KEGG ORTHOLOGY: K10158

ORTHOLOGY: K10158

Entry

K10158                      KO

Symbol

B3GAT3

Name

galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [EC:2.4.1.135]

Pathway

map00532

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

map00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

map01100

Metabolic pathways

Module

M00057

Glycosaminoglycan biosynthesis, linkage tetrasaccharide

Reaction

R05928

Disease

H01498

Multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
    K10158  B3GAT3; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
   00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    K10158  B3GAT3; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K10158  B3GAT3; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Enzymes [BR:ko01000]
2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.135  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
     K10158  B3GAT3; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
Glycosyltransferases [BR:ko01003]
Glycan extension
  O-Glycan
   K10158  B3GAT3; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

Other DBs

GO:

0015018

CAZy:

GT43

Genes

HSA:	26229(B3GAT3)

PTR:	740388(B3GAT3)

PPS:	103783318(B3GAT3)

GGO:	109028750(B3GAT3)

PON:	100458701(B3GAT3)

PPYG:

129008224(B3GAT3)

NLE:	100592146(B3GAT3)

HMH:	116468888(B3GAT3)

SSYN:

129488696(B3GAT3)

MCC:	718744(B3GAT3)

MCF:	101867087(B3GAT3)

MTHB:

126935491

MNI:	105469443(B3GAT3)

CSAB:

103234006(B3GAT3)

CATY:

105577553(B3GAT3)

PANU:

101012905(B3GAT3)

TGE:	112605682(B3GAT3)

MLEU:

105549041(B3GAT3)

RRO:	104679349(B3GAT3)

RBB:	108533582(B3GAT3)

TFN:	117081104(B3GAT3)

PTEH:

111524301 111532260

CANG:

105512275(B3GAT3)

CJC:	100395367(B3GAT3)

SBQ:	101034661(B3GAT3)

CIMI:

108286267(B3GAT3) 108297652

ANAN:

105718641(B3GAT3)

CSYR:

103264742(B3GAT3)

MMUR:

105878602(B3GAT3)

LCAT:

123641313(B3GAT3)

PCOQ:

105827019(B3GAT3)

OGA:	100948864(B3GAT3)

MMU:	72727(B3gat3)

MCAL:

110285876(B3gat3)

MPAH:

110320357(B3gat3)

RNO:	293722(B3gat3)

MCOC:

116103532(B3gat3)

ANU:	117698980(B3gat3)

MUN:	110557462(B3gat3)

CGE:	100689419(B3gat3)

MAUA:

121141157(B3gat3)

PROB:

127228824(B3gat3)

PLEU:

114683612(B3gat3)

MORG:

121454137(B3gat3)

MFOT:

126498498

AAMP:

119800517(B3gat3)

NGI:	103737681(B3gat3)

HGL:	101717898(B3gat3)

CPOC:

100731926(B3gat3)

CCAN:

109681240(B3gat3)

DORD:

105995546(B3gat3)

DSP:	122105199(B3gat3)

PLOP:

125362763(B3gat3)

NCAR:

124960761

MMMA:

107135919(B3gat3)

OCU:

100350294

OPI:	101521347(B3GAT3)

TUP:	102472891(B3GAT3)

GVR:	103591081(B3GAT3)

CFA:	483785(B3GAT3)

CLUD:

112659540(B3GAT3)

VVP:	112924375(B3GAT3)

VLG:	121501700(B3GAT3)

NPO:	129503214(B3GAT3)

AML:	100467358(B3GAT3)

UMR:	103678187(B3GAT3)

UAH:	113247005(B3GAT3)

UAR:	123789827(B3GAT3)

ELK:

111150202

LLV:

125078491

MPUF:

101693078(B3GAT3)

MNP:	132020037(B3GAT3)

MLK:	131813948(B3GAT3)

NVS:	122913006(B3GAT3)

ORO:	101373124(B3GAT3)

EJU:	114220493(B3GAT3)

ZCA:	113914299(B3GAT3)

MLX:	118015942(B3GAT3)

NSU:	110575899(B3GAT3)

LWW:

102745335

FCA:	101089044(B3GAT3)

PYU:	121023675(B3GAT3)

PCOO:

112851886(B3GAT3)

PBG:	122483892(B3GAT3)

PVIV:

125147078(B3GAT3)

LRUF:

124505796

PTG:	102948861(B3GAT3)

PPAD:

109246589(B3GAT3)

PUC:

125932295

AJU:

106981737

HHV:	120249216(B3GAT3)

BTA:	404162(B3GAT3)

BOM:	102269297(B3GAT3)

BIU:	109554349(B3GAT3)

BBUB:

102399906(B3GAT3)

BBIS:

104998689(B3GAT3)

CHX:	102172516(B3GAT3)

OAS:	101111917(B3GAT3)

BTAX:

128068709(B3GAT3)

ODA:	120874565(B3GAT3)

CCAD:

122430606(B3GAT3)

MBEZ:

129548868(B3GAT3)

SSC:	397642(B3GAT3)

CFR:	102505525(B3GAT3)

CBAI:

105070128(B3GAT3)

CDK:	105091529(B3GAT3)

VPC:	102540773(B3GAT3)

BACU:

103002629(B3GAT3)

BMUS:

118899058(B3GAT3)

LVE:	103078862(B3GAT3)

OOR:	101279944(B3GAT3)

DLE:	111183870(B3GAT3)

PCAD:

102996092(B3GAT3)

PSIU:

116758116(B3GAT3)

NASI:

112402064(B3GAT3)

ECB:	100063587(B3GAT3)

EPZ:	103558932(B3GAT3)

EAI:	106826833(B3GAT3)

MYD:	102752313(B3GAT3)

MMYO:

118648962(B3GAT3)

MLF:	102440153(B3GAT3)

MDT:	132241545(B3GAT3)

PKL:	118707238(B3GAT3)

EFUS:

103303742(B3GAT3)

MNA:	107543104(B3GAT3)

DRO:	112317373(B3GAT3)

SHON:

118991611(B3GAT3)

AJM:	119035322(B3GAT3)

PDIC:

114499679(B3GAT3)

PHAS:

123829591(B3GAT3)

MMF:	118628796(B3GAT3)

PPAM:

129068435(B3GAT3)

HAI:	109384098(B3GAT3)

RFQ:	117031229(B3GAT3)

PALE:

102891455(B3GAT3)

PGIG:

120600844(B3GAT3)

PVP:	105297798(B3GAT3)

RAY:	107501598(B3GAT3)

MJV:	108393625(B3GAT3)

TOD:	119250084(B3GAT3)

SARA:

101554897(B3GAT3)

SETR:

126017693(B3GAT3)

LAV:	100672369(B3GAT3)

TMU:

101344059

ETF:	101664595(B3GAT3)

DNM:	101447746(B3GAT3)

MDO:	100010236(B3GAT3)

GAS:	123251159(B3GAT3) 123254274

SHR:	100935255(B3GAT3)

AFZ:

127540701

PCW:	110195593(B3GAT3)

TVP:	118855543(B3GAT3)

OAA:	100075413(B3GAT3)

APLA:

119715103(B3GAT3)

ACYG:

136788633 136789200

AFUL:

116501695(B3GAT3)

OTC:

121339074

OMA:

130262857

PHI:	102105592(B3GAT3)

SVG:

106864156

SHAB:

115614604(B3GAT3)

ACHC:

115338325(B3GAT3)

AGEN:

126033863

RTD:	128901816(B3GAT3)

ASN:	102375316(B3GAT3)

AMJ:	102563043(B3GAT3)

PSS:	102460502(B3GAT3)

CMY:	102941550(B3GAT3)

DCC:	119859352(B3GAT3)

CPIC:

101940176(B3GAT3)

CABI:

116835867(B3GAT3)

MRV:	120409148(B3GAT3)

ACS:	100567109(b3gat3)

ASAO:

132764311(B3GAT3)

PVT:	110081006(B3GAT3)

SUND:

121915744(B3GAT3)

PBI:	103057546(B3GAT3)

PMUR:

107292413(B3GAT3)

CTIG:

120316945(B3GAT3)

PGUT:

117658422(B3GAT3)

APRI:

131186408(B3GAT3)

PTEX:

113452662 113452663

NSS:	113426894(B3GAT3)

VKO:	123032606(B3GAT3)

PMUA:

114586454(B3GAT3)

PRAF:

128403751(B3GAT3)

ZVI:	118075696(B3GAT3)

HCG:	128337095(B3GAT3)

GJA:	107120072(B3GAT3)

STOW:

125441696(B3GAT3)

EMC:	129338582(B3GAT3)

XLA:	398597(b3gat3.L)

XTR:	594895(b3gat3)

NPR:	108794145(B3GAT3)

RTEM:

120917560(B3GAT3)

BBUF:

120980564(B3GAT3)

BGAR:

122920464(B3GAT3)

MUO:	115479566(B3GAT3)

GSH:	117365953(B3GAT3)

DRE:	192334(b3gat3)

SRX:	107749807 107750592

SANH:

107669233 107691906

SGH:	107563076 107588211(b3gat3)

CCAR:

109044808 109093054 109093075

CAUA:

113052095 113105829

CGIB:

127961154 128017105

PTET:

122349711(b3gat3)

LROH:

127168917(b3gat3)

OMC:	131544528(b3gat3)

PPRM:

120470365(b3gat3)

RKG:	130102712(b3gat3)

MAMB:

125264566(b3gat3)

CIDE:

127516343

CERY:

137030995(b3gat3)

MASI:

127414861 127434094

TROS:

130552083(b3gat3)

TDW:	130420870(b3gat3)

MANU:

129440780(b3gat3)

IPU:

108268305

IFU:	128610069(b3gat3)

PHYP:

113539858(b3gat3)

SMEO:

124387453(b3gat3)

TFD:	113635141(b3gat3)

TVC:	132848638(b3gat3)

TRN:	134311573(b3gat3)

AMEX:

103028547(b3gat3)

CMAO:

118826263(b3gat3)

EEE:	113579800(b3gat3)

CHAR:

105895533(b3gat3)

TRU:	654312(b3gat3)

TFS:	130522247(b3gat3)

TNG:	GSTEN00025864G001

LCO:	104918106(b3gat3)

NCC:

104960743

TBEN:

117487961(b3gat3)

CGOB:

115023909(b3gat3)

PGEO:

117463830(b3gat3)

GACU:

117549424(b3gat3)

EMAC:

134876313(b3gat3)

ELY:	117272641(b3gat3)

EFO:	125884207(b3gat3)

PLEP:

121962326(b3gat3)

SLUC:

116042344(b3gat3)

ECRA:

117934656(b3gat3)

ESP:	116707125(b3gat3)

PFLV:

114545607(b3gat3)

GAT:	120822759(b3gat3)

PPUG:

119223329(b3gat3)

AFB:	129093283(b3gat3)

CLUM:

117748074(b3gat3)

PSWI:

130211536(b3gat3)

MSAM:

119912927(b3gat3)

SCHU:

122869880(b3gat3)

CUD:	121504191(b3gat3)

ALAT:

119027139(b3gat3)

MZE:	101480695(b3gat3)

ONL:	100690672(b3gat3)

OAU:	116317880(b3gat3)

OLA:	100049460(b3gat3)

OML:	112156302(b3gat3)

CSAI:

133419951(b3gat3)

XMA:	102238000(b3gat3)

XCO:	114157307(b3gat3)

XHE:	116733254(b3gat3)

PRET:

103480760(b3gat3)

PFOR:

103153608(b3gat3)

PLAI:

106948298(b3gat3)

PMEI:

106916892(b3gat3)

GAF:	122820549(b3gat3)

PPRL:

129373279(b3gat3)

CVG:	107098300(b3gat3)

CTUL:

119786650(b3gat3)

GMU:	124880029(b3gat3)

NFU:	107377135(b3gat3)

KMR:	108242856(b3gat3)

ALIM:

106524984(b3gat3)

NWH:	119416873(b3gat3)

AOCE:

111577134(b3gat3)

MCEP:

125024038(b3gat3)

CSEM:

103384246(b3gat3)

POV:	109634838 109634839

SSEN:

122766531(b3gat3)

HHIP:

117751990(b3gat3)

HSP:	118102862(b3gat3)

PPLT:

128429912(b3gat3)

SMAU:

118300167(b3gat3)

LCF:

108888787

SDU:	111231304(b3gat3)

SLAL:

111666406(b3gat3)

XGL:	120797325(b3gat3)

HCQ:	109515067(b3gat3)

SSCV:

125976589

SBIA:

133494421(b3gat3)

PEE:	133397935(b3gat3)

PTAO:

133472640(b3gat3)

BPEC:

110156246(b3gat3)

MALB:

109965809(b3gat3)

BSPL:

114846720(b3gat3)

SJO:	128384223(b3gat3)

SASA:

106578098(b3gat3)

STRU:

115194688(b3gat3)

OTW:	112264921(b3gat3)

OMY:	110531396(b3gat3)

OGO:	124008150(b3gat3)

ONE:	115120586(b3gat3)

OKI:	109906305(b3gat3)

OKE:	118368998(b3gat3)

SALP:

112071457(b3gat3)

SNH:	120036529(b3gat3)

CCLU:

121554359(b3gat3)

ELS:	105005687(b3gat3)

SFM:	108925220(b3gat3)

PKI:	111834547(b3gat3)

AANG:

118223369(b3gat3)

PSPA:

121306256(b3gat3)

ARUT:

117398626 117969046

PSEX:

120539226(b3gat3)

LCM:	102364764(B3GAT3)

CMK:	103171591(b3gat3)

RTP:	109923317(b3gat3)

CPLA:

122543784(b3gat3)

HOC:	132836087(b3gat3)

PMRN:

116948463(B3GAT3)

LRJ:	133352686(B3GAT3)

BFO:

118409812

BBEL:

109470262

CIN:	100101808 100169942(uglcat2l) 100175613 100175845 100177555 100184469 778533(uglcat1)

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG32775(GlcAT-I)

DER:

6550975

DSE:

6612533

DSI:	Dsimw501_GD16673(Dsim_GD16673)

DYA:	Dyak_GE16334(Dyak_GlcAT-I)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16402

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108355037 108380978

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:	119633595 119644773

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ004318

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105676258(GlcAT-I)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100123025(B3gat)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206695

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:	124366811 124372686 124372749 124372852

MQU:	128986627 128986723

PHU:	Phum_PHUM392280

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_306759

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:	126999242 127006270

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:	119449050 119457671 119462285 119462286

RSAN:

119374842 119382239

RMP:	119167104 119185027

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:	129217219 129234027

SDM:

118182299

LPOL:

106457048 106457629 106466316 106471034

PMEO:

129593282

CEL:	CELE_ZK1307.5(sqv-8)

CBR:	CBG_01067(Cbr-sqv-8)

CRQ:	GCK72_003664

BMY:	BM_BM7663(Bma-sqv-8)

LOA:	LOAG_10227

LGI:	LOTGIDRAFT_138821

PVUL:

126831843

PCAN:

112570763 112571566 112571568 112572092 112572836

BGT:	106062171 106062172 106075993

GAE:

121371236

HRF:	124144700 124146500

HRJ:	124255322 124279993 124280050

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

128208193 128208194 128208195 128208547

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_083130

OVI:	T265_10612

EGL:

EGR_08995

LLON:

135485101 135485457

NVE:	5501376 5515084

EPA:	110231340 110231377 110238008

ATEN:

116299039 116304551 116304564

ADF:	107333203 107338753

AMIL:

114957550 114957552 114958103

PDAM:

113670983 113671023 113683985

SPIS:

111331995 111341772 111341773

DGT:	114517763 114517764

XEN:	124453356 124456107

HMG:

100200928

HSY:	130642024 130642027 130647165

RES:	135681826 135689679

TAD:	TRIADDRAFT_49638

AQU:	100631822 100632450 100632577 100632704 100632957 100633352 100641762 100641889

MBR:	MONBRDRAFT_16483 MONBRDRAFT_27343

» show all

Reference

PMID:10842173

Authors

Ouzzine M, Gulberti S, Netter P, Magdalou J, Fournel-Gigleux S

Title

Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues.

Journal

J Biol Chem 275:28254-60 (2000)
DOI:10.1074/jbc.M002182200

Sequence

[hsa:26229]

Reference

PMID:12511570

Authors

Kim BT, Tsuchida K, Lincecum J, Kitagawa H, Bernfield M, Sugahara K

Title

Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids.

Journal

J Biol Chem 278:9116-24 (2003)
DOI:10.1074/jbc.M209344200

Sequence

[dme:Dmel_CG32775]

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