KEGG   ORTHOLOGY: K10226
Entry
K10226                      KO                                     

Name
FADS2
Definition
acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]
Pathway
ko00592  alpha-Linolenic acid metabolism
ko01040  Biosynthesis of unsaturated fatty acids
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01212  Fatty acid metabolism
ko03320  PPAR signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00592 alpha-Linolenic acid metabolism
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
   01040 Biosynthesis of unsaturated fatty acids
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.3  acyl-CoA 6-desaturase
     K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Lipid biosynthesis proteins [BR:ko01004]
 Desaturase
  Front-end
   K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Other DBs
RN: R03814 R07861 R07933 R11110 R11111 R12167 R12168 R12170 R12171 R12172
GO: 0016213
Genes
HSA: 9415(FADS2)
PTR: 451244(FADS2)
PPS: 100980611(FADS2)
GGO: 109024898(FADS2)
PON: 100190814(FADS2)
NLE: 100596455(FADS2)
MCC: 719037(FADS2)
MCF: 101926688(FADS2)
CSAB: 103234245(FADS2)
RRO: 104679373(FADS2)
RBB: 108533600(FADS2)
CJC: 100387410(FADS2)
SBQ: 101051429(FADS2)
MMU: 56473(Fads2)
MCAL: 110285898(Fads2)
MPAH: 110322460(Fads2)
RNO: 83512(Fads2)
MUN: 110548092(Fads2)
CGE: 100757464(Fads2)
NGI: 103729125(Fads2)
HGL: 101726663(Fads2)
CCAN: 109695673(Fads2)
OCU: 100352712(FADS2)
TUP: 102475407(FADS2)
CFA: 483792(FADS2)
VVP: 112911087(FADS2)
AML: 100470289(FADS2) 100470779
UMR: 103666104 103678231(FADS2)
UAH: 113246983(FADS2)
ORO: 101364529(FADS2)
FCA: 101085071(FADS2)
PTG: 102968308(FADS2) 102969100
PPAD: 109246554(FADS2) 109261216
AJU: 106986967(FADS2) 106988351
BTA: 521822(FADS2)
BOM: 102275533(FADS2)
BIU: 109554370(FADS2)
BBUB: 102396145 102405983(FADS2)
CHX: 100861212(FADS2) 102171133(FADS2)
OAS: 101108497 101108615(FADS2)
SSC: 444997(FADS2)
CFR: 102506325(FADS2)
CDK: 105091525(FADS2) 105104977
BACU: 103000252(FADS2)
LVE: 103083143(FADS2)
OOR: 101275563(FADS2)
DLE: 111183883(FADS2)
PCAD: 114487991(FADS2)
ECB: 100062709(FADS2)
EPZ: 103543786 103567043(FADS2)
EAI: 106847560(FADS2)
MYB: 102261893(FADS2)
MYD: 102773468(FADS2)
MNA: 107527684(FADS2)
HAI: 109390019(FADS2)
DRO: 112317237(FADS2)
PALE: 102894063(FADS2) 107196578
RAY: 107501589(FADS2)
MJV: 108407763(FADS2)
LAV: 100677680
TMU: 101347025
MDO: 100009895(FADS2)
SHR: 100930034(FADS2)
PCW: 110195307(FADS2)
OAA: 100086288
GGA: 423122(FADS2)
MGP: 100549977
CJO: 107314439(FADS2)
NMEL: 110400735(FADS2)
APLA: 101798758(FADS2)
ACYG: 106033870
TGU: 100222881(FADS2)
LSR: 110484926(FADS2)
SCAN: 103822123(FADS2)
GFR: 102040567(FADS2)
FAB: 101810111(FADS2)
PHI: 102112585(FADS2)
PMAJ: 107205402(FADS2)
CCAE: 111930632
CCW: 104697641
ETL: 114067866
FPG: 101910606(FADS2)
FCH: 102058085(FADS2)
CLV: 102098615(FADS2)
EGZ: 104122147
NNI: 104009393(FADS2)
ACUN: 113481354
PADL: 103925785(FADS2)
AAM: 106490046
ASN: 102382989
AMJ: 102563693(FADS2)
PSS: 102460236(FADS2)
CMY: 102933275(FADS2)
CPIC: 101936434
ACS: 100551818(fads2)
PVT: 110086191(FADS2)
PBI: 103050551(FADS2)
PMUR: 107300095
TSR: 106538426(FADS2)
PMUA: 114600538
GJA: 107108854(FADS2)
XLA: 399058(fads2.S) 446688(fads2.L)
XTR: 100145314(fads2)
NPR: 108794176(FADS2)
DRE: 140615(fads2)
SRX: 107754339
IPU: 100305117(fads2) 108275104
AMEX: 103027972(fads2)
EEE: 113588191(fads2)
LCO: 104937137(fads2)
NCC: 104956187(fads2)
AOCE: 111582148(fads2)
CSEM: 103380276(fads2)
POV: 109623584(fads2)
LCF: 108886851(fads2)
SDU: 111229900(fads2)
SLAL: 111666947(fads2)
HCQ: 109507604(fads2)
BPEC: 110167702(fads2)
SASA: 100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b)
OTW: 112264870
SALP: 112071110
ELS: 105018065(fads2)
LCM: 102349949(FADS2)
CMK: 103174861(fads2)
RTP: 109937250(fads2)
DPA: 109544444
OBI: 106867675
SHX: MS3_06568
AQU: 100632154
 » show all
Reference
PMID:9867867
  Authors
Cho HP, Nakamura MT, Clarke SD
  Title
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
  Journal
J Biol Chem 274:471-7 (1999)
DOI:10.1074/jbc.274.1.471
  Sequence
[hsa:9415] [mmu:56473]

KEGG   ENZYME: 1.14.19.3
Entry
EC 1.14.19.3                Enzyme                                 

Name
acyl-CoA 6-desaturase;
Delta6-desaturase;
Delta6-fatty acyl-CoA desaturase;
Delta6-acyl CoA desaturase;
fatty acid Delta6-desaturase;
fatty acid 6-desaturase;
linoleate desaturase;
linoleic desaturase;
linoleic acid desaturase;
linoleoyl CoA desaturase;
linoleoyl-coenzyme A desaturase;
long-chain fatty acid Delta6-desaturase;
linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase;
linoleoyl-CoA desaturase;
FADS2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
Reaction(IUBMB)
(1) linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R03814];
(2) alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R07933]
Reaction(KEGG)
Substrate
linoleoyl-CoA [CPD:C02050];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080];
alpha-linolenoyl-CoA [CPD:C16162]
Product
gamma-linolenoyl-CoA [CPD:C03035];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001];
stearidonoyl-CoA [CPD:C16163]
Comment
An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA [4], and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate [3]. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase.
History
EC 1.14.19.3 created 1986 as EC 1.14.99.25, transferred 2000 to EC 1.14.19.3, modified 2015
Pathway
ec00591  Linoleic acid metabolism
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
Orthology
K00508  linoleoyl-CoA desaturase
K10226  acyl-CoA 6-desaturase (Delta-6 desaturase)
Genes
HSA: 9415(FADS2)
PTR: 451244(FADS2)
PPS: 100980611(FADS2)
GGO: 109024898(FADS2)
PON: 100190814(FADS2)
NLE: 100596455(FADS2)
MCC: 719037(FADS2)
MCF: 101926688(FADS2)
CSAB: 103234245(FADS2)
RRO: 104679373(FADS2)
RBB: 108533600(FADS2)
CJC: 100387410(FADS2)
SBQ: 101051429(FADS2)
MMU: 56473(Fads2)
MCAL: 110285898(Fads2)
MPAH: 110322460(Fads2)
RNO: 83512(Fads2)
MUN: 110548092(Fads2)
CGE: 100757464(Fads2)
NGI: 103729125(Fads2)
HGL: 101726663(Fads2)
CCAN: 109695673(Fads2)
OCU: 100352712(FADS2)
TUP: 102475407(FADS2)
CFA: 483792(FADS2)
VVP: 112911087(FADS2)
AML: 100470289(FADS2) 100470779
UMR: 103666104 103678231(FADS2)
UAH: 113246983(FADS2)
ORO: 101364529(FADS2)
FCA: 101085071(FADS2)
PTG: 102968308(FADS2) 102969100
PPAD: 109246554(FADS2) 109261216
AJU: 106986967(FADS2) 106988351
BTA: 521822(FADS2)
BOM: 102275533(FADS2)
BIU: 109554370(FADS2)
BBUB: 102396145 102405983(FADS2)
CHX: 100861212(FADS2) 102171133(FADS2)
OAS: 101108497 101108615(FADS2)
SSC: 444997(FADS2)
CFR: 102506325(FADS2)
CDK: 105091525(FADS2) 105104977
BACU: 103000252(FADS2)
LVE: 103083143(FADS2)
OOR: 101275563(FADS2)
DLE: 111183883(FADS2)
PCAD: 114487991(FADS2)
ECB: 100062709(FADS2)
EPZ: 103543786 103567043(FADS2)
EAI: 106847560(FADS2)
MYB: 102261893(FADS2)
MYD: 102773468(FADS2)
MNA: 107527684(FADS2)
HAI: 109390019(FADS2)
DRO: 112317237(FADS2)
PALE: 102894063(FADS2) 107196578
RAY: 107501589(FADS2)
MJV: 108407763(FADS2)
LAV: 100677680
TMU: 101347025
MDO: 100009895(FADS2)
SHR: 100930034(FADS2)
PCW: 110195307(FADS2)
OAA: 100086288
GGA: 423122(FADS2)
MGP: 100549977
CJO: 107314439(FADS2)
NMEL: 110400735(FADS2)
APLA: 101798758(FADS2)
ACYG: 106033870
TGU: 100222881(FADS2)
LSR: 110484926(FADS2)
SCAN: 103822123(FADS2)
GFR: 102040567(FADS2)
FAB: 101810111(FADS2)
PHI: 102112585(FADS2)
PMAJ: 107205402(FADS2)
CCAE: 111930632
CCW: 104697641
ETL: 114067866
FPG: 101910606(FADS2)
FCH: 102058085(FADS2)
CLV: 102098615(FADS2)
EGZ: 104122147
NNI: 104009393(FADS2)
ACUN: 113481354
PADL: 103925785(FADS2)
AAM: 106490046
ASN: 102382989
AMJ: 102563693(FADS2)
PSS: 102460236(FADS2)
CMY: 102933275(FADS2)
CPIC: 101936434
ACS: 100551818(fads2)
PVT: 110086191(FADS2)
PBI: 103050551(FADS2)
PMUR: 107300095
TSR: 106538426(FADS2)
PMUA: 114600538
GJA: 107108854(FADS2)
XLA: 399058(fads2.S) 446688(fads2.L)
XTR: 100145314(fads2)
NPR: 108794176(FADS2)
DRE: 140615(fads2)
SRX: 107754339
IPU: 100305117(fads2) 108275104
AMEX: 103027972(fads2)
EEE: 113588191(fads2)
LCO: 104937137(fads2)
NCC: 104956187(fads2)
AOCE: 111582148(fads2)
CSEM: 103380276(fads2)
POV: 109623584(fads2)
LCF: 108886851(fads2)
SDU: 111229900(fads2)
SLAL: 111666947(fads2)
HCQ: 109507604(fads2)
BPEC: 110167702(fads2)
SASA: 100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b)
OTW: 112264870
SALP: 112071110
ELS: 105018065(fads2)
LCM: 102349949(FADS2)
CMK: 103174861(fads2)
RTP: 109937250(fads2)
DPA: 109544444
OBI: 106867675
SHX: MS3_06568
AQU: 100632154
ECOS: EC958_1504
ECC: c1695
ESE: ECSF_1212
ELC: i14_1525
ELD: i02_1525
ELF: LF82_208
ECOJ: P423_06960
EFE: EFER_1726
EEC: EcWSU1_02601(des6)
SRL: SOD_c26990(des1) SOD_c27000(des)
ECA: ECA0116
XCC: XCC3878
XCB: XC_3964
XCP: XCR_0405
XCV: XCV4052
XAX: XACM_3829
XAC: XAC3959
XCI: XCAW_00342(desA)
XOM: XOO4186(XOO4186)
XOO: XOO4446(DesA)
XOP: PXO_03878(desA3)
XOR: XOC_4266
XAL: XALC_2600
XPH: XppCFBP6546_14725(XppCFBP6546P_14725)
SML: Smlt2831
SMT: Smal_2285
SMZ: SMD_2477
PSD: DSC_07755
LEZ: GLE_4391
LEM: LEN_0825
DKO: I596_2530
PAE: PA4888(desB)
PAEV: N297_5058
PAEI: N296_5058
PAG: PLES_52741(desB)
PAF: PAM18_5000(desB)
PAEP: PA1S_26540
PAEM: U769_26805
PAEL: T223_27000
PAEU: BN889_05439(desB)
PAEG: AI22_07455
PAEC: M802_5056
PAEO: M801_4923
PMY: Pmen_0669
PMK: MDS_0755
PPSE: BN5_0558
PCQ: PcP3B5_56390(desA3)
PKC: PKB_5205(desA3)
ACB: A1S_2458
ABM: ABSDF1089
ABY: ABAYE1018
ABN: AB57_2885
ABB: ABBFA_00986(desA3_1)
ABX: ABK1_2787
ABH: M3Q_2969
ABAD: ABD1_24450
ABAZ: P795_4665
ABAU: IX87_08950
ABAA: IX88_15485
ACC: BDGL_001925(des6)
ACI: ACIAD1208
AGU: AS4_14300
AUG: URS_3054
AMAL: I607_05595
AMAE: I876_05885
AMAO: I634_05920
AMAD: I636_06350
AMAI: I635_06295
AMAC: MASE_05440
GPS: C427_2135
APAC: S7S_15795
TOL: TOL_2040
CVI: CV_1644(desD) CV_2452
BUB: BW23_4705
BSTG: WT74_24150
ADE: Adeh_1021
CCX: COCOR_07436(des6)
HOH: Hoch_5632
SYN: sll0262(desD(des6))
SYZ: MYO_119490(desD(des6))
SYY: SYNGTS_1931(desD)
SYT: SYNGTI_1930(desD)
SYS: SYNPCCN_1929(desD)
SYQ: SYNPCCP_1929(desD)
SYJ: D082_30330(desD)
AMR: AM1_1073
MAR: MAE_48160(desD)
MPK: VL20_3454
MVZ: myaer102_21530(desD)
ARP: NIES39_J03090(desD)
PUV: PUV_10250(des6)
WCH: wcw_0161
FMR: Fuma_00671(desA)
SACI: Sinac_0398
PHE: Phep_0579
SMIZ: 4412673_01383(desA3_1) 4412673_04012(desA3_2)
SDJ: NCTC13534_02135(desA3)
SLI: Slin_4655
FAE: FAES_3358 FAES_4414(desD)
GFO: GFO_1576
FPS: FP0413
FJG: BB050_00859(desA3_1) BB050_02987(desA3_2)
FIN: KQS_11875
MARM: YQ22_03825
CBAL: M667_08640
CBAT: M666_08605
DDO: I597_1302(desA3)
ZGA: ZOBELLIA_1067(des6-2) ZOBELLIA_755(des6-1)
MLT: VC82_2131
EAO: BD94_3599
CHZ: CHSO_0007
WIN: WPG_2001
TMAR: MARIT_2781
AALG: AREALGSMS7_02543(desA3)
MARF: CJ739_552
MESQ: C7H62_0634
SRG: XF24_00844(desA3)
 » show all
Reference
1  [PMID:7212717]
  Authors
Okayasu T, Nagao M, Ishibashi T, Imai Y.
  Title
Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes.
  Journal
Arch Biochem Biophys 206:21-8 (1981)
DOI:10.1016/0003-9861(81)90061-8
Reference
2  [PMID:9867867]
  Authors
Cho HP, Nakamura MT, Clarke SD
  Title
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
  Journal
J Biol Chem 274:471-7 (1999)
DOI:10.1074/jbc.274.1.471
  Sequence
[hsa:9415] [mmu:56473]
Reference
3  [PMID:10903473]
  Authors
Sprecher H
  Title
Metabolism of highly unsaturated n-3 and n-6 fatty acids.
  Journal
Biochim Biophys Acta 1486:219-31 (2000)
DOI:10.1016/S1388-1981(00)00077-9
Reference
4  [PMID:12713571]
  Authors
Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM
  Title
Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.
  Journal
J Invest Dermatol 120:707-14 (2003)
DOI:10.1046/j.1523-1747.2003.12123.x
Reference
5  [PMID:15769252]
  Authors
Domergue F, Abbadi A, Zahringer U, Moreau H, Heinz E
  Title
In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri.
  Journal
Biochem J 389:483-90 (2005)
DOI:10.1042/BJ20050111
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.3
IUBMB Enzyme Nomenclature: 1.14.19.3
ExPASy - ENZYME nomenclature database: 1.14.19.3
BRENDA, the Enzyme Database: 1.14.19.3
CAS: 9082-66-0

KEGG   REACTION: R12171
Entry
R12171                      Reaction                               

Name
(11Z,14Z)-icosadienoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (8,9 cis-dehydrogenating)
Definition
(11Z,14Z)-Icosadienoyl-CoA + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 8,11,14-Eicosatrienoyl-CoA + 2 Ferricytochrome b5 + 2 H2O
Equation
C16180 + 2 C00999 + C00007 + 2 C00080 <=> C03595 + 2 C00996 + 2 C00001
Enzyme
Pathway
rn01040  Biosynthesis of unsaturated fatty acids
rn01212  Fatty acid metabolism
Orthology
K10226  acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]

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