KEGG   ORTHOLOGY: K10150
Entry
K10150                      KO                                     

Name
cysO
Definition
cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
Pathway
ko00260  Glycine, serine and threonine metabolism
ko00270  Cysteine and methionine metabolism
ko00920  Sulfur metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01230  Biosynthesis of amino acids
Module
M00035  Methionine degradation
M00338  Cysteine biosynthesis, homocysteine + serine => cysteine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
   00270 Cysteine and methionine metabolism
    K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.47  cysteine synthase
     K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
    2.5.1.65  O-phosphoserine sulfhydrylase
     K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.22  cystathionine beta-synthase
     K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Other DBs
RN: R00891 R00897 R01290 R03601 R04859 R04942 R07274
GO: 0004124 0033847 0004122
Genes
APE: APE_1586(cysK)
ACJ: ACAM_0997(cysK)
DFD: Desfe_0630
DMU: Desmu_0644
TAG: Tagg_1314
IAG: Igag_1783
THG: TCELL_0171
HBU: Hbut_1585
PFM: Pyrfu_1108
PDL: Pyrde_0768
PIS: Pisl_1761
TPE: Tpen_1605
ASC: ASAC_0793
ACIA: SE86_05800
CCAI: NAS2_0810
 » show all
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
  Sequence
[ape:APE_1586]

KEGG   ENZYME: 2.5.1.65
Entry
EC 2.5.1.65                 Enzyme                                 

Name
O-phosphoserine sulfhydrylase;
O-phosphoserine(thiol)-lyase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
Reaction(IUBMB)
O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate [RN:R07274]
Reaction(KEGG)
R07274;
(other) R00897
Substrate
O-phospho-L-serine [CPD:C01005];
hydrogen sulfide [CPD:C00283]
Product
L-cysteine [CPD:C00097];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine.
History
EC 2.5.1.65 created 2004
Pathway
ec00270  Cysteine and methionine metabolism
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Genes
APE: APE_1586(cysK)
ACJ: ACAM_0997(cysK)
DFD: Desfe_0630
DMU: Desmu_0644
TAG: Tagg_1314
IAG: Igag_1783
THG: TCELL_0171
HBU: Hbut_1585
PFM: Pyrfu_1108
PDL: Pyrde_0768
PIS: Pisl_1761
TPE: Tpen_1605
ASC: ASAC_0793
ACIA: SE86_05800
CCAI: NAS2_0810
 » show all
Reference
1  [PMID:12965218]
  Authors
Mino K, Ishikawa K.
  Title
A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
FEBS Lett 551:133-8 (2003)
DOI:10.1016/S0014-5793(03)00913-X
Reference
2  [PMID:12644499]
  Authors
Mino K, Ishikawa K.
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
  Sequence
[ape:APE_1586]
Reference
3  [PMID:12554945]
  Authors
Mino K, Oda Y, Ataka M, Ishikawa K.
  Title
Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
Acta Crystallogr D Biol Crystallogr 59:338-40 (2003)
DOI:10.1107/S0907444902017900
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.65
IUBMB Enzyme Nomenclature: 2.5.1.65
ExPASy - ENZYME nomenclature database: 2.5.1.65
BRENDA, the Enzyme Database: 2.5.1.65
CAS: 1071505-11-7

KEGG   REACTION: R00897
Entry
R00897                      Reaction                               

Name
O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase;
O3-acetyl-L-serine acetate-lyase (adding hydrogen sulfide)
Definition
O-Acetyl-L-serine + Hydrogen sulfide <=> L-Cysteine + Acetate
Equation
Reaction class
RC00020  C00033_C00979
RC02814  C00097_C00283
RC02821  C00097_C00979
Enzyme
2.5.1.47        2.5.1.65
Pathway
rn00270  Cysteine and methionine metabolism
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01230  Biosynthesis of amino acids
Module
M00021  Cysteine biosynthesis, serine => cysteine
Orthology
K01738  cysteine synthase [EC:2.5.1.47]
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
K13034  L-3-cyanoalanine synthase/ cysteine synthase [EC:2.5.1.47 4.4.1.9]
K17069  O-acetylhomoserine/O-acetylserine sulfhydrylase [EC:2.5.1.49 2.5.1.47]
Other DBs
RHEA: 14832

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