL:

106472895

LGI:	LOTGIDRAFT_53959

PVUL:

BGT:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

LJP:

LAK:

LLON:

AQU:

ATH:	AT5G58760(DDB2)

ALY:

9300664

CRB:

17877047

CSAT:

104726455 104736015 104761975

EUS:	EUTSA_v10013126mg

BRP:

103851625

BNA:	106387387 106388037

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10028135mg

PVY:

MINC:

TCC:

GRA:

GHI:	107936460 121212677

GAB:

HSYR:

DZI:

EGR:

GMX:	100527914 100793506

GSJ:	114383374 114396565

PVU:	PHAVU_008G261700g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131620725 131634886

LJA:

130733998

ADU:

107458384

AIP:

107609534

AHF:	112702883 112766368

LANG:

109355773

PCIN:

129301818

QSA:	O6P43_014034

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:	103939228 103960749

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

PNZ:

JRE:	109002051 109009014

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107759199 107760564

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

121763054 121763234 121788334

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110683452 110688270

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119266858 119274608

TAES:

123060019 123068492 123076991

TUA:

125542498

LPER:

127325841

LRD:	124660982 124667098

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	122008605 122016863

DCT:

110108807

PEQ:

110017980

AOF:	109821912 109837752

MSIN:

131244006

NCOL:

116253846

ATR:

18437948

SMO:	SELMODRAFT_21554 SELMODRAFT_31884

PPP:

112285391

VCN:	VOLCADRAFT_117128

MNG:	MNEG_10255

CSL:	COCSUDRAFT_2514

CVR:	CHLNCDRAFT_26064

APRO:

F751_3019

GSL:	Gasu_51510

CCP:	CHC_T00004000001

» show all

Reference

PMID:16260596

Authors

Kulaksiz G, Reardon JT, Sancar A

Title

Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.

Journal

Mol Cell Biol 25:9784-92 (2005)
DOI:10.1128/MCB.25.22.9784-9792.2005

Sequence

[hsa:1643]

Reference

PMID:16473935

Authors

Kapetanaki MG, Guerrero-Santoro J, Bisi DC, Hsieh CL, Rapic-Otrin V, Levine AS

Title

The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.

Journal

Proc Natl Acad Sci U S A 103:2588-93 (2006)
DOI:10.1073/pnas.0511160103

Sequence

[hsa:1643]

Reference

PMID:8530102

Authors

Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S

Title

Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.

Journal

Genomics 29:62-9 (1995)
DOI:10.1006/geno.1995.1215

Sequence

[hsa:1643]

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