KEGG ORTHOLOGY: K10160

ORTHOLOGY: K10160

Entry

K10160                      KO

Symbol

TLR4, CD284

Name

toll-like receptor 4

Pathway

map04064

NF-kappa B signaling pathway

map04066

HIF-1 signaling pathway

map04145

Phagosome

map04151

PI3K-Akt signaling pathway

map04217

Necroptosis

map04613

Neutrophil extracellular trap formation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04936

Alcoholic liver disease

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05133

Pertussis

map05134

Legionellosis

map05135

Yersinia infection

map05140

Leishmaniasis

map05142

Chagas disease

map05144

Malaria

map05145

Toxoplasmosis

map05146

Amoebiasis

map05152

Tuberculosis

map05161

Hepatitis B

map05162

Measles

map05164

Influenza A

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05205

Proteoglycans in cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05417

Lipid and atherosclerosis

Disease

H00821

Age-related macular degeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
   04066 HIF-1 signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
   04151 PI3K-Akt signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K10160  TLR4, CD284; toll-like receptor 4
  09143 Cell growth and death
   04217 Necroptosis
    K10160  TLR4, CD284; toll-like receptor 4
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K10160  TLR4, CD284; toll-like receptor 4
   04620 Toll-like receptor signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
   04621 NOD-like receptor signaling pathway
    K10160  TLR4, CD284; toll-like receptor 4
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K10160  TLR4, CD284; toll-like receptor 4
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K10160  TLR4, CD284; toll-like receptor 4
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K10160  TLR4, CD284; toll-like receptor 4
   05161 Hepatitis B
    K10160  TLR4, CD284; toll-like receptor 4
   05171 Coronavirus disease - COVID-19
    K10160  TLR4, CD284; toll-like receptor 4
   05164 Influenza A
    K10160  TLR4, CD284; toll-like receptor 4
   05162 Measles
    K10160  TLR4, CD284; toll-like receptor 4
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K10160  TLR4, CD284; toll-like receptor 4
   05132 Salmonella infection
    K10160  TLR4, CD284; toll-like receptor 4
   05131 Shigellosis
    K10160  TLR4, CD284; toll-like receptor 4
   05135 Yersinia infection
    K10160  TLR4, CD284; toll-like receptor 4
   05133 Pertussis
    K10160  TLR4, CD284; toll-like receptor 4
   05134 Legionellosis
    K10160  TLR4, CD284; toll-like receptor 4
   05152 Tuberculosis
    K10160  TLR4, CD284; toll-like receptor 4
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K10160  TLR4, CD284; toll-like receptor 4
   05144 Malaria
    K10160  TLR4, CD284; toll-like receptor 4
   05145 Toxoplasmosis
    K10160  TLR4, CD284; toll-like receptor 4
   05140 Leishmaniasis
    K10160  TLR4, CD284; toll-like receptor 4
   05142 Chagas disease
    K10160  TLR4, CD284; toll-like receptor 4
  09163 Immune disease
   05323 Rheumatoid arthritis
    K10160  TLR4, CD284; toll-like receptor 4
   05321 Inflammatory bowel disease
    K10160  TLR4, CD284; toll-like receptor 4
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K10160  TLR4, CD284; toll-like receptor 4
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K10160  TLR4, CD284; toll-like receptor 4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K10160  TLR4, CD284; toll-like receptor 4
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K10160  TLR4, CD284; toll-like receptor 4
   04090 CD molecules
    K10160  TLR4, CD284; toll-like receptor 4
   00536 Glycosaminoglycan binding proteins
    K10160  TLR4, CD284; toll-like receptor 4
Membrane trafficking [BR:ko04131]
Endocytosis
  Phagocytosis
   Toll-like receptors
    K10160  TLR4, CD284; toll-like receptor 4
Pattern recognition receptors [BR:ko04054]
Membrane-bound pattern recognition receptors
  Toll-like receptors
   K10160  TLR4, CD284; toll-like receptor 4
CD molecules [BR:ko04090]
Proteins
  K10160  CD284, TLR4; toll-like receptor 4
Glycosaminoglycan binding proteins [BR:ko00536]
Hyaluronan
  Cell surface receptors
   K10160  TLR4, CD284; toll-like receptor 4

Genes

HSA:	7099(TLR4)

PTR:	743242(TLR4)

PPS:	100980644(TLR4)

GGO:	101148715(TLR4)

PON:	100457237(TLR4)

PPYG:

129044357(TLR4)

NLE:	100601154(TLR4)

HMH:	116475593(TLR4)

SSYN:

129478959(TLR4)

MCC:	574360(TLR4)

MCF:	102136906(TLR4)

MTHB:

126936830

MNI:	105487117(TLR4)

CSAB:

103218937(TLR4)

CATY:

105600415(TLR4)

PANU:

101009041(TLR4)

TGE:	112608006(TLR4)

MLEU:

105534560(TLR4)

RRO:	104658520(TLR4)

RBB:	108530054(TLR4)

TFN:	117098762(TLR4)

PTEH:

111550322(TLR4)

CANG:

105517525(TLR4)

CJC:	100399012(TLR4)

SBQ:	101043935(TLR4)

CIMI:

108286470(TLR4)

ANAN:

105731135(TLR4)

CSYR:

103255573(TLR4)

MMUR:

105873668(TLR4)

LCAT:

123646094(TLR4)

PCOQ:

105826455(TLR4)

OGA:	100956359(TLR4)

MMU:	21898(Tlr4)

MCAL:

110293229(Tlr4)

MPAH:

110323586(Tlr4)

RNO:	29260(Tlr4)

MCOC:

116096145(Tlr4)

ANU:	117709586(Tlr4)

MUN:	110565332(Tlr4)

CGE:	100689329(Tlr4)

MAUA:

101824088(Tlr4)

PROB:

127224882(Tlr4)

PLEU:

114705782(Tlr4)

MORG:

121433864(Tlr4)

MFOT:

126507954

AAMP:

119818005(Tlr4)

NGI:	103734505(Tlr4)

HGL:	101715916(Tlr4)

CPOC:

100724803(Tlr4)

CCAN:

109700701(Tlr4)

DORD:

105996175(Tlr4)

DSP:	122107098(Tlr4)

PLOP:

125347394(Tlr4)

NCAR:

124964909

MMMA:

107152144(Tlr4)

OCU:	100009497(TLR4)

OPI:	101536535(TLR4)

TUP:	102501464(TLR4)

GVR:	103602848(TLR4)

CFA:	403417(TLR4)

CLUD:

112650004(TLR4)

VVP:	112923099(TLR4)

VLG:	121496246(TLR4)

NPO:	129494517(TLR4)

AML:	100472815(TLR4)

UMR:	103670382(TLR4)

UAH:	113266343(TLR4)

UAR:	123788027(TLR4)

ELK:

111146042

LLV:

125083203

MPUF:

101690347(TLR4)

MNP:	132024470(TLR4)

MLK:	131812598(TLR4)

NVS:	122917312(TLR4)

ORO:	101371071(TLR4)

EJU:	114212737(TLR4)

ZCA:	113934760(TLR4)

MLX:	118017761(TLR4)

NSU:	110581529(TLR4)

LWW:	102749618(TLR4)

FCA:	493698(TLR4)

PYU:	121034896(TLR4)

PCOO:

112860159(TLR4)

PBG:	122475419(TLR4)

PVIV:

125150458(TLR4)

LRUF:

124503507

PTG:	102959529(TLR4)

PPAD:

109269905(TLR4)

PUC:

125920696

AJU:

106977278

HHV:	120240966(TLR4)

BTA:	281536(TLR4)

BOM:	102288174(TLR4)

BIU:	109563399(TLR4)

BBUB:

102407022(TLR4)

BBIS:

104994776(TLR4)

CHX:	100860955(TLR4)

OAS:	554263(TLR4)

BTAX:

128052396(TLR4)

ODA:	120864691(TLR4)

CCAD:

122431924(TLR4)

MBEZ:

129557207(TLR4)

SSC:	399541(TLR4)

CFR:	102522349(TLR4)

CBAI:

105070721(TLR4)

CDK:	105104576(TLR4)

VPC:	102529688(TLR4)

BACU:

103015759(TLR4)

BMUS:

118897312(TLR4)

LVE:	103074659(TLR4)

OOR:	101282217(TLR4)

DLE:	111177277(TLR4)

PCAD:

102983076(TLR4)

PSIU:

116755398(TLR4)

NASI:

112411200(TLR4)

ECB:	100066890(TLR4) 111771935

EPZ:	103562040(TLR4)

EAI:	106824214(TLR4)

MYB:	102253644(TLR4)

MYD:	102756242(TLR4)

MMYO:

118667106(TLR4)

MLF:	102437402(TLR4)

MDT:	132212331(TLR4)

PKL:	118716098(TLR4)

EFUS:

103295671(TLR4)

MNA:	107537636(TLR4)

DRO:	112306266(TLR4)

SHON:

118995970(TLR4)

AJM:	119056324(TLR4)

PDIC:

114510836(TLR4)

PHAS:

123820226(TLR4)

MMF:	118629497(TLR4)

PPAM:

129079317(TLR4)

HAI:	109385740(TLR4)

RFQ:	117032253(TLR4)

PALE:

102897365(TLR4)

PGIG:

120605781(TLR4)

PVP:	105292652(TLR4)

RAY:	107514466(TLR4)

MJV:	108400680(TLR4)

TOD:	119232116(TLR4)

SARA:

101548691(TLR4)

SETR:

126009607(TLR4)

LAV:	100654493(TLR4)

TMU:

101353470

ETF:	101660600(TLR4)

DNM:	101436464(TLR4)

MDO:	100014467(TLR4)

GAS:	123235393(TLR4)

SHR:	100927125(TLR4)

AFZ:

127550519

PCW:	110211357(TLR4)

TVP:	118840860(TLR4)

OAA:	114811053(TLR4)

GGA:	417241(TLR4)

PCOC:

116234179(TLR4)

MGP:	100540712(TLR4)

CJO:	107321682(TLR4)

TPAI:

128074093(TLR4)

LMUT:

125702708(TLR4)

NMEL:

110406939(TLR4)

APLA:

101799388(TLR4)

ACYG:

106037141(TLR4)

CATA:

118252184(TLR4)

AFUL:

116496923(TLR4)

TGU:	100216357(TLR4)

LSR:	110482234(TLR4)

SCAN:

103819051(TLR4)

PMOA:

120507511(TLR4)

OTC:	121336957(TLR4)

PRUF:

121357685(TLR4)

GFR:	102037892(TLR4)

FAB:	101813378(TLR4)

OMA:	130260187(TLR4)

PHI:	102101350(TLR4)

PMAJ:

107211898(TLR4)

CCAE:

111936941(TLR4)

CCW:	104688244(TLR4)

CBRC:

103619761(TLR4)

ETL:	114054565(TLR4)

ZAB:	102066609(TLR4)

ZLE:	135454965(TLR4)

ACHL:

103800748(TLR4)

SVG:	106851398(TLR4)

MMEA:

130580416(TLR4)

HRT:	120761701(TLR4)

SATI:

136369572(TLR4)

FPG:	101922930(TLR4)

FCH:	102055613(TLR4)

CCRI:

104163441(TLR4)

NNT:	104405963(TLR4)

SHAB:

115617148(TLR4)

ACUN:

113486459(TLR4)

TALA:

104363890(TLR4)

ACHC:

115335358(TLR4)

HALD:

104315685(TLR4)

HLE:	104833958(TLR4)

AGEN:

126052181

GCL:

127023661

CSTI:

104553328(TLR4)

LDI:	104343793(TLR4)

MNB:	103777492(TLR4)

DPUB:

104306136(TLR4)

AVIT:

104272743(TLR4)

BRHI:

104494590(TLR4)

EGZ:	104122702(TLR4)

NNI:	104022122(TLR4)

PCRI:

104030095(TLR4)

PCAO:

104052918(TLR4)

PADL:

103912903(TLR4)

AFOR:

103901380(TLR4)

FGA:	104083104(TLR4)

GSTE:

104255144(TLR4)

CLV:	102096659(TLR4)

MUI:	104547901(TLR4)

PGUU:

104461937(TLR4)

PLET:

104625786(TLR4)

EHS:	104513030(TLR4)

CMAC:

104484970(TLR4)

CUCA:

104066770(TLR4)

TEO:	104373107(TLR4)

BREG:

104636809(TLR4)

OHA:	104330230(TLR4)

ACAR:

104522704(TLR4)

CPEA:

104397933(TLR4)

CVF:	104289137(TLR4)

RTD:	128917628(TLR4)

AAM:	106499946(TLR4)

AROW:

112963054(TLR4)

NPD:	112955980(TLR4)

TGT:	104572062(TLR4)

DNE:	112991331(TLR4)

SCAM:

104139792(TLR4)

ASN:	102383551(TLR4)

AMJ:	102574232(TLR4)

CPOO:

109313858(TLR4)

GGN:	109292881(TLR4)

PSS:	102448887(TLR4)

CMY:	102941701(TLR4)

CCAY:

125623505(TLR4)

DCC:	119844229(TLR4)

CPIC:

101954201(TLR4)

TST:	117867273(TLR4)

CABI:

116835169(TLR4)

MRV:	120386592(TLR4)

ACS:	100559216(tlr4)

ASAO:

132763647(TLR4)

PVT:	110088887(TLR4)

SUND:

121936774(TLR4)

PBI:	103060306(TLR4)

PMUR:

107285740(TLR4)

CTIG:

120298812(TLR4)

TSR:	106546496(TLR4)

PGUT:

117656869(TLR4)

APRI:

131186010(TLR4)

PTEX:

113443881(TLR4)

NSS:	113426496(TLR4)

VKO:	123028389(TLR4)

PMUA:

114589367(TLR4)

PRAF:

128406350(TLR4)

ZVI:	118083676(TLR4)

HCG:	128338801(TLR4)

GJA:	107106055(TLR4)

STOW:

125441539(TLR4)

EMC:	129341810(TLR4)

XLA:

108700046

NPR:

108794768

RTEM:

120913060(TLR4)

BBUF:

120977785(TLR4)

BGAR:

122946542(TLR4)

MUO:	115472530(TLR4)

GSH:	117367365(TLR4)

DRE:	403131(tlr4ba) 403132(tlr4bb) 795671(tlr4al)

SRX:	107708380 107708382 107708458 107747448

SANH:

107678592 107678593 107690165 107690199

SGH:	107576986 107582517

CCAR:

109100795

CAUA:

113057155 113057156 113057539 113112929

CGIB:

127969856 127969859 127969860 128026398

PTET:

122356438(tlr4al) 122356439 122356446

LROH:

127175170(tlr4bb) 127175171 127175172 127175174 127175175

OMC:	131552009 131552803

PPRM:

120479739(tlr4bb) 120479740 120479741

RKG:	130083093(tlr4bb) 130083094(tlr4al) 130083095

MAMB:

125276617 125276618(tlr4bb) 125276619

CIDE:

127525007 127525009 127525012

CERY:

137019969 137020384(tlr4bb) 137020385

MASI:

127412476

TROS:

130558706 130559273(tlr4bb) 130559437

TDW:	130431695(tlr4ba) 130431697(tlr4bb) 130431698

MANU:

129415784 129416215 129416621 129416700 129416861

IPU:

IFU:

PHYP:

SMEO:

TFD:	113639828 113639965

TVC:	132847218 132847219

TRN:

134315113

AMEX:

111195965 111196020 111196037

CMAO:

118810322 118810323 118810324

CHAR:

105911563

LOC:	102693850(tlr4)

PSPA:

121303579

ARUT:

117396808

PVUL:

126811810 126815029 126817967 126820929 126821986 126823795 126824198 126825316 126825358

GAE:	121367635 121369801 121370316

HRF:	124115484 124115485 124117461 124117468 124126783 124129306 124141456 124141459 124142299 124148630 124151810

HRJ:	124252808 124253891 124266916 124269410 124269429 124273048 124274128 124277510 124277520 124286564 124287212

CRG:	105324673 105324721 105336099 117681451 117681463 117683974

CANU:

128156319 128184366 128184562 128185905 128185907 128186340 128191248 128192641

CVN:	111102898 111103073 111112136 111112139 111118728 111119086 111128415

OED:	125649145 125667628 125675846 125682194 125682359

MYI:	110449935 110462584

PMAX:

117321101 117322243 117328236 117328500 117337974 117340338 117340468

MMER:

123529774 123542318

RPHI:

132733837 132738576 132739446

DPOL:

127839578 127844882 127845373 127845853 127860898

LJP:	135461939 135477097 135478155 135480245 135480384 135480637

LLON:

135485993 135486215 135486393 135490615

» show all

Reference

PMID:9237759

Authors

Medzhitov R, Preston-Hurlburt P, Janeway CA Jr

Title

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.

Journal

Nature 388:394-7 (1997)
DOI:10.1038/41131

Sequence

[hsa:7099]

Reference

PMID:17560196

Authors

Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ

Title

Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis.

Journal

J Pediatr Surg 42:927-32; discussion 933 (2007)
DOI:10.1016/j.jpedsurg.2007.01.023

Sequence

[mmu:21898]

Reference

PMID:20711192

Authors

Schmidt M, Raghavan B, Muller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ, Galanos C, Roth J, Skerra A, Martin SF, Freudenberg MA, Goebeler M

Title

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel.

Journal

Nat Immunol 11:814-9 (2010)
DOI:10.1038/ni.1919

Sequence

[hsa:7099]

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Ontology (5)   
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Pathway (62)   
   KEGG PATHWAY (62)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (5)   
   KEGG DRUG (5)   
Gene (550)   
   KEGG GENES (441)   
   KEGG MGENES (77)   
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