KEGG ORTHOLOGY: K10226

ORTHOLOGY: K10226

Entry

K10226                      KO

Symbol

FADS2

Name

acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]

Pathway

map00592

alpha-Linolenic acid metabolism

map01040

Biosynthesis of unsaturated fatty acids

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01212

Fatty acid metabolism

map03320

PPAR signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00592 alpha-Linolenic acid metabolism
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
   01040 Biosynthesis of unsaturated fatty acids
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.3  acyl-CoA 6-desaturase
     K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Lipid biosynthesis proteins [BR:ko01004]
Desaturase
  Front-end
   K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)

Other DBs

RN:	R03814 R07861 R07933 R11110 R11111 R12167 R12168 R12170 R12171 R12172

GO:

0016213

Genes

HSA:	9415(FADS2)

PTR:	451244(FADS2)

PPS:	100980611(FADS2)

GGO:	109024898(FADS2)

PON:	100190814(FADS2)

NLE:	100596455(FADS2)

HMH:	116468868(FADS2)

MCC:	719037(FADS2)

MCF:	101926688(FADS2)

MTHB:

126935474

MNI:	105469424(FADS2)

CSAB:

103234245(FADS2)

CATY:

105577581(FADS2)

PANU:

100126749(FADS2)

TGE:	112606127(FADS2)

MLEU:

105549019(FADS2)

RRO:	104679373(FADS2)

RBB:	108533600(FADS2)

TFN:	117080261(FADS2)

PTEH:

111524318(FADS2)

CANG:

105512289(FADS2)

CJC:	100387410(FADS2)

SBQ:	101051429(FADS2)

CIMI:

108286221(FADS2)

CSYR:

103269267(FADS2)

MMUR:

105878617(FADS2)

LCAT:

123641268(FADS2)

PCOQ:

105825053(FADS2)

OGA:	100953713(FADS2)

MMU:	56473(Fads2)

MCAL:

110285898(Fads2)

MPAH:

110322460(Fads2)

RNO:	83512(Fads2)

MCOC:

116103546(Fads2)

ANU:	117707574(Fads2)

MUN:	110548092(Fads2)

CGE:	100757464(Fads2)

MAUA:

101844598(Fads2)

PROB:

127228840(Fads2)

PLEU:

114703436(Fads2)

MORG:

121453878(Fads2)

MFOT:

126498526

AAMP:

119814598(Fads2)

NGI:	103729125(Fads2)

HGL:	101726663(Fads2)

CPOC:

100724176(Fads2)

CCAN:

109695673(Fads2)

DORD:

105993195 105995277(Fads2)

DSP:	122104886(Fads2)

PLOP:

125362342(Fads2)

NCAR:

124958641

OCU:	100352712(FADS2)

OPI:	101520480(FADS2)

TUP:	102475407(FADS2)

GVR:	103604810(FADS2)

CFA:	483792(FADS2)

CLUD:

112659414(FADS2)

VVP:	112911087(FADS2)

VLG:	121472257(FADS2)

NPO:	129500992(FADS2)

AML:	100470289(FADS2)

UMR:	103678231(FADS2)

UAH:	113246983(FADS2)

UAR:	123785126(FADS2)

ELK:

111149586

LLV:

125078518

MPUF:

101675571(FADS2)

NVS:	122912990(FADS2)

ORO:	101364529(FADS2)

EJU:	114220204(FADS2)

ZCA:	113914859(FADS2)

MLX:	118015922(FADS2)

NSU:	110576322(FADS2)

LWW:

102726376

FCA:	101085071(FADS2)

PYU:	121043312(FADS2)

PCOO:

112851879(FADS2)

PBG:	122483864(FADS2)

LRUF:

124505588

PTG:	102968308(FADS2) 102969100

PPAD:

109246554(FADS2) 109261216

PUC:

125911228

AJU:	106986967 106988351

HHV:	120227477 120227525 120246152(FADS2)

BTA:	521822(FADS2)

BOM:	102275533(FADS2)

BIU:	109554370(FADS2)

BBUB:

102405983(FADS2)

BBIS:

104998707(FADS2)

CHX:	100861212 102171133(FADS2)

OAS:	101108497 101108615(FADS2)

BTAX:

128069159(FADS2)

ODA:	120874547(FADS2)

CCAD:

122431166(FADS2) 122451127

SSC:	444997(FADS2)

CFR:	102506325(FADS2)

CBAI:

105070113(FADS2)

CDK:	105091525(FADS2) 105104977

VPC:	102535510 102543923(FADS2)

BACU:

103000252(FADS2)

LVE:	103083143(FADS2)

OOR:	101275563(FADS2)

DLE:	111183883(FADS2)

PCAD:

114487991(FADS2)

PSIU:

116757879(FADS2)

NASI:

112402052(FADS2)

ECB:	100062709(FADS2)

EPZ:	103543786 103567043(FADS2)

EAI:	106847560(FADS2)

MYB:	102261893(FADS2)

MYD:	102773468(FADS2)

MMYO:

118649000(FADS2)

MLF:

102433969

MNA:	107527684(FADS2)

PKL:	118707198(FADS2)

HAI:	109390019(FADS2)

DRO:	112317237(FADS2)

SHON:

118996917(FADS2)

AJM:	119043681(FADS2)

PDIC:

114499454(FADS2)

PHAS:

123829520(FADS2)

MMF:	118627539(FADS2)

RFQ:	117030358(FADS2)

PALE:

102894063(FADS2)

PGIG:

120600650(FADS2)

PVP:	105297786(FADS2)

RAY:	107501589(FADS2)

MJV:	108407763(FADS2)

TOD:	119250071(FADS2)

SARA:

101540602(FADS2)

LAV:

100677680

TMU:

101347025

ETF:	101661366(FADS2)

DNM:	101419118(FADS2)

MDO:	100009895(FADS2)

GAS:	123252763(FADS2)

SHR:	100930034(FADS2)

AFZ:

127541862

PCW:	110195307(FADS2)

OAA:

100086288

GGA:	423122(FADS2)

PCOC:

116239008(FADS2)

MGP:

100549977

CJO:	107314439(FADS2)

TPAI:

128085490

NMEL:

110400735(FADS2)

APLA:

101798758(FADS2)

ACYG:

106033870

AFUL:

116489695(FADS2)

TGU:	100222881(FADS2)

LSR:	110484926(FADS2)

SCAN:

103822123(FADS2)

PMOA:

120499564(FADS2)

OTC:	121339150(FADS2)

PRUF:

121354750(FADS2)

GFR:	102040567(FADS2)

FAB:	101810111(FADS2)

PHI:	102112585(FADS2)

PMAJ:

107205402

CCAE:

111930632

CCW:	104697641(FADS2)

CBRC:

103614698(FADS2)

ETL:

114067866

ZAB:

102066733

ACHL:

103799150

SVG:	106854756(FADS2)

FPG:	101910606(FADS2)

FCH:	102058085(FADS2)

CLV:	102098615(FADS2)

EGZ:

104122147

NNI:	104009393(FADS2)

PLET:

PCRI:

PCAO:

ACUN:

TALA:

104369427(FADS2)

PADL:

103925785(FADS2)

AFOR:

103905746(FADS2)

ACHC:

115352166(FADS2)

HALD:

104323730

HLE:	104829423(FADS2)

AGEN:

GCL:

CCRI:

CSTI:

EHS:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:	104339401(FADS2)

NNT:

104413574

SHAB:

115606141

DPUB:

104304413(FADS2)

PGUU:

104458947

ACAR:

104523447

CPEA:

104397494(FADS2)

AVIT:

104271174

CVF:	104287520(FADS2)

CUCA:

104062412(FADS2)

TEO:

BRHI:

AAM:

AROW:

NPD:	112948004(FADS2)

TGT:

104566742

DNE:	112991695(FADS2)

SCAM:

104139314(FADS2)

ASN:

102382989

AMJ:	102563693(FADS2)

CPOO:

109318131

GGN:	109295789(FADS2)

PSS:	102460236(FADS2)

CMY:

102933275

CPIC:

101936434(FADS2)

TST:	117877425(FADS2)

CABI:

116830902(FADS2)

MRV:

120403580

ACS:	100551818(fads2)

PVT:	110086191(FADS2)

SUND:

121930482

PBI:	103050551(FADS2)

PMUR:

107300095

CTIG:

120312451

TSR:	106538426(FADS2)

PGUT:

PTEX:

NSS:

VKO:

PMUA:

ZVI:

HCG:

GJA:	107108854(FADS2)

STOW:

125427058

XLA:	399058(fads2.S) 446688(fads2.L)

XTR:	100145314(fads2)

NPR:	108794176(FADS2)

RTEM:

120917257(FADS2)

BBUF:

120981189(FADS2)

BGAR:

122920199(FADS2)

DRE:	140615(fads2)

SRX:

107754339

SANH:

107655157 107674834

SGH:	107551431 107561173

CCAR:

109079315 109089845 109112895

CAUA:

113042868 113043033 113060802 113066630

CGIB:

127946970 128014141

PTET:

122330662(fads2)

LROH:

127157126(fads2)

PPRM:

120474050(fads2)

MAMB:

125246733(fads2)

CIDE:

127506530

MASI:

127435798 127437192

IPU:	100305117 108275104

PHYP:

113529790 113529791

SMEO:

124392159 124392817(fads2)

TFD:	113660036 113660090

AMEX:

103027972(fads2)

CMAO:

118811918(fads2)

EEE:	113588191(fads2)

CHAR:

105904229(fads2)

LCO:	104937137(fads2)

NCC:	104956187(fads2)

CGOB:

115010175(fads2)

ELY:	117262279(fads2)

EFO:	125887440(fads2)

PLEP:

121949837(fads2)

SLUC:

116038811 116038812

ECRA:

117949003

ESP:	116693333 116693334

PFLV:

114560045 114560046(fads2)

GAT:	120809502(fads2) 120813621 120829775

PPUG:

119195671(fads2)

MSAM:

119884848 119893991(fads2) 119914409

SCHU:

122875428(fads2)

CUD:	121515126(fads2)

ALAT:

119023767(fads2)

MZE:	101473241 101473919 101474216

ONL:	100534418(fadsd6) 100700077 100700348

OAU:	116326238 116326239 116326240

OLA:	101156321 101156571 101156814

OML:	112139866 112151777 112151778

XMA:	102222635 102222890 102223144

XCO:	114151212 114151221 114151228

XHE:	116729101 116729638 116732254

PRET:

103466509 103466510 103466511

PFOR:

103141299 103141300 103141301

PLAI:

106955830 106955832 106955833

PMEI:

106921859 106921860 106921863

GAF:	122835839 122835840(fads2) 122835841

CVG:	107096151 107096160 107096161

CTUL:

119787411 119787428 119787429

GMU:	124878229 124878243(fads2) 124878251

NFU:	107388683 107388684 107388685 107388686

KMR:	108230083(fads2) 108230084

ALIM:

106521189 106521190 106521191

NWH:	119416317 119416318(fads2) 119416319 119416460

AOCE:

111582148(fads2)

MCEP:

125014531(fads2)

CSEM:

103380276(fads2)

POV:	109623584(fads2)

SSEN:

122760510 122775367(fads2)

HHIP:

117763209(fads2) 117777344

HSP:	118109441(fads2)

LCF:

108886851

SDU:	111229900(fads2)

SLAL:

111666947(fads2)

XGL:	120793558(fads2)

HCQ:	109507604(fads2)

SSCV:

125970130

BPEC:

110167702(fads2)

MALB:

109971223 109971244

BSPL:

114856803(fads2)

SASA:

100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b)

STRU:

115192896 115192933 115192934 115192935

OTW:	112237565 112237566 112237567(fads2) 112264870

OMY:	100135943(fd6d) 110521168 110521170(fads2) 110522693

OGO:	124037455 124037456 124037457 124037484

ONE:	115124847 115124994 115128068 115144681

SALP:

112071110

SNH:	120042185 120042187 120042189 120052325

CCLU:

121540732 121540762 121540763 121540765

ELS:	105018065(fads2)

SFM:	108921004 108929076

PKI:	111833692 111846795

AANG:

118215202(fads2)

PSPA:

121330343

ARUT:

117434917(fads2)

PSEX:

120535951(fads2)

LCM:	102349949(FADS2)

CMK:

103174861

RTP:	109937250(fads2)

CPLA:

122557873(fads2)

BFO:

118428221

BBEL:

109463898

SPU:	105441844 581114 586594

APLC:

110985398 110985778 110985855 110985906

AJC:

117113999

SKO:	100373185 100377526

DPA:

109544444

HRO:	HELRODRAFT_76893

LGI:	LOTGIDRAFT_113523 LOTGIDRAFT_143229 LOTGIDRAFT_198790

PCAN:

112556233 112566738

BGT:	106060307 106066585 106080202

GAE:	121387335 121387621 121387746

HRF:	124123564 124149223 124149233

HRJ:	124253964 124284977

CRG:	105318549 105330734

MYI:	110449385 110461670

PMAX:

117317607 117317694

MCAF:

127717696 127717925 127718229 127718232

MMER:

123538004 123538337 123563593

DPOL:

127845194 127846985 127849143 127865988

OBI:

106867675

OSN:

115223335

LAK:	106159034 106169957 112042655

SMM:	Smp_132740

SHX:	MS3_00001558(FADS1_1)

OVI:	T265_11098 T265_12033

AQU:

100632154

OLU:	OSTLU_3430

OTA:	OT_ostta13g01040

BPG:	Bathy17g00650

MIS:	MICPUN_82337

MPP:	MICPUCDRAFT_32578

ACAN:

ACA1_260130

» show all

Reference

PMID:9867867

Authors

Cho HP, Nakamura MT, Clarke SD

Title

Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.

Journal

J Biol Chem 274:471-7 (1999)
DOI:10.1074/jbc.274.1.471

Sequence

[hsa:9415] [mmu:56473]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (12)   
   KEGG PATHWAY (12)   
Chemical reaction (12)   
   KEGG ENZYME (1)   
   KEGG REACTION (10)   
   KEGG RCLASS (1)   
Gene (1937)   
   KEGG GENES (503)   
   KEGG MGENES (166)   
   RefGene (1263)   
   OC (5)   
Literature (1)   
   PubMed (1)   
All databases (1966)   

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