KEGG   ORTHOLOGY: K10535
Entry
K10535                      KO                                     

Name
hao
Definition
hydroxylamine dehydrogenase [EC:1.7.2.6]
Pathway
ko00910  Nitrogen metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Module
M00528  Nitrification, ammonia => nitrite
M00804  Complete nitrification, comammox, ammonia => nitrite => nitrate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K10535  hao; hydroxylamine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.2  With a cytochrome as acceptor
    1.7.2.6  hydroxylamine dehydrogenase
     K10535  hao; hydroxylamine dehydrogenase
Other DBs
RN: R10164
GO: 0047991
Genes
VFL: AL536_13820
GHO: AL542_00990
SSE: Ssed_3758 Ssed_4366
SHL: Shal_1091
SWD: Swoo_4755
HALC: EY643_14770
MCA: MCA0956
METU: GNH96_08475
MAH: MEALZ_1830(hao)
MBUR: EQU24_08350
MMAI: sS8_3996
NOC: Noc_0892
NHL: Nhal_1085
NWA: Nwat_0758
NTT: TAO_0474(haoA)
SVA: SVA_2722
RFR: Rfer_0059
NEU: NE0962(hao2) NE2044(hao1) NE2339(hao3)
HCE: HCW_02425
HCM: HCD_03625
CFZ: CSG_11900
CGRA: CGRAC_2027
CHYO: CHH_0728
HEBR: AEBR_2203
NAM: NAMH_1280
GME: Gmet_0142
GLO: Glov_1044
GBM: Gbem_3667
DEU: DBW_1324
DFL: DFE_0004
DBA: Dbac_0217
ADE: Adeh_1764
MSC: BN69_3242
SIL: SPOA0201
MAGQ: MGMAQ_1797
MGM: Mmc1_0550
MIN: Minf_2434(cccA)
MKC: kam1_2135
PLH: VT85_05655(hao1)
PBOR: BSF38_05477(hao1)
AGV: OJF2_56510(hao1)
KST: KSMBR1_1220(hdh) KSMBR1_1764(hao_1) KSMBR1_2163(hao_2) KSMBR1_2670(hao_3) KSMBR1_3040(hao_4) KSMBR1_3397(hao_5) KSMBR1_3422(hao_6) KSMBR1_3442(hao_7) KSMBR1_3792(hao_8)
ALUS: STSP2_00683(hao1)
IAL: IALB_0863
MRO: MROS_1112
NIO: NITINOP_0065(hao)
NJA: NSJP_2412
MOX: DAMO_2285 DAMO_2473(hao)
GAC: GACE_1826
GAH: GAH_00817
IHO: Igni_0955
AG: CUQ65042(hao)
 » show all
Reference
  Authors
Hommes NG, Sayavedra-Soto LA, Arp DJ
  Title
Transcript analysis of multiple copies of amo (encoding ammonia monooxygenase) and hao (encoding hydroxylamine oxidoreductase) in Nitrosomonas europaea.
  Journal
J Bacteriol 183:1096-100 (2001)
DOI:10.1128/JB.183.3.1096-1100.2001
  Sequence

KEGG   ENZYME: 1.7.2.6
Entry
EC 1.7.2.6                  Enzyme                                 

Name
hydroxylamine dehydrogenase;
HAO (ambiguous);
hydroxylamine oxidoreductase (ambiguous);
hydroxylamine oxidase (misleading)
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With a cytochrome as acceptor
Sysname
hydroxylamine:ferricytochrome-c oxidoreductase
Reaction(IUBMB)
(1) hydroxylamine + H2O + 4 ferricytochrome c = nitrite + 4 ferrocytochrome c + 5 H+ [RN:R10164];
(2) hydroxylamine + 3 ferricytochrome c = nitric oxide + 3 ferrocytochrome c + 3 H+ [RN:R10165]
Reaction(KEGG)
R10164 R10165
Substrate
hydroxylamine [CPD:C00192];
H2O [CPD:C00001];
ferricytochrome c [CPD:C00125]
Product
nitrite [CPD:C00088];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080];
nitric oxide [CPD:C00533]
Comment
The enzymes from the nitrifying bacterium Nitrosomonas europaea [1,4] and the methylotrophic bacterium Methylococcus capsulatus [5] are hemoproteins with seven c-type hemes and one specialized P-460-type heme per subunit. The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate [3]. While nitrite is the main product, the enzyme from Nitrosomonas europaea can produce nitric oxide as well [2].
History
EC 1.7.2.6 created 1972 as EC 1.7.3.4, part transferred 2012 to EC 1.7.2.6
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10535  hydroxylamine dehydrogenase
Genes
VFL: AL536_13820
GHO: AL542_00990
SSE: Ssed_3758 Ssed_4366
SHL: Shal_1091
SWD: Swoo_4755
HALC: EY643_14770
MCA: MCA0956
METU: GNH96_08475
MAH: MEALZ_1830(hao)
MBUR: EQU24_08350
MMAI: sS8_3996
NOC: Noc_0892
NHL: Nhal_1085
NWA: Nwat_0758
NTT: TAO_0474(haoA)
SVA: SVA_2722
RFR: Rfer_0059
NEU: NE0962(hao2) NE2044(hao1) NE2339(hao3)
HCE: HCW_02425
HCM: HCD_03625
CFZ: CSG_11900
CGRA: CGRAC_2027
CHYO: CHH_0728
HEBR: AEBR_2203
NAM: NAMH_1280
GME: Gmet_0142
GLO: Glov_1044
GBM: Gbem_3667
DEU: DBW_1324
DFL: DFE_0004
DBA: Dbac_0217
ADE: Adeh_1764
MSC: BN69_3242
SIL: SPOA0201
MAGQ: MGMAQ_1797
MGM: Mmc1_0550
MIN: Minf_2434(cccA)
MKC: kam1_2135
PLH: VT85_05655(hao1)
PBOR: BSF38_05477(hao1)
AGV: OJF2_56510(hao1)
KST: KSMBR1_1220(hdh) KSMBR1_1764(hao_1) KSMBR1_2163(hao_2) KSMBR1_2670(hao_3) KSMBR1_3040(hao_4) KSMBR1_3397(hao_5) KSMBR1_3422(hao_6) KSMBR1_3442(hao_7) KSMBR1_3792(hao_8)
ALUS: STSP2_00683(hao1)
IAL: IALB_0863
MRO: MROS_1112
NIO: NITINOP_0065(hao)
NJA: NSJP_2412
MOX: DAMO_2285 DAMO_2473(hao)
GAC: GACE_1826
GAH: GAH_00817
IHO: Igni_0955
 » show all
Reference
1  [PMID:5758552]
  Authors
Rees MK.
  Title
Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I. Purification of hydroxylamine oxidase.
  Journal
Biochemistry 7:353-66 (1968)
DOI:10.1021/bi00841a045
Reference
2  [PMID:497235]
  Authors
Hooper AB, Terry KR
  Title
Hydroxylamine oxidoreductase of Nitrosomonas. Production of nitric oxide from hydroxylamine.
  Journal
Biochim Biophys Acta 571:12-20 (1979)
DOI:10.1016/0005-2744(79)90220-1
Reference
3  [PMID:7117545]
  Authors
Hooper AB, Balny C.
  Title
Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics.
  Journal
FEBS Lett 144:299-303 (1982)
DOI:10.1016/0014-5793(82)80658-3
Reference
4  [PMID:6289867]
  Authors
Lipscomb JD, Hooper AB.
  Title
Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy.
  Journal
Biochemistry 21:3965-72 (1982)
DOI:10.1021/bi00260a010
Reference
5  [PMID:18650926]
  Authors
Poret-Peterson AT, Graham JE, Gulledge J, Klotz MG
  Title
Transcription of nitrification genes by the methane-oxidizing bacterium, Methylococcus capsulatus strain Bath.
  Journal
ISME J 2:1213-20 (2008)
DOI:10.1038/ismej.2008.71
Other DBs
ExplorEnz - The Enzyme Database: 1.7.2.6
IUBMB Enzyme Nomenclature: 1.7.2.6
ExPASy - ENZYME nomenclature database: 1.7.2.6
BRENDA, the Enzyme Database: 1.7.2.6
CAS: 9075-43-8

KEGG   REACTION: R10164
Entry
R10164                      Reaction                               

Name
hydroxylamine:ferricytochrome-c oxidoreductase
Definition
Hydroxylamine + H2O + 4 Ferricytochrome c <=> Nitrite + 4 Ferrocytochrome c + 5 H+
Equation
C00192 + C00001 + 4 C00125 <=> C00088 + 4 C00126 + 5 C00080
Reaction class
RC00016  C00125_C00126
RC00383  C00088_C00192
Enzyme
Pathway
rn00910  Nitrogen metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00528  Nitrification, ammonia => nitrite
M00804  Complete nitrification, comammox, ammonia => nitrite => nitrate
Orthology
K10535  hydroxylamine dehydrogenase [EC:1.7.2.6]
Other DBs
RHEA: 45035

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