KEGG   ORTHOLOGY: K10251
Entry
K10251                      KO                                     

Name
HSD17B12, KAR, IFA38
Definition
17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
Pathway
ko00062  Fatty acid elongation
ko00140  Steroid hormone biosynthesis
ko01040  Biosynthesis of unsaturated fatty acids
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01212  Fatty acid metabolism
Module
M00415  Fatty acid elongation in endoplasmic reticulum
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
   00140 Steroid hormone biosynthesis
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
   01040 Biosynthesis of unsaturated fatty acids
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
    1.1.1.330  very-long-chain 3-oxoacyl-CoA reductase
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Other DBs
RN: R02352 R02353 R04681 R04682 R07759 R08945 R08980 R10826
COG: COG0300
GO: 0004303
Genes
HSA: 51144(HSD17B12)
PTR: 741010(HSD17B12)
PPS: 100971612(HSD17B12)
GGO: 101126579(HSD17B12)
PON: 100439025(HSD17B12)
NLE: 100600308(HSD17B12)
MCC: 106993263(HSD17B12)
MCF: 101867269(HSD17B12)
CSAB: 103237147(HSD17B12)
RRO: 104673891(HSD17B12)
RBB: 108519261(HSD17B12)
CJC: 100399351(HSD17B12)
SBQ: 101037623(HSD17B12)
MMU: 56348(Hsd17b12)
MCAL: 110306681(Hsd17b12)
MPAH: 110318386(Hsd17b12)
RNO: 84013(Hsd17b12)
MUN: 110540580(Hsd17b12)
CGE: 100751291(Hsd17b12)
NGI: 103746669(Hsd17b12)
HGL: 101706276 101717552(Hsd17b12)
CCAN: 109700741(Hsd17b12)
OCU: 100346603(HSD17B12) 103347152
TUP: 102495234(HSD17B12)
CFA: 475939(HSD17B12)
VVP: 112914444(HSD17B12)
AML: 100484147(HSD17B12)
UMR: 103672348(HSD17B12)
UAH: 113265017(HSD17B12)
ORO: 101367938(HSD17B12)
ELK: 111149694
FCA: 101082595(HSD17B12)
PTG: 102963001(HSD17B12)
PPAD: 109279204(HSD17B12)
AJU: 106978054(HSD17B12)
BTA: 508455 789567(HSD17B12)
BOM: 102274407(HSD17B12) 102278627
BIU: 109569664(HSD17B12) 109572870
BBUB: 102394606 102395741(HSD17B12)
CHX: 102169696 102186887(HSD17B12)
OAS: 101110086(HSD17B12) 101112590 114109406
SSC: 100312972(HSD17B12)
CFR: 102505228 102515430(HSD17B12)
CDK: 105095461 105106832(HSD17B12)
BACU: 102998439(HSD17B12)
LVE: 103068441(HSD17B12)
OOR: 101273198 101279942(HSD17B12)
DLE: 111180753 111184015(HSD17B12)
PCAD: 102977062(HSD17B12) 102995699
ECB: 100050075(HSD17B12) 100070719
EPZ: 103556451(HSD17B12) 103566841
EAI: 106843965(HSD17B12) 106848436
MYB: 102263289 102263627(HSD17B12)
MYD: 102758451 102766960(HSD17B12)
MNA: 107525487(HSD17B12) 107536738
HAI: 109391968(HSD17B12)
DRO: 112303253(HSD17B12) 112312939
PALE: 102889386(HSD17B12)
RAY: 107511892(HSD17B12)
MJV: 108391004 108402895(HSD17B12)
LAV: 100656306(HSD17B12) 111749606
MDO: 100013277(HSD17B12)
SHR: 100917982(HSD17B12) 100923950
OAA: 100079057(HSD17B12)
GGA: 769787(HSD17B12)
MGP: 104911119(HSD17B12) 104911129
CJO: 107314810(HSD17B12)
NMEL: 110402080(HSD17B12)
APLA: 101803586(HSD17B12)
ACYG: 106044159(HSD17B12)
TGU: 100223843(HSD17B12)
LSR: 110472034(HSD17B12)
SCAN: 103827003(HSD17B12)
GFR: 102039695(HSD17B12)
FAB: 101807632(HSD17B12)
PHI: 102106801(HSD17B12)
PMAJ: 107206004(HSD17B12)
CCAE: 111930136(HSD17B12)
CCW: 104688088(HSD17B12)
ETL: 114062366(HSD17B12)
FPG: 101917180(HSD17B12)
FCH: 102056639(HSD17B12)
CLV: 102085015(HSD17B12)
EGZ: 104134096(HSD17B12)
NNI: 104019569(HSD17B12)
ACUN: 113481381(HSD17B12)
PADL: 103921723(HSD17B12)
AAM: 106498375(HSD17B12)
ASN: 102368497 102381002(HSD17B12)
AMJ: 102559362(HSD17B12)
PSS: 102445815(HSD17B12) 112544543
CMY: 102938030(HSD17B12) 102939820
CPIC: 101950937(HSD17B12)
PVT: 110081502(HSD17B12)
PBI: 103049647(HSD17B12)
PMUR: 107289668(HSD17B12)
TSR: 106550332(HSD17B12)
PMUA: 114596283(HSD17B12)
GJA: 107119118(HSD17B12) 107120158
XLA: 108711776 379747(hsd17b12.S) 444506(LOC100497556.S) 495218(hsd17b12.L)
XTR: 100497556 549988(hsd17b12)
NPR: 108785839(HSD17B12) 108794729 108800692
DRE: 322626(hsd17b12b) 327417(hsd17b12a) 368367(hsd20b2)
IPU: 100528251(dh12b) 108259770 108275383(hsd17b12)
PHYP: 113529736(hsd17b12) 113531207 113540909
AMEX: 103024613 103027081(hsd17b12) 103033448
LCO: 104922399(hsd17b12) 104925842 104937328
MZE: 101464359 101469758 101474165(hsd17b12)
ONL: 100534526(hsd17b12) 100698702(hsd17b12) 100703825
CVG: 107092201(hsd17b12) 107094051 107102295
KMR: 108234813 108245742(hsd17b12) 108248270
CSEM: 103378812 103379805(hsd17b12) 103395421
SDU: 111223976 111229620(hsd17b12) 111234380
SLAL: 111644335 111650479(hsd17b12) 111654023
MALB: 109959449 109965090 109973524(hsd17b12)
SALP: 111950141 111962105(hsd17b12) 111972052
ELS: 105006117(hsd17b12) 105023923 105025310
SFM: 108918746 108934676 108942280(hsd17b12)
PKI: 111841056 111859443(hsd17b12) 111860853
LCM: 102348665 102362094(HSD17B12)
CMK: 103174968(hsd17b12)
APLC: 110981629
DME: Dmel_CG1444(spidey)
DSE: 6620253
DSI: Dsimw501_GD16868(Dsim_GD16868) Dsimw501_GD21890(Dsim_GD21890) Dsimw501_GD21891(Dsim_GD21891) Dsimw501_GD29058(Dsim_GD29058)
DAN: 6503875
BMAN: 114251904
FCD: 110850806
CEL: CELE_C06B3.4(stdh-1) CELE_C06B3.5(stdh-3) CELE_C56G2.6(let-767) CELE_F11A5.12(stdh-2) CELE_F25G6.5(stdh-4)
CBR: CBG11441 CBG11442 CBG19695(Cbr-let-767)
TSP: Tsp_02573
PCAN: 112558929
MYI: 110454786
ADF: 107343948
ATH: AT1G24470(KCR2) AT1G67730(KCR1)
LJA: Lj0g3v0295429.1(Lj0g3v0295429.1) Lj4g3v2717040.1(Lj4g3v2717040.1) Lj6g3v0585170.1(Lj6g3v0585170.1)
CANN: 107860712
NTO: 104087941
DOSA: Os04t0116600-01(Os04g0116600) Os04t0483500-01(Os04g0483500) Os06t0298700-00(Os06g0298700) Os06t0299100-01(Os06g0299100) Os06t0300200-00(Os06g0300200)
ATS: 109733083(LOC109733083) 109733956(LOC109733956) 109733958(LOC109733958) 109743960(LOC109743960) 109744922(LOC109744922) 109745871(LOC109745871) 109746082(LOC109746082) 109746886(LOC109746886) 109747761(LOC109747761) 109755743(LOC109755743) 109756557(LOC109756557) 109765204(LOC109765204) 109765210(LOC109765210) 109766544(LOC109766544) 109766795(LOC109766795) 109768745(LOC109768745) 109771085(LOC109771085) 109772730(LOC109772730) 109773274(LOC109773274) 109773689(LOC109773689) 109779269(LOC109779269) 109781113(LOC109781113) 109781925(LOC109781925) 109782273(LOC109782273)
AOF: 109823841
PPP: 112290473
APRO: F751_1671
SCE: YBR159W(IFA38)
ERC: Ecym_2565
NCS: NCAS_0B02360(NCAS0B02360)
NDI: NDAI_0C05330(NDAI0C05330)
TPF: TPHA_0L01460(TPHA0L01460)
TBL: TBLA_0H03430(TBLA0H03430)
TDL: TDEL_0B01260(TDEL0B01260)
KAF: KAFR_0E03020(KAFR0E03020)
PIC: PICST_79198(YBO9)
CAL: CAALFM_CR06070WA(CaO19.3859)
SLB: AWJ20_1871(IFA38)
NCR: NCU04462
NTE: NEUTE1DRAFT79325(NEUTE1DRAFT_79325)
MBE: MBM_06633
ANI: AN5861.2
ANG: ANI_1_488024(An02g03570)
CIM: CIMG_08188 CIMG_11390(CIMG04755)
PTE: PTT_14300
CNE: CNI00690
CNB: CNBH0660
TASA: A1Q1_07306
ABP: AGABI1DRAFT112492(AGABI1DRAFT_112492)
ABV: AGABI2DRAFT192460(AGABI2DRAFT_192460)
MGL: MGL_1839
MRT: MRET_1973
DFA: DFA_11026
EHI: EHI_118210(18.t00033) EHI_163540(256.t00010) EHI_165070(127.t00009)
PCB: PCHAS_052260(PC000268.05.0)
CPV: cgd3_2370
SPAR: SPRG_04210
TCR: 506219.40
BCEN: DM39_5665
BMK: DM80_3022
FLN: FLA_0019
 » show all
Reference
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM.
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J Biol Chem 277:35440-9 (2002)
DOI:10.1074/jbc.M205620200
  Sequence
[sce:YBR159W]
Reference
  Authors
Luu-The V, Tremblay P, Labrie F
  Title
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.
  Journal
Mol Endocrinol 20:437-43 (2006)
DOI:10.1210/me.2005-0058
  Sequence
[hsa:51144]
Reference
  Authors
Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L
  Title
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase.
  Journal
Plant Physiol 150:1174-91 (2009)
DOI:10.1104/pp.109.137497
  Sequence
[ath:AT1G67730]

KEGG   ENZYME: 1.1.1.330
Entry
EC 1.1.1.330                Enzyme                                 

Name
very-long-chain 3-oxoacyl-CoA reductase;
very-long-chain 3-ketoacyl-CoA reductase;
very-long-chain beta-ketoacyl-CoA reductase;
KCR (gene name);
IFA38 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + NADPH + H+ [RN:R10826]
Reaction(KEGG)
R10826;
(other) R07759
Substrate
very-long-chain (3R)-3-hydroxyacyl-CoA [CPD:C20878];
NADP+ [CPD:C00006]
Product
very-long-chain 3-oxoacyl-CoA [CPD:C20877];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
History
EC 1.1.1.330 created 2012
Pathway
ec00062  Fatty acid elongation
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Genes
HSA: 51144(HSD17B12)
PTR: 741010(HSD17B12)
PPS: 100971612(HSD17B12)
GGO: 101126579(HSD17B12)
PON: 100439025(HSD17B12)
NLE: 100600308(HSD17B12)
MCC: 106993263(HSD17B12)
MCF: 101867269(HSD17B12)
CSAB: 103237147(HSD17B12)
RRO: 104673891(HSD17B12)
RBB: 108519261(HSD17B12)
CJC: 100399351(HSD17B12)
SBQ: 101037623(HSD17B12)
MMU: 56348(Hsd17b12)
MCAL: 110306681(Hsd17b12)
MPAH: 110318386(Hsd17b12)
RNO: 84013(Hsd17b12)
MUN: 110540580(Hsd17b12)
CGE: 100751291(Hsd17b12)
NGI: 103746669(Hsd17b12)
HGL: 101706276 101717552(Hsd17b12)
CCAN: 109700741(Hsd17b12)
OCU: 100346603(HSD17B12) 103347152
TUP: 102495234(HSD17B12)
CFA: 475939(HSD17B12)
VVP: 112914444(HSD17B12)
AML: 100484147(HSD17B12)
UMR: 103672348(HSD17B12)
UAH: 113265017(HSD17B12)
ORO: 101367938(HSD17B12)
ELK: 111149694
FCA: 101082595(HSD17B12)
PTG: 102963001(HSD17B12)
PPAD: 109279204(HSD17B12)
AJU: 106978054(HSD17B12)
BTA: 508455 789567(HSD17B12)
BOM: 102274407(HSD17B12) 102278627
BIU: 109569664(HSD17B12) 109572870
BBUB: 102394606 102395741(HSD17B12)
CHX: 102169696 102186887(HSD17B12)
OAS: 101110086(HSD17B12) 101112590 114109406
SSC: 100312972(HSD17B12)
CFR: 102505228 102515430(HSD17B12)
CDK: 105095461 105106832(HSD17B12)
BACU: 102998439(HSD17B12)
LVE: 103068441(HSD17B12)
OOR: 101273198 101279942(HSD17B12)
DLE: 111180753 111184015(HSD17B12)
PCAD: 102977062(HSD17B12) 102995699
ECB: 100050075(HSD17B12) 100070719
EPZ: 103556451(HSD17B12) 103566841
EAI: 106843965(HSD17B12) 106848436
MYB: 102263289 102263627(HSD17B12)
MYD: 102758451 102766960(HSD17B12)
MNA: 107525487(HSD17B12) 107536738
HAI: 109391968(HSD17B12)
DRO: 112303253(HSD17B12) 112312939
PALE: 102889386(HSD17B12)
RAY: 107511892(HSD17B12)
MJV: 108391004 108402895(HSD17B12)
LAV: 100656306(HSD17B12) 111749606
MDO: 100013277(HSD17B12)
SHR: 100917982(HSD17B12) 100923950
OAA: 100079057(HSD17B12)
GGA: 769787(HSD17B12)
MGP: 104911119(HSD17B12) 104911129
CJO: 107314810(HSD17B12)
NMEL: 110402080(HSD17B12)
APLA: 101803586(HSD17B12)
ACYG: 106044159(HSD17B12)
TGU: 100223843(HSD17B12)
LSR: 110472034(HSD17B12)
SCAN: 103827003(HSD17B12)
GFR: 102039695(HSD17B12)
FAB: 101807632(HSD17B12)
PHI: 102106801(HSD17B12)
PMAJ: 107206004(HSD17B12)
CCAE: 111930136(HSD17B12)
CCW: 104688088(HSD17B12)
ETL: 114062366(HSD17B12)
FPG: 101917180(HSD17B12)
FCH: 102056639(HSD17B12)
CLV: 102085015(HSD17B12)
EGZ: 104134096(HSD17B12)
NNI: 104019569(HSD17B12)
ACUN: 113481381(HSD17B12)
PADL: 103921723(HSD17B12)
AAM: 106498375(HSD17B12)
ASN: 102368497 102381002(HSD17B12)
AMJ: 102559362(HSD17B12)
PSS: 102445815(HSD17B12) 112544543
CMY: 102938030(HSD17B12) 102939820
CPIC: 101950937(HSD17B12)
PVT: 110081502(HSD17B12)
PBI: 103049647(HSD17B12)
PMUR: 107289668(HSD17B12)
TSR: 106550332(HSD17B12)
PMUA: 114596283(HSD17B12)
GJA: 107119118(HSD17B12) 107120158
XLA: 108711776 379747(hsd17b12.S) 444506(LOC100497556.S) 495218(hsd17b12.L)
XTR: 100497556 549988(hsd17b12)
NPR: 108785839(HSD17B12) 108794729 108800692
DRE: 322626(hsd17b12b) 327417(hsd17b12a) 368367(hsd20b2)
IPU: 100528251(dh12b) 108259770 108275383(hsd17b12)
PHYP: 113529736(hsd17b12) 113531207 113540909
AMEX: 103024613 103027081(hsd17b12) 103033448
LCO: 104922399(hsd17b12) 104925842 104937328
MZE: 101464359 101469758 101474165(hsd17b12)
ONL: 100534526(hsd17b12) 100698702(hsd17b12) 100703825
CVG: 107092201(hsd17b12) 107094051 107102295
KMR: 108234813 108245742(hsd17b12) 108248270
CSEM: 103378812 103379805(hsd17b12) 103395421
SDU: 111223976 111229620(hsd17b12) 111234380
SLAL: 111644335 111650479(hsd17b12) 111654023
MALB: 109959449 109965090 109973524(hsd17b12)
SALP: 111950141 111962105(hsd17b12) 111972052
ELS: 105006117(hsd17b12) 105023923 105025310
SFM: 108918746 108934676 108942280(hsd17b12)
PKI: 111841056 111859443(hsd17b12) 111860853
LCM: 102348665 102362094(HSD17B12)
CMK: 103174968(hsd17b12)
APLC: 110981629
DME: Dmel_CG1444(spidey)
DSE: 6620253
DSI: Dsimw501_GD16868(Dsim_GD16868) Dsimw501_GD21890(Dsim_GD21890) Dsimw501_GD21891(Dsim_GD21891) Dsimw501_GD29058(Dsim_GD29058)
DAN: 6503875
BMAN: 114251904
FCD: 110850806
CEL: CELE_C06B3.4(stdh-1) CELE_C06B3.5(stdh-3) CELE_C56G2.6(let-767) CELE_F11A5.12(stdh-2) CELE_F25G6.5(stdh-4)
CBR: CBG11441 CBG11442 CBG19695(Cbr-let-767)
TSP: Tsp_02573
PCAN: 112558929
MYI: 110454786
ADF: 107343948
ATH: AT1G24470(KCR2) AT1G67730(KCR1)
LJA: Lj0g3v0295429.1(Lj0g3v0295429.1) Lj4g3v2717040.1(Lj4g3v2717040.1) Lj6g3v0585170.1(Lj6g3v0585170.1)
CANN: 107860712
NTO: 104087941
DOSA: Os04t0116600-01(Os04g0116600) Os04t0483500-01(Os04g0483500) Os06t0298700-00(Os06g0298700) Os06t0299100-01(Os06g0299100) Os06t0300200-00(Os06g0300200)
ATS: 109733083(LOC109733083) 109733956(LOC109733956) 109733958(LOC109733958) 109743960(LOC109743960) 109744922(LOC109744922) 109745871(LOC109745871) 109746082(LOC109746082) 109746886(LOC109746886) 109747761(LOC109747761) 109755743(LOC109755743) 109756557(LOC109756557) 109765204(LOC109765204) 109765210(LOC109765210) 109766544(LOC109766544) 109766795(LOC109766795) 109768745(LOC109768745) 109771085(LOC109771085) 109772730(LOC109772730) 109773274(LOC109773274) 109773689(LOC109773689) 109779269(LOC109779269) 109781113(LOC109781113) 109781925(LOC109781925) 109782273(LOC109782273)
AOF: 109823841
PPP: 112290473
APRO: F751_1671
SCE: YBR159W(IFA38)
ERC: Ecym_2565
NCS: NCAS_0B02360(NCAS0B02360)
NDI: NDAI_0C05330(NDAI0C05330)
TPF: TPHA_0L01460(TPHA0L01460)
TBL: TBLA_0H03430(TBLA0H03430)
TDL: TDEL_0B01260(TDEL0B01260)
KAF: KAFR_0E03020(KAFR0E03020)
PIC: PICST_79198(YBO9)
CAL: CAALFM_CR06070WA(CaO19.3859)
SLB: AWJ20_1871(IFA38)
NCR: NCU04462
NTE: NEUTE1DRAFT79325(NEUTE1DRAFT_79325)
MBE: MBM_06633
ANI: AN5861.2
ANG: ANI_1_488024(An02g03570)
CIM: CIMG_08188 CIMG_11390(CIMG04755)
PTE: PTT_14300
CNE: CNI00690
CNB: CNBH0660
TASA: A1Q1_07306
ABP: AGABI1DRAFT112492(AGABI1DRAFT_112492)
ABV: AGABI2DRAFT192460(AGABI2DRAFT_192460)
MGL: MGL_1839
MRT: MRET_1973
DFA: DFA_11026
EHI: EHI_118210(18.t00033) EHI_163540(256.t00010) EHI_165070(127.t00009)
PCB: PCHAS_052260(PC000268.05.0)
CPV: cgd3_2370
SPAR: SPRG_04210
TCR: 506219.40
BCEN: DM39_5665
BMK: DM80_3022
FLN: FLA_0019
 » show all
Reference
1  [PMID:11792704]
  Authors
Beaudoin F, Gable K, Sayanova O, Dunn T, Napier JA
  Title
A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase.
  Journal
J Biol Chem 277:11481-8 (2002)
DOI:10.1074/jbc.M111441200
  Sequence
[sce:YBR159W]
Reference
2  [PMID:12087109]
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J Biol Chem 277:35440-9 (2002)
DOI:10.1074/jbc.M205620200
  Sequence
[sce:YBR159W]
Reference
3  [PMID:19439572]
  Authors
Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L
  Title
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase.
  Journal
Plant Physiol 150:1174-91 (2009)
DOI:10.1104/pp.109.137497
  Sequence
[ath:AT1G67730]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.330
IUBMB Enzyme Nomenclature: 1.1.1.330
ExPASy - ENZYME nomenclature database: 1.1.1.330
BRENDA, the Enzyme Database: 1.1.1.330

KEGG   REACTION: R07759
Entry
R07759                      Reaction                               

Name
3-hydroxyoctadecanoyl-CoA:NADP+ oxidoreductase
Definition
3-Oxostearoyl-CoA + NADPH + H+ <=> 3-Hydroxyoctadecanoyl-CoA + NADP+
Equation
Reaction class
RC00001  C00005_C00006
RC00029  C16216_C16217
Enzyme
Pathway
rn01040  Biosynthesis of unsaturated fatty acids
rn01212  Fatty acid metabolism
Orthology
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]

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